69 completed, 13 unknown, 6 terminated, 4 not yet recruiting. 86 Not applicable, 7 Phase 2, 4 Phase 1, 1 Phase 3.
Follow Manipulation, Spinal: new trials by email Literature Review of Manipulation, Spinal trials Research Report on Manipulation, Spinal
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Lumbar Spinal Manipulation in Stroke Lumbar Spinal Manipulation, Placebo Lumbar Spinal Manipulation - Stroke | Not applicable | Not yet recruiting | Bitlis Eren University | 52 | 2026-12-15 | 2026-10-22 |
| Effects of Virtual Reality Exergames Versus Spinal Manipulation in Chronic Nonspecific Low Back Pain Virtual Reality, Spinal manipulation - Chronic Nonspecific Low-back Pain, CNSLBP | Not applicable | Recruiting | Cairo University | 80 | 2026-10-01 | 2026-10-15 |
| Neuroscience Education and Spinal Manipulation on Health Locus of Control in Low Back Pain Pain Neuroscience Education (PNE), Spinal Manipulation (SM) - Low Back Pain | Not applicable | Not yet recruiting | Centro Universitário Augusto Motta | 74 | 2026-07-01 | 2026-06-10 |
| The Effect of Spinal Manipulation on Heart Rate Variability in Children With Cerebral Palsy. Spinal manipulation, Sham Procedure - Cerebral Palsy (CP) | Not applicable | Recruiting | International Clinic of Rehabilitation, Ukraine | 20 | 2026-05-01 | 2026-05-29 |
| Validating a Clinical Prediction Rule to Guide Manual Therapy and Exercise for Neck Pain Relief Cervical Manipulation, Exercise, Mobilization - Neck Pain Musculoskeletal, Neck Pain Treatment | Not applicable | Active not recruiting | Baylor University | 160 | 2025-06-01 | 2026-09-14 |
| Clinical Study on the Use of Massage to Reconstruct the Function of Lumbar Stabilizer Muscles and Improve the "Muscle and Bone Imbalance" of Lumbar Disc Herniation Spinal Manipulation, Medication - Lumbar Disc Herniation | Not applicable | Not yet recruiting | The First Affiliated Hospital of Zhejiang Chinese Medical University | 96 | 2025-04-30 | 2025-04-27 |
| Effects of Cervical Manipulation on Cervical Rotation Motion and Shoulder Rotational Motion and Strength in Overhead Athletes cervical manipulation - Cervical Spine, Manipulation, Spinal | Not applicable | Completed | Sacred Heart University | 20 | 2025-04-07 | 2025-09-03 |
| Neuromuscular Effects of Spinal Manipulation in Individuals Following Anterior Cruciate Ligament Reconstruction Spinal Manipulation - Anterior Cruciate Ligament Reconstruction | Not applicable | Completed | Universidad Rey Juan Carlos | 20 | 2025-03-03 | 2025-06-27 |
| to Stuidy the Effect of Cognitive Behavior Threapy CBT on Problematic Smartphone Use Patients With Tension Type Headache cognitive behavioral therapy, sub-occipital inhibitory pressure, deep friction massage - Tension Type Headache, Smartphone Addiction | Not applicable | Completed | Hatem Mostafa | 64 | 2025-01-29 | 2026-09-16 |
| Comparison Between Lumbar Stabilization Exercises and Lumbar Manipulation on Multifidus Muscle in Chronic Low Back Pain This Study Will Investigate and Compare the Effect of Lumbar Stabilization Exercises and Manipulation on Multifidus Muscle in Chronic Low Back Pain Stretching and strengthening exercises for back muscles, Lumbar stabilization Exercises, Lumbar Manipulation - Chronic Low Back Pain (CLBP) | Not applicable | Not yet recruiting | Cairo University | 60 | 2025-01-20 | 2025-01-28 |
| B Vitamin Supplementation to Chiropractic Management of Chronic LBP: Pilot Clinical Trial (VCLBP) Spinal Manipulation - Recurrent Low Back Pain | Not applicable | Unknown | University of Western States | 60 | 2024-11-15 | 2024-08-29 |
| Influence of Verbal Suggestion on the Therapeutic Effect of the Joint Manipulation Lumbar manipulation, Positive communication - placebo, Negative communication - nocebo - Back Pain | Not applicable | Completed | John Paul II University in Biała Podlaska | 64 | 2024-10-14 | 2025-02-06 |
| The Effects of Cervical and Thoracic Manipulation Therapy Applied to Weightlifting Athletes Spinal Manipulation - Weightlifting, Breathing | Not applicable | Unknown | Selcuk University | 40 | 2024-10-04 | 2024-09-23 |
