134 completed, 22 recruiting, 17 unknown, 17 withdrawn. 81 Phase 1, 76 Phase 2, 44 Phase 3, 28 Not applicable, 10 Early Phase 1.
Follow nabiximols: new trials by email Literature Review of nabiximols trials Research Report on nabiximols
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Behavioral Pharmacology of THC and Beta-Myrcene Placebo, THC, Beta-Myrcene - Cannabis Use | Phase 1 | Not yet recruiting | Johns Hopkins University | 32 | 2027-07-01 | 2026-07-31 |
| Efficacy and Tolerance of THC 25: CBD 25 in Patients With Severe Pruritus: a Multicenter, Double-blind, Randomized, Placebo-controlled Study Cannabis oil, Placebo - Pruritus | Phase 2 | Not yet recruiting | University Hospital, Brest | 218 | 2027-01-01 | 2026-06-12 |
| A Phase IIb Study of Nabiximols for Spasticity Due to Neuromyelitis Optica Spectrum Disorders Nabiximols, Placebo - NMO Spectrum Disorder, Spasticity, Muscle | Phase 2 | Withdrawn | Michael, Levy M.D.,Ph.D. | 2026-12-31 | 2025-07-16 | |
| Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance Cannabis - Cannabis Use, Impaired Driving | Phase 1 | Not yet recruiting | Johns Hopkins University | 40 | 2026-12-01 | 2026-10-16 |
| Cannabis Effects on Opioid Self-Administration Cannabis, Placebo Cannabis, Intranasal Opioid Agonist - Opioid Use Disorder, Cannabis Use | Phase 1 | Not yet recruiting | Shanna Babalonis, PhD | 30 | 2026-11-30 | 2026-10-14 |
| Lung Health and Breath Biomarkers: Acute Effects of Inhaled Cannabis Cannabis (THC), Tobacco Cigarette - Cannabis Use, Tobacco | Early Phase 1 | Not yet recruiting | Hannah Harris | 12 | 2026-11-01 | 2026-10-06 |
| Evaluating the Delivery and Effects of THC Vaping Liquids in the Bloodstream Biospecimen Collection, Cannabis sativa Extract, Nicotine - Cannabis Dependence | Early Phase 1 | Not yet recruiting | Roswell Park Cancer Institute | 60 | 2026-10-15 | 2026-09-25 |
| Repeated Administration of Cannabis Varying in THC and CBD Cannabis - Cannabis | Phase 2 | Suspended | New York State Psychiatric Institute | 100 | 2026-10-01 | 2026-09-01 |
| Effects of Various Cannabis Strains on Perceptual, Subjective and Objective Use Outcomes Cannabis, 0 mg THC (placebo) - Cannabis Intoxication | Phase 1 | Recruiting | Johns Hopkins University | 70 | 2026-09-15 | 2026-09-18 |
| A Study of Inhaled Cannabidiol in Healthy Occasional Cannabis Users Cannabis, placebo - Cannabis | Phase 1 / Phase 2 | Not yet recruiting | Centre hospitalier de l'Université de Montréal (CHUM) | 80 | 2026-09-01 | 2025-12-22 |
| Wayne State Warriors Marijuana Clinical Research Program: Cannabinoid Adjunct to Prolonged Exposure & Recovery Cannabidiol (CBD) only, Placebo only, Delta-9-tetrahydrocannabinol (THC) only - PTSD, Post Traumatic Stress Disorder | Phase 1 / Phase 2 | Not yet recruiting | Leslie Lundahl | 280 | 2026-09-01 | 2026-08-26 |
| Cannabis for Obesity Trial Cannabis, Placebo - Obesity | Phase 2 | Recruiting | Joshua A. Lile, Ph.D. | 40 | 2026-08-05 | 2026-08-07 |
| Cannabis Vs Opioids Pain Management Objective Testing Comparisons Monochromatic Infrared Photo Energy (MIRE), Transcutaneous Electrical Nerve Stimulation, Opioids - Chronic Pain, Circulatory Disorders | Not applicable | Not yet recruiting | American Association of Sensory Electrodiagnostic Medicine | 1000 | 2026-06-03 | 2025-12-29 |
| Pregnenolone as a Treatment for Cannabis Intoxication Cannabis, Pregnenolone 250 mg, Pregnenolone 500 mg - Cannabis Intoxication | Phase 2 | Recruiting | Johns Hopkins University | 20 | 2026-04-24 | 2026-09-29 |
| Cannabis extrAct in Oncology Patients for the Treatment of TUmor Related Symptom Burden Cannabis Extract Oil, Placebo - Advanced Malignant Solid Tumor | Phase 2 | Not yet recruiting | National Cancer Institute, Naples | 156 | 2026-04-01 | 2026-03-10 |
