Intervertebral Disc Degeneration: Clinical Trials

178 completed, 70 unknown, 48 recruiting, 48 terminated. 176 Not applicable, 41 Phase 2, 30 Phase 1, 23 Phase 3, 15 Phase 4.

By phase and status

Phase	Trials	Status
Not applicable	176	Completed 71, Unknown 29, Terminated 23, Recruiting 18, Withdrawn 16, Active not recruiting 9, Not yet recruiting 7, Enrolling by invitation 3
Phase 2	41	Completed 18, Unknown 9, Withdrawn 5, Active not recruiting 3, Terminated 3, Recruiting 2, Not yet recruiting 1
Phase 1	30	Completed 13, Unknown 4, Recruiting 3, Terminated 3, Withdrawn 3, Not yet recruiting 2, Active not recruiting 1, Suspended 1
Phase 3	23	Completed 8, Unknown 4, Active not recruiting 3, Recruiting 3, Terminated 2, Withdrawn 2, Enrolling by invitation 1
Phase 4	15	Completed 7, Unknown 3, Recruiting 2, Withdrawn 2, Terminated 1
Early Phase 1	2	Recruiting 1, Withdrawn 1

Follow Intervertebral Disc Degeneration: new trials by email Literature Review of Intervertebral Disc Degeneration trials Research Report on Intervertebral Disc Degeneration

