3589 completed, 553 recruiting, 459 terminated, 451 unknown. 5691 Phase 2, 739 Phase 1, 651 Phase 3.
Follow Mental Disorders: new trials by email Literature Review of Mental Disorders trials Research Report on Mental Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of Cannabidiol on Psychiatric Symptoms, Cognition, and Cannabis Consumption in Cannabis Users With Recent-Onset Psychosis Cannabidiol (CBD), Placebo - Schizophrenia Spectrum Disorders, Cannabis Use | Phase 2 | Withdrawn | University of Maryland, Baltimore | 2050-01-01 | 2021-04-19 | |
| Dynamic Treatment Regimes for Opioid Use Disorder Medication for opioid use disorder, psychotherapy - Opioid Use Disorder | Phase 2 | Not yet recruiting | Brigham and Women's Hospital | 75 | 2028-07-01 | 2025-11-04 |
| Department of Defense PTSD Adaptive Platform Trial - Intervention D - SLS-002 Intervention D SLS-002, Intervention D Placebo - Post Traumatic Stress Disorder | Phase 2 | Suspended | Global Coalition for Adaptive Research | 200 | 2028-05-01 | 2026-05-20 |
| Terazosin for Dementia With Lewy Bodies Terazosin Hydrochloride, Placebo - Dementia With Lewy Bodies | Phase 1 / Phase 2 | Not yet recruiting | Qiang Zhang | 40 | 2027-10-01 | 2026-03-12 |
| AV-1959R Vaccine in Individuals With Preclinical Alzheimer's Disease AV-1959R, Placebo - Preclinical Alzheimer's Disease, Alzheimer Disease | Phase 2 | Not yet recruiting | Institute for Molecular Medicine | 160 | 2027-10-01 | 2026-10-21 |
| Terazosin And Metabolic Engagement in Alzheimer's Disease Terazosin (Hytrin), Placebo - Alzheimer s Disease | Phase 2 | Not yet recruiting | Qiang Zhang | 100 | 2027-08-01 | 2026-09-01 |
| Department of Defense PTSD Adaptive Platform Trial - Intervention B - Vilazodone Intervention B Vilazodone Hydrochloride (HCl), Intervention B Placebo - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | Global Coalition for Adaptive Research | 200 | 2027-08-01 | 2026-05-20 |
| Medically Supervised Ibogaine With 12-Month Digital Recovery Support for Opioid Use Disorder Ibogaine Hydrochloride, Extended-release naltrexone injection, 380 mg, Matching Oral Placebo - Opioid Use Disorder, Opioid Withdrawal | Phase 1 / Phase 2 | Not yet recruiting | Clive Michelsen | 60 | 2027-07-01 | 2026-10-13 |
| Efficacy and Safety of NTI164 in Children and Young Adults With Rett Syndrome NTI164, Placebo - RETT Syndrome With Proven MECP2 Mutation, Rett Syndrome | Phase 2 / Phase 3 | Not yet recruiting | Fenix Innovation Group | 40 | 2027-07-01 | 2026-09-09 |
| Written Exposure Therapy Plus Adjunctive Methylphenidate Treatment for Veterans With PTSD Written Exposure Therapy (WET), methylphenidate (MPH), placebo (PBO) - PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | VA Office of Research and Development | 138 | 2027-07-01 | 2026-10-29 |
| Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD Principal Investigator Transcranial direct current stimulation (tDCS), Cognitive training - Cognition, Brain Injuries | Phase 2 | Not yet recruiting | VA Office of Research and Development | 46 | 2027-05-24 | 2026-02-17 |
| Inpatient Buprenorphine Induction With Psilocybin for Opioid Use Disorder Psilocybin - Opioid Use Disorder | Phase 2 | Withdrawn | Johns Hopkins University | 2027-04-01 | 2026-02-23 | |
| Naloxone for Opioid Associated Out of Hospital Cardiac Arrest Naloxone 2 MG, Saline 2ml - Heart Arrest, Out-Of-Hospital, Opioid Overdose | Phase 2 | Not yet recruiting | University of California, San Francisco | 98 | 2027-03-01 | 2026-09-11 |
| A Clinical Trial of Iron Supplementation for Youth With ADHD and Restless Sleep Ferrous Sulfate, Placebo - ADHD, Sleep Problems | Phase 1 / Phase 2 | Not yet recruiting | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 70 | 2027-03-01 | 2026-05-04 |
| A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) Glycerol Tributyrate - MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus) | Phase 1 / Phase 2 | Not yet recruiting | George Washington University | 24 | 2027-03-01 | 2026-10-05 |
| Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder Psilocybin - Treatment Resistant Depression, Substance Use Disorders | Phase 1 / Phase 2 | Not yet recruiting | Indiana University | 50 | 2027-02-01 | 2026-10-23 |
| Inhaled Cannabis for Treatment of PTSD High THC Cannabis, Placebo cannabis - Post Traumatic Stress Disorder PTSD | Phase 2 | Not yet recruiting | Multidisciplinary Association for Psychedelic Studies | 320 | 2027-02-01 | 2026-08-11 |
| Psilocybin for Methamphetamine Use Disorder Psilocybin (single oral capsule administered at one of two dose levels, Dose A or Dose B; specific doses withheld during conduct)., Manualized cognitive behavioral therapy platform (2 preparation + 2 integration sessions). - Methamphetamine Use Disorder | Phase 2 | Not yet recruiting | Peter Hendricks | 42 | 2027-02-01 | 2026-09-21 |
| PRECISION-E2: Teverelix in Women With Endometriosis - Pharmacodynamics, Safety and Precision Medicine Correlates Teverelix DP, Teverelix DP Placebo - Endometriosis Pelvic, Endometriosis Ovaries | Phase 2 | Not yet recruiting | Antev Ltd. | 84 | 2027-02-01 | 2026-11-03 |
| Lisdexamfetamine For the Treatment of Conduct Disorder in Children Lidexamfetamine - Conduct Disorder | Phase 2 | Not yet recruiting | Orygen | 30 | 2027-02-01 | 2026-11-06 |
Showing 20 of 5691. Sign in to see all of them.
