77 completed, 28 unknown, 14 recruiting, 11 not yet recruiting. 69 Not applicable, 20 Phase 2, 14 Phase 3, 11 Phase 1, 10 Phase 4.
Follow this condition Literature Review of Sciatica trials Research Report on Sciatica
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hypersound Treatment for Chronic Neuropathic and Radicular Pain Hypersound RF-PNS system, Sham Hypersound - Chronic Neuropathic Pain, Radiculopathy | Not applicable | Not yet recruiting | Hypersound Medical Inc | 71 | 2027-06-01 | 2026-09-21 |
| Corticosteroid Lumbar Epidural Analgesia for Radicular Pain 2 SP-102, Placebo, Dexamethasone Sodium Phosphate 10 MG/ML - Lumbosacral Radicular Pain | Phase 3 | Not yet recruiting | Semnur Pharmaceuticals, Inc. | 755 | 2027-02-01 | 2026-09-09 |
| Randomized Evaluation of Lumbar Injection Effectiveness and Function Triojection® System, Selective Nerve Root Block (SNRB) - Lumbar Radiculopathy, Lumbar Disc Herniation | Not applicable | Not yet recruiting | SpinaFX Medical Inc. | 300 | 2027-01-15 | 2026-10-07 |
| Effect of Transfer of Energy Capacitive and Resistive on Chronic Discogenic Sciatica Transfer of Energy Capacitive and Resistive (TECAR) therapy, conventional physical therapy program - Lumbar Radiculopathy | Not applicable | Recruiting | Cairo University | 34 | 2026-09-21 | 2026-09-28 |
| Dose Dependent Steroid Injections Triamcinolone 10 Mg/mL Injectable Suspension, Triamcinolone 40 Mg/mL Injectable Suspension, Triamcinolone 80 Mg/mL Injectable Suspension - Lumbar Radiculopathy, Sciatica | Phase 4 | Not yet recruiting | University of Miami | 150 | 2026-09-15 | 2026-08-12 |
| Mirror Image Spine Correction Exercises Versus Conservative Physiotherapy for Lumbar Radiculopathy Mirror Image Spine Correction Exercises, Conservative Physiotherapy - Radiculopathy, Radiculopathy Lumbar | Not applicable | Not yet recruiting | University of Sharjah | 64 | 2026-09-01 | 2026-04-30 |
| Success Rates and Safety of Steroid Injections in Managing Spinal and Sacro-Iliac Pain (CORTisone Injection Spine Study) triamcinolone acetonide (Kenalog), Celestone Soluspan 6Mg/Ml Suspension for Injection, Depo-Medrol 40Mg/Ml Suspension for Injection - Back Pain Lower Back, Neck Pain | Phase 4 | Recruiting | Igor Wilderman. MD | 500 | 2026-07-30 | 2026-08-13 |
| Comparing Two Soft Tissues Technique on Piriformis Syndrome Patients Myofascial Release, Post Isometric Relaxation - Piriformis Syndrome, Musculoskeletal Abnormalities | Not applicable | Not yet recruiting | University of Faisalabad | 26 | 2026-06-30 | 2026-06-30 |
| Comparing the Effectiveness of Tensioner Vs Slider Neurodynamic Techniques in Patients With Sciatica Slider Neurodynamic Technique Group, Tensioner Neurodynamic Technique Group - Sciatica, Sciatica Pain | Not applicable | Recruiting | Ibadat International University, Islamabad | 80 | 2026-06-03 | 2026-06-08 |
| Comparing Ultrasound-Guided Transgluteal Nerve Block to Standard Care nerve block with ropivacaine, Standard medical treatment - Sciatica Acute | Not applicable | Recruiting | University of California, San Francisco | 100 | 2026-05-26 | 2026-06-02 |
| Efficacy of Sciatic Nerve Electrical Stimulation and Therapeutic Exercise in the Management of Low-back Related Leg Pain Percutaneous Electrical Nerve Stimulation, Placebo Transcutaneous Electrical Nerve Stimulation, Transcutaneous Electrical Nerve Stimulation - Sciatica | Not applicable | Recruiting | Universidad Complutense de Madrid | 88 | 2026-05-13 | 2026-05-14 |
| Immediate and 1-week Efficacy of a Single Session of Sciatic Nerve Electrical Stimulation in the Management of Low-back Related Leg Pain Percutaneous Electrical Nerve Stimulation, Placebo Transcutaneous Electrical Nerve Stimulation, Transcutaneous Electrical Nerve Stimulation - Sciatica | Not applicable | Recruiting | Universidad Complutense de Madrid | 88 | 2026-05-13 | 2026-05-14 |
| Segmental Decompression Versus Wide Decompression With Fixation for Degenerative Lumbar Canal Stenosis Segmental Decompression, Wide Decompression with Fixation - Degenerative Lumbar Spinal Stenosis | Not applicable | Not yet recruiting | Assiut University | 56 | 2026-05-01 | 2026-04-21 |
| Electroacupuncture for Insomnia in Patients With Chronic Sciatica Due to Lumbar Disc Herniation: a Randomized Controlled Trial Electroacupuncture, Sham electroacupuncture - Sciatica, Lumbar Disc Herniation | Not applicable | Not yet recruiting | Shanghai Yueyang Integrated Medicine Hospital | 114 | 2026-05-01 | 2026-05-08 |
