Epilepsy: Clinical Trials

1174 completed, 324 unknown, 312 recruiting, 180 terminated. 701 Not applicable, 349 Phase 3, 293 Phase 2, 184 Phase 1, 159 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	701	Completed 281, Unknown 131, Recruiting 130, Not yet recruiting 41, Terminated 36, Withdrawn 31, Active not recruiting 29, Enrolling by invitation 22
Phase 3	349	Completed 229, Terminated 51, Recruiting 24, Unknown 15, Withdrawn 14, Active not recruiting 10, Enrolling by invitation 3, Suspended 3
Phase 2	293	Completed 165, Terminated 40, Recruiting 27, Unknown 26, Active not recruiting 13, Withdrawn 11, Not yet recruiting 6, Enrolling by invitation 3, Suspended 2
Phase 1	184	Completed 133, Recruiting 12, Terminated 10, Unknown 10, Active not recruiting 9, Not yet recruiting 5, Withdrawn 3, Enrolling by invitation 1, Suspended 1
Phase 4	159	Completed 92, Unknown 26, Terminated 17, Recruiting 10, Withdrawn 6, Not yet recruiting 4, Active not recruiting 3, Enrolling by invitation 1
Early Phase 1	25	Recruiting 9, Not yet recruiting 5, Unknown 5, Completed 3, Terminated 3

Follow Epilepsy: new trials by email Literature Review of Epilepsy trials Research Report on Epilepsy

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
High-Intensity Focused Ultrasonic Ablation of the Centromedian Thalamic Nucleus for Treatment of Medically Refractory Generalized Epilepsy in Patients Ages 18 Years to 89 Years Intervention 1, Intervention 2 - Idiopathic Generalized Epilepsy	Not applicable	Not yet recruiting	Oregon Health and Science University	10	2027-02-01	2026-10-28
Sleep-Driven Adaptive Neuromodulation in Lennox-Gastaut Syndrome Personalized Adaptive Deep Brain Stimulation Therapy, Conventional Non-Personalized Deep Brain Stimulation Therapy - Lennox Gastaut Syndrome (LGS), Epilepsy	Not applicable	Not yet recruiting	University of Minnesota	4	2027-01-01	2026-10-07
CEST-based Biomarkers to Delineate the Epileptogenic Zone CEST sequence on a 7-Tesla MRI - Epilepsy (Treatment Refractory)	Not applicable	Not yet recruiting	Fondation Ophtalmologique Adolphe de Rothschild	20	2027-01-01	2026-10-01
A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to Epidiolex Epidiolex 100 mg/mL Oral Solution - Dravet Syndrome (DS), Lennox-Gastaut Syndrome (LGS)	Phase 4	Not yet recruiting	Elizabeth Donner	25	2027-01-01	2026-09-11
Cholinergic Enhancement of Theta COBENFY KarXT (50/20 mg), Control - Epilepsy, Seizures	Early Phase 1	Not yet recruiting	University of Texas Southwestern Medical Center	50	2026-12-01	2026-09-29
Accelerated iTBS for Depression and Suicidality Accelerated Intermittent Theta Burst (aiTBS), Electroconvulsive therapy (ECT) - Major Depressive Disorder, Suicide	Not applicable	Not yet recruiting	University of Iowa	50	2026-12-01	2025-05-20
Electrophysiologic Mechanisms of Ketamine Antidepressant Response Ketamine - Epilepsy, Depressive Symptoms	Phase 2	Not yet recruiting	Emory University	37	2026-12-01	2026-08-17
Epileptiform Potential of Fully Immersive Virtual Reality Virtual Reality Headset, display off, Virtual Reality Headset, Display only, Virtual Reality Headset, Display and Hand Control - Epilepsy, Seizure	Not applicable	Not yet recruiting	Dartmouth-Hitchcock Medical Center	40	2026-12-01	2026-08-27
A Study to Investigate the Effect of Gradual Titration to Optimize Cannabidiol Treatment in Adults With LGS Cannabidiol Oral Solution - Lennox-Gastaut Syndrome	Phase 4	Not yet recruiting	Jazz Pharmaceuticals	40	2026-11-18	2026-10-22
Health Literacy Project Health Literacy Educational Session- Comparator, Health Literacy Educational Session - Epilepsy	Not applicable	Not yet recruiting	Duke University	60	2026-11-01	2026-09-09
Self-management for Youth With Epilepsy Pilot SMART-Y - Epilepsy	Not applicable	Not yet recruiting	University Hospitals Cleveland Medical Center	18	2026-11-01	2026-10-15
Acute Stimulation and Modulation of Stereotyped High-Frequency Oscillations Brain Interchange System - Epilepsy	Not applicable	Not yet recruiting	Mayo Clinic	8	2026-11-01	2026-08-11
Peri-procedural Weighted Blanket Use for ECT Weighted blanket, Usual Care Group - Post-ect Agitation, Post-ictal Agitation	Not applicable	Not yet recruiting	Mayo Clinic	200	2026-11-01	2026-10-28
Biomarker Targeted Stimulation for Epileptiform Events Biomarker Targeted Stimulation (BTS) - Epilepsy	Not applicable	Not yet recruiting	Cadence Neuroscience	40	2026-11-01	2026-10-27
EASEE® System Pivotal Study for the United States of America Implantable minimaly invasive brain stimulator - Drug-Resistant Focal Epilepsy	Not applicable	Not yet recruiting	Precisis US, Inc.	200	2026-10-31	2026-08-28
Antiseizure Medications and CBC in Children With Epilepsy Epilepsy		Not yet recruiting	Assiut University	80	2026-10-20	2026-10-20
Translational Recording and Characterization of Epilepsy Signals Using Subgaleal EEG During Standard-of-care SEEG Monitoring EEG Record only - Epilepsy (Treatment Refractory)	Early Phase 1	Not yet recruiting	Adraxe Corp.	15	2026-10-15	2026-09-16
Studying Heart Rhythms With a Wearable Sensor to Detect and Predict Seizures in People With Epilepsy Textile-based wearable electrocardiography - Epilepsy, Temporal Lobe, Drug Resistant Epilepsy		Not yet recruiting	Acibadem University	40	2026-10-15	2026-09-23
Overnight TI in TLE Non-invasive Temporal Interference (TI) Stimulation Targeting Bilateral Hippocampi - Temporal Lobe Epilepsy (TLE), Drug Resistant Epilepsy	Not applicable	Recruiting	Duke University	20	2026-10-15	2026-10-16
Impact of Epilepsy on Motor Function, Fatigue, and Quality of Life Functional and Quality of Life Assessments - Epilepsy		Not yet recruiting	Borna Farhoomand	40	2026-10-01	2026-10-02

