Central Nervous System Neoplasms: Clinical Trials

1521 completed, 539 recruiting, 409 unknown, 396 terminated. 1105 Phase 2, 866 Phase 1, 695 Not applicable, 205 Phase 3, 88 Early Phase 1.

By phase and status

Phase	Trials	Status
Phase 2	1105	Completed 515, Terminated 160, Recruiting 142, Unknown 119, Active not recruiting 79, Withdrawn 54, Not yet recruiting 29, Suspended 7
Phase 1	866	Completed 450, Terminated 132, Recruiting 109, Active not recruiting 71, Withdrawn 42, Unknown 36, Not yet recruiting 19, Suspended 7
Not applicable	695	Completed 249, Recruiting 156, Unknown 105, Terminated 56, Not yet recruiting 41, Active not recruiting 39, Withdrawn 35, Suspended 8, Enrolling by invitation 6
Phase 3	205	Completed 96, Unknown 36, Recruiting 23, Terminated 19, Active not recruiting 18, Not yet recruiting 8, Withdrawn 5
Early Phase 1	88	Completed 31, Terminated 17, Recruiting 16, Active not recruiting 7, Not yet recruiting 7, Withdrawn 6, Unknown 3, Enrolling by invitation 1
Phase 4	63	Completed 31, Unknown 14, Recruiting 9, Terminated 4, Active not recruiting 2, Enrolling by invitation 2, Withdrawn 1

Follow this condition Literature Review of Central Nervous System Neoplasms trials Research Report on Central Nervous System Neoplasms

