1006 completed, 543 unknown, 516 recruiting, 233 not yet recruiting. 927 Not applicable, 371 Phase 2, 323 Phase 3, 150 Phase 4, 131 Phase 1.
Follow Ischemic Stroke: new trials by email Literature Review of Ischemic Stroke trials Research Report on Ischemic Stroke
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Essential Acute Stroke Care in Low Resource Settings: a Pilot studY Acute stroke care Intervention arm - Acute Stroke | Not applicable | Not yet recruiting | The George Institute | 300 | 2027-12-30 | 2026-06-11 |
| COOLing of the Ischemic PENumbra in Patients With Acute Ischemic Stroke. PEN-Cool Conductive Head-and-Neck Cooling System, Standard Reperfusion Therapy / Routine Care - Acute Ischemic Stroke | Not applicable | Not yet recruiting | Christian Medical College and Hospital, Ludhiana, India | 55 | 2027-09-01 | 2026-09-28 |
| Glial Fibrillary Acidic Protein Testing and Handheld Near Infrared Spectroscopy Technology CEREBO in India. GFAP/D-Dimer Point-of-Care Testing & CEREBO Near-Infrared Spectroscopy (NIRS), CT Head - Stroke | Not applicable | Not yet recruiting | Christian Medical College and Hospital, Ludhiana, India | 232 | 2027-09-01 | 2026-09-28 |
| Prospective Observational Multimodal Neuromonitoring in Adult NSICU Patients Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic | Not yet recruiting | University of Texas Southwestern Medical Center | 300 | 2027-07-01 | 2026-10-23 | |
| EDAS Revascularization for Symptomatic Intracranial Atherosclerotic Steno-occlusive Disease Encephaloduroarteriosynangiosis (EDAS), Intensive medical management - Intracranial Atherosclerosis, Intracranial Arterial Stenosis | Not applicable | Not yet recruiting | Cedars-Sinai Medical Center | 170 | 2027-05-01 | 2026-10-22 |
| The Effectiveness of Patch-Based Screening for Pre-Symptomatic Atrial Fibrillation to Improve Patient Outcome Zio XT® Patch - Atrial Fibrillation | Not applicable | Not yet recruiting | VA Office of Research and Development | 24060 | 2027-03-08 | 2026-06-30 |
| CC-101 (f/k/a NR1) Neural Stem Cell Transplantation for Adults With Chronic Ischemic Stroke CC-101 (f/k/a NR1) Intracerebral Transplantation, Tacrolimus, Sham Surgical Control - Chronic Ischemic Stroke | Phase 2 | Not yet recruiting | Clarion Cells, Inc. | 36 | 2027-01-01 | 2026-07-17 |
| Efficacy and Safety of Tenecteplase Among acutE Ischemic Stroke Patients With Recent Ingestion of Direct Oral Anticoagulant Intravenous tenecteplase (TNK), Placebo - Acute Ischemic Stroke | Phase 3 | Not yet recruiting | Hackensack Meridian Health | 660 | 2027-01-01 | 2026-06-02 |
| Combined Acupuncture-Based Therapy for Rehabilitation After Ischemic Stroke Electro-Field Acupuncture, Electro-Acupuncture, Cerebrolysin - Ischemic Stroke, Hemiplegia | Not applicable | Not yet recruiting | National Hospital of Acupuncture, Vietnam | 440 | 2026-12-01 | 2026-09-29 |
| Low-Intensity Monitoring Nursing After Thrombolysis for Acute Ischemic Stroke lower frequency of assessment of neurological impairment and vital signs, standard frequency of assessment of neurological impairment and vital signs - Stroke, Ischemic | Not applicable | Not yet recruiting | Shengjing Hospital | 864 | 2026-12-01 | 2026-10-08 |
| REVascularization In Large VEssel Occlusion for Acute Ischemic Stroke SOFIA Flow 88 Aspiration Catheter - Acute Ischemic Stroke | Not applicable | Not yet recruiting | Microvention-Terumo, Inc. | 200 | 2026-12-01 | 2026-05-26 |
| A Phase II Clinical Study of LT3001 for Injection in the Treatment of Acute Ischemic Stroke LT3001 Drug:high dose, LT3001 Drug: low dose, Placebo - Acute Ischemic Stroke | Phase 2 | Not yet recruiting | Shanghai Pharmaceuticals Holding Co., Ltd | 300 | 2026-12-01 | 2026-10-19 |
| A Study to Evaluate Cenvacibart (REGN7508) for Secondary Stroke Prevention in Adult Participants Cenvacibart, Placebo - Secondary Stroke | Phase 3 | Not yet recruiting | Regeneron Pharmaceuticals | 6106 | 2026-11-20 | 2026-10-15 |
| A Multicenter, Three-Arm, Open-Label, Endpoint-Blinded Randomized Controlled Trial to Evaluate the Optimal Duration of Early Tirofiban After Intravenous Thrombolysis in Acute Ischemic Stroke Tirofiban Injection, No Interventions - Acute Ischemic Stroke | Phase 2 / Phase 3 | Not yet recruiting | Xinqiao Hospital of Chongqing | 1482 | 2026-11-19 | 2026-09-25 |
| Lumbrokinase vs Placebo in Moderate-to-Severe Ischemic Stroke Lumbrokinase, Lumbrokinase Placebo - Ischemic Stroke, Acute | Phase 4 | Not yet recruiting | Xinqiao Hospital of Chongqing | 1196 | 2026-11-01 | 2026-08-13 |
