86 completed, 12 withdrawn, 11 terminated, 11 unknown. 49 Phase 2, 27 Not applicable, 20 Phase 3, 16 Phase 4, 13 Phase 1.
Follow this drug Literature Review of Cycloserine trials Research Report on Cycloserine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ONE-P TMS Military Veterans D-Cycloserine (DCS), Placebo, Intermittent Theta Burst Stimulation (iTBS) - PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | Fidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA | 50 | 2026-11-01 | 2026-08-20 |
| ONE-P TMS First Responders D-Cycloserine (DCS), Placebo, Intermittent Theta Burst Stimulation (iTBS) - PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | Fidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA | 50 | 2026-11-01 | 2026-08-19 |
| Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101 TMS, NRX-101 - Major Depression | Early Phase 1 | Not yet recruiting | Mclean Hospital | 30 | 2026-09-01 | 2026-09-22 |
| Synaptic Mechanisms of Intermittent Theta Burst Stimulation for Major Depressive Disorder Sham iTBS, TMS, D-cycloserine - Major Depression, Healthy Participants | Phase 1 / Phase 2 | Not yet recruiting | Mclean Hospital | 100 | 2026-09-01 | 2026-08-14 |
| Varenicline and Accelerated Transcranial Magnetic Stimulation (TMS) for Quitting Nicotine Use (Pilot Study) Varenicline, Transcranial Magnetic Stimulation, Transcranial Magnetic Stimulation Sham - Nicotine Dependence, Transcranial Magnetic Stimulation | Phase 4 | Recruiting | Massachusetts General Hospital | 30 | 2026-07-02 | 2026-09-15 |
| A Pilot Trial of One-Day Accelerated TMS and D-cycloserine in Suicidal Patients With Borderline Personality Disorder TMS, D-Cycloserine (DCS) - Borderline Personality Disorder (BPD) | Phase 1 / Phase 2 | Recruiting | Mclean Hospital | 20 | 2026-06-10 | 2026-08-05 |
| Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression D-Cycloserine (DCS), Continuous theta-burst stimulation (cTBS), Transcranial Magnetic Stimulation Sham - Major Depression | Early Phase 1 | Recruiting | Mclean Hospital | 80 | 2026-03-11 | 2026-05-13 |
| 6 Months of Bedaquiline(BDQ), Delamanid(DLM), Linezolid(LZD) and Levofloxacin(LFX) in RR-TB Patients in Hubei Province bedaquiline, Delamanid (DLM), Linezolid (LZD) - Treat to Target, Treatment Duration | Not applicable | Not yet recruiting | Wuhan Pulmonary Hospital | 52 | 2025-09-30 | 2025-09-30 |
| Novel and Conventional Interventions for Cognitive and Emotional Flexibility in Patient Trauma D-Cycloserine (DCS), Transcranial Magnetic Stimulation, Unified Protocol - Depression, Anxiety | Phase 2 | Active not recruiting | Mclean Hospital | 75 | 2025-06-01 | 2026-10-09 |
| Medial Enhancement Technique for the Treatment of Old Femoral Neck Fractures cannulated compression screws + iliac bone graft, DCS + medial support plate + iliac bone graft - Fracture of Neck of Femur | Not applicable | Not yet recruiting | Chinese PLA General Hospital | 400 | 2024-12-10 | 2024-12-04 |
| D-Cycloserine for Serine Palmitoyltransferase Inhibition D-cycloserine - Hereditary Spastic Paraplegia | Phase 4 | Completed | Massachusetts General Hospital | 1 | 2024-07-10 | 2026-04-21 |
| NRX-101 for Complicated Urinary Tract Infection (UTI) Including Pyelonephritis NRX101 (a fixed dose combination of D-cycloserine (DCS) and lurasidone HCl (lurasidone)) - Urinary Tract Infections, Pyelonephritis | Phase 2 | Unknown | NeuroRx, Inc. | 13 | 2024-03-31 | 2023-11-13 |
| iTBS+D-Cycloserine for Youth Suicide D-Cycloserine, intermittent Theta-Burst-repetitive Transcranial Magnetic Stimulation, Placebo oral tablet - Suicidal Ideation, Suicide, Attempted | Phase 2 | Recruiting | University of Calgary | 54 | 2024-03-11 | 2024-11-12 |
| Effect of DCS on Post-Endodontic Pain Calcium Hydroxide (CH), Diclofenac Sodium (DCS), Calcium Hydroxide + Diclofenac Sodium (CH + DCS) - Post Endodontic Pain | Not applicable | Completed | Mustafa Kemal University | 90 | 2024-01-22 | 2025-08-22 |
