79 completed, 12 unknown, 8 terminated, 4 recruiting. 110 Phase 2, 21 Phase 1, 15 Phase 3.
Follow Low Back Pain: new trials by email Literature Review of Low Back Pain trials Research Report on Low Back Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Semaglutide for Low Back Pain Semaglutide (administered by PDS290 pen-injector), Placebo (administered by PDS290 pen-injector) - Lower Back Pain, Obesity (BMI>30) | Phase 2 | Not yet recruiting | Washington University School of Medicine | 250 | 2027-02-01 | 2026-07-28 |
| A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Chronic Low Back Pain LY4065967, Placebo - Chronic Pain, Low Back Pain | Phase 2 | Recruiting | Eli Lilly and Company | 150 | 2026-08-12 | 2026-11-04 |
| Ketamine-assisted Integrative Treatment for Veterans With Chronic Low Back Pain and Comorbid Depression Ketamine hydrochloride, Minimally Enhanced Usual Care, Brief narrative intervention - Chronic Low Back Pain, Depression | Phase 2 | Recruiting | VA Office of Research and Development | 44 | 2025-12-03 | 2025-12-18 |
| Development and Evaluation of Computerized Chemosensory-Based Orbitofrontal Networks Training for Treatment of Pain (CBOT-P) Computerized Chemosensory-Based Orbitofrontal Cortex Training for Pain, Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) - Chronic Pain, Low Back Pain | Phase 2 | Recruiting | Evon Medics LLC | 220 | 2024-10-23 | 2024-11-04 |
| PRP Spinoplasty for Chronic Low Back Pain With Multiple Pathologies: A Quasi-Experimental Study Spinoplasty with Platelet Rich Plasma - Lower Back Pain Chronic, Lumbar Disc Disease | Phase 2 | Completed | Allmed Medical Center | 35 | 2024-09-15 | 2025-12-08 |
| Comparison of the Efficacy of Diclofenac Sodium and Subcutaneous 5% Dextrose Injection in Low Back Pain. 5% dextrose prolotherapy, Diclofenac 75mg/ml - Low Back Pain, Mechanical | Phase 1 / Phase 2 | Enrolling by invitation | Aksaray University Training and Research Hospital | 150 | 2024-07-15 | 2025-02-19 |
| Dose-Response Characterization of VER-01 in the Treatment of Patients With Chronic Non-specific Low Back Pain VER-01, Placebo - Chronic Non-specific Low Back Pain | Phase 2 | Completed | Vertanical GmbH | 652 | 2024-06-28 | 2025-08-11 |
| Dronabinol as an Adjunct for Reducing Pain Dronabinol, Placebo - Low Back Pain, Chronic Pain | Phase 2 | Recruiting | Christopher D. Verrico | 75 | 2024-06-15 | 2026-05-18 |
| Open-label Placebo in Manual Therapy Open-label placebo, Osteopathic manipulative treatment - Low Back Pain, Recurrent | Phase 2 | Completed | Studio Osteopatico Busto Arsizio | 31 | 2024-02-26 | 2025-08-11 |
| Efficacy and Safety of S (+) - Ibuprofen in the Treatment of Mechanical Low Back Pain S (+) - Ibuprofen, Ibuflex® - Low Back Pain, Mechanical, Low Back Pain | Phase 2 | Completed | Apsen Farmaceutica S.A. | 177 | 2022-06-03 | 2026-09-08 |
| Safety and Efficacy of SP-103 in Subjects With Moderate to Severe Acute Lower Back Pain SP-103, Placebo - Moderate to Severe Acute Lower Back Pain | Phase 2 | Completed | Scilex Pharmaceuticals, Inc. | 76 | 2022-04-29 | 2026-07-06 |
| Breathing and Attention Training for Chronic Low Back Pain Breathing and Attention Training - Chronic Low-back Pain | Phase 1 / Phase 2 | Completed | University of Florida | 29 | 2021-07-18 | 2024-06-10 |
| Alberta Back Care Pathway (ABCp) ABCp, Usual Care - Low Back Pain | Phase 2 | Completed | University of Alberta | 713 | 2021-03-31 | 2026-10-26 |
| Treating Negative Affect in Low Back Pain Patients Antidepressant, Enhanced Fear Avoidance Rehabilitation - Chronic Low Back Pain, Negative Affectivity | Phase 2 | Completed | Ajay Wasan, MD, Msc | 308 | 2021-03-31 | 2026-08-28 |
