18 completed, 3 terminated, 1 suspended, 1 unknown. 7 Not applicable, 4 Phase 4, 1 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 7 | Completed 6, Unknown 1 |
| Phase 4 | 4 | Terminated 3, Completed 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 2 | 1 | Completed 1 |
Follow Cyberonics, Inc.: new trials by email
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| VITARIA Registry Study VITARIA System - Congestive Heart Failure | Suspended | Cyberonics, Inc. | 200 | 2015-08-01 | 2017-01-31 | |
| Vagus Nerve Stimulation Titration Protocol to Improve Tolerance and Accelerate Adaptation Vagus Nerve Stimulation Therapy - Epilepsy, Seizures | Completed | Cyberonics, Inc. | 67 | 2015-04-28 | 2018-07-23 | |
| Autonomic Regulation Therapy in Heart Failure With Preserved Ejection Fraction Vagus Nerve Stimulation (VNS) - Congestive Heart Failure | Not applicable | Completed | Cyberonics, Inc. | 52 | 2014-08-01 | 2023-05-06 |
| VNS Therapy Automatic Magnet Mode Outcomes Study in Epilepsy Patients Exhibiting Ictal Tachycardia (E-37) M106 VNS Therapy System - Epilepsy | Not applicable | Completed | Cyberonics, Inc. | 20 | 2013-07-01 | 2015-11-24 |
| Autonomic Neural Regulation Therapy to Enhance Myocardial Function in Heart Failure (ANTHEM-HF) Study Vagus Nerve Stimulation (VNS) - Congestive Heart Failure | Phase 1 / Phase 2 | Completed | Cyberonics, Inc. | 60 | 2012-07-01 | 2015-02-19 |
| Study to Evaluate a New Device Designed to Collect Heart Activity and Body Movement Data ProGuardian - Epilepsy | Not applicable | Completed | Cyberonics, Inc. | 147 | 2012-06-01 | 2020-08-05 |
| 3-Dimensional Accelerometer Sub-Study Accelerometer Device - Epilepsy | Not applicable | Completed | Cyberonics, Inc. | 16 | 2012-05-01 | 2014-08-07 |
| ECG Vector Determination Epilepsy | Completed | Cyberonics, Inc. | 29 | 2011-11-01 | 2012-08-21 | |
| Physiological and Biomechanical Data Collection Study in Epilepsy Subjects Epilepsy | Completed | Cyberonics, Inc. | 20 | 2011-11-01 | 2012-08-21 | |
| Seizure Detection and Automatic Magnet Mode Performance Study Model 106 VNS Therapy System - Epilepsy | Not applicable | Completed | Cyberonics, Inc. | 31 | 2011-03-01 | 2016-01-22 |
| PuLsE 2-Observational Long-Term Effectiveness Follow-Up Study of PuLsE 1 Epilepsy | Completed | Cyberonics, Inc. | 81 | 2011-03-01 | 2014-10-16 | |
| Vagus Nerve Stimulation Clinical Outcomes Measured Prospectively in Patients Stimulated Epilepsy | Completed | Cyberonics, Inc. | 124 | 2011-01-01 | 2019-09-23 | |
| Heartbeat Sensitivity Calibration Using the ECG Accessory ECG Comparisons in Normal Healthy Subject | Completed | Cyberonics, Inc. | 1 | 2010-12-01 | 2011-01-24 | |
| Heart Rate Changes During Normal Activity, Exercise, and Seizures in Subjects With Epilepsy Exercise - Epilepsy | Completed | Cyberonics, Inc. | 30 | 2010-09-01 | 2012-03-15 | |
| Heart Rate Changes During Normal Activity, Exercise, and Sleep in Normal Healthy Subjects With and Without Epilepsy Healthy, Exercise | Completed | Cyberonics, Inc. | 50 | 2010-09-01 | 2011-01-24 | |
| Heart Rate Changes in Subjects With Epilepsy No intervention planned, observational study only. - Epilepsy | Completed | Cyberonics, Inc. | 98 | 2010-08-01 | 2014-08-07 | |
| Transcranial Direct Current Stimulation (tDCS) As A Tool For Prospective Responder Identification Before Vagus Nerve Stimulation (VNS) Implantation transcranial direct current stimulation - Epilepsy | Not applicable | Unknown | University of Luebeck | 70 | 2007-09-01 | 2010-01-28 |
| Study Comparing Best Medical Practice With or Without VNS Therapy in Pharmacoresistant Partial Epilepsy Patients Vagal Nerve Simulation (VNS) Therapy, Best Medical Practive - Epilepsy, Partial Epilepsy | Phase 4 | Terminated | Cyberonics, Inc. | 122 | 2006-02-01 | 2015-01-26 |
| Treatment-Resistant Depression Registry Major Depressive Disorder | Completed | Cyberonics, Inc. | 795 | 2006-01-01 | 2015-12-23 | |
| Study Comparing Outcomes for Patients With Treatment Resistant Depression Who Receive VNS Therapy at Different Doses VNS Therapy - Depression | Phase 4 | Completed | Cyberonics, Inc. | 331 | 2006-01-01 | 2014-01-07 |
Showing 20 of 23. Sign in to see all of them.
Epilepsy (14) · Heart Failure (3) · Depression (2) · Depressive Disorder, Major (2) · Epilepsies, Partial (2) · Seizures (2) · Bipolar Disorder (1) · Depressive Disorder, Treatment-Resistant (1) · Motor Activity (1)
Vagus Nerve Stimulation (4) · Therapeutics (2) · Anticonvulsants (1) · Exercise (1) · Transcranial Direct Current Stimulation (1)
United States (15) · Germany (7) · Belgium (5) · United Kingdom (5) · Netherlands (3) · Canada (2) · France (2) · India (2) · Italy (2) · Norway (2) · Sweden (2) · Austria (1) · Israel (1) · Spain (1)
Bryan Olin (3) · Bryan Olin, Ph.D (2) · Douglas Denham, DO (2) · Jason Begnaud (2) · Mark Bunker, PharmD (2) · Adam K. Ashton, MD (1) · Ananda Pandurangi, MD (1) · Anne Gilbert, MD (1) · Anthony D'Agostino, MD (1) · Anthony Rothschild, MD (1) · Arnold Mech, MD (1) · Arthur Holt, MD (1) · Azfar Malik, MD (1) · Basanti Basu, M.D. (1) · Carol C Base, RN, MS (1)
PMID 16139580, PMID 16139581, PMID 16139582, PMID 18571625, PMID 18786301, PMID 23122916, PMID 24754318, PMID 25187002, PMID 26552564, PMID 26601770, PMID 27221316, PMID 27450311, PMID 28359201, PMID 32358769, PMID 33590355, PMID 35360224, PMID 36934987, PMID 37429122