Spinal Diseases: Clinical Trials

1699 completed, 548 unknown, 347 recruiting, 191 terminated. 1284 Not applicable, 282 Phase 3, 247 Phase 4, 221 Phase 2, 108 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	1284	Completed 653, Unknown 236, Recruiting 134, Not yet recruiting 85, Terminated 62, Active not recruiting 47, Withdrawn 41, Enrolling by invitation 20, Suspended 6
Phase 3	282	Completed 190, Active not recruiting 22, Unknown 22, Terminated 19, Recruiting 15, Withdrawn 7, Not yet recruiting 5, Enrolling by invitation 2
Phase 4	247	Completed 137, Unknown 38, Recruiting 20, Terminated 20, Not yet recruiting 12, Withdrawn 12, Active not recruiting 5, Enrolling by invitation 2, Suspended 1
Phase 2	221	Completed 107, Unknown 41, Terminated 28, Recruiting 18, Withdrawn 11, Active not recruiting 7, Not yet recruiting 7, Enrolling by invitation 2
Phase 1	108	Completed 56, Recruiting 12, Terminated 11, Unknown 10, Not yet recruiting 8, Withdrawn 6, Active not recruiting 3, Enrolling by invitation 1, Suspended 1
Early Phase 1	15	Completed 5, Recruiting 3, Unknown 3, Withdrawn 2, Not yet recruiting 1, Terminated 1

Follow Spinal Diseases: new trials by email Literature Review of Spinal Diseases trials Research Report on Spinal Diseases