| Efficacy of Intradiscal Injection of Autologous BM-MSC in Subjects With Chronic LBP Due to Multilevel Lumbar IDD Autologous BM-MSC, Sham - Intervertebral Disc Degeneration, Chronic Low-back Pain | Phase 2 | Unknown | Fondazione Policlinico Universitario Campus Bio-Medico | 52 | 2021-03-22 | 2025-05-25 |
| Effect of Abaloparatide on Lumbar Disc Degeneration Abaloparatide, Placebo - Degeneration Disc Intervertebral | Phase 2 | Withdrawn | Johns Hopkins University | 2021-03-01 | 2021-04-12 | |
| Persica 002 Phase 1b PP353 vs Placebo in the Treatment of Low Back Pain PP353, Placebo - Chronic Low-back Pain | Phase 1 / Phase 2 | Completed | Persica Pharmaceuticals Ltd | 43 | 2020-01-20 | 2026-03-27 |
| Effects of Metformin on Low Back Pain Metformin, Placebo - Low Back Pain | Phase 2 | Terminated | Gwendolyn Sowa | 23 | 2020-01-07 | 2025-02-21 |
| Safety and Efficacy of SX600 Administered by Lumbosacral Transforaminal Epidural Injection for Radicular Pain SX600, Placebo - Lumbar Radiculopathy | Phase 1 / Phase 2 | Terminated | SpineThera Australia PTY LTD | 56 | 2019-11-04 | 2024-01-10 |
| Efficacy of Intradiscal Injection of Autologous BM-MSC in Worker Patients Affected by Chronic LBP Due to Multilevel IDD Autologous BM-MSC, Sham Procedure - Intervertebral Disc Degeneration, Chronic Low-back Pain | Phase 2 | Completed | Fondazione Policlinico Universitario Campus Bio-Medico | 48 | 2019-11-03 | 2025-05-25 |
Showing 20 of 110. Sign in to see all of them.
Back Pain (14) · Chronic Pain (13) · Intervertebral Disc Degeneration (13) · Pain (12) · Motor Activity (8) · Radiculopathy (8) · Sciatica (8) · Neuralgia (4) · Acute Pain (3) · Bronchiolitis Obliterans Syndrome (3) · Agnosia (2) · Depression (2) · Health Education (2) · Intervertebral disc disease (2)
Neurologic Manifestations (110) · Pathological Conditions, Signs and Symptoms (110) · Signs and Symptoms (110) · Pain (98) · Back Pain (96) · Nervous System Diseases (19) · Musculoskeletal Diseases (18) · Neuromuscular Diseases (15) · Bone Diseases (14) · Peripheral Nervous System Diseases (14) · Spinal Diseases (14) · Behavior (12) · Mononeuropathies (8) · Sciatic Neuropathy (8) · Neuralgia (7)
Exercise (4) · Manipulation, Osteopathic (3) · Manipulation, Spinal (3) · Naproxen (3) · Sodium Chloride (3) · tanezumab (3) · Cognitive Behavioral Therapy (2) · Cycloserine (2) · Dronabinol (2) · Duloxetine Hydrochloride (2) · Genes, mos (2) · Ibuprofen (2) · Lidocaine (2) · Manipulation, Chiropractic (2) · Massage (2)
Johns Hopkins University (4) · National Institute of Dental and Craniofacial Research (NIDCR) (3) · Northwestern Health Sciences University (3) · Pfizer (3) · Fondazione Policlinico Universitario Campus Bio-Medico (2) · Janssen Pharmaceutical K.K. (2) · Kovacs Foundation (2) · NEMA Research, Inc. (2) · Northwestern University (2) · Red de Terapia Celular (2) · University of Florida (2) · University of North Texas Health Science Center (2) · Ahmad Jabir Rahyussalim (1) · Ajay Wasan, MD, Msc (1) · Aksaray University Training and Research Hospital (1)
United States (58) · Spain (8) · Canada (6) · Italy (6) · United Kingdom (6) · Germany (5) · Australia (4) · Brazil (3) · Denmark (3) · France (3) · Turkey (Türkiye) (3) · Austria (2) · Belgium (2) · Finland (2) · Hungary (2)
Charlotte Richmond, PhD (2) · Gert Bronfort, DC, PhD (2) · Joseph V Pergolizzi, MD (2) · Aage Indahl, Ph.d (1) · Adrian Jury, MD (1) · Ajay Wasan, MD, MSc (1) · Aleksandra Zgierska, MD PhD (1) · Alex F Manini, MD, MS, FACMT (1) · Ana Sanchez, MD, PhD (1) · Annette C Toledano, MD (1) · Anthony Rosner, PhD (1)
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