296 completed, 101 unknown, 50 terminated, 33 recruiting. 208 Not applicable, 155 Phase 2, 74 Phase 3, 73 Phase 1, 60 Phase 4.
Follow Ascorbic Acid: new trials by email Literature Review of Ascorbic Acid trials Research Report on Ascorbic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Vitamin C and Hiprex in rUTI Methenamine Hippurate 1g BD, Methenamine Hippurate 1g BD + Vitamin C 1g BD - Urinary Tract Infections | Early Phase 1 | Not yet recruiting | University Hospitals of North Midlands NHS Trust | 20 | 2027-01-01 | 2026-02-11 |
| The Effectiveness of a Weight-dependent Algorithm for Dosing Vitamin D. Vitamin D3, Calcium, and Vitamin C - Hypovitaminosis D | Not applicable | Not yet recruiting | Atlantic Health System | 200 | 2027-01-01 | 2026-10-20 |
| Effect of Vitamin C Administration on Intraoperative Bleeding in Patients Undergoing Sinusoscopy Ascorbic acid, Placebo - Chronic Rhinosinusitis, Intraoperative Bleeding | Phase 2 | Not yet recruiting | Assiut University | 78 | 2026-11-01 | 2026-10-08 |
| Vitamin C With Steroids for Gastrointestinal GVHD Vitamin C (Ascorbic Acid) - Graft-versus-host-disease (GVHD), Gastrointestinal | Early Phase 1 | Not yet recruiting | Baylor College of Medicine | 35 | 2026-11-01 | 2026-10-13 |
| COMPARISON OF TOPICAL VITAMIN C VS NIACINAMIDE IN TREATMENT OF MELASMA Ascorbic acid, niacinamide - Melasma | Not applicable | Not yet recruiting | Pak Emirates Military Hospital | 100 | 2026-11-01 | 2026-10-22 |
| Injectable Platelet-Rich Fibrin and Microneedling With or Without Vitamin C for Gingival Phenotype Augmentation. Microneedling, Injectable Platelet-Rich Fibrin (i-PRF), Vitamin C - Thin Gingival Phenotype | Not applicable | Not yet recruiting | University of Science and Technology, Yemen | 27 | 2026-10-01 | 2026-10-06 |
| Rutin and Ascorbic Acid for Prevention of Vancomycin-Induced Nephrotoxicity in Adult Patients" - a Clinical Trial Protocol Evaluating Whether Combined Rutin/Vitamin C Supplementation Reduces Kidney Toxicity From Vancomycin, Compared to Vitamin C Alone and Control. Rutin + Ascorbic Acid (RUTA C60®), Ascorbic Acid (C-Retard®) - Nephrotoxicity, Acute Kidney Injuries | Not applicable | Enrolling by invitation | Ain Shams University | 120 | 2026-10-01 | 2026-10-14 |
| Dietary Supplements in Patients With Coronary Artery Bypass Grafting for Improving the Quality of Healthcare Delivery. Vitamin C, Omega 3 PUFA (EPO/DHA), Lignin, Lactulose - Cardio-pulmonary Bypass, Cardiovascular Diseases | Not applicable | Not yet recruiting | Nicosia General Hospital | 108 | 2026-09-01 | 2026-05-13 |
| NCT + PD1 + Ketogenic Diet and/or Vitamin C for LARC Short-Course Radiotherapy, PD-1 monoclonal antibody, mFOLFOX6 regimen - Rectal Adenocarcinoma, High-Risk Cancer | Phase 2 | Not yet recruiting | Sixth Affiliated Hospital, Sun Yat-sen University | 100 | 2026-09-01 | 2026-08-14 |
| Parenteral Ascorbic Acid Repletion in TransplantatIon Ascorbic acid, Placebo - Liver Transplant Failure and Rejection | Phase 4 | Withdrawn | University of Wisconsin, Madison | 2026-09-01 | 2026-09-18 | |
| Antidepressant Therapy for Improved Blood Vessel Health After Preeclampsia Paroxetine Hydrochloride, Ascorbic acid (Vitamin C) - Preeclampsia, Endothelial Function | Early Phase 1 | Recruiting | Anna Stanhewicz, PhD | 40 | 2026-08-11 | 2026-10-28 |
| Effect of Tocopherol and Ascorbic Acid on Neuroinflammation Markers Associated With Neuropeptide Expression in the AgRP/NPY and POMC Pathways in Mexican Population With Obesity Ascorbic acid (Vitamin C), tocopherol alpha, Ascorbic acid + tocopherol alpha - Obesity (BMI>30), Neuroinflammation | Not applicable | Not yet recruiting | Autonomous University of Morelos | 192 | 2026-08-10 | 2026-08-24 |
| A Study of CA201A Eye Drops to Prevent Corneal Endothelial Cell Loss in Patients Undergoing Cataract Surgery Ophthalmic solution (matching formulation without ascorbic acid), Ascorbic acid ophthalmic solution 5% - Corneal Endothelial Cell Loss, Corneal Endothelial Damage Following the Hard Nuclear Cataract Surgery | Phase 2 | Recruiting | Caravel Oculus Pty Ltd | 200 | 2026-07-28 | 2026-08-06 |