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Study to Determine the Safety and Tolerability of TG-C in Subjects With Back Pain Due to Degenerative Disc Disease TG-C High Dose, TG-C Mid Dose, TG-C Low Dose - Degenerative Disc Disease	Phase 1	Not yet recruiting	Kolon TissueGene, Inc.	24	2027-01-19	2026-08-20
SCLife®-LDD hUC-MSCs Injection Therapy for Patients With Lumbar Intervertebral Disc Degeneration human umbilical cord mesenchymal stem cell suspension, total endoscopic extraction of lumbar nucleus pulposus - Lumbar Disc Degeneration	Phase 1	Suspended	Sclnow Biotechnology Co., Ltd.	20	2026-12-31	2026-04-27
Prospective Study of ProteiOS in Lumbar Interbody Fusion (TLIF) Allograft-derived growth factor (ProteiOS®), Standard of Care (SOC) - Degenerative Disc Disease, Spinal Stenosis Lumbar	Not applicable	Not yet recruiting	Isto Biologics	280	2026-12-01	2026-08-20
Degenerative Changes After Treatment of Thoracolumbar Junction Fractures Thoracolumbar Spine Fracture, Facet Joint Degeneration		Not yet recruiting	Sklifosovsky Institute of Emergency Care	150	2026-11-01	2026-07-01
Kore Fiber PLF Study Kore Fiber, Autologous bone graft - Degenerative Lumbar Spine Diseases, Lumbar Degenerative Disc Disease	Not applicable	Not yet recruiting	Kolosis Bio, LLC	75	2026-11-01	2026-10-22
Lumbar Fusion With Nanotube Versus Titanium Cage Adaptix nanoPEEK Cage, Capstone PTC Cage - Degenerative Disc Disease, Lumbar Fusion	Not applicable	Not yet recruiting	Francis Farhadi	108	2026-10-01	2026-10-16
Association of Subcutaneous Fat Index, Paraspinal Muscle Characteristics, and Facet Morphology With Lumbar Facet Joint Degeneration Lumbar Magnetic Resonance Imaging (MRI) - Chronic Low Back Pain, Lumbar Facet Joint Degeneration		Recruiting	Marmara University	300	2026-09-01	2026-10-06
Pilot Study of ZetaFuse™ Bone Graft for the Treatment of Cervical Degenerative Disc Disease Cervical Fusion (ZetaFuse™ Bone Graft) - Radiculopathy, Cervical, Myelopathy Cervical	Not applicable	Recruiting	Zetagen Therapeutics, Inc	10	2026-09-01	2025-04-24
Biologic Injection For Adults With Lumbar Disc Herniation Bone Marrow Aspirate Concentrate (BMAC) - Degenerative Disc Disease, DDD	Not applicable	Recruiting	Weill Medical College of Cornell University	90	2026-08-30	2026-07-29
Reliability and Reproducibility of CT-Based Facet Joint Measurements in Patients With AOSpine Type A2, A3, and A4 Thoracolumbar Fractures Computed Tomography Image Review - Facet Joint Arthritis, Facet Joints; Degeneration		Not yet recruiting	Sklifosovsky Institute of Emergency Care	12	2026-08-01	2026-07-15
Intradiscal rhGDF-6 for the Treatment of Lumbar Disc Degeneration High Dose, Low Dose - Disc Degenerative Disease, Back Pain	Phase 1 / Phase 2	Not yet recruiting	Cartago Biotech Pty Ltd	60	2026-07-04	2026-06-25
Evaluation of the Safety and Effectiveness of the CORUS™ Posterior Cervical Stabilization System 3D (PCSS 3D) for the Treatment of 2-level Cervical Degenerative Disease Circumferential Cervical Fusion (CCF), Anterior Cervical Discectomy and Fusion - Degenerative Disc Disease(DDD)	Not applicable	Not yet recruiting	Providence Medical Technology, Inc.	225	2026-06-30	2026-07-23
Efficacy and Safety of Novosis Putty in Transforaminal Lumbar Interbody Fusion for Patients With Lumbar Degenerative Disc Disease Novosis Putty, Standard of Care - Degenerative Disc Disease	Phase 3	Recruiting	CGBio Inc.	316	2026-06-11	2026-08-26
Evaluation of the Effectiveness of Physical Therapy for Low Back Pain According to Magnetic Resonance Imaging Findings Standard Physical Therapy Program - Low Back Pain, Physical Therapy	Not applicable	Not yet recruiting	Bahçeşehir University	120	2026-06-10	2026-06-16
Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury EC5026 oral tablet, Placebo oral tablet - Spinal Cord Injuries, Neuropathic Pain	Phase 1	Recruiting	EicOsis Human Health Inc.	36	2026-05-01	2026-07-10
PMCF Study on the Effectiveness and Safety of METROSAN Spinal Systems and BONEGRAFT Filling Materials Titania® Cervical Interbody Fusion Cage (Titanium), Titania® Cervical Interbody Fusion Cage (PEEK), Titania® Posterior Cervical Stabilization System - Degenerative Disc Disease (DDD), Spinal Stenosis		Recruiting	Metrosan End. ve Elk. Mek. Cihazlar ve Tibbi Malz. San. Tic. Ltd. Co.	561	2026-04-27	2026-05-29
MDT-0123 Japan Study MDT-0123, ICBG - Disc Degeneration, Spinal Deformity	Phase 3	Recruiting	Medtronic Spinal and Biologics	140	2026-04-24	2026-09-09
Proprio Spine Measurement Tool Intraoperative spinal measurement system - Intervertebral Disc Degeneration, Intervertebral Disc Displacement	Not applicable	Withdrawn	Duke University		2026-04-20	2026-04-23
Patient Reported Outcome Measurements Registration in Spinal Pathologies and Neuromodulation Spinal Pathologies, Pain		Recruiting	Jessa Hospital	5000	2026-04-01	2026-04-27
Clinical and MRI Findings in Lumbar Disc Disease Lumbar Disc Disease, Low Back Pain		Not yet recruiting	Assiut University	96	2026-04-01	2026-04-08

Showing 20 of 432. Sign in to see all of them.

