2119 completed, 253 unknown, 219 recruiting, 192 terminated. 3064 Phase 1, 739 Phase 2.
Follow Mental Disorders: new trials by email Literature Review of Mental Disorders trials Research Report on Mental Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Terazosin for Dementia With Lewy Bodies Terazosin Hydrochloride, Placebo - Dementia With Lewy Bodies | Phase 1 / Phase 2 | Not yet recruiting | Qiang Zhang | 40 | 2027-10-01 | 2026-03-12 |
| Neuronavigation-guided FUS-induced BBB Opening in Alzheimer's Disease Patients and Its Effects on Brain Amyloid and Tau Neuronavigation-guided single-element focused ultrasound transducer, Lumason, Magnetic Resonance Imaging (MRI) with or without gadolinium contrast agents - Alzheimer Disease, Early Onset | Phase 1 | Not yet recruiting | Columbia University | 6 | 2027-08-01 | 2026-05-13 |
| Medically Supervised Ibogaine With 12-Month Digital Recovery Support for Opioid Use Disorder Ibogaine Hydrochloride, Extended-release naltrexone injection, 380 mg, Matching Oral Placebo - Opioid Use Disorder, Opioid Withdrawal | Phase 1 / Phase 2 | Not yet recruiting | Clive Michelsen | 60 | 2027-07-01 | 2026-10-13 |
| Familial Fecal Microbiota Transplant for the Treatment of Subjects With Autism Spectrum Disorders Fecal Microbiota Transplant - Autism, Autism Spectrum Disorder | Phase 1 | Not yet recruiting | ProgenaBiome | 10 | 2027-05-01 | 2026-09-18 |
| A Clinical Trial of Iron Supplementation for Youth With ADHD and Restless Sleep Ferrous Sulfate, Placebo - ADHD, Sleep Problems | Phase 1 / Phase 2 | Not yet recruiting | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 70 | 2027-03-01 | 2026-05-04 |
| A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) Glycerol Tributyrate - MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus) | Phase 1 / Phase 2 | Not yet recruiting | George Washington University | 24 | 2027-03-01 | 2026-10-05 |
| Psilocybin Assisted Psychotherapy for Treatment Resistant Depression and Co-occurring Substance Use Disorder Psilocybin - Treatment Resistant Depression, Substance Use Disorders | Phase 1 / Phase 2 | Not yet recruiting | Indiana University | 50 | 2027-02-01 | 2026-10-23 |
| Effects of Cannabidiol (CBD) on a Fixed Dose of Delta-9-tetrahydrocannabinol (THC) 0mg THC + 0mg CBD Brownie, 10mg THC + 0mg CBD Brownie, 10mg THC + 10mg CBD Brownie - Cannabis Intoxication | Phase 1 | Not yet recruiting | Johns Hopkins University | 70 | 2027-02-01 | 2026-10-15 |
| A Phase I/II Study of PDC-1421 for Treating Depression in Cancer Patients PDC-1421 Capsule - Major Depressive Disorder | Phase 1 / Phase 2 | Not yet recruiting | BioLite, Inc. | 12 | 2027-01-15 | 2026-04-20 |
| Repurposing a Combination Antiretroviral Drug Therapy to Target Retrotransposons and Treat Early Alzheimer's Disease Emtricitabine and tenofovir disoproxil fumarate combination, Placebo - Alzheimer's Disease | Phase 1 | Not yet recruiting | Brigham and Women's Hospital | 20 | 2026-12-01 | 2026-08-31 |
| Reestablishing Normal Gut-brain Interaction in Anorexia Nervose With Normal Gut Microbiota Psychotherapy as usual combined with single dose normal gut microbiota, Psychotherapy treatment as usual (TAU) - Anorexia Nervosa | Phase 1 | Not yet recruiting | Haukeland University Hospital | 36 | 2026-12-01 | 2026-09-24 |
| ADEPT Psilocybin-Assisted Therapy With DBT for Borderline Personality Disorder Psilocybin, Psilocybin-Assisted Therapy With Dialectical Behavior Therapy - Borderline Personality Disorder, Borderline Personality Pathology | Phase 1 | Not yet recruiting | University of Minnesota | 18 | 2026-12-01 | 2026-09-22 |
| Longitudinal PET Imaging of Antipsychotic Binding to the Dopamine-3 Receptor in Schizophrenia Brexpiprazole, Cariprazine, [11C] PHNO - Schizoaffective Disorder, Schizophreniform Disorder | Phase 1 | Not yet recruiting | New York State Psychiatric Institute | 100 | 2026-12-01 | 2026-07-20 |
| Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive Performance Cannabis - Cannabis Use, Impaired Driving | Phase 1 | Not yet recruiting | Johns Hopkins University | 40 | 2026-12-01 | 2026-10-16 |
| Minocycline In Neurocognitive Outcomes - Sickle Cell Disease Minocycline, Placebo - Sickle Cell Disease, Cognitive Impairment | Phase 1 | Not yet recruiting | University of Cincinnati | 30 | 2026-12-01 | 2026-11-03 |
| Shortened LSD Intervention for Major Depressive Disorder LSD, Risperidone - Major Depression Moderate, Major Depression Severe | Phase 1 | Not yet recruiting | Johns Hopkins University | 10 | 2026-12-01 | 2026-11-03 |
| MLS101 Study in PMDD MLS101 psilocybin, Placebo capsules - Premenstrual Dysphoric Disorder ( PMDD), PMDD | Phase 1 | Not yet recruiting | MycoMedica Life Sciences PBC | 32 | 2026-12-01 | 2026-11-05 |
| Cannabis and Opioid Use Disorder, Study 2 Inhaled Cannabis, Intranasal Opioid - Opioid Use Disorders, Cannabis Use | Phase 1 | Not yet recruiting | University of Kentucky | 100 | 2026-11-30 | 2026-10-09 |
| Cannabis Effects on Opioid Self-Administration Cannabis, Placebo Cannabis, Intranasal Opioid Agonist - Opioid Use Disorder, Cannabis Use | Phase 1 | Not yet recruiting | Shanna Babalonis, PhD | 30 | 2026-11-30 | 2026-10-14 |
| A Study to Learn How Different Amounts of the Study Medicine Called PF-08161842 Are Tolerated and Act in the Body in Healthy and Older Adults PF-08161842, Placebo for PF-08161842 - Alzheimer Disease | Phase 1 | Not yet recruiting | Pfizer | 98 | 2026-11-17 | 2026-10-30 |
Showing 20 of 3064. Sign in to see all of them.
