102 completed, 14 unknown, 6 terminated, 5 withdrawn. 134 Phase 3, 15 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 134 | Completed 102, Unknown 14, Terminated 6, Withdrawn 5, Active not recruiting 3, Recruiting 3, Not yet recruiting 1 |
| Phase 2 | 15 | Completed 12, Unknown 2, Active not recruiting 1 |
Follow Low Back Pain: new trials by email Literature Review of Low Back Pain trials Research Report on Low Back Pain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Ultrasound-Guided Dextrose Prolotherapy in Ehlers-Danlos Syndrome Patients Dextrose 50% Intravenous Solution, Lidocaine 1% Injectable Solution - Ehlers-Danlos Syndrome, Low Back Pain | Phase 3 | Withdrawn | Tulane University | 2026-10-05 | 2026-10-08 | |
| Spinal Bracing in Adults With Painful Degenerative Scoliosis: a Randomized Controlled Open Trial Custom-molded lumbar-sacral orthosis, Usual Care - Degenerative Scoliosis, Scoliosis Idiopathic | Phase 3 | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 130 | 2026-09-01 | 2026-05-01 |
| Anesthetic Block of the Erector Muscles of the Lumbar Spine to Relieve Acute Lumbar Pain: Pilot Study Ropivacaine and dexamethasone injection solution, Sodium Chloride 0.9% Injection Solution - Lumbago | Phase 3 | Recruiting | Elsan | 40 | 2026-03-24 | 2026-06-10 |
| A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease IDCT (rebonuputemcel), Sham (No Treatment) - Degenerative Disc Disease | Phase 3 | Recruiting | DiscGenics, Inc. | 162 | 2025-12-23 | 2026-10-15 |
| Efficacy of Antibiotic Treatment for Patients With Chronic Low Back Pain and Modic Type I Changes - Randomized Placebo-controlled Trial Amoxicillin, Placebo - MSK Conditions, Chronic Low Back Pain (CLBP) | Phase 3 | Active not recruiting | Bart Koes | 144 | 2025-04-02 | 2026-09-14 |
| Home-based Cycling for People With Lumbar Spinal Stenosis Home-based cycling program, usual care - Symptomatic Lumbar Spinal Stenosis | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 302 | 2025-02-10 | 2025-11-20 |
| Efficacy and Safety in the Combination of Celecoxib / Pregabalin / Vitamin B for Low Back Chronic Pain Celecoxib+Pregabalin+Vitamin B fixed dose, Celecoxib + Vitamin B fixed dose, Pregabalin + Vitamin B fixed dose - Chronic Low-back Pain | Phase 3 | Completed | Laboratorios Silanes S.A. de C.V. | 192 | 2024-04-11 | 2025-04-04 |
| Long Term Efficacy and Tolerability of AP707 in Patients With Chronic Back Pain Adezunap (AP707), Placebo - Pain, Pain Syndrome | Phase 3 | Unknown | Apurano Pharmaceuticals GmbH | 558 | 2023-11-02 | 2024-01-31 |
| Efficacy and Tolerability of AP707 in Patients With Chronic Back Pain Adezunap (AP707), Placebo - Pain, Pain Syndrome | Phase 3 | Unknown | Apurano Pharmaceuticals GmbH | 558 | 2023-11-02 | 2024-01-31 |
| Nonpharmacologic Pain Management in FQHC Primary Care Clinics Brief Pain Teleconsult, Telehealth Physical Therapy - Low Back Pain, Chronic Pain | Phase 3 | Active not recruiting | University of Utah | 500 | 2021-11-04 | 2026-04-07 |
| Efficacy and Safety of FIRTECH in Patients With Mild to Moderate Acute Low Back Pain ITP FIRTECH - Low Back Pain | Phase 3 | Completed | Sanofi | 221 | 2021-11-04 | 2025-09-09 |
| To Evaluate the Superiority of Fixed Combination (Orfenadrine 35mg, Acetaminophen 325mg, Caffeine 65mg and Diclofenac Sodium 50mg) Compared to Voltaren® (Diclofenac Sodium 50mg) in the Treatment of Acute Postural Low Back Pain. orphenadrine, acetaminophen, caffeine and diclofenac sodium, Diclofenac Sodium 50 MG, Placebo (for experimental drug) - Postural Low Back Pain, Mechanical Low Back Pain | Phase 3 | Unknown | Ache Laboratorios Farmaceuticos S.A. | 110 | 2021-01-01 | 2020-09-03 |
| Security and Efficacy of Dorilax® (Fixed Association of Paracetamol 350 mg, Carisoprodol 150 mg and Caffeine 50 mg) Plus Thermal Band Compared to Placebo Plus Thermal Band in the Treatment of Acute Low Back Pain. Thermal Band, Dorilax®, Placebo - Low Back Pain | Phase 3 | Withdrawn | Ache Laboratorios Farmaceuticos S.A. | 2020-01-01 | 2019-07-08 | |
| The Prognostic Value of Biomarkers and the Effect of Tolperisone in Acute Low Back Pain and Sciatic Pain "BETA" Tolperisone Hydrochloride, Placebo - Low Back Pain | Phase 3 | Unknown | Semmelweis University | 150 | 2019-12-13 | 2024-04-17 |
| Efficacy of Intradiscal Injection of BM-MSC in Subjects With Chronic Low Back Pain (LBP) Due to Lumbar Degenerative Disc Disease (DDD) Unresponsive Allogenic BM-MSCs Injection, Sham Procedure - Recurrent Low Back Pain, Degenerative Disc Disease (DDD) | Phase 2 / Phase 3 | Active not recruiting | University Hospital, Montpellier | 113 | 2019-02-18 | 2025-09-30 |
| BackToBasic: Infliximab in Chronic Low Back Pain and Modic Changes Biosimilar Infliximab, Placebo - Low Back Pain | Phase 3 | Completed | Oslo University Hospital | 128 | 2018-12-12 | 2024-03-08 |
| Bone Marrow Concentrate (BMC) Injection in Intervertebral Discs Bone Marrow Concentrate - Low Back Pain, Disc Disease | Phase 2 / Phase 3 | Unknown | Stem Cures | 80 | 2018-11-21 | 2020-09-22 |
| Spinal Manipulation and Patient Self-Management for Preventing Acute to Chronic Back Pain Supported-Self Management (SSM), Spinal Manipulation Therapy (SMT), SMT + SSM - Acute Pain, Low Back Pain, Mechanical | Phase 3 | Completed | University of Minnesota | 1000 | 2018-11-01 | 2025-10-16 |
| Ibuprofen With or Without Acetaminophen for Low Back Pain Acetaminophen, Ibuprofen 600 mg, Educational intervention - Low Back Pain | Phase 3 | Completed | Montefiore Medical Center | 120 | 2018-10-16 | 2024-02-28 |
| Fibrin for Chronic Multi-level Discogenic Low Back Pain Fibrin sealant - Low Back Pain, Disc Disease | Phase 2 / Phase 3 | Unknown | Pauza, Kevin, MD | 400 | 2018-06-11 | 2020-11-09 |
Showing 20 of 134. Sign in to see all of them.