| Spinal Manipulation For Menstrual Symptoms and Sleep in Individuals With Primary Dysmenorrhea Connective Tissue Massage (CTM), Spinal Manipulation, Sham Spinal Manipulation - Primary Dysmenorrhea, Dysmenorrhea | Not applicable | Completed | Istanbul University - Cerrahpasa | 75 | 2024-09-16 | 2026-04-15 |
| Manipulation and Dry Needling in Patients With Cervicogenic Headache and WAD II Dry Needling,Thrust Manipulation, Exercise,Non-thrust Mobilization - Cervicogenic Headache, Whiplash Injuries | Not applicable | Recruiting | Alabama Physical Therapy & Acupuncture | 120 | 2024-07-20 | 2025-05-11 |
| The Effect of Lumbar and Sacroiliac Manipulation on Football Players Lumbar spinal manipulation, Sacroiliac joint manipulation - Sports Physical Therapy, Neuromuscular Subluxation of Joint | Not applicable | Completed | SEFA HAKTAN HATIK | 45 | 2024-05-01 | 2024-08-23 |
| Effects of Lumbar Spinal Manipulation in Subjects With Chronic Low Back Pain spinal manipulation, simulated manipulation - Low Back Pain | Not applicable | Unknown | Universidad de Córdoba | 34 | 2024-05-01 | 2024-05-06 |
| Comparison of the Effect of Spinal Manipulation by Gender Spinal Manipulation - Mechanical Low Back Pain, Chronic Pain | Not applicable | Completed | SEFA HAKTAN HATIK | 62 | 2024-04-01 | 2024-08-29 |
| Effect of Lumbar Manipulation on Intervertebral Motion, Pain, and Disability Lumbar Manipulation, Sham Lumbar Manipulation - Low Back Pain | Not applicable | Unknown | Ithaca College | 40 | 2024-02-27 | 2024-03-08 |
| Validation of the Cervicothoracic Differentiation Test spinal manipulation - Neck Pain | Not applicable | Completed | University of Hartford | 40 | 2024-02-20 | 2024-07-11 |
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Low Back Pain (27) · Neck Pain (12) · Back Pain (7) · Pain (4) · Post-Traumatic Headache (4) · Headache (3) · Intervertebral Disc Displacement (3) · Stroke (3) · Bronchiolitis Obliterans Syndrome (2) · Bruxism (2) · Cerebral Palsy (2) · Chronic Pain (2) · Hypertension (2) · Muscle Weakness (2) · Spinal Stenosis (2)
Alabama Physical Therapy & Acupuncture (4) · Canadian Memorial Chiropractic College (4) · University of Florida (4) · University of Western States (4) · Université du Québec à Trois-Rivières (4) · Cairo University (3) · Balgrist University Hospital (2) · Grant Sanders (2) · International Clinic of Rehabilitation, Ukraine (2) · Palmer College of Chiropractic (2) · Real Centro Universitario Maria Cristina (2) · SEFA HAKTAN HATIK (2) · Santa Catarina Federal University (2) · Shin Kong Wu Ho-Su Memorial Hospital (2) · The First Affiliated Hospital of Zhejiang Chinese Medical University (2)
United States (33) · Canada (11) · Spain (9) · Brazil (7) · Turkey (Türkiye) (6) · Egypt (3) · Chile (2) · Denmark (2) · Portugal (2) · Switzerland (2) · Taiwan (2) · Ukraine (2) · Belgium (1) · China (1) · France (1)
Brian Swanson, PT, DSc (2) · Greg Wells, PhD (2) · James Dunning, DPT (2) · John J Triano, DC, PhD (2) · Lin-Fen Hsieh, M.D (2) · Martin Descarreaux, DC, PhD (2) · Michael Noseworthy, PhD (2) · Mitchell Haas, DC, MA (2) · Ahmed El Melhat (1) · Amanda Packer, MSc (1) · Arantxa Ortega-De Mues, PhD (1) · Benjamin Hidalgo, PhD-s (1)
PMID 11175682, PMID 11390343, PMID 11558625, PMID 11690728, PMID 11805661, PMID 11872884, PMID 12544957, PMID 12670669, PMID 15365964, PMID 15611489, PMID 16155277, PMID 16210710, PMID 16305273, PMID 16326235, PMID 16386067, PMID 16511926, PMID 16837235, PMID 16911795, PMID 17023251, PMID 17142640, PMID 17668269, PMID 17936054, PMID 1834753, PMID 18492844, PMID 19028251, PMID 19208371, PMID 19521015, PMID 19632904, PMID 19797305, PMID 19837005, PMID 20114095, PMID 20497573, PMID 20605552, PMID 20634268, PMID 20838622, PMID 20937919, PMID 21303529, PMID 2157581, PMID 21979312, PMID 22081365, PMID 22585595, PMID 22694756, PMID 22895940, PMID 22923162, PMID 23206961, PMID 23886844, PMID 24139233, PMID 24361109, PMID 24378321, PMID 24410959
R01AT006334 (2), R01AT007311 (1), R21AT002324 (1), U01AT001908 (1)