| Procedural Framing and Epidural Steroid Injection Outcomes Behavioral manipulation of ESI expectations, No behavioral manipulation of ESI expectations, No behavioral manipulation of pharmacotherapy expectations - Lumbosacral Radiculopathy | Not applicable | Recruiting | Northwestern University | 210 | 2026-03-30 | 2026-08-18 |
| Two-leg Rotation and Sciatica standard physical therapy, 2 leg rotation - Sciatica Due to Intervertebral Disc Disorder | Not applicable | Completed | University of Hail | 80 | 2026-03-15 | 2026-09-10 |
| Diagnostic Accuracy of Clinical Tests and Diagnostic Criteria for Piriformis Syndrome Ultrasound-Guided Piriformis Injection - Piriformis Syndrome, Gluteal Pain | Not applicable | Not yet recruiting | Istanbul University - Cerrahpasa | 75 | 2026-03-15 | 2026-03-17 |
| FINDISC-Pain, Finnish Discectomy Trial on the Benefits and Harms of Surgery in Patients With Lumbar Disc Herniation Microdiscectomy, Placebo-surgery - Lumbar Disc Herniation With Radiculopathy, Sciatica | Not applicable | Recruiting | Helsinki University Central Hospital | 122 | 2026-02-19 | 2026-05-22 |
| The Role of Temporal Changes in Pain Response After Transforaminal Epidural Steroid Injection on Treatment Success Transforaminal epidural steroid injection - Lumbar Disc Herniation, Lumbar Radiculopathy | Not yet recruiting | Marmara University | 120 | 2026-02-15 | 2026-01-26 | |
| Study to Evaluate Safety of C-1101 Versus Sterile Saline in Adults With Chronic Painful Lumbosacral Radiculopathy C-1101, Placebo: Sterile Saline - Lumbosacral Radicular Pain, Sciatic Radiculopathy | Phase 1 | Recruiting | Consano Bio | 24 | 2025-12-03 | 2026-10-21 |
Showing 20 of 143. Sign in to see all of them.
Low Back Pain (47) · Radiculopathy (35) · Intervertebral Disc Displacement (29) · Back Pain (19) · Pain (12) · Chronic Pain (7) · Intervertebral disc disease (5) · Neuralgia (5) · Agnosia (4) · Motor Activity (4) · Piriformis Muscle Syndrome (4) · Complex Regional Pain Syndromes (3) · Intervertebral Disc Degeneration (3) · Neck Pain (3)
Mononeuropathies (143) · Nervous System Diseases (143) · Neurologic Manifestations (143) · Pathological Conditions, Signs and Symptoms (143) · Neuromuscular Diseases (142) · Peripheral Nervous System Diseases (142) · Sciatic Neuropathy (142) · Signs and Symptoms (142) · Neuralgia (138) · Pain (131) · Back Pain (41) · Musculoskeletal Diseases (38) · Bone Diseases (36) · Spinal Diseases (35) · Pathological Conditions, Anatomical (29)
Acupuncture Therapy (8) · Electroacupuncture (7) · Nerve Growth Factor (4) · Physical Therapy Modalities (4) · Phytotherapy (4) · Transcutaneous Electric Nerve Stimulation (4) · Acetaminophen (3) · Cupping Therapy (3) · Dexamethasone (3) · Methylprednisolone (3) · Morphine (3) · Triamcinolone Acetonide (3) · Control Groups (2) · Diclofenac (2) · Ibuprofen (2)
Riphah International University (7) · Jaseng Medical Foundation (6) · Biogen (4) · Johns Hopkins University (4) · Kaiser Permanente (3) · National Institute of Dental and Craniofacial Research (NIDCR) (3) · Universidad Complutense de Madrid (3) · University of Lahore (3) · Assistance Publique - Hôpitaux de Paris (2) · Cairo University (2) · Istanbul University - Cerrahpasa (2) · Marmara University (2) · Medtronic Spinal and Biologics (2) · Nantes University Hospital (2) · Semnur Pharmaceuticals, Inc. (2)
United States (42) · Pakistan (14) · France (8) · South Korea (8) · Turkey (Türkiye) (8) · Canada (7) · Australia (5) · Spain (5) · Egypt (4) · Israel (4) · Netherlands (4) · China (3) · Belgium (2) · Denmark (2) · Germany (2)
Steven P Cohen, MD (4) · Dmitri Lissin, MD (2) · Aaron Bernstein, PhD (1) · Aiza Yousaf, MSOMPT (1) · Amnah Anum, MSPT (1) · Andrew L. Avins, MD, MPH (1) · Anne Haugen, MD,PhD (1) · Aruba Saeed, Phd (1) · Asim Arif, PhD (1) · Beliz Belgen Kaygisiz, PT, PhD (1) · Binash Afzal, PHD* (1)
PMID 11145807, PMID 12384756, PMID 12897484, PMID 15115710, PMID 15454701, PMID 15615926, PMID 15844437, PMID 16192528, PMID 16371894, PMID 17414235, PMID 19301989, PMID 19387178, PMID 20433733, PMID 20506391, PMID 21267044, PMID 21686825, PMID 21912311, PMID 22059194, PMID 22157067, PMID 22508732, PMID 23684469, PMID 23877110, PMID 25230270, PMID 25313534, PMID 25603749, PMID 25794202, PMID 25883095, PMID 25962165, PMID 25988461, PMID 26459006, PMID 26596627, PMID 26813755, PMID 27162893, PMID 27634158, PMID 28259854, PMID 28836092, PMID 29177632, PMID 30056385, PMID 30651139, PMID 31415416, PMID 31481010, PMID 31578925, PMID 32021387, PMID 33017565, PMID 33705612, PMID 33981160, PMID 34196963, PMID 34989876, PMID 35701830, PMID 38318303
2014 (1), K12NS130673 (1), R01AR053960 (1), R34AT011209 (1)