322 terminated. 322 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 322 | Terminated 322 |
Follow Nervous System Diseases: new trials by email Literature Review of Nervous System Diseases trials Research Report on Nervous System Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Perampanel in the Treatment of Refractory Status Epilepticus Perampanel - Refractory Status Epilepticus | Phase 4 | Terminated | Wayne State University | 1 | 2025-10-10 | 2025-10-14 |
| Acute Migraine Treatment in the ED With Gepants Rimegepant, Zavegepant - Migraine Headaches | Phase 4 | Terminated | Icahn School of Medicine at Mount Sinai | 9 | 2025-06-05 | 2026-04-29 |
| Double-blind Randomized Controlled Trial Comparing Suvorexant 20 mg to Placebo for Treatment of Insomnia in Cancer Survivors Suvorexant Tablets, Placebo Control - Breast Cancer, Insomnia | Phase 4 | Terminated | Medical University of South Carolina | 6 | 2024-09-20 | 2026-08-12 |
| Search to Advance Limited Use of Opioids Pilot: Optimization of Non-Opioid Therapy With a Steroid Dexamethasone 8mg, Placebo - Pain Management | Phase 4 | Terminated | Rutgers, The State University of New Jersey | 8 | 2023-11-27 | 2025-06-04 |
| Antiseizure Medication in Seizure Networks at Early Acute Brain Injury Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product - Brain Injuries, Acute, Brain Injuries, Traumatic | Phase 4 | Terminated | University of North Carolina, Chapel Hill | 5 | 2023-11-20 | 2025-11-14 |
| Contributions to Hypertension With Androgen Deprivation Therapy Gonadotropin Releasing Hormone Agonists (GNRH), Androgen receptor (AR) inhibitor, Placebo - Androgen Deprivation Therapy, Prostate Cancer | Phase 4 | Terminated | University of Colorado, Denver | 10 | 2023-09-20 | 2026-09-02 |
| Impact of Maxigesic on Delirium After Minimally Invasive Lung Surgery in Elderly Patients Acetaminophen and Ibuprofen, Normal saline - Delirium, Aged | Phase 4 | Terminated | Korea University Guro Hospital | 25 | 2023-06-15 | 2025-09-05 |
| Evolution of Post-Stroke Shoulder Pain With a Capsular Pattern With Physiotherapy Alone Versus Coupled With Mild Arthrographic Distension With Cortisone Physiotherapy alone, Glenohumeral injection of 40mg (1cc) of Triamcinolone and 7cc of 0.5% Bupivacaine coupled with physiotherapy - Shoulder Pain | Phase 4 | Terminated | Claire Bourgeois | 50 | 2023-05-21 | 2026-03-25 |
| A Study of Intrathecal Hydromorphone for Pediatric Idiopathic Scoliosis Repair Hydromorphone 2.5 mcg/kg, Hydromorphone 2.75 mcg/kg, Hydromorphone 3 mcg/kg - Pain Control | Phase 4 | Terminated | Mayo Clinic | 31 | 2023-03-23 | 2026-05-14 |
| Oral Statins and Protection From Hearing Loss Statin, methylprednisolone, dexamethasone - Sudden Sensorineural Hearing Loss | Phase 4 | Terminated | Northwestern University | 3 | 2023-02-09 | 2026-10-29 |
| Multidimensional Integrated Assessment to Test the Efficacy and Response to Ozanimod in Multiple Sclerosis. Ozanimod Oral Capsule - Multiple Sclerosis | Phase 4 | Terminated | I.R.C.C.S. Fondazione Santa Lucia | 30 | 2023-01-31 | 2025-01-15 |
| A Study to Investigate the Radiological Onset of Action After Treatment Initiation With Subcutaneous (SC) Natalizumab in Participants With Relapsing-Remitting Multiple Sclerosis (RRMS) Natalizumab - Multiple Sclerosis, Relapsing-Remitting | Phase 4 | Terminated | Biogen | 1 | 2023-01-23 | 2024-06-21 |
| Comparing Local Anesthesia With and Without iPACK Block Real iPACK block (20 mL of 0.25% bupivacaine, 2.5mcg/mL epinephrine, and 50mcg/mL preservative-free dexamethasone), Sham iPACK block with 20ml normal saline - Osteo Arthritis Knee, Analgesia | Phase 4 | Terminated | University of Calgary | 10 | 2022-10-30 | 2026-06-01 |
| Tandem OnabotulinumtoxinA Galcanezumab Emerging Therapeutic Headache Elimination Research Study Galcanezumab, Placebo - Migraine | Phase 4 | Terminated | Diamond Headache Clinic | 2 | 2022-10-01 | 2023-09-29 |
| Natalizumab and Chronic Inflammation Natalizumab 300 MG in 15 ML Injection - Multiple Sclerosis | Phase 4 | Terminated | Vanderbilt University Medical Center | 1 | 2022-09-16 | 2024-04-18 |
| Erector Spinae Block for Spine Surgery Liposomal bupivacaine, Bupivacaine - Lumbar Radiculopathy | Phase 4 | Terminated | Icahn School of Medicine at Mount Sinai | 13 | 2022-08-31 | 2024-05-29 |
| ITM vs QL for Pediatric Open Lower Abdominal Procedures Intrathecal Morphine, Quadratus lumborum block - Pain Control, Ureteral Reimplantation | Phase 4 | Terminated | Medical University of South Carolina | 14 | 2022-08-17 | 2025-04-15 |
| A Study In Neuromyelitis Optica Spectrum Disorder (NMOSD) With Satralizumab As An Intervention Satralizumab 120 mg - Neuromyelitis Optica Spectrum Disorder, NMOSD | Phase 4 | Terminated | Hoffmann-La Roche | 4 | 2022-08-02 | 2025-01-22 |
| Evaluation of the Efficacy of Almotriptan and Ubrogepant for the Acute Treatment of Migraine Almotriptan 12.5 Mg Oral Tablet, Ubrogepant 50Mg Tab - Migraine With Aura, Migraine Without Aura | Phase 4 | Terminated | Messoud Ashina, MD | 8 | 2022-06-30 | 2025-05-31 |
| CBT-I Augmentation of Medication for Drinking in AUD Cognitive Behavioral Therapy for Insomnia, Sleep Hygiene Education - Alcohol Use Disorder With Insomnia | Phase 4 | Terminated | VA Office of Research and Development | 82 | 2022-06-15 | 2025-02-28 |
Showing 20 of 322. Sign in to see all of them.
