483 completed, 103 recruiting, 86 unknown, 83 terminated. 188 Not applicable, 182 Phase 3, 138 Phase 2, 67 Phase 4, 46 Phase 1.
Follow Seizures: new trials by email Literature Review of Seizures trials Research Report on Seizures
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) Glycerol Tributyrate - MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus) | Phase 1 / Phase 2 | Not yet recruiting | George Washington University | 24 | 2027-03-01 | 2026-10-05 |
| High-Intensity Focused Ultrasonic Ablation of the Centromedian Thalamic Nucleus for Treatment of Medically Refractory Generalized Epilepsy in Patients Ages 18 Years to 89 Years Intervention 1, Intervention 2 - Idiopathic Generalized Epilepsy | Not applicable | Not yet recruiting | Oregon Health and Science University | 10 | 2027-02-01 | 2026-10-28 |
| A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to Epidiolex Epidiolex 100 mg/mL Oral Solution - Dravet Syndrome (DS), Lennox-Gastaut Syndrome (LGS) | Phase 4 | Not yet recruiting | Elizabeth Donner | 25 | 2027-01-01 | 2026-09-11 |
| Cholinergic Enhancement of Theta COBENFY KarXT (50/20 mg), Control - Epilepsy, Seizures | Early Phase 1 | Not yet recruiting | University of Texas Southwestern Medical Center | 50 | 2026-12-01 | 2026-09-29 |
| COMparison Between Anakinra and Tocilizumab in NORSE - "COMBAT-NORSE" Anakinra, Tocilizumab, Standard medical treatment - New Onset Refractory Status Epilepticus, New-Onset Refractory Status Epilepticus | Phase 3 | Not yet recruiting | Yale University | 438 | 2026-12-01 | 2026-08-19 |
| Epileptiform Potential of Fully Immersive Virtual Reality Virtual Reality Headset, display off, Virtual Reality Headset, Display only, Virtual Reality Headset, Display and Hand Control - Epilepsy, Seizure | Not applicable | Not yet recruiting | Dartmouth-Hitchcock Medical Center | 40 | 2026-12-01 | 2026-08-27 |
| Lily's Grace Temporal Interference TES-TI, Sham Stimulation, Structural and Functional MRI - Epilepsy | Not applicable | Not yet recruiting | University of Wisconsin, Madison | 24 | 2026-11-01 | 2026-10-30 |
| A Clinical Study to Assess the Safety, Tolerability and Pharmacokinetics of Orally Administered Cannabidiol Capsules (AVAT-121) and Epidyolex® in Healthy Adults AVAT-121, AVAT-121 and Epidyolex® - Focal Onset Seizure | Phase 1 | Not yet recruiting | Avata Biosciences Holdings Ltd | 44 | 2026-10-20 | 2026-11-05 |
| Human Cognition During Surgery: Stimulation-based and Cholinergic Modulation Cobenfy KarXT pill (50/20 mg), Placebo - Epilepsy, Essential Tremor | Early Phase 1 | Not yet recruiting | University of Texas Southwestern Medical Center | 30 | 2026-10-01 | 2026-07-23 |
| Predictors of Outcomes of Convulsive Status Epilepticus Status Epilepticus, Convulsive Status Epilepticus | Not yet recruiting | Assiut University | 100 | 2026-10-01 | 2026-10-01 | |
| The TTM and ASM Trial Prophylactic ASM, Hypothermic, Normothermic - Critical Care Medicine, Emergency Medical Services | Phase 1 | Not yet recruiting | National Taiwan University Hospital | 100 | 2026-09-17 | 2026-10-07 |
| Safety and Efficacy of AV078 in Participants With Tuberous Sclerosis Complex (TSC) Refractory Epilepsy (RESTOR-1) AV078, Placebo - Tuberous Sclerosis Complex, Epilepsy | Phase 2 | Not yet recruiting | Aeovian Pharmaceuticals, Inc. | 42 | 2026-09-01 | 2026-09-29 |
| Study of the Pharmacokinetics, Safety, and Tolerability of ZONISADE in Children 1 Month to 17 Years of Age With Partial-onset Seizures Zonisamide Oral Product - Seizures, Seizures, Focal | Phase 4 | Not yet recruiting | Azurity Pharmaceuticals | 40 | 2026-09-01 | 2026-09-15 |