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
A Study Using Brain Stimulation and Behavioral Therapy to Increase Extent of Resection in Low-Grade Gliomas RNS System Implantation - Glioma, Glioma Intracranial	Not applicable	Not yet recruiting	Medical College of Wisconsin	3	2028-08-01	2026-10-13
Phase 1/2 Study Evaluating the Safety, PK/PD, and Clinical Activity of Oral JBI-778 in Patients With Brain Metastases, Leptomeningeal Disease, or Recurrent High Grade Glioma JBI-778 - Brain Metastases From Solid Tumors, Leptomeningeal Disease	Phase 1 / Phase 2	Not yet recruiting	Jubilant Therapeutics Inc.	113	2028-04-01	2026-08-07
A Multicenter Study to Assess the Feasibility of 5-Aminolevulinic Acid (5-ALA) in Pediatric Brain Tumor Patients Aminolevulinic acid hydrochloride - Pediatric Brain Tumor	Phase 2	Not yet recruiting	Costas Hadjipanayis	20	2027-08-01	2026-10-07
H3K27M-specific Immune Effector Cells Targeting DMG/DIPG H3K27M-EIEs - Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma	Phase 1 / Phase 2	Not yet recruiting	Shenzhen Geno-Immune Medical Institute	30	2027-06-30	2026-08-27
Use of Shear Wave Elastography for Intraoperative Brain and Tumor Stiffness Measurements Non-Interventional Study - Brain Tumor, Recurrent Brain Tumor		Not yet recruiting	Mayo Clinic	30	2027-06-01	2026-09-16
Study of Relatlimab and Nivolumab (Opdualag) in Replication Repair Deficient HGG and DIPG Opdualag - High Grade Glioma, Diffuse Intrinsic Pontine Glioma	Phase 2	Not yet recruiting	Nationwide Children's Hospital	12	2027-03-01	2026-09-09
Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG) Tovorafenib - High Grade Glioma (HGG) of the Brain With BRAF Aberration, High Grade Glioma (III or IV)	Phase 2	Not yet recruiting	Nationwide Children's Hospital	79	2027-02-01	2026-10-20
Trastuzumab Deruxtecan + Stereotactic Radiosurgery (SRS) in HER2+ Breast Cancer Brain Metastases Trastuzumab Deruxtecan, Stereotactic Radiosurgery - Breast Cancer, HER2-positive Breast Cancer	Phase 1	Not yet recruiting	Baptist Health South Florida	20	2027-01-01	2026-10-01
Listen Aphasia Pilot Study LISTEN (AI-based AAC smartphone app) - Aphasia, Malignant Brain Tumor	Not applicable	Not yet recruiting	Dana-Farber Cancer Institute	80	2027-01-01	2026-07-28
A Prospective Study of the Safety and Efficacy of 3D-printed Non-rigid Biomimetic Implant in Cervical and Thoracolumbar Spine 3D-printed custom-made non-rigid biomimetic implant - Spinal Tumor	Not applicable	Not yet recruiting	National Taiwan University Hospital	18	2027-01-01	2025-12-17
ctDNA-Guided Intraventricular Therapy for CNS Malignancies CSF ctDNA-Guided Clinical Management - Leptomeningeal Disease, Glioblastoma	Not applicable	Not yet recruiting	Alireza Mansouri	77	2027-01-01	2026-07-08
Immune Modulatory DC Vaccine Against Brain Tumor Immunomodulatory DC vaccine to target DIPG and GBM - Diffuse Intrinsic Pontine Glioma or Glioblastoma	Phase 1	Not yet recruiting	Shenzhen Geno-Immune Medical Institute	10	2026-12-31	2026-08-26
Evaluating Biomarkers of Cognitive Dysfunction in Patients With Cancer Blood sample, Brain magnetic resonance imaging (MRI), Brain Health Assessment - Brain Tumor Adult, Brain Metastases From Solid Tumors		Not yet recruiting	University of California, San Francisco	40	2026-12-15	2026-10-15
Effectiveness of a Visual Telerehabilitation Program on Visual Perception in Children, Adolescents and Young Adults With Hemianopsia Consecutive to a Brain Tumour Visual Stimulation, standard of care - Hemianopsia, Virtual Reality	Not applicable	Not yet recruiting	Institut National de la Santé Et de la Recherche Médicale, France	120	2026-12-01	2026-09-16
IMPT Versus IMRT for Diffuse Intrinsic Pontine Glioma Intensity-Modulated Proton Therapy (IMPT), Intensity-Modulated Radiation Therapy (IMRT) - Diffuse Intrinsic Pontine Gliomas (DIPG)	Phase 3	Not yet recruiting	Shandong Cancer Hospital and Institute	142	2026-12-01	2026-10-09
Perimetry Based on Eye-movements in Patients With (Supra)Sellar Tumors SONDA - Pituitary Tumor, Visual Fields Hemianopsia		Not yet recruiting	University Medical Center Groningen	30	2026-12-01	2026-07-23
A Study of ONC201 for Refractory Meningioma ONC201 - Meningioma, Refractory Meningioma	Phase 2	Withdrawn	University of Nebraska		2026-12-01	2026-01-26
Targeted LSAM-Cisplatin Infusion in Gliomas, Evaluation of Response LSAM-Cisplatin - Diffuse Midline Glioma (DMG), Diffuse Intrinsic Pontine Glioma (DIPG)	Phase 1 / Phase 2	Not yet recruiting	NanOlogy, LLC	20	2026-12-01	2026-08-18
Panitumumab-IRDye800 to Detect Pediatric Neoplasms During Neurosurgical Procedures Panitumumab-IRDye800, Pinpoint-IR9000 endoscopic/handheld device, Explorer Air camera - Brain Tumor	Phase 1 / Phase 2	Recruiting	Stanford University	12	2026-12-01	2026-09-29
OLIG2 Inhibitor CT-179 for Recurrent and Newly-diagnosed Glioblastoma CT-179 - Recurrent Glioblastoma, Newly Diagnosed MGMT Unmethylated Glioblastoma	Phase 1	Not yet recruiting	Olivia Newton-John Cancer Research Institute	54	2026-12-01	2026-07-31

Showing 20 of 3414. Sign in to see all of them.

Narrower conditions

Brain Neoplasms (2363)  ·  Glioblastoma (729)  ·  Glioma (595)  ·  Astrocytoma (442)  ·  Gliosarcoma (364)  ·  Oligodendroglioma (306)  ·  Neoplasms (251)  ·  Meningioma (239)  ·  Breast Neoplasms (219)  ·  Medulloblastoma (204)  ·  Carcinoma, Non-Small-Cell Lung (192)  ·  Pituitary Neoplasms (192)  ·  Neoplasm Metastasis (170)  ·  Ependymoma (167)