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Smartphone App for Adolescents With Idiopathic Scoliosis DinSkoliose smartphone application - Adolescence Idiopathic Scoliosis, AIS	Not applicable	Not yet recruiting	Oslo Metropolitan University	30	2028-04-01	2026-07-07
Comparative Effectiveness of Two Different Approaches to Radiofrequency Ablation of Lumbar Medial Branch Nerves Radiofrequency ablation of lumbar medial branch nerves. - Lumbar Spondylosis	Not applicable	Not yet recruiting	Milton S. Hershey Medical Center	25	2027-08-01	2026-11-02
Extension Study of Safety and Tolerability of DDY391 in Participants With Moderate to Severe Psoriatic Arthritis (CDDY391A12201-extension) DDY391 - Moderate to Severe Psoriatic Arthritis	Phase 2	Not yet recruiting	Novartis Pharmaceuticals	88	2027-02-10	2026-11-06
Study to Determine the Safety and Tolerability of TG-C in Subjects With Back Pain Due to Degenerative Disc Disease TG-C High Dose, TG-C Mid Dose, TG-C Low Dose - Degenerative Disc Disease	Phase 1	Not yet recruiting	Kolon TissueGene, Inc.	24	2027-01-19	2026-08-20
Randomized Evaluation of Lumbar Injection Effectiveness and Function Triojection® System, Selective Nerve Root Block (SNRB) - Lumbar Radiculopathy, Lumbar Disc Herniation	Not applicable	Not yet recruiting	SpinaFX Medical Inc.	300	2027-01-15	2026-10-07
A Study of Zasocitinib in Adults With Psoriatic Arthritis (LATITUDE PsA NeXt) Placebo, Zasocitinib - Psoriatic Arthritis	Phase 3	Not yet recruiting	Takeda	644	2027-01-11	2026-10-27
Patient-Reported Outcomes Dashboard With Goal Setting to Support Shared Decision-Making in Inflammatory Arthritis Patient-Reported Outcomes Dashboard With Goal Setting - Arthritis, Psoriatic (PsA), Arthritis, Rheumatoid (RA)	Not applicable	Not yet recruiting	Northwestern University	160	2027-01-01	2026-10-15
CANLINK: Evaluation of the Intralink Intradiscal Device for Low Back Pain Due to Degenerative Disc Disease Pain treatment - Degenerative Disc Disease(DDD)	Not applicable	Not yet recruiting	Spinal Simplicity LLC	40	2027-01-01	2026-11-06
Selective Nerve Root Block Versus Sham to Reduce Surgery for Lumbar Disc Herniation Selective Nerve Root Block, Sham Procedure - Lumbar Disc Herniation, Lumbar Radiculopathy	Not applicable	Not yet recruiting	Karolinska Institutet	262	2027-01-01	2026-10-27
Remimazolam vs Propofol for Motor and Somatosensory Evoked Potentials in Spinal Tumor Surgery Remimazolam, Propofol - Spinal Cord Neoplasms, Spinal Neoplasms	Phase 4	Not yet recruiting	Beijing Tsinghua Chang Gung Hospital	190	2027-01-01	2026-10-28
SCLife®-LDD hUC-MSCs Injection Therapy for Patients With Lumbar Intervertebral Disc Degeneration human umbilical cord mesenchymal stem cell suspension, total endoscopic extraction of lumbar nucleus pulposus - Lumbar Disc Degeneration	Phase 1	Suspended	Sclnow Biotechnology Co., Ltd.	20	2026-12-31	2026-04-27
Continued Access to Deucravacitinib for Adult SLE/SjD and Pediatric PsO/PsA Study Completers Deucravacitinib - Systemic Lupus Erythematosus, Sjögren's Disease	Phase 3	Not yet recruiting	Bristol-Myers Squibb	2300	2026-12-31	2026-09-03
Apremilast and Adalimumab in Psoriatic Arthritis Patients Adalimumab, Apremilast - Psoriatic Arthritis, Ultrasound Assessment	Not applicable	Not yet recruiting	Tanta University	60	2026-12-30	2026-09-08
Phase 2 Trial of FT2109 for the Treatment of Psoriatic Arthritis FT2109 Dosing Regimen 1, FT2109 Dosing Regimen 2, Matching Placebo - Psoriatic Arthritis (PsA)	Phase 2	Not yet recruiting	Forward Therapeutics	210	2026-12-01	2026-10-09
Prospective Study of ProteiOS in Lumbar Interbody Fusion (TLIF) Allograft-derived growth factor (ProteiOS®), Standard of Care (SOC) - Degenerative Disc Disease, Spinal Stenosis Lumbar	Not applicable	Not yet recruiting	Isto Biologics	280	2026-12-01	2026-08-20
Effects of Land- and Water-Based Exercise in Axial Spondyloarthritis Land-Based Combined Exercise Program, Aquatic Combined Exercise Program, Home Exercise Program - Axial Spondyloarthritis and Ankylosing Spondylitis	Not applicable	Not yet recruiting	Izmir University of Economics	50	2026-12-01	2026-09-22
Continuous Erector Spinae Block for Analgesia Following Lumbar Decompression Continuous erector spinae plane block - Lumbar Spinal Stenosis, Lumbar Radiculopathy	Not applicable	Not yet recruiting	Nova Scotia Health Authority	100	2026-12-01	2026-02-17
Phase Ia Study of MST-931 in Healthy Adult Subjects MST-931, MST-931 Placebo - Ankylosing Spondylitis (AS)	Phase 1	Recruiting	Mabsoft Therapeutics (Shanghai) Co., Ltd.	32	2026-11-30	2026-11-03
Comparing the Extent to Which Apremilast is Made Available in the Body After Administration as an Extended-release or Immediate-release Formulation Apremilast XR, Apremilast IR - Psoriasis, Arthritis, Psoriatic	Phase 1	Not yet recruiting	Amgen	114	2026-11-18	2026-11-02
A Comparison of the Effects of Exercise Methods for Adolescent Hyperkyphosis on the Sensorimotor System Kyphosis-Specific Schroth Exercise Program, Conventional Exercise Program - Kyphosis Postural Thoracic, Kyphosis	Not applicable	Not yet recruiting	Istanbul University - Cerrahpasa	58	2026-11-15	2026-11-09

Showing 20 of 3259. Sign in to see all of them.

