Bone Diseases: Clinical Trials

4484 completed, 1284 unknown, 821 recruiting, 501 terminated. 2856 Not applicable, 811 Phase 2, 793 Phase 3, 685 Phase 4, 453 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	2856	Completed 1537, Unknown 508, Recruiting 292, Not yet recruiting 163, Terminated 125, Active not recruiting 115, Withdrawn 70, Enrolling by invitation 34, Suspended 12
Phase 2	811	Completed 446, Unknown 101, Terminated 98, Recruiting 53, Withdrawn 40, Active not recruiting 36, Not yet recruiting 24, Enrolling by invitation 10, Suspended 3
Phase 3	793	Completed 551, Unknown 73, Terminated 68, Recruiting 32, Active not recruiting 31, Withdrawn 19, Not yet recruiting 13, Enrolling by invitation 5, Suspended 1
Phase 4	685	Completed 412, Unknown 95, Terminated 59, Recruiting 45, Withdrawn 28, Not yet recruiting 23, Active not recruiting 18, Enrolling by invitation 4, Suspended 1
Phase 1	453	Completed 282, Unknown 45, Terminated 43, Recruiting 27, Not yet recruiting 20, Withdrawn 14, Active not recruiting 13, Suspended 5, Enrolling by invitation 4
Early Phase 1	55	Completed 24, Unknown 16, Recruiting 7, Withdrawn 4, Terminated 2, Active not recruiting 1, Not yet recruiting 1