Broader conditions

Nervous System Diseases (3402)  ·  Nervous System Neoplasms (3402)  ·  Neoplasms by Site (3401)  ·  Neoplasms (3163)  ·  Central Nervous System Diseases (2816)  ·  Brain Diseases (2735)  ·  Neoplasms by Histologic Type (1705)  ·  Neoplasms, Nerve Tissue (1544)  ·  Neuroectodermal Tumors (1419)  ·  Neoplasms, Germ Cell and Embryonal (1413)  ·  Neoplasms, Glandular and Epithelial (1355)  ·  Neoplasms, Neuroepithelial (1260)  ·  Glioma (631)  ·  Pathological Conditions, Signs and Symptoms (498)

Interventions

Temozolomide (255)  ·  Radiotherapy (224)  ·  Radiosurgery (145)  ·  Bevacizumab (126)  ·  Magnetic Resonance Spectroscopy (113)  ·  Carboplatin (88)  ·  Cyclophosphamide (64)  ·  Etoposide (61)  ·  Vincristine (55)  ·  Filgrastim (54)  ·  Cisplatin (53)  ·  Irinotecan (53)  ·  Nivolumab (47)  ·  Radiation (45)  ·  Surgical Procedures, Operative (45)

Sponsors

National Cancer Institute (NCI) (193)  ·  M.D. Anderson Cancer Center (113)  ·  Duke University (78)  ·  Memorial Sloan Kettering Cancer Center (72)  ·  Children's Oncology Group (49)  ·  Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (48)  ·  Mayo Clinic (43)  ·  St. Jude Children's Research Hospital (43)  ·  Case Comprehensive Cancer Center (33)  ·  Massachusetts General Hospital (33)  ·  European Organisation for Research and Treatment of Cancer - EORTC (30)  ·  City of Hope Medical Center (28)  ·  Jonsson Comprehensive Cancer Center (28)  ·  Dana-Farber Cancer Institute (26)  ·  Beijing Tiantan Hospital (24)

Countries

United States (1984)  ·  China (286)  ·  Canada (269)  ·  France (252)  ·  Germany (160)  ·  Italy (145)  ·  United Kingdom (142)  ·  Netherlands (124)  ·  Australia (110)  ·  Switzerland (104)  ·  Spain (103)  ·  Belgium (82)  ·  South Korea (76)  ·  Taiwan (65)  ·  Austria (56)

Top investigators

Henry S. Friedman, MD (19)  ·  Stuart A. Grossman, MD (13)  ·  David A. Reardon, MD (11)  ·  John Boockvar, MD (10)  ·  Maryam Fouladi, MD (10)  ·  Amar Gajjar, MD (9)  ·  Jeffrey J. Raizer, MD (9)  ·  Darell D. Bigner, MD, PhD (8)  ·  Katherine E Warren, M.D. (8)  ·  Roger Stupp, MD (8)  ·  David Peereboom, MD (7)  ·  Edward G. Shaw, MD (7)  ·  Jonathan L. Finlay, MB, ChB (7)

Results publications

PMID 34081125, PMID 31401903, PMID 19801201, PMID 16757720, PMID 23545055, PMID 25349290, PMID 27243238, PMID 27458945, PMID 30118397, PMID 31809241, PMID 41213248, PMID 14722039, PMID 15117425, PMID 15758009, PMID 16200343, PMID 16648043, PMID 17705175, PMID 19556464, PMID 20694800, PMID 21041710, PMID 21584645, PMID 21865400, PMID 23243055, PMID 23377664, PMID 23956241, PMID 25098701, PMID 25113840, PMID 25209242, PMID 25303679, PMID 25614945, PMID 25789053, PMID 26148750, PMID 26334749, PMID 26827696, PMID 27488294, PMID 27744512, PMID 28039367, PMID 28592387, PMID 28640703, PMID 29077941, PMID 29122701, PMID 29151359, PMID 29343557, PMID 29982805, PMID 30059262, PMID 30670498, PMID 31062234, PMID 31587882, PMID 31838007, PMID 32058845

NIH funding

2023 (17), P30CA033572 (17), U01CA062475 (17), U01CA081457 (16), U10CA180886 (14), P30CA043703 (12), 2015 (11), P30CA138292 (11), UM1CA097452 (11), 2014 (10), P30CA006973 (10), U01CA062399 (10), U01CA137443 (10), U10CA098543 (10), UM1CA081457 (10)