| High-Dose Vitamin C in G6PDA and Pyruvate Kinase Deficiency: A Safety Study Vitamin C - Pyruvate Kinase Deficiency, Glucose 6 Phosphate Dehydrogenase Deficiency | Phase 1 | Not yet recruiting | University of Utah | 3 | 2026-07-15 | 2026-05-28 |
| To Assess Dose Proportionality and Pharmacokinetic Linearity of Saninova Tablets in Healthy Participants Under Fasting Conditions Vitamin C, Vitamin B2, Astragalus Root dry extract etc - Bioavailability and Pharmacokinetics | Not applicable | Not yet recruiting | Sichuan Credit Pharmaceutical Co., Ltd. | 32 | 2026-06-01 | 2026-07-01 |
| Renoprotective Role of Vitamin C and Coenzyme Q10 in Nephrotoxicity Vitamin C, Coenzyme Q 10 - Nephrotoxicity | Phase 2 / Phase 3 | Not yet recruiting | Ain Shams University | 75 | 2026-04-20 | 2026-03-17 |
| Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled Trial Vitamin C, Standard of Care (SOC) - Acute-on-Chronic Liver Failure (ACLF) | Not applicable | Not yet recruiting | Institute of Liver and Biliary Sciences, India | 110 | 2026-04-01 | 2026-03-25 |
| High-dose Ascorbate (HDA) in Combination With Standard of Care Azacitidine and Venetoclax in Acute Myeloid Leukemia (AML) Azacitidine, Venetoclax, High-dose ascorbate - Acute Myeloid Leukemia | Phase 1 | Recruiting | Kittika Poonsombudlert | 30 | 2026-03-18 | 2026-08-31 |
| Ascorbate in Myelodysplastic Syndrome High-dose ascorbate, Azacitidine - Myelodysplastic Syndromes | Phase 2 | Suspended | Prajwal Dhakal | 38 | 2026-03-11 | 2026-10-09 |
| Effect of Co-enzyme Q10 and Vitamin C Alone or in Combination After a Surgical Gingival Depigmentation surgical depigmentation, Coenzyme Q10, Vitamin C - Depigmentation Treatment, Depigmentation | Not applicable | Recruiting | Al-Azhar University | 20 | 2026-03-02 | 2026-07-01 |
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Sepsis (33) · COVID-19 (32) · Shock, Septic (27) · Pancreatic Neoplasms (16) · Inflammation (15) · Cardiovascular Diseases (13) · Diabetes Mellitus, Type 2 (13) · Multiple Myeloma (13) · Anemia, Iron-Deficiency (12) · Neoplasms (12) · Myelodysplastic Syndromes (11) · Obesity (11) · Anemia (10) · Coronavirus Infections (10) · Diabetes Mellitus (9)
Cairo University (16) · Ain Shams University (10) · Virginia Commonwealth University (8) · Seoul National University Hospital (7) · University of Kansas Medical Center (6) · American University of Beirut Medical Center (5) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (5) · Swiss Federal Institute of Technology (5) · GlaxoSmithKline (4) · Joseph J. Cullen, MD, FACS (4) · Thomas Jefferson University (4) · Al-Azhar University (3) · Augusta University (3) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (3) · Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal (3)
United States (199) · Egypt (37) · China (33) · Canada (25) · South Korea (18) · Spain (18) · United Kingdom (14) · Mexico (11) · Italy (10) · Brazil (9) · Switzerland (9) · Greece (8) · India (8) · Indonesia (8) · Netherlands (8)
Jeanne Drisko, MD (3) · Sabine Hazan, MD (3) · Channing Paller, MD (2) · Daniel A Monti, MD (2) · Guopei Luo, MD (2) · In-Young Choi, PhD (2) · James R. Berenson, MD (2) · John M. Buatti, MD (2) · Joseph J Cullen, MD (2) · Joseph J Cullen, MD, FACS (2) · Joseph J. Cullen, MD, FACS (2) · Junwen Ou, PhD (2) · Mark A Levine, M.D. (2)
PMID 37916745, PMID 19237716, PMID 24484547, PMID 25386668, PMID 26212172, PMID 26903338, PMID 27940189, PMID 28282690, PMID 28291237, PMID 28366679, PMID 31573637, PMID 32809003, PMID 33620405, PMID 34473343, PMID 37877585, PMID 1, PMID 10488881, PMID 10636366, PMID 10722036, PMID 10924859, PMID 11005733, PMID 1138591, PMID 11445675, PMID 11502226, PMID 11573006, PMID 11689441, PMID 11696744, PMID 11730365, PMID 11859596, PMID 12454520, PMID 12473574, PMID 12545007, PMID 12697586, PMID 12700374, PMID 14502051, PMID 14605526, PMID 14665353, PMID 14671251, PMID 15111369, PMID 15179561, PMID 15365964, PMID 15557412, PMID 15635556, PMID 15724034, PMID 15829878, PMID 16029672, PMID 16078959, PMID 1607900, PMID 16570523, PMID 16953900
P30CA086862 (5), U01CA140206 (3), 2014 (2), 2015 (2), P01CA217797 (2), P30CA036727 (2), 1UM1HL116885-01 (1), 2005 (1), 2008 (1), 2009 (1), 2016 (1), 2018 (1), 2023 (1), K23HL080231 (1), N01HV68165 (1)