Chronic Pain (26) · Back Pain (20) · Pain (19) · Osteoarthritis (13) · Radiculopathy (7) · Intervertebral Disc Degeneration (6) · Sciatica (5) · Agnosia (4) · Bronchiolitis Obliterans Syndrome (4) · Neuralgia (4) · Spinal Stenosis (4) · Motor Activity (3) · Arthritis, Rheumatoid (2) · Constipation (2)
Pathological Conditions, Signs and Symptoms (134) · Signs and Symptoms (134) · Neurologic Manifestations (133) · Pain (115) · Back Pain (114) · Musculoskeletal Diseases (27) · Nervous System Diseases (17) · Arthritis (14) · Joint Diseases (14) · Rheumatic Diseases (14) · Neuromuscular Diseases (13) · Peripheral Nervous System Diseases (13) · Bone Diseases (11) · Spinal Diseases (10) · Immune System Diseases (6)
Tapentadol (7) · Buprenorphine (6) · Oxycodone (5) · Acetaminophen (4) · Celecoxib (4) · Acupuncture Therapy (3) · Ibuprofen (3) · Lidocaine (3) · Amoxicillin (2) · Carisoprodol (2) · Diclofenac (2) · Duration of Therapy (2) · Esomeprazole (2) · Etoricoxib (2) · Exercise (2)
Purdue Pharma LP (7) · BioDelivery Sciences International (6) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (5) · Pfizer (4) · Assistance Publique - Hôpitaux de Paris (3) · Federal University of São Paulo (3) · Kaiser Permanente (3) · Montefiore Medical Center (3) · Teva Branded Pharmaceutical Products R&D, Inc. (3) · Ache Laboratorios Farmaceuticos S.A. (2) · Apurano Pharmaceuticals GmbH (2) · AstraZeneca (2) · Charite University, Berlin, Germany (2) · Endo USA Inc., a Keenova Therapeutics Company (2) · Grünenthal GmbH (2)
United States (62) · Germany (13) · France (9) · Japan (8) · Brazil (7) · Canada (5) · Italy (5) · South Korea (5) · Norway (4) · Poland (4) · Spain (4) · Czechia (3) · Denmark (3) · Hungary (3) · Switzerland (3)
Andrew Finn, PharmD (5) · Benjamin W Friedman, MD, MS (2) · Daniel Cherkin, PhD (2) · Lewis M. Fredane, MD (2) · Naotsugu Oyama (2) · Aage Indahl, Ph.d (1) · Adelfia Urenda-Quezada (1) · Ajay Wasan, M.D., MSc. (1) · Alex Oefeldt, Therapist (1) · Anamaria Jones, PT (1) · Andre M Beer, MD, PhD (1)
PMID 23340531, PMID 24985410, PMID 16215338, PMID 16616268, PMID 18654615, PMID 19301989, PMID 19380256, PMID 19433697, PMID 19860906, PMID 20075014, PMID 20119464, PMID 20147878, PMID 20521870, PMID 20602712, PMID 21083513, PMID 21083918, PMID 21807566, PMID 21945130, PMID 22059194, PMID 22087222, PMID 22231424, PMID 22336956, PMID 22437221, PMID 22443293, PMID 22508732, PMID 22591121, PMID 22802542, PMID 22984233, PMID 23212429, PMID 23475406, PMID 23508598, PMID 23530709, PMID 23703422, PMID 23709304, PMID 23739758, PMID 23759340, PMID 24139233, PMID 24183364, PMID 24353047, PMID 24361999, PMID 24410959, PMID 24704126, PMID 24904748, PMID 24906419, PMID 24916058, PMID 24928639, PMID 24965494, PMID 25002440, PMID 25352050, PMID 25993547
2009 (2), 2014 (1), 2015 (1), 2017 (1), K24AT002422 (1), P01AT002048 (1), R01AT000985 (1), U01AT001110 (1), U01AT001908 (1), UL1RR024153 (1)