Alzheimer Disease (558) · Schizophrenia (369) · Depressive Disorder, Major (211) · Substance-Related Disorders (190) · Depression (177) · Anxiety Disorders (166) · Cognitive Dysfunction (154) · Opioid-Related Disorders (150) · Alcoholism (135) · Marijuana Abuse (129) · Stress Disorders, Post-Traumatic (125) · Dementia (102) · Tobacco Use Disorder (96) · Psychotic Disorders (94) · Cocaine-Related Disorders (92)
Nervous System Diseases (999) · Neurocognitive Disorders (812) · Chemically-Induced Disorders (765) · Central Nervous System Diseases (738) · Brain Diseases (734) · Neurodegenerative Diseases (641) · Dementia (587) · Substance-Related Disorders (575) · Tauopathies (550) · Behavior (411) · Pathological Conditions, Signs and Symptoms (384) · Schizophrenia Spectrum and Other Psychotic Disorders (380) · Mood Disorders (339) · Signs and Symptoms (290)
nabiximols (52) · Ketamine (51) · Dronabinol (49) · Cognitive Behavioral Therapy (38) · Donepezil (34) · Risperidone (32) · Buprenorphine (31) · Psilocybin (31) · Ethanol (30) · Therapeutics (30) · Sugars (29) · Naltrexone (26) · Dexmedetomidine (23) · Aripiprazole (22) · Nicotine (22)
GlaxoSmithKline (108) · Yale University (106) · National Institute on Drug Abuse (NIDA) (97) · Johns Hopkins University (53) · Eli Lilly and Company (52) · Pfizer (45) · Otsuka Pharmaceutical Development & Commercialization, Inc. (41) · Wyeth is now a wholly owned subsidiary of Pfizer (40) · New York State Psychiatric Institute (39) · Merck Sharp & Dohme LLC (38) · University of California, Los Angeles (36) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (35) · National Institute of Mental Health (NIMH) (27) · AstraZeneca (25) · VA Office of Research and Development (24)
United States (1902) · United Kingdom (170) · Canada (136) · China (122) · Germany (80) · Australia (66) · Netherlands (58) · Japan (52) · France (49) · Israel (48) · Sweden (45) · Spain (44) · South Korea (43) · Belgium (32) · Brazil (27)
Danna Jennings, MD (11) · Walter Ling, M.D. (8) · Danna L Jennings, MD (7)
PMID 29912955, PMID 22700038, PMID 33884617, PMID 25974235, PMID 29480210, PMID 32250312, PMID 32628945, PMID 33079196, PMID 34242666, PMID 34255068, PMID 35141873, PMID 36208817, PMID 36463457, PMID 37811711, PMID 37996817, PMID 38236223, PMID 38244179, PMID 38489195, PMID 38767196, PMID 42423707, PMID 42560883, PMID 12150647, PMID 22775772, PMID 22992330, PMID 24447534, PMID 25150403, PMID 25789616, PMID 26493637, PMID 26925577, PMID 27955995, PMID 28013354, PMID 28204607, PMID 28350572, PMID 28351364, PMID 28695535, PMID 29063518, PMID 30052328, PMID 30134967, PMID 30355322, PMID 31527291, PMID 31784354, PMID 32141724, PMID 32241310, PMID 33605440, PMID 33788154, PMID 34173005, PMID 34521461, PMID 35690720, PMID 35963959, PMID 37120522
2014 (12), 2016 (11), 2023 (10), 2015 (9), 2017 (8), 2019 (7), 2025 (6), P50DA018197 (6), 2009 (4), 2018 (4), P50DA018185 (4), U54DA036151 (4), P50DA009262 (3), P50DA036114 (3), R01DA010017 (3)