| Innovating Shorter, All- Oral, Precised, Individualized Treatment Regimen for Rifampicin Resistant Tuberculosis：Contezolid, Delamanid and Bedaquiline Cohort Bedaquiline, Delamanid, Contezolid - Pulmonary Tuberculosis, Rifampicin-resistant Tuberculosis | Phase 3 | Active not recruiting | Beijing Chest Hospital | 186 | 2023-12-22 | 2025-04-01 |
| Assisting Smokers to Switch to an e-Cigarette by Accelerating Learning of Adaptive Habits Using D-cycloserine d-cycloserine, Juul e-cigarette - Smoking Cessation, Harm Reduction | Phase 2 | Completed | Rose Research Center, LLC | 25 | 2023-10-20 | 2026-01-20 |
| D-Cycloserine Augmentation of Intermittent Theta Burst Stimulation (iTBS) in Depression (COGENT) D-Cycloserine, Intermittent Theta Burst Stimulation - Major Depressive Disorder | Phase 2 | Active not recruiting | The Alfred | 180 | 2023-04-21 | 2025-12-04 |
| D-cycloserine Augmented Treatment for Youth With Tic Disorders d-cycloserine, Placebo pill, Behavior Therapy - Tourette Syndrome | Early Phase 1 | Withdrawn | Johns Hopkins University | 2023-04-15 | 2023-04-14 | |
| D-Cycloserine+iTBS PK Study D-cycloserine, Transcranial Magnetic Stimulator - Major Depressive Disorder | Phase 1 | Completed | University of Calgary | 12 | 2022-10-12 | 2023-09-11 |
| iTBS-DCS in Fibromyalgia D-Cycloserine, Placebo oral tablet, iTBS repetitive Transcranial Magnetic Stimulation (rTMS) - Fibromyalgia | Phase 2 | Terminated | University of Calgary | 47 | 2022-08-29 | 2025-08-17 |
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Stress Disorders, Post-Traumatic (14) · Depressive Disorder, Major (11) · Obsessive-Compulsive Disorder (11) · Schizophrenia (10) · Anxiety Disorders (7) · Depression (6) · Bipolar Disorder (5) · Panic Disorder (5) · Phobia, Social (5) · Psychotic Disorders (5) · Smoking (5) · Substance-Related Disorders (5) · Chronic Pain (4) · Combat Disorders (4) · Opioid-Related Disorders (4)
Massachusetts General Hospital (14) · Boston University Charles River Campus (8) · University of Calgary (8) · Mclean Hospital (6) · New York State Psychiatric Institute (5) · University of California, Los Angeles (4) · Emory University (3) · Hartford Hospital (3) · Indiana University (3) · Northwestern University (3) · University of Arkansas (3) · University of Oxford (3) · Yale University (3) · Beijing Chest Hospital (2) · Charite University, Berlin, Germany (2)
United States (89) · Canada (13) · China (5) · Germany (4) · Israel (4) · Australia (3) · United Kingdom (3) · South Korea (2) · Argentina (1) · Belgium (1) · Botswana (1) · Brazil (1) · Denmark (1) · Netherlands (1) · Norway (1)
Alexander McGirr, MD PhD (3) · Alexander McGirr, MD, PhD (3) · Eric Storch, Ph.D. (3) · Christopher J. McDougle, MD (2) · David Tolin, PhD (2) · Donald C Goff, M.D. (2) · Donald Goff, MD (2) · Fidel Vila-Rodriguez, M.D., PhD, FRCPC, DFAPA (2) · Joshua C Brown, MD, PhD (2) · Mark H Pollack, MD (2) · Michael S Scheeringa, MD, MPH (2) · Michael W. Otto, Ph.D. (2) · Sabine Wilhelm, PhD (2) · A-Dong Shen, Master (1) · A. Eden Evins, MD, MPH (1)
PMID 37811711, PMID 24506079, PMID 28569390, PMID 33583058, PMID 15276398, PMID 15474895, PMID 15502972, PMID 15840453, PMID 16470119, PMID 16677714, PMID 16988514, PMID 17898352, PMID 18366444, PMID 18795962, PMID 18799288, PMID 18989231, PMID 19588358, PMID 19811776, PMID 20002783, PMID 20303474, PMID 20570701, PMID 20632458, PMID 20817153, PMID 21124304, PMID 21283017, PMID 21292243, PMID 21723096, PMID 22083071, PMID 22129166, PMID 22530208, PMID 22694905, PMID 23059145, PMID 23098672, PMID 23305215, PMID 23332511, PMID 23392467, PMID 23497788, PMID 23599046, PMID 23870811, PMID 24038728, PMID 24485587, PMID 24743802, PMID 24938849, PMID 25162818, PMID 25261418, PMID 25407158, PMID 25441015, PMID 25566387, PMID 25950206, PMID 25959631
P50MH060450 (3), R01DA010017 (2), R01MH075889 (2), 1RC1MH088969-01 (1), 2014 (1), K20DA000191 (1), K23MH068627 (1), R01CA129639 (1), R01DA017904 (1), R01DA023188 (1), R01DK100924 (1), R01MH059807 (1), R01MH070880 (1), R01MH072961 (1), R01MH078308 (1)