Narrower conditions

Spondylolisthesis (77)  ·  Spinal Stenosis (63)  ·  Low Back Pain (62)  ·  Intervertebral Disc Displacement (42)  ·  Spondylosis (23)  ·  Back Pain (22)  ·  Radiculopathy (21)  ·  Intervertebral disc disease (16)  ·  Spinal Diseases (10)  ·  Scoliosis (8)  ·  Constriction, Pathologic (6)  ·  Klippel-Feil Syndrome (6)  ·  Lymphoma, Follicular (6)  ·  Musculoskeletal Diseases (6)

Broader conditions

Bone Diseases (428)  ·  Musculoskeletal Diseases (426)  ·  Spinal Diseases (422)  ·  Pathological Conditions, Signs and Symptoms (128)  ·  Signs and Symptoms (91)  ·  Neurologic Manifestations (90)  ·  Pain (85)  ·  Spondylolysis (75)  ·  Spondylosis (63)  ·  Back Pain (54)  ·  Pathological Conditions, Anatomical (48)  ·  Hernia (41)  ·  Nervous System Diseases (34)  ·  Neuromuscular Diseases (23)  ·  Peripheral Nervous System Diseases (23)

Interventions

Transplantation, Autologous (16)  ·  Total Disc Replacement (8)  ·  Spinal Fusion (7)  ·  Sodium Chloride (6)  ·  salicylhydroxamic acid (6)  ·  Saline Solution (5)  ·  Gene Fusion (4)  ·  Injections (3)  ·  Pedicle Screws (3)  ·  Standard of Care (3)  ·  Anesthetics, Local (2)  ·  Clonidine (2)  ·  Epinephrine (2)  ·  Exercise (2)  ·  Fibrin Tissue Adhesive (2)

Sponsors

Medtronic Spinal and Biologics (22)  ·  NuVasive (18)  ·  DePuy Spine (9)  ·  Zimmer Biomet (9)  ·  Orthofix Inc. (7)  ·  Aesculap AG (6)  ·  Mesoblast, Ltd. (6)  ·  Rush University Medical Center (6)  ·  Globus Medical Inc (5)  ·  Kuros Biosurgery AG (5)  ·  VIVEX Biologics, Inc. (5)  ·  Baxano Surgical, Inc. (4)  ·  Duke University (4)  ·  LDR Spine USA (4)  ·  Ohio State University (4)

Countries

United States (223)  ·  Germany (26)  ·  China (16)  ·  France (16)  ·  Italy (13)  ·  Turkey (Türkiye) (13)  ·  Australia (11)  ·  Belgium (10)  ·  South Korea (10)  ·  Spain (10)  ·  Canada (9)  ·  Netherlands (8)  ·  Switzerland (8)  ·  Czechia (7)  ·  Russia (7)

Top investigators

Kyle Malone, MS (8)  ·  Kern Singh, MD (5)  ·  Michael Hess, MD (4)  ·  Domagoj Coric, MD (3)  ·  Joel Batts (3)  ·  Roger Brown (3)  ·  Alan T Villavicencio, MD (2)  ·  Christopher Centeno, MD (2)  ·  Donna Skerrett, MD (2)  ·  Douglas Beall, MD (2)  ·  Eeric Truumees, MD (2)  ·  Fred Geisler, MD (2)  ·  Huub Kreuwel, Ph.D (2)

Results publications

PMID 21286714, PMID 22885827, PMID 25839385, PMID 31442616, PMID 31451936, PMID 36477416, PMID 38127138, PMID 10795032, PMID 11074683, PMID 12592542, PMID 15346999, PMID 15949778, PMID 15995108, PMID 16025024, PMID 16025025, PMID 16028736, PMID 16055269, PMID 16619677, PMID 16757774, PMID 16784908, PMID 17141065, PMID 17206138, PMID 17332991, PMID 18038420, PMID 1834753, PMID 18790684, PMID 19564761, PMID 19699503, PMID 20084410, PMID 20380708, PMID 20975594, PMID 21256071, PMID 21596740, PMID 21699471, PMID 21799397, PMID 22246644, PMID 22460400, PMID 22706091, PMID 22744618, PMID 23080427, PMID 23104197, PMID 23138404, PMID 23303884, PMID 23307678, PMID 23429319, PMID 23783372, PMID 23978994, PMID 24010901, PMID 24253778, PMID 24365899

NIH funding

2019 (3), 2017 (1), K23DA020681 (1)