14 completed, 12 recruiting, 6 terminated, 6 unknown. 50 Phase 2, 7 Phase 1, 4 Phase 3.
Follow Head Injuries, Closed: new trials by email Literature Review of Head Injuries, Closed trials Research Report on Head Injuries, Closed
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Memantine Targeting Neurovascular Dysfunction After Mild and Moderate Traumatic Brain Injury (MEND) Memantine - Traumatic Brain Injury, Mild Traumatic Brain Injury | Phase 2 | Not yet recruiting | Nova Scotia Health Authority | 45 | 2027-06-01 | 2026-10-09 |
| Natural History of MTBI-related Convergence Insufficiency & Effectiveness of Vision Therapy for MTBI-related CI Office-Based Vergence/Accommodative Therapy with Movement (OBVAM) - Convergence Insufficiency | Phase 2 | Not yet recruiting | Salus University | 100 | 2026-11-01 | 2025-02-27 |
| Hyperbaric Oxygen Therapy for Veterans With TBI and PCS: A Biomarker Study Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury (TBI) Patients, Post Concussive Symptoms | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 34 | 2026-10-01 | 2026-09-30 |
| HBOT Effects on First Responders' Cognition and Well-Being Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 54 | 2026-09-11 | 2026-10-01 |
| Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athletes With Co-morbid Depression and Concussion ONE-D TMS protocol and d-cycloserine (125 mg) - Concussion, Depression | Phase 2 / Phase 3 | Not yet recruiting | University of Florida | 35 | 2026-09-01 | 2026-08-18 |
| BCAAs in Concussion 3.0 BCAA, Placebo - Concussion (Diagnosis), MTBI - Mild Traumatic Brain Injury | Phase 2 | Recruiting | Akiva Cohen | 150 | 2026-08-05 | 2026-09-03 |
| Long-Term Outcomes Following HBOT Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury, Post-Concussive Symptoms | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 35 | 2026-06-18 | 2026-07-28 |
| Naturally Produced Cannabinoids for Neuroprotection From Concussion Broad spectrum cannabinoid formulation, Placebo gel capsule - Healthy | Phase 2 | Recruiting | University of Regina | 60 | 2026-06-01 | 2026-07-21 |
| Veterans' Cognitive Function, Mental Health, and Quality of Life After Hyperbaric Oxygen Therapy Hyperbaric Oxygen Therapy - TBI Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 54 | 2025-10-01 | 2025-10-09 |
| Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms HRV Coherence Ratio, NSI, Pittsburgh Sleep Quality Index (PSQI) - Autonomic Nervous System Disease, Concussive Injury | Phase 2 / Phase 3 | Recruiting | Virginia Commonwealth University | 148 | 2025-09-02 | 2026-09-22 |
| A Randomised, Double-blind, Placebo-controlled Phase 2a Pilot Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ONP-002 in Adults With Mild Traumatic Brain Injury Neurosteroid enantiomer - Mild Traumatic Brain Injury, Concussion | Phase 2 | Not yet recruiting | Oragenics, Inc. | 40 | 2025-06-01 | 2025-03-11 |
| BCAAs in Concussion 2.0 BCAA, Placebo - Concussion, Brain, Concussion, Mild | Phase 2 | Completed | Akiva Cohen | 17 | 2025-04-01 | 2026-09-03 |
| Memantine as an Additive Therapy in Patients With Traumatic Brain Injury Memantine, Mannitol - Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury (TBI) | Phase 2 / Phase 3 | Not yet recruiting | Mansoura University | 80 | 2025-03-25 | 2025-04-06 |
| Personalized Brain Stimulation to Treat Chronic Concussive Symptoms Active cTBS, Inactive/Sham cTBS, Imaginal exposure - Post-Concussion Syndrome, Concussion, Brain | Phase 2 | Recruiting | University of California, Los Angeles | 75 | 2024-03-06 | 2026-02-24 |
| Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History High Definition Transcranial Direct Current Stimulation - Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder | Phase 2 | Recruiting | University of Texas Southwestern Medical Center | 75 | 2023-04-20 | 2026-07-20 |
| Acute Concussion and Melatonin Melatonin 3 MG, Placebo - Concussion, Mild, Concussion, Brain | Phase 2 | Unknown | Children's National Research Institute | 254 | 2023-03-01 | 2024-02-07 |
| Modulating Exercise Dosage to Improve Concussion Recovery High Dose Exercise - Concussion, Brain, Treatment | Phase 1 / Phase 2 | Recruiting | University of Colorado, Denver | 178 | 2022-08-05 | 2026-08-31 |
| Treatment of Acute PTH With a CGRP Receptor mAb in Military Service Members and Civilians With mTBI Erenumab 140 Mg/mL Subcutaneous Solution, Placebo - Posttraumatic Headache, Mild Traumatic Brain Injury | Phase 2 | Recruiting | Henry M. Jackson Foundation for the Advancement of Military Medicine | 404 | 2022-07-19 | 2024-02-22 |
| Hyperbaric Oxygen Effects on Persistent Post-concussive Symptoms Hyperbaric oxygen at 1.5 ATA, Sham treatment - Persistent Post-concussive Syndrome, Concussion Post Syndrome | Phase 2 | Completