36 completed, 9 unknown, 5 recruiting, 2 terminated. 55 Phase 1, 21 Phase 2.
Follow Low Back Pain: new trials by email Literature Review of Low Back Pain trials Research Report on Low Back Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Adia Med of Winter Park LLC Lower Back Pain Research Study Umbilical Cord Blood-Derived Stem Cells and Exosomes, Placebo IV - Chronic Mechanical Lower Back Pain, Lower Back Pain | Phase 1 | Recruiting | Adia Med of Winter Park LLC | 100 | 2026-06-16 | 2026-06-17 |
| Hormones, Outcomes, and Pain Pathways in Exercise Study Interventional Sports bra - Breast Pain, Mastalgia | Phase 1 | Recruiting | University of Houston | 140 | 2026-05-17 | 2026-06-02 |
| Safety and PK of Intrathecal CNTX-3001 for Intractable Chronic Low Back Pain CNTX-3001, Placebo - Lower Back Pain | Phase 1 | Recruiting | Centrexion Therapeutics | 16 | 2026-03-01 | 2026-03-23 |
| Sodium Aescinate for the Treatment of Low Back Pain (LBP) in Adults Sodium Aescinate Tablets, Placebo - Low Back Pain, Paraspinal Muscle | Phase 1 | Recruiting | Xijing Hospital | 40 | 2026-03-01 | 2026-03-20 |
| Study of PIPE-791 for Subjects With Chronic Osteoarthritis Pain or Chronic Low Back Pain PIPE-791, Placebo - Chronic Osteoarthritis Pain, Chronic Low Back Pain | Phase 1 | Completed | Contineum Therapeutics | 43 | 2025-02-04 | 2026-03-18 |
| Comparison of the Efficacy of Diclofenac Sodium and Subcutaneous 5% Dextrose Injection in Low Back Pain. 5% dextrose prolotherapy, Diclofenac 75mg/ml - Low Back Pain, Mechanical | Phase 1 / Phase 2 | Enrolling by invitation | Aksaray University Training and Research Hospital | 150 | 2024-07-15 | 2025-02-19 |
| Safety and Feasibility of Umbilical Cord Wharton's Jelly Allograft Injections for Lumbar Pain Lumbar Injections with 10cc's of Wharton's Jelly Allograft - Low Back Pain | Phase 1 | Recruiting | R3 Stem Cell | 100 | 2024-03-25 | 2024-04-11 |
| Development and Evaluation of Computerized Chemosensory Based Orbitofrontal Networks Training for Treatment of Pain Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) short burst paradigm, Computerized Chemosensory-Based Orbitofrontal Cortex Training (CBOT) long burst paradigm, Computerized Chemosensory-Based Orbitofrontal Cortex Training plus beta caryophyllene (CBOT-Plus) - Chronic Pain, Low Back Pain | Phase 1 | Completed | Evon Medics LLC | 86 | 2023-04-27 | 2024-01-23 |
| Breathing and Attention Training for Chronic Low Back Pain Breathing and Attention Training - Chronic Low-back Pain | Phase 1 / Phase 2 | Completed | University of Florida | 29 | 2021-07-18 | 2024-06-10 |
| Allogeneic BM-MSCs in Patients with Lumbar Facet Arthropathy Single bilateral intra-articular injection of allogeneic BM-MSCs for lumbar facet joint arthropathy - Facet-Mediated Low Back Pain | Phase 1 | Completed | Mayo Clinic | 10 | 2020-04-28 | 2024-12-19 |
| Persica 002 Phase 1b PP353 vs Placebo in the Treatment of Low Back Pain PP353, Placebo - Chronic Low-back Pain | Phase 1 / Phase 2 | Completed | Persica Pharmaceuticals Ltd | 43 | 2020-01-20 | 2026-03-27 |
| Safety and Efficacy of SX600 Administered by Lumbosacral Transforaminal Epidural Injection for Radicular Pain SX600, Placebo - Lumbar Radiculopathy | Phase 1 / Phase 2 | Terminated | SpineThera Australia PTY LTD | 56 | 2019-11-04 | 2024-01-10 |
| Gonyautoxin 2/3 in the Treatment of Acute Back Pain: A Clinical Proof-of-concept Study GTX 2/3, Placebo - Back Pain, Acute Pain | Phase 1 / Phase 2 | Completed | Algenis SpA | 30 | 2019-10-11 | 2021-03-16 |
| Application of LED Photobiomodulation in the Treatment of Chronic Low Back Pain LED Photobiomodulation, Placebo LED Photobiomodulation - Low Back Pain | Phase 1 / Phase 2 | Unknown | University of Nove de Julho | 76 | 2019-08-01 | 2019-07-01 |