Alzheimer Disease (713) · Depressive Disorder, Major (507) · Depression (456) · Schizophrenia (446) · Alcoholism (384) · Cognitive Dysfunction (364) · Anxiety Disorders (334) · Stress Disorders, Post-Traumatic (322) · Substance-Related Disorders (277) · Opioid-Related Disorders (276) · Dementia (227) · Tobacco Use Disorder (204) · Cocaine-Related Disorders (199) · Autism Spectrum Disorder (179) · Bipolar Disorder (177)
Nervous System Diseases (1725) · Chemically-Induced Disorders (1419) · Neurocognitive Disorders (1249) · Substance-Related Disorders (1138) · Central Nervous System Diseases (1115) · Brain Diseases (1105) · Behavior (1006) · Neurodegenerative Diseases (933) · Pathological Conditions, Signs and Symptoms (906) · Mood Disorders (742) · Dementia (721) · Signs and Symptoms (718) · Tauopathies (700) · Neurologic Manifestations (565)
Psilocybin (105) · Ketamine (104) · Sugars (98) · Cognitive Behavioral Therapy (97) · Buprenorphine (85) · Cannabidiol (76) · Naltrexone (76) · Sodium Chloride (68) · Therapeutics (67) · Risperidone (62) · Varenicline (52) · Bupropion (50) · Methylphenidate (50) · Acetylcysteine (49) · nabiximols (49)
Yale University (134) · National Institute on Drug Abuse (NIDA) (130) · New York State Psychiatric Institute (130) · Johns Hopkins University (81) · University of Pennsylvania (75) · Medical University of South Carolina (73) · Massachusetts General Hospital (68) · VA Office of Research and Development (62) · GlaxoSmithKline (53) · Pfizer (53) · National Institute of Mental Health (NIMH) (52) · University of California, Los Angeles (51) · University of Chicago (43) · Stanford University (42) · Eli Lilly and Company (40)
United States (3680) · Canada (434) · Germany (250) · France (231) · United Kingdom (218) · Spain (190) · Australia (177) · China (147) · Poland (121) · Japan (117) · Netherlands (114) · Italy (108) · Israel (97) · Brazil (93) · Taiwan (92)
Warren Bickel, Ph.D. (17) · Walter Ling, M.D. (16)
PMID 37811711, PMID 37142273, PMID 37230961, PMID 40342086, PMID 28433500, PMID 36375174, PMID 31065731, PMID 31572236, PMID 36130734, PMID 32500209, PMID 34510411, PMID 34582562, PMID 36463457, PMID 33974419, PMID 38489195, PMID 42560883, PMID 23146246, PMID 25890643, PMID 25918556, PMID 25938124, PMID 32368793, PMID 33189083, PMID 34532852, PMID 36006807, PMID 39800465, PMID 40603145, PMID 20707781, PMID 29480210, PMID 32250312, PMID 32364251, PMID 32628945, PMID 33079196, PMID 33854317, PMID 33884617, PMID 33972795, PMID 34091867, PMID 34242666, PMID 34255068, PMID 34817851, PMID 35092868, PMID 36208817, PMID 36369028, PMID 38236223, PMID 38706271, PMID 38767196, PMID 42171126, PMID 12150647, PMID 18632997, PMID 20565514, PMID 20732631
2023 (26), 2025 (24), 2015 (23), 2009 (21), 2016 (21), 2019 (19), 2017 (18), 2014 (17), 2018 (14), P50DA009236 (13), 2008 (9), P50DA009262 (9), R01DA008391 (7), P50DA012756 (6), P50DA018197 (6)