Agnosia (38) · Multiple Sclerosis (25) · Pain (25) · Stroke (19) · Parkinson Disease (17) · Sleep Apnea, Obstructive (14) · Delirium (13) · Multiple Sclerosis, Relapsing-Remitting (13) · Epilepsy (12) · Migraine Disorders (12) · Sleep Initiation and Maintenance Disorders (12) · Seizures (10) · Sleep Wake Disorders (9) · Alzheimer Disease (8) · Brain Injuries, Traumatic (8)
Pathological Conditions, Signs and Symptoms (164) · Central Nervous System Diseases (141) · Signs and Symptoms (141) · Brain Diseases (133) · Neurologic Manifestations (133) · Neurobehavioral Manifestations (68) · Mental Disorders (66) · Cardiovascular Diseases (50) · Pathologic Processes (48) · Vascular Diseases (48) · Immune System Diseases (43) · Perceptual Disorders (41) · Cerebrovascular Disorders (38) · Autoimmune Diseases (36)
Acetaminophen (11) · Saline Solution (11) · Dexmedetomidine (8) · Bupivacaine (7) · Fentanyl (7) · Ibuprofen (7) · Morphine (7) · Sodium Chloride (7) · Sugars (7) · Dexamethasone (6) · Pregabalin (6) · Botulinum Toxins, Type A (5) · Donepezil (5) · Ketamine (5) · Adrenocorticotropic Hormone (4)
Novartis Pharmaceuticals (6) · VA Office of Research and Development (6) · Biogen (5) · Pfizer (5) · University of Chicago (5) · Cedars-Sinai Medical Center (4) · Emory University (4) · Genzyme, a Sanofi Company (4) · Icahn School of Medicine at Mount Sinai (4) · University of Sao Paulo (4) · Weill Medical College of Cornell University (4) · Columbia University (3) · Cyberonics, Inc. (3) · Duke University (3) · Fondation Ophtalmologique Adolphe de Rothschild (3)
United States (197) · Germany (22) · France (19) · Canada (15) · Netherlands (11) · Switzerland (11) · United Kingdom (11) · Italy (10) · Spain (8) · Sweden (8) · Australia (6) · Belgium (6) · Brazil (6) · Denmark (6) · Israel (6)
Claudio Gobbi, MD (2) · Dong-Xin Wang, MD, PhD (2) · Edmund Volkerts, PhD (2) · Messoud Ashina, Prof. (2) · Roger K Cady, MD (2) · Roya Yumul, MD, PhD (2) · Roya Yumul, MD., PhD (2) · Aaron A Cohen, MD, MSc (1)
PMID 33238043, PMID 1015603, PMID 11331167, PMID 11331334, PMID 11374619, PMID 11472277, PMID 12411815, PMID 12548273, PMID 12560416, PMID 14622770, PMID 15269315, PMID 15683149, PMID 16691088, PMID 17138203, PMID 17413915, PMID 18172212, PMID 18647805, PMID 18686750, PMID 18760148, PMID 18762870, PMID 18996225, PMID 19157368, PMID 19174373, PMID 19690943, PMID 20592293, PMID 20663131, PMID 20802298, PMID 20959867, PMID 21056464, PMID 21070885, PMID 21111490, PMID 21123449, PMID 21697501, PMID 21712481, PMID 22506940, PMID 22523379, PMID 22913568, PMID 23019248, PMID 23292288, PMID 23490405, PMID 23514019, PMID 23569691, PMID 23767916, PMID 23788067, PMID 23878064, PMID 23989301, PMID 24105303, PMID 24733354, PMID 24754318, PMID 2589650
2018 (3), 2015 (2), 2016 (2), K23MH067710 (2), R01NS057594 (2), 2005 (1), 2008 (1), 2009 (1), 2014 (1), 2017 (1), I01CX001957 (1), I21RX002180 (1), K23AG044441 (1), R01DA036564 (1), R01DK110771 (1)