1190 completed, 360 unknown, 257 recruiting, 132 terminated. 1191 Not applicable, 130 Phase 2, 101 Phase 3, 95 Phase 4, 58 Phase 1.
Follow Sleep Apnea, Obstructive: new trials by email Literature Review of Sleep Apnea, Obstructive trials Research Report on Sleep Apnea, Obstructive
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| PAP Systems External Clinical Studies (ECS) PAP System A (with Amalfi) then PAP System B (with CLA11), PAP System B (with CLA11) then PAP System A (with Amalfi) - Obstructive Sleep Apnea | Not applicable | Not yet recruiting | ResMed | 30 | 2028-08-01 | 2026-04-24 |
| Testing Settings of NovaResp's cMAP® Software During Home PAP Therapy Dynamic cMAP, Direct cMAP - Obstructive Sleep Apnea | Not applicable | Not yet recruiting | NovaResp Technologies Inc | 50 | 2027-11-30 | 2026-10-27 |
| Oxytocin for Respiratory Compromise and Hypoventilation Induced by Drugs Intranasal Oxytocin 40 i.u., Intranasal Placebo Spray - Obesity & Overweight, Respiratory Depression | Phase 2 | Not yet recruiting | George Washington University | 100 | 2027-05-15 | 2026-10-29 |
| KPAP vs EPR for Efficacy APAP + KPAP, APAP + EPR - Obstructive Sleep Apnea | Not applicable | Not yet recruiting | SleepRes Inc. | 24 | 2027-03-01 | 2026-08-04 |
| Automated vs Manual Polysomnography Scoring in Adults With Obstructive Sleep Apnea Polysomnographic Scoring (Automated vs. Manual) - Obstructive Sleep Apnea | Not yet recruiting | Ain Shams University | 50 | 2027-02-01 | 2026-09-23 | |
| C-LIFT Efficacy in Patients With Obstructive Sleep Apnea C-Lift - Obstructive Sleep Apnea (OSA) | Not applicable | Not yet recruiting | Ata Murat Kaynar | 10 | 2027-01-01 | 2026-09-08 |
| PAP-NAP Device Clinical Study APL Device - Obstructive Sleep Apnea | Not applicable | Not yet recruiting | ResMed | 10 | 2027-01-01 | 2026-08-27 |
| Pediatric/Adolescent WatchPAT 400 Reliability Pilot Study WatchPAT 400 - Pediatric Sleep Disordered Breathing, Obstructive Sleep Apnea | Not applicable | Not yet recruiting | Milton S. Hershey Medical Center | 35 | 2026-12-01 | 2026-10-05 |
| Natural History of Central and Mixed Sleep Apneas Followed by Maxillomandibular Advancement for Obstructive Sleep Apnea Sleep Apnea Syndrome (OSAS), Central Sleep Apnea | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 60 | 2026-12-01 | 2026-05-19 | |
| Splintless Versus Conventional Maxillomandibular Advancement Surgery for Obstructive Sleep Apnea Splintless MMA surgery, Splint MMA surgery - Sleep Apnea Syndrome (OSAS), Orthognathic Surgical Procedures | Not applicable | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 66 | 2026-12-01 | 2026-05-20 |
| UBT251 Injection Phase Ⅲ Study (OSA-NPAP) UBT251, Placebo - Obstructive Sleep Apnea, Obesity | Phase 3 | Not yet recruiting | The United Bio-Technology (Hengqin) Co., Ltd. | 150 | 2026-12-01 | 2026-11-03 |
| Supplemental Oxygen for Sleep-Disordered Breathing in Adults With Chronic Opioid Use. Sham Air, Supplemental Oxygen - Sleep-disordered Breathing, Chronic Opioid Use | Phase 2 | Not yet recruiting | University of California, San Diego | 62 | 2026-12-01 | 2026-11-06 |
| Association Between Metabolic Associated Fatty Liver Disease and Obstructive Sleep Apnea Obstructive Sleep Apnea, Metabolic Dysfunction-Associated Steatotic Liver Disease | Not yet recruiting | Assiut University | 127 | 2026-12-01 | 2026-11-02 | |
| Hypoglossal Nerve Stimulation in Obstructive Sleep Apnea With Complete Concentric Collapse Inspire Hypoglossal Nerve Stimulation System - Obstructive Sleep Apnea | Not applicable | Not yet recruiting | Brigham and Women's Hospital | 20 | 2026-12-01 | 2026-10-27 |
| The Impact of Myofunctional Therapy on Children With Sleep Apnea and Obesity Myofunctional therapy - Obstructive Sleep Apnea (OSA) and Obesity | Not applicable | Not yet recruiting | Université Catholique de Louvain | 62 | 2026-12-01 | 2026-11-09 |