Showing 20 of 2305. Sign in to see all of them.

Narrower conditions

Seizures (456)  ·  Drug Resistant Epilepsy (246)  ·  Epilepsies, Partial (238)  ·  Epilepsies, Myoclonic (92)  ·  Lennox Gastaut Syndrome (68)  ·  Epilepsy, Temporal Lobe (62)  ·  Depression (58)  ·  Spasms, Infantile (47)  ·  Migraine Disorders (40)  ·  Epilepsy, Generalized (37)  ·  Nervous System Diseases (35)  ·  Brain Diseases (34)  ·  Anxiety Disorders (31)  ·  Parkinson Disease (30)

Broader conditions

Central Nervous System Diseases (2287)  ·  Brain Diseases (2271)  ·  Nervous System Diseases (2270)  ·  Pathological Conditions, Signs and Symptoms (676)  ·  Signs and Symptoms (612)  ·  Neurologic Manifestations (595)  ·  Epileptic Syndromes (306)  ·  Mental Disorders (205)  ·  Epilepsy, Generalized (199)  ·  Congenital, Hereditary, and Neonatal Diseases and Abnormalities (177)  ·  Genetic Diseases, Inborn (134)  ·  Behavior (121)  ·  Pathologic Processes (115)  ·  Epilepsies, Partial (91)

Interventions

Levetiracetam (97)  ·  Lacosamide (53)  ·  eslicarbazepine acetate (53)  ·  Lamotrigine (52)  ·  Cannabidiol (46)  ·  Topiramate (44)  ·  perampanel (42)  ·  brivaracetam (41)  ·  Valproic Acid (39)  ·  Carbamazepine (29)  ·  Pregabalin (28)  ·  Electroencephalography (26)  ·  Zonisamide (24)  ·  Oxcarbazepine (23)  ·  Diet, Ketogenic (22)

Sponsors

UCB Pharma (67)  ·  GlaxoSmithKline (57)  ·  National Institute of Neurological Disorders and Stroke (NINDS) (49)  ·  Bial - Portela C S.A. (45)  ·  Hospices Civils de Lyon (34)  ·  Eisai Inc. (30)  ·  Mayo Clinic (26)  ·  NYU Langone Health (25)  ·  Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (25)  ·  Jazz Pharmaceuticals (23)  ·  Xuanwu Hospital, Beijing (22)  ·  Assistance Publique Hopitaux De Marseille (21)  ·  Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (21)  ·  Assistance Publique - Hôpitaux de Paris (20)  ·  SK Life Science, Inc. (20)

Countries

United States (971)  ·  France (307)  ·  United Kingdom (176)  ·  Germany (174)  ·  Italy (167)  ·  China (144)  ·  Spain (141)  ·  Belgium (135)  ·  Canada (131)  ·  Poland (120)  ·  Australia (114)  ·  Hungary (82)  ·  Netherlands (77)  ·  Czechia (73)  ·  South Korea (72)

Top investigators

Liankun Ren, MD (16)  ·  William H Theodore, M.D. (8)  ·  Eric H Kossoff, MD (7)  ·  Marc Kamin, MD (6)  ·  Anli Liu, MD (5)

Results publications

PMID 26899665, PMID 33825230, PMID 35305920, PMID 33461041, PMID 34218211, PMID 35285519, PMID 27265725, PMID 34768178, PMID 34870321, PMID 37059702, PMID 27335114, PMID 27589414, PMID 27608437, PMID 27988967, PMID 28004320, PMID 28236727, PMID 28279891, PMID 29414542, PMID 29908435, PMID 32432339, PMID 32588435, PMID 33089492, PMID 33338829, PMID 34155568, PMID 35582748, PMID 38788664, PMID 10660394, PMID 17283312, PMID 17888078, PMID 18777484, PMID 19327967, PMID 19863578, PMID 19889013, PMID 20331461, PMID 21095488, PMID 22512894, PMID 25663221, PMID 25912051, PMID 26471380, PMID 26666500, PMID 27683846, PMID 28086164, PMID 28276064, PMID 28538134, PMID 28557750, PMID 29063814, PMID 29363050, PMID 29486396, PMID 29768152, PMID 31048098

NIH funding

2014 (30), 2018 (12), 2023 (11), 2015 (8), 2017 (8), 2004 (7), 2008 (7), 2016 (7), 2009 (5), 2019 (5), 2005 (4), 2025 (2), 5UL1TR001420-03 (2), R01NS074409 (2), R01NS094257 (2)