| HOBSCOTCH-YOUTH and Young Adults HOBSCOTCH/HOBSCOTCH-YOUTH - Epilepsy, Cognitive Dysfunction, Cognitive Disorder | Not applicable | Recruiting | Dartmouth-Hitchcock Medical Center | 300 | 2026-09-01 | 2026-11-02 |
| Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures RAP-219, Placebo - Focal Seizure, Epilepsy | Phase 3 | Recruiting | Rapport Therapeutics Inc. | 312 | 2026-09-01 | 2026-11-12 |
| Outcomes After Planned Discontinuation of AntiSeizure Medication Discontinue antiseizure medications - Epilepsy | Phase 4 | Recruiting | University of Michigan | 40 | 2026-08-01 | 2026-08-06 |
| Effects of a Sigle Dose of Ayahuasca in Patients With Psychogenic Non-epileptic Seizures: an Open Label Clinical Trial Ayahuasca - Non Epileptic Seizures | Phase 1 / Phase 2 | Recruiting | University of Sao Paulo | 15 | 2026-07-01 | 2026-08-05 |
| Prospective Natural History Study of POLG Disease PolG, Primary Mitochondrial Myopathy | Recruiting | The POLG Foundation | 300 | 2026-06-17 | 2026-09-15 | |
| Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1 RAP-219, Placebo - Focal Seizure, Epilepsy | Phase 3 | Recruiting | Rapport Therapeutics Inc. | 333 | 2026-06-05 | 2026-11-12 |
| Use of Cognitive Aid Methods in the Management of Status Epilepticus Management of status epilepticus with paper cognitive aids, Management of status epilepticus with digital cognitive aids, Management of status epilepticus with no cognitive aid - Last Year Medical Student | Not applicable | Not yet recruiting | Ankara University | 76 | 2026-05-25 | 2026-05-29 |
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Epilepsy (420) · Status Epilepticus (118) · Epilepsies, Partial (76) · Drug Resistant Epilepsy (36) · Brain Diseases (24) · Psychogenic Nonepileptic Seizures (24) · Lennox Gastaut Syndrome (22) · Seizures, Febrile (22) · Brain Injuries, Traumatic (20) · Heart Arrest (20) · Epilepsies, Myoclonic (18) · Epilepsy, Generalized (17) · Brain Neoplasms (15) · Conversion Disorder (15)
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Levetiracetam (65) · Topiramate (28) · perampanel (27) · Lacosamide (20) · Valproic Acid (20) · Phenytoin (16) · Cannabidiol (13) · Lorazepam (12) · Midazolam (12) · Diazepam (11) · Ketamine (11) · Oxcarbazepine (11) · Pregabalin (10) · ganaxolone (10) · Carbamazepine (9)
National Institute of Neurological Disorders and Stroke (NINDS) (32) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (19) · Eisai Inc. (16) · SK Life Science, Inc. (15) · GlaxoSmithKline (14) · UCB Pharma (13) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (12) · Jazz Pharmaceuticals (11) · Marinus Pharmaceuticals (11) · Sohag University (11) · University of Alabama at Birmingham (11) · Eisai Co., Ltd. (10) · Johns Hopkins University (9) · Roxane Laboratories (9) · Assiut University (8)
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PMID 35305920, PMID 37059702, PMID 23663001, PMID 25823975, PMID 25878175, PMID 33825230, PMID 34768178, PMID 34870321, PMID 18070841, PMID 19327967, PMID 19652140, PMID 19863578, PMID 21673279, PMID 22512894, PMID 22633629, PMID 28086164, PMID 29063814, PMID 29363050, PMID 30232735, PMID 31048098, PMID 31672143, PMID 32690786, PMID 33540241, PMID 34528245, PMID 34957550, PMID 35965432, PMID 36176044, PMID 10023117, PMID 10227614, PMID 10371538, PMID 10431771, PMID 10536541, PMID 10553858, PMID 10598599, PMID 10598642, PMID 10660394, PMID 10768306, PMID 10768307, PMID 10903015, PMID 10908900, PMID 10982087, PMID 11207795, PMID 11472278, PMID 11839862, PMID 11903468, PMID 12428025, PMID 12552030, PMID 12558580, PMID 12601694, PMID 12609370
2014 (14), 2023 (7), 2018 (6), 2017 (4), 2015 (3), 2019 (3), 2016 (2), R01NS074409 (2), R61MH127155 (2), 1IK2RD000605-01A2 (1), 2008 (1), 2009 (1), 2025 (1), 5RC1MD004563-02 (1), 5UL1TR002373-03 (1)