| Diaphragmatic Ultrasound and Hypoxic Burden in "Osa" Obstructive Sleep Apnea | Not yet recruiting | Assiut University | 95 | 2026-12-01 | 2026-11-13 | |
| Fentanyl Versus Opioid Free Multimodal Analgesia for Perioperative Pain Control in Children With Mild to Moderate Obstructive Sleep Apnea Group A: Fentanyl-Based Analgesia, Group B: Opioid-Free Multimodal Analgesia - Adenotonsillectomy, Obstructive Sleep Apnea (OSA) | Not applicable | Not yet recruiting | Ain Shams University | 64 | 2026-11-30 | 2026-02-27 |
| Use of a Mandibular Advancement Appliance in Children With Obstructive Sleep Apnea DynaFlex Dorsal Accu-Fit - Obstructive Sleep Apnea (OSA), Pediatric Obstructive Sleep Apnea (OSA) | Not applicable | Not yet recruiting | National Institute of Dental and Craniofacial Research (NIDCR) | 25 | 2026-11-18 | 2026-11-13 |
| Evaluation of the Diagnostic Capacity of a Smart Mattress Versus Conventional Polysomnography Integrated polysomnographic assessment with smart mattress. - Obstructive Sleep Apnea (OSA) | Not yet recruiting | Hospital San Pedro de Logroño | 500 | 2026-11-17 | 2026-03-03 | |
| Heart and Brain Blood Flow in Obstructive Sleep Apnea Obstructive Sleep Apnea (OSA) | Not yet recruiting | Copenhagen University Hospital, Rigshospitalet | 50 | 2026-11-15 | 2026-11-03 |
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Sleep Apnea Syndromes (392) · Obesity (119) · Hypertension (75) · Obesity Hypoventilation Syndrome (73) · Snoring (66) · Sleep Wake Disorders (60) · Apnea (58) · Pulmonary Disease, Chronic Obstructive (56) · Sleep Initiation and Maintenance Disorders (46) · Sleep Apnea, Central (41) · Disorders of Excessive Somnolence (36) · Stroke (34) · Heart Failure (33) · Diabetes Mellitus, Type 2 (31)
Dyssomnias (2229) · Nervous System Diseases (2227) · Sleep Disorders, Intrinsic (2227) · Respiratory Tract Diseases (2224) · Respiration Disorders (2214) · Apnea (2176) · Sleep Wake Disorders (2174) · Sleep Apnea Syndromes (1842) · Pathological Conditions, Signs and Symptoms (545) · Signs and Symptoms (416) · Nutritional and Metabolic Diseases (280) · Cardiovascular Diseases (225) · Nutrition Disorders (204) · Overnutrition (204) · Mental Disorders (201)
Continuous Positive Airway Pressure (187) · Polysomnography (46) · Occlusal Splints (36) · Acetazolamide (18) · Exercise (16) · Therapeutics (15) · Eszopiclone (14) · Atomoxetine Hydrochloride (13) · Noninvasive Ventilation (12) · Standard of Care (12) · Modafinil (11) · Myofunctional Therapy (11) · Surveys and Questionnaires (11) · Dexmedetomidine (10) · Bariatric Surgery (9)
Fisher and Paykel Healthcare (66) · ResMed (54) · University Hospital, Grenoble (48) · Brigham and Women's Hospital (42) · University of California, San Diego (30) · Chinese University of Hong Kong (25) · VA Office of Research and Development (24) · National Taiwan University Hospital (21) · University Hospital, Antwerp (21) · University of Michigan (21) · Mayo Clinic (17) · The University of Hong Kong (17) · Assiut University (16) · University of Pennsylvania (16) · Chang Gung Memorial Hospital (15)
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PMID 15781100, PMID 21454399, PMID 25348130, PMID 26094920, PMID 40123555, PMID 8464434, PMID 17765762, PMID 1798888, PMID 19234106, PMID 19536571, PMID 19960649, PMID 20522795, PMID 21123449, PMID 21372306, PMID 21539679, PMID 22131599, PMID 22334808, PMID 22926176, PMID 23016888, PMID 23589584, PMID 23675433, PMID 24810282, PMID 25601979, PMID 25915102, PMID 25950418, PMID 26402736, PMID 26567858, PMID 26923627, PMID 27091542, PMID 27242272, PMID 27406165, PMID 27435610, PMID 27452767, PMID 27571048, PMID 28117479, PMID 28162150, PMID 28527878, PMID 28548301, PMID 29146865, PMID 29616142, PMID 30100576, PMID 30935737, PMID 31368798, PMID 31467191, PMID 32347984, PMID 33745505, PMID 34739082, PMID 34999843, PMID 35442180, PMID 36450944
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