2174 completed, 618 unknown, 323 terminated, 277 recruiting. 3820 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 3820 | Completed 2174, Unknown 618, Terminated 323, Recruiting 277, Not yet recruiting 172, Withdrawn 155, Active not recruiting 78, Enrolling by invitation 19, Suspended 4 |
Follow Nervous System Diseases: new trials by email Literature Review of Nervous System Diseases trials Research Report on Nervous System Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RCT: Trazodone vs Quetiapine vs Placebo for Treating ICU Delirium (TraQ) Trazodone, Quetiapine, Placebo - Delirium, Morality | Phase 4 | Withdrawn | University of Southern California | 2028-03-01 | 2026-05-04 | |
| Gastrointestinal Dopamine Decarboxylase and Levodopa Pharmacokinetics Levodopa (L-dopa) - Parkinson's Disease | Phase 4 | Not yet recruiting | Beth Israel Deaconess Medical Center | 40 | 2027-07-01 | 2026-08-28 |
| Calcitonin Gene-related Peptide Antibody in Acute Mountain Sickness Fremanezumab 225 Mg/1.5 mL Subcutaneous Solution, Placebo - Acute Mountain Sickness | Phase 4 | Not yet recruiting | Insel Gruppe AG, University Hospital Bern | 30 | 2027-06-01 | 2026-07-01 |
| Nortriptyline Compared With Amitriptyline for Migraine Prevention at SQUH Nortriptyline, Amitriptyline - Migraine | Phase 4 | Not yet recruiting | Sultan Qaboos University | 90 | 2027-05-01 | 2026-10-02 |
| Lorazepam for Delirium Prevention in Critically Ill Patients With High Anttila-Index Lorazepam 1 mg, Placebo - Delirium Confusional State | Phase 4 | Not yet recruiting | University Hospital, Basel, Switzerland | 260 | 2027-03-01 | 2026-02-27 |
| Doxycycline Boosted Therapy in Lyme Borreliosis: DoBo Study. Hydroxychloroquin, Placebo, Doxycycline - Lyme Borreliosis, Nervous System | Phase 4 | Not yet recruiting | Radboud University Medical Center | 50 | 2027-03-01 | 2026-08-27 |
| Examining Analgesic Synergy and Efficacy in Trauma Care Buprenorphine, Oxycodone - Opioid Use Disorder | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 282 | 2027-03-01 | 2026-10-28 |
| Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty Liposomal Bupivacaine, Bupivacaine, Clonidine, Epinephrine, Buprenorphine and Dexamethasone (BPV-CEBD) Combination - Knee Arthroplasty, Total | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 90 | 2027-02-01 | 2026-08-25 |
| Migraine Menopause Study Eptinezumab 100 mg or Eptinezumab 300 mg administered intravenously in 100 mL saline solution, Placebo Normal Saline (NS) - Migraine, Menopausal | Phase 4 | Not yet recruiting | Alberta Neurologic Centre | 120 | 2027-02-01 | 2026-11-04 |
| Suzetrigine (Journavx) as Multimodal Therapy for Pain Management in Adults Undergoing Surgery for Hip Fracture Suzetrigine (Journavx) - Hip Fractures (ICD-10 72.01-72.2), Post Operative Analgesia | Phase 4 | Not yet recruiting | Beth Israel Deaconess Medical Center | 79 | 2027-01-05 | 2026-10-29 |
| RESCUE: PCSK9 Inhibitors for Carotid Vulnerable Plaque Remodeling Intervention 1, Intervention 3, Intervention 2 - Atherosclerosis Cerebral, Carotid Plaque | Phase 4 | Not yet recruiting | Keqiang Zhao | 120 | 2027-01-01 | 2026-09-15 |
| Effect of Atogepant on the Vestibulo-Ocular Reflex in Healthy Adults and Adults With Migraine Atogepant 60 mg, Placebo - Migraine Disorders, Brain, Healthy Adult Participants | Phase 4 | Not yet recruiting | Konrad Peter Weber | 80 | 2027-01-01 | 2026-09-17 |
| A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to Epidiolex Epidiolex 100 mg/mL Oral Solution - Dravet Syndrome (DS), Lennox-Gastaut Syndrome (LGS) | Phase 4 | Not yet recruiting | Elizabeth Donner | 25 | 2027-01-01 | 2026-09-11 |
| Lumbar Drain With Intrathecal Nicardipine in Aneurysmal Subarachnoid Hemorrhage Normal Saline, Nicardipine - Subarachnoid Hemorrhage | Phase 4 | Not yet recruiting | Wake Forest University Health Sciences | 214 | 2027-01-01 | 2026-10-01 |
| Remimazolam vs Propofol for Motor and Somatosensory Evoked Potentials in Spinal Tumor Surgery Remimazolam, Propofol - Spinal Cord Neoplasms, Spinal Neoplasms | Phase 4 | Not yet recruiting | Beijing Tsinghua Chang Gung Hospital | 190 | 2027-01-01 | 2026-10-28 |