Narrower conditions

Arthritis, Psoriatic (595)  ·  Spondylitis, Ankylosing (524)  ·  Intervertebral Disc Displacement (439)  ·  Intervertebral Disc Degeneration (434)  ·  Spinal Stenosis (417)  ·  Scoliosis (403)  ·  Arthritis, Rheumatoid (273)  ·  Spondylolisthesis (205)  ·  Spondylarthritis (196)  ·  Low Back Pain (189)  ·  Axial Spondyloarthritis (178)  ·  Psoriasis (143)  ·  Spondylosis (131)  ·  Kyphosis (105)

Broader conditions

Bone Diseases (3247)  ·  Musculoskeletal Diseases (3235)  ·  Joint Diseases (1311)  ·  Spondylitis (1271)  ·  Arthritis (1211)  ·  Spondylarthropathies (1089)  ·  Spondylarthritis (1076)  ·  Pathological Conditions, Signs and Symptoms (928)  ·  Skin and Connective Tissue Diseases (726)  ·  Ankylosis (652)  ·  Skin Diseases (622)  ·  Skin Diseases, Papulosquamous (608)  ·  Signs and Symptoms (518)  ·  Spinal Curvatures (500)

Interventions

Etanercept (81)  ·  Adalimumab (76)  ·  secukinumab (58)  ·  Infliximab (52)  ·  Exercise (51)  ·  golimumab (37)  ·  Methotrexate (34)  ·  Physical Therapy Modalities (30)  ·  Surveys and Questionnaires (30)  ·  Sodium Chloride (28)  ·  Saline Solution (26)  ·  apremilast (26)  ·  Surgical Procedures, Operative (22)  ·  Gene Fusion (21)  ·  bimekizumab (21)

Sponsors

Novartis Pharmaceuticals (48)  ·  Assistance Publique - Hôpitaux de Paris (40)  ·  Pfizer (39)  ·  AbbVie (36)  ·  Assiut University (30)  ·  Marmara University (30)  ·  Medtronic Spinal and Biologics (28)  ·  Cairo University (26)  ·  Seoul National University Hospital (26)  ·  Peking University Third Hospital (25)  ·  Amgen (24)  ·  Hacettepe University (24)  ·  Janssen Research & Development, LLC (23)  ·  Charite University, Berlin, Germany (22)  ·  Chinese University of Hong Kong (21)

Countries

United States (847)  ·  Turkey (Türkiye) (401)  ·  France (320)  ·  China (271)  ·  Germany (241)  ·  Canada (222)  ·  Spain (173)  ·  Poland (168)  ·  United Kingdom (165)  ·  Italy (151)  ·  South Korea (145)  ·  Czechia (131)  ·  Belgium (118)  ·  Netherlands (109)  ·  Russia (106)

Top investigators

Kyle Malone, MS (9)  ·  Joachim Sieper, MD (6)  ·  Joel Batts (5)

Results publications

PMID 40194794, PMID 41807031, PMID 31203228, PMID 37316690, PMID 38446397, PMID 41965705, PMID 42386286, PMID 34618347, PMID 35305260, PMID 38488975, PMID 38488976, PMID 39120849, PMID 30473179, PMID 33722947, PMID 34795065, PMID 35393269, PMID 36178584, PMID 36642439, PMID 36792107, PMID 37906417, PMID 37982966, PMID 38683479, PMID 39120848, PMID 39624020, PMID 40241921, PMID 40875187, PMID 41039829, PMID 11074683, PMID 19297344, PMID 22048651, PMID 30018799, PMID 30739254, PMID 31077258, PMID 31112005, PMID 31909868, PMID 31964419, PMID 32006348, PMID 32352653, PMID 32816215, PMID 33227175, PMID 33351179, PMID 33857180, PMID 34536218, PMID 34773130, PMID 34870800, PMID 35429281, PMID 36058784, PMID 36282526, PMID 36526796, PMID 36754548

NIH funding

2015 (20), 2016 (17), 2017 (17), 2023 (16), 2009 (14), 2019 (13), 2014 (11), 2018 (10), 2025 (7), 2005 (4), 2008 (4), U01AR045444 (3), 1UL1RR024150-01 (1), K08CA237619 (1), K23AR077088 (1)