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Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Smartphone App for Adolescents With Idiopathic Scoliosis DinSkoliose smartphone application - Adolescence Idiopathic Scoliosis, AIS	Not applicable	Not yet recruiting	Oslo Metropolitan University	30	2028-04-01	2026-07-07
Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting Maxillary sinus floor elevation grafting with synthetic bone substitute. - Bone Loss, Osteoclastic, Bone Loss, Alveolar	Phase 1	Not yet recruiting	Pontificia Universidade Católica do Rio Grande do Sul	20	2027-12-15	2026-09-21
Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial testosterone cypionate, finasteride, placebo injection - Spinal Cord Injury, Spinal Cord Injuries	Phase 2 / Phase 3	Not yet recruiting	VA Office of Research and Development	300	2027-10-01	2026-08-04
Comparative Effectiveness of Two Different Approaches to Radiofrequency Ablation of Lumbar Medial Branch Nerves Radiofrequency ablation of lumbar medial branch nerves. - Lumbar Spondylosis	Not applicable	Not yet recruiting	Milton S. Hershey Medical Center	25	2027-08-01	2026-11-02
Combination Immunotherapy Targeting Sarcomas Multiple sarcoma-specific CAR-T cells and sarcoma vaccines - Sarcoma, Osteoid Sarcoma	Phase 1 / Phase 2	Not yet recruiting	Shenzhen Geno-Immune Medical Institute	20	2027-07-01	2026-11-02
The AgRP and GH/IGF-1 Axis in Children Growth Hormone Deficiency		Not yet recruiting	Columbia University	156	2027-06-10	2026-09-25
Safety and Efficacy Evaluation of 4th Generation Safety-engineered CAR T Cells Targeting Sarcomas Sarcoma-specific CAR-T cells - Sarcoma, Osteoid Sarcoma	Phase 1 / Phase 2	Not yet recruiting	Shenzhen Geno-Immune Medical Institute	20	2027-06-01	2026-10-30
Evaluation of an Intensified Systematic Screening for Congenital Hypothyroidism in Premature Newborns Blood test - Congenital Hypothyroidism		Not yet recruiting	University Hospital, Lille	1600	2027-03-01	2026-05-22
Extension Study of Safety and Tolerability of DDY391 in Participants With Moderate to Severe Psoriatic Arthritis (CDDY391A12201-extension) DDY391 - Moderate to Severe Psoriatic Arthritis	Phase 2	Not yet recruiting	Novartis Pharmaceuticals	88	2027-02-10	2026-11-06
Phase 3 Long Term Safety Extension Study of LUM-201 in Children With Growth Hormone Deficiency LUM-201 - Growth Hormone Deficiency (GHD)	Phase 3	Not yet recruiting	Lumos Pharma	150	2027-02-01	2026-07-08
Study to Determine the Safety and Tolerability of TG-C in Subjects With Back Pain Due to Degenerative Disc Disease TG-C High Dose, TG-C Mid Dose, TG-C Low Dose - Degenerative Disc Disease	Phase 1	Not yet recruiting	Kolon TissueGene, Inc.	24	2027-01-19	2026-08-20
Randomized Evaluation of Lumbar Injection Effectiveness and Function Triojection® System, Selective Nerve Root Block (SNRB) - Lumbar Radiculopathy, Lumbar Disc Herniation	Not applicable	Not yet recruiting	SpinaFX Medical Inc.	300	2027-01-15	2026-10-07
Sequential Treatment With Romosozumab Followed by Denosumab vs. Zoledronic Acid for Gains in HIP BMD Romosozumab, Zoledronic Acid 5 MG in 5 ML Injection, Calcium 500 mg and Vitamin D3 800 IU - Osteoporosis in Post-menopausal Women	Phase 4	Not yet recruiting	Sahlgrenska University Hospital	216	2027-01-11	2026-08-19
A Study of Zasocitinib in Adults With Psoriatic Arthritis (LATITUDE PsA NeXt) Placebo, Zasocitinib - Psoriatic Arthritis	Phase 3	Not yet recruiting	Takeda	644	2027-01-11	2026-10-27
Intraoperative Neuromonitoring of Sacral Reflexes to Predict Post Operative Function in Patients Undergoing Sacrectomy for Pelvic Bone Malignancy or Patients Undergoing Spinal Procedures Without Sacral Root Involvement Intraoperative Nerve Monitoring, Surgical Procedure, Survey Administration - Bone Neoplasm, Metastatic Malignant Neoplasm in the Bone	Not applicable	Recruiting	City of Hope Medical Center	50	2027-01-10	2026-11-10
Patient-Reported Outcomes Dashboard With Goal Setting to Support Shared Decision-Making in Inflammatory Arthritis Patient-Reported Outcomes Dashboard With Goal Setting - Arthritis, Psoriatic (PsA), Arthritis, Rheumatoid (RA)	Not applicable	Not yet recruiting	Northwestern University	160	2027-01-01	2026-10-15
Mesenchymal Cell Therapy in Osteogenesis Imperfecta (OI) Bone marrow-derived mesenchymal stromal cells (MSCs) - Osteogenesis Imperfecta, Osteogenesis Imperfecta Type III	Phase 1 / Phase 2	Not yet recruiting	Emory University	12	2027-01-01	2026-05-08
Routine Validation and Reproducibility Testing of Laboratory Assays and Research Techniques Used for Endocrine, Cardiometabolic, and Musculoskeletal Disorder Research (VALD) Endothelial cell collection - Obesity and Obesity-related Medical Conditions, Diabetes		Recruiting	Bettina Mittendorfer	100	2027-01-01	2026-05-07
Romosozumab and Denosumab Combination Therapy for Osteoporosis Romosozumab, Romosozumab and Denosumab - Postmenopausal Osteoporosis	Phase 4	Not yet recruiting	Massachusetts General Hospital	100	2027-01-01	2026-11-03
CANLINK: Evaluation of the Intralink Intradiscal Device for Low Back Pain Due to Degenerative Disc Disease Pain treatment - Degenerative Disc Disease(DDD)	Not applicable	Not yet recruiting	Spinal Simplicity LLC	40	2027-01-01	2026-11-06

Showing 20 of 8138. Sign in to see all of them.