| Aciclovir Versus Placebo for HSV-2 Meningitis Acyclovir 50 MG/ML, Placebo - Herpes Simplex 2, Meningitis, Viral | Phase 4 | Not yet recruiting | Jacob Bodilsen | 150 | 2027-01-01 | 2026-10-28 |
| Anti-inflammatory and Anti-thrombotic Therapy With colcHicine and Low Dose Rivaroxaban for Major Adverse Cardiovascular Events Reduction in Ischemic Stroke Rivaroxaban 2.5 Mg Oral Tablet, Colchicine 0.5 MG, Placebo Rivaroxaban - Ischemic Stroke | Phase 4 | Not yet recruiting | Brazilian Clinical Research Institute | 4500 | 2027-01-01 | 2026-10-30 |
| Ceasing Alpha-blockers Early After Resection of the Prostate (The CLEAR Trial) Tamsulosin hydrochloride 0.2 mg, Placebo - Benign Prostatic Hyperplasia | Phase 4 | Not yet recruiting | Shanghai East Hospital | 400 | 2026-12-01 | 2026-09-29 |
| Efficacy of Topical Lidocaine Gel vs. Oral Duloxetine for Painful Diabetic Peripheral Neuropathy Topical Lidocaine 2% Gel, Duloxetine (60 MG) - Painful Diabetic Neuropathy (PDN), Diabetic Neuropathies | Phase 4 | Not yet recruiting | Wah Medical college , POF hospital | 80 | 2026-12-01 | 2026-09-02 |
| Effect of Midazolam Given at Induction on Recall of Propofol Injection Pain Midazolam, Lidocaine Hydrochloride 2%, Propofol 1% - Propofol Injection Pain, Postoperative Recall of Pain | Phase 4 | Not yet recruiting | Atlas University | 150 | 2026-12-01 | 2026-11-03 |
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Agnosia (434) · Stroke (232) · Parkinson Disease (172) · Pain (171) · Multiple Sclerosis (166) · Migraine Disorders (159) · Ischemic Stroke (147) · Pain, Postoperative (139) · Alzheimer Disease (137) · Sleep Initiation and Maintenance Disorders (137) · Epilepsy (117) · Sleep Apnea, Obstructive (95) · Emergence Delirium (94) · Delirium (91) · Multiple Sclerosis, Relapsing-Remitting (81)
Pathological Conditions, Signs and Symptoms (1831) · Central Nervous System Diseases (1797) · Brain Diseases (1603) · Signs and Symptoms (1542) · Neurologic Manifestations (1474) · Neurobehavioral Manifestations (805) · Mental Disorders (801) · Pathologic Processes (638) · Cardiovascular Diseases (636) · Vascular Diseases (620) · Cerebrovascular Disorders (520) · Perceptual Disorders (445) · Neuromuscular Diseases (432) · Neurocognitive Disorders (406)
Saline Solution (143) · Dexmedetomidine (139) · Sodium Chloride (117) · Bupivacaine (82) · Propofol (77) · Acetaminophen (75) · Lidocaine (66) · Ketamine (65) · Aspirin (61) · Morphine (59) · Botulinum Toxins, Type A (58) · Dexamethasone (57) · Pregabalin (52) · Fentanyl (51) · Gabapentin (48)
Novartis Pharmaceuticals (60) · Biogen (35) · Massachusetts General Hospital (35) · Pfizer (28) · Seoul National University Hospital (28) · GlaxoSmithKline (27) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (26) · Genzyme, a Sanofi Company (25) · Ain Shams University (23) · Peking University First Hospital (23) · Sanofi (23) · Mayo Clinic (22) · Novartis (22) · VA Office of Research and Development (22) · Assiut University (21)
United States (1318) · China (394) · Canada (197) · France (192) · Germany (186) · Spain (160) · South Korea (155) · Italy (154) · United Kingdom (139) · Turkey (Türkiye) (101) · Egypt (96) · Denmark (94) · Brazil (90) · Netherlands (85) · Belgium (81)
Dong-Xin Wang, MD, PhD (15) · Roger K Cady, MD (10)
PMID 33238043, PMID 33189083, PMID 25771069, PMID 37467180, PMID 12221155, PMID 16731270, PMID 24957314, PMID 27611736, PMID 29030456, PMID 34515113, PMID 35833913, PMID 37303034, PMID 38018702, PMID 11914403, PMID 12525714, PMID 12760985, PMID 12807523, PMID 15041597, PMID 15114210, PMID 15613435, PMID 15827109, PMID 17197840, PMID 17917842, PMID 18757238, PMID 19574236, PMID 19645909, PMID 20518581, PMID 21256799, PMID 21592984, PMID 21869730, PMID 22027076, PMID 22230384, PMID 22880024, PMID 22897803, PMID 23567060, PMID 25019647, PMID 26184397, PMID 27475753, PMID 27513651, PMID 27834686, PMID 28304224, PMID 28527771, PMID 28545923, PMID 28573499, PMID 30084288, PMID 30206821, PMID 30521533, PMID 30571333, PMID 31020900, PMID 31802967
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