| In-Vehicle Real-Time Cannabis Influenced Driving Detection Cannabis (THC) - Driving Under the Influence, Cannabis-impaired Driving | Not applicable | Completed | University of Bern | 45 | 2026-01-05 | 2026-07-20 |
| Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 4 Cannabis (smoked flower) - Cannabis, Memory | Recruiting | L. Cinnamon Bidwell | 64 | 2025-12-10 | 2026-07-01 | |
| THC and CBD: A Controlled Human Study Probing a Harm Reduction Strategy Placebo, THC, CBD 20 mg - Abuse, Drug, Pain | Phase 1 | Recruiting | University of California, Los Angeles | 30 | 2025-11-05 | 2025-12-17 |
| Oral and Topical Phytocannabinoids for Psoriasis Oral Cannabis Extract, Topical cannabis cream - Psoriasis Vulgaris | Phase 2 | Active not recruiting | Federal University of Latin American Integration | 37 | 2025-11-01 | 2026-09-24 |
| THC Titration of High-Potency Cannabis Concentrates Cannabis (30% THC Concentrate), Cannabis (60% THC Concentrate), Cannabis (90% THC Concentrate) - THC | Not applicable | Recruiting | Centre for Addiction and Mental Health | 48 | 2025-10-01 | 2026-06-11 |
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Marijuana Abuse (109) · Pain (30) · Multiple Sclerosis (23) · Muscle Spasticity (17) · Neuralgia (10) · Neoplasms (9) · Substance-Related Disorders (8) · Driving Under the Influence (7) · Anxiety Disorders (5) · Cancer Pain (5) · Chronic Pain (5) · Peripheral Nervous System Diseases (5) · Alcohol Drinking (4) · Alcoholic Intoxication (4) · Marijuana Smoking (4)
Jazz Pharmaceuticals (37) · Johns Hopkins University (15) · New York State Psychiatric Institute (14) · Centre for Addiction and Mental Health (10) · University of California, San Diego (9) · GW Pharmaceuticals Ltd (7) · Federal University of Latin American Integration (5) · Yale University (5) · Hadassah Medical Organization (4) · Shanna Babalonis, PhD (4) · University of California, San Francisco (4) · Battelle Memorial Institute (3) · Center for Medicinal Cannabis Research (3) · Radboud University Medical Center (3) · TO Pharmaceuticals (3)
United States (104) · United Kingdom (37) · Canada (29) · Israel (21) · Czechia (9) · Italy (8) · Poland (8) · Brazil (7) · Germany (7) · Romania (6) · Spain (6) · France (5) · Bulgaria (4) · Hungary (4) · India (4)
Ryan Vandrey, PhD (6) · Margaret Haney, Ph.D. (4) · Shanna Babalonis, PhD (3) · Tory Spindle, PhD (3) · Barbara Hoggart, MBBS, FRCA (2) · Bernard Le Foll, MD, PhD (2) · Didier Jutras-Aswad, MD,MS (2) · Donald I Abrams, M.D. (2) · Godfrey Pearlson, M.D (2) · Jeremy R Johnson, MB ChB (2) · Marcel Olde Rikkert, prof. dr. (2) · Nathaniel M Schuster, MD (2) · Thomas D Marcotte, PhD (2) · Ziva Cooper, PhD (2) · A. Eden Evins, MD (1)
PMID 25475413, PMID 34532852, PMID 15327042, PMID 19896326, PMID 23141881, PMID 26144593, PMID 26257143, PMID 28576350, PMID 31527291, PMID 33623076, PMID 34173005, PMID 12465055, PMID 12648025, PMID 15094417, PMID 15561385, PMID 16186518, PMID 16214880, PMID 16317825, PMID 17063973, PMID 17086911, PMID 17355549, PMID 17429350, PMID 17566383, PMID 17916224, PMID 17997224, PMID 18546344, PMID 18728826, PMID 19587829, PMID 19883531, PMID 20076976, PMID 20307378, PMID 20829244, PMID 21049267, PMID 21362108, PMID 21671456, PMID 21878454, PMID 21953990, PMID 22076835, PMID 22483680, PMID 22741619, PMID 22878432, PMID 23052407, PMID 23179176, PMID 23180178, PMID 23742737, PMID 23750331, PMID 24151639, PMID 24420962, PMID 24778283, PMID 25649017
2009 (4), R01DA052431 (3), 2014 (2), 2019 (2), P50DA009236 (2), R01DA043475 (2), R01DA045700 (2), R01DA052295 (2), 2016 (1), 2025 (1), P20GM130414 (1), R01DA013196 (1), R01DA019239 (1), R01DA026799 (1), R01DA034699 (1)