Narrower conditions

Osteoporosis (1556)  ·  Bone Diseases, Metabolic (661)  ·  Arthritis, Psoriatic (595)  ·  Spondylitis, Ankylosing (522)  ·  Intervertebral Disc Displacement (439)  ·  Intervertebral Disc Degeneration (434)  ·  Spinal Stenosis (417)  ·  Scoliosis (403)  ·  Arthritis, Rheumatoid (401)  ·  Osteoporosis, Postmenopausal (332)  ·  Alveolar Bone Loss (308)  ·  Osteonecrosis (258)  ·  Bone Neoplasms (253)  ·  Dwarfism, Pituitary (252)  ·  Osteoarthritis (213)

Broader conditions

Musculoskeletal Diseases (8055)  ·  Spinal Diseases (3085)  ·  Nutritional and Metabolic Diseases (2546)  ·  Metabolic Diseases (2497)  ·  Pathological Conditions, Signs and Symptoms (1966)  ·  Bone Diseases, Metabolic (1681)  ·  Joint Diseases (1622)  ·  Arthritis (1468)  ·  Spondylitis (1269)  ·  Skin and Connective Tissue Diseases (1256)  ·  Nervous System Diseases (1124)  ·  Spondylarthropathies (1087)  ·  Spondylarthritis (1074)  ·  Bone Diseases, Developmental (1024)

Interventions

Denosumab (136)  ·  Zoledronic Acid (127)  ·  Alendronate (123)  ·  Teriparatide (113)  ·  Exercise (112)  ·  Human Growth Hormone (99)  ·  Cholecalciferol (93)  ·  Vitamin D (91)  ·  Etanercept (84)  ·  Calcium (81)  ·  Risedronic Acid (79)  ·  Adalimumab (76)  ·  Growth Hormone (62)  ·  secukinumab (58)  ·  Blood Specimen Collection (55)

Sponsors

Cairo University (117)  ·  Novartis Pharmaceuticals (102)  ·  Pfizer (83)  ·  Amgen (81)  ·  Assistance Publique - Hôpitaux de Paris (76)  ·  Zimmer Biomet (75)  ·  Eli Lilly and Company (66)  ·  Assiut University (65)  ·  National Taiwan University Hospital (49)  ·  Istituto Ortopedico Rizzoli (48)  ·  University of Aarhus (48)  ·  Massachusetts General Hospital (47)  ·  Merck Sharp & Dohme LLC (46)  ·  Hospices Civils de Lyon (45)  ·  Columbia University (39)

Countries

United States (2377)  ·  France (757)  ·  Turkey (Türkiye) (634)  ·  Germany (519)  ·  Canada (518)  ·  China (514)  ·  Italy (507)  ·  United Kingdom (457)  ·  Spain (425)  ·  Poland (314)  ·  Egypt (309)  ·  Denmark (286)  ·  South Korea (265)  ·  Belgium (258)  ·  Australia (238)

Results publications

PMID 38979716, PMID 40194794, PMID 41807031, PMID 31203228, PMID 37316690, PMID 38446397, PMID 39151033, PMID 41965705, PMID 42386286, PMID 21037195, PMID 34231877, PMID 34618347, PMID 35305260, PMID 35866376, PMID 38488975, PMID 38488976, PMID 38649657, PMID 39120849, PMID 26529632, PMID 30473179, PMID 31401903, PMID 33722947, PMID 34795065, PMID 35393269, PMID 36178584, PMID 36642439, PMID 36792107, PMID 37906417, PMID 37982966, PMID 38683479, PMID 39120848, PMID 39624020, PMID 40241921, PMID 40576086, PMID 40875187, PMID 41039829, PMID 42470570, PMID 11074683, PMID 12795371, PMID 15691354, PMID 15726851, PMID 17259801, PMID 17984237, PMID 19297344, PMID 22048651, PMID 29876969, PMID 30018799, PMID 30739254, PMID 30935731, PMID 31077258

NIH funding

2016 (34), 2015 (33), 2017 (27), 2018 (26), 2023 (25), 2019 (24), 2014 (23), 2009 (20), 2008 (14), 2025 (12), 2005 (11), 2004 (6), R01DK073039 (4), P50AR044855 (3), P50AT000090 (3)