| Post-Stroke Enhancement of Delirium Outcomes With Reduction in Neuro-checks Decreased Neuro Checks overnight - Stroke, Acute, Stroke, Ischemic | Not applicable | Suspended | Medical University of South Carolina | 538 | 2026-11-01 | 2026-04-09 |
| Stimulation-Temperature-Oxygen-Positioning Multimodal Neuroprotection for Acute Ischemic Stroke (STOP) Stimulation-Temperature-Oxygen-Positioning (STOP) Multimodal Neuroprotective Strategy, Guideline-Based Reperfusion Therapy and Standard Stroke-Unit Care - Acute Ischemic Stroke | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 380 | 2026-11-01 | 2026-09-25 |
| MSC Secretome and rTMS for Motor Recovery After Subacute Ischemic Stroke Mesenchymal Stem Cell-Derived Secretome, Active Repetitive Transcranial Magnetic Stimulation, 0.9% Sodium Chloride Placebo - Ischemic Stroke | Not applicable | Not yet recruiting | Jumraini Tammasse | 205 | 2026-11-01 | 2026-10-21 |
| Testing a New Treatment Strategy to Improve Secondary Stroke Prevention for Older Adults: The STROKE75+ Trial Edoxaban 15 mg, Aspirin or clopidogrel - Stroke, Ischemic | Phase 3 | Recruiting | Sunnybrook Health Sciences Centre | 1204 | 2026-11-01 | 2026-10-23 |
| EEG Feedback-Based Vagus Nerve Stimulation for Post-Stroke Dysphagia EEG Biofeedback-Guided taVNS, Conventional taVNS - Ischemic Stroke, Post-stroke Dysphagia | Not applicable | Not yet recruiting | First Affiliated Hospital of Fujian Medical University | 60 | 2026-11-01 | 2026-10-26 |
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Stroke (839) · Hemorrhagic Stroke (155) · Atrial Fibrillation (129) · Ischemic Attack, Transient (99) · Cerebrovascular Disorders (82) · Cerebral Hemorrhage (77) · Brain Ischemia (65) · Ischemia (60) · Cerebral Infarction (47) · Thrombosis (47) · Brain Diseases (45) · Brain Infarction (44) · Cardiovascular Diseases (44) · Myocardial Infarction (44)
Nervous System Diseases (2554) · Central Nervous System Diseases (2553) · Vascular Diseases (2549) · Cardiovascular Diseases (2538) · Brain Diseases (2537) · Cerebrovascular Disorders (2500) · Stroke (1743) · Pathological Conditions, Signs and Symptoms (643) · Pathologic Processes (493) · Heart Diseases (213) · Signs and Symptoms (189) · Brain Ischemia (167) · Necrosis (155) · Infarction (150) · Ischemia (143)
Aspirin (83) · Clopidogrel (62) · Tissue Plasminogen Activator (58) · Tenecteplase (56) · Standard of Care (27) · Sodium Chloride (26) · Transcranial Direct Current Stimulation (24) · Injections (23) · Thrombectomy (23) · Cilostazol (22) · Rivaroxaban (21) · Saline Solution (21) · Tirofiban (21) · Ticagrelor (19) · apixaban (19)
Beijing Tiantan Hospital (84) · Xuanwu Hospital, Beijing (51) · Capital Medical University (44) · General Hospital of Shenyang Military Region (34) · Second Affiliated Hospital, Zhejiang University, School of Medicine (31) · Assistance Publique - Hôpitaux de Paris (21) · Kafrelsheikh University (21) · Yi Yang (20) · Xijing Hospital (18) · Assiut University (17) · Insel Gruppe AG, University Hospital Bern (17) · Dongzhimen Hospital, Beijing (16) · Charite University, Berlin, Germany (15) · Nanfang Hospital, Southern Medical University (14) · Penumbra Inc. (14)
China (726) · United States (473) · France (164) · Germany (161) · Spain (135) · Canada (115) · United Kingdom (89) · South Korea (85) · Switzerland (83) · Italy (77) · Taiwan (62) · Australia (59) · Turkey (Türkiye) (53) · Denmark (52) · Belgium (51)
Raul G Nogueira, MD (12) · Yongjun Wang, MD (11) · Yongjun Wang (9) · Yamei Tang (8) · Feng Gao, MD (7) · Min Lou, PhD, MD (5) · Sven Poli, Dr. med. (5) · Ying Gao, MD (5) · Cuong Tran Chi, Doctor (4) · Gang Zhao, MD (4) · Jeffrey Saver, MD (4) · Lixia Xue, M.D., Ph.D. (4)
PMID 31867054, PMID 18190818, PMID 34515113, PMID 16731270, PMID 2375765, PMID 34813082, PMID 35857365, PMID 21899409, PMID 22435369, PMID 25671797, PMID 26898852, PMID 29129157, PMID 31067369, PMID 31662037, PMID 34487721, PMID 36289001, PMID 36398903, PMID 12221155, PMID 12807523, PMID 17702958, PMID 18815396, PMID 20075087, PMID 20185783, PMID 22474060, PMID 22738918, PMID 24876082, PMID 25671798, PMID 25677596, PMID 25726502, PMID 25882376, PMID 25882510, PMID 28052979, PMID 28428348, PMID 28780236, PMID 29694815, PMID 29766770, PMID 30045949, PMID 31239326, PMID 31899551, PMID 32905623, PMID 33175411, PMID 33588596, PMID 34125952, PMID 34906976, PMID 36446950, PMID 38372981, PMID 39908448, PMID 10591382, PMID 10905241, PMID 15800226
2023 (8), 2016 (6), 2019 (6), 2015 (5), 2017 (5), 2018 (5), 2025 (3), 2008 (2), P50NS044148 (2), R01EY027314 (2), U01EB021183 (2), U01NS054630 (2), 1OT2NS129366-01 (1), 1UG3NS133209-01A1 (1), 1UG3NS134619-01A1 (1)