| BOL-DP-o-04 in Patients With Low Back Pain and Sciatica BOL-DP-o-04 + SCO, Placebo + SCO - Low Back Pain, Sciatica | Phase 1 / Phase 2 | Completed | Breath of Life International Pharma Ltd | 26 | 2018-11-27 | 2022-12-08 |
| Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Intervertebral Disc Degeneration IDCT, Saline Solution, Sodium Hyaluronate - Degenerative Disc Disease | Phase 1 | Completed | DiscGenics, Inc. | 60 | 2018-02-26 | 2023-01-25 |
| A Single Ascending Dose Study of Safety and Tolerability of STA363 Compared to Placebo in 15 Patients With Chronic Discogenic Low Back Pain STA363, Placebo - Low Back Pain | Phase 1 | Completed | Stayble Therapeutics | 15 | 2017-03-27 | 2020-02-18 |
| Sensory Effects of Oral Opioid Treatment in Patients With Chronic Low Back Pain Oxycodone or morphine sulfate immediate release (MSIR), Placebo Treatment - Low Back Pain | Phase 1 | Completed | Brigham and Women's Hospital | 35 | 2017-01-06 | 2026-02-04 |
| Cayenne Pepper Cataplasm - Safety Study Cayenne Pepper topical, Electrical stimulation, Massage - Low Back Pain | Phase 1 / Phase 2 | Completed | University of Primorska | 30 | 2016-03-15 | 2018-02-20 |
| New Approaches in Evaluating Patients' Response to Botulinum Toxins in the Treatment of Chronic Neck Pain and Back Pain Botulinum Toxins - Cervicalgia, Low Back Pain | Phase 1 | Unknown | VA Connecticut Healthcare System | 60 | 2016-03-01 | 2017-12-07 |
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Chronic Pain (6) · Pain (5) · Back Pain (4) · Intervertebral Disc Degeneration (4) · Sciatica (4) · Motor Activity (3) · Neck Pain (3) · Acute Pain (2) · Intervertebral Disc Displacement (2) · Agnosia (1) · Arthritis (1) · Body Weight (1) · Bronchiolitis Obliterans Syndrome (1) · Chest Pain (1)
Neurologic Manifestations (55) · Pathological Conditions, Signs and Symptoms (55) · Signs and Symptoms (55) · Back Pain (51) · Pain (50) · Musculoskeletal Diseases (8) · Nervous System Diseases (8) · Bone Diseases (6) · Spinal Diseases (6) · Neuromuscular Diseases (5) · Peripheral Nervous System Diseases (5) · Mononeuropathies (4) · Neuralgia (4) · Pathologic Processes (4) · Sciatic Neuropathy (4)
Acupuncture Therapy (2) · Cognitive Behavioral Therapy (2) · Genes, mos (2) · Manipulation, Spinal (2) · Mindfulness (2) · Sodium Chloride (2) · Acetaminophen (1) · Acupuncture, Ear (1) · Anti-Bacterial Agents (1) · Athletic Tape (1) · Botulinum Toxins (1) · Botulinum Toxins, Type A (1) · Diclofenac (1) · Electric Stimulation (1) · Ergonomics (1)
University of Florida (3) · Icahn School of Medicine at Mount Sinai (2) · National Center for Complementary and Integrative Health (NCCIH) (2) · Red de Terapia Celular (2) · The University of Queensland (2) · University of Bologna (2) · Adia Med of Winter Park LLC (1) · Aksaray University Training and Research Hospital (1) · Algenis SpA (1) · Anglo-European College of Chiropractic (1) · AstraZeneca (1) · Baylis Medical Company (1) · Breath of Life International Pharma Ltd (1) · Brigham and Women's Hospital (1) · Centrexion Therapeutics (1)
United States (25) · Spain (4) · Australia (3) · United Kingdom (3) · Brazil (2) · Italy (2) · South Korea (2) · Sweden (2) · Austria (1) · Canada (1) · Chile (1) · China (1) · Denmark (1) · Germany (1) · Israel (1)
Aleksandra Zgierska, MD PhD (1) · Alex F Manini, MD, MS, FACMT (1) · Ana Paula A Rubira, master (1) · Ana Sanchez, MD, PhD (1) · Anthony Rosner, PhD (1) · Avril Drummond, PhD (1) · Bambi Alyagon, MSc (1) · Bruce Vrooman, M.D. (1) · Carol M Coole, MSc (1) · Charles Nwaokobia (1) · David C Noriega, MD, PhD (1) · Duncan McHale, MBBS MRCP (1) · Durval C Kraychet (1)
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1UG3NS123965-01 (1), 2015 (1), 2018 (1), R01AR084021 (1), R21AR055716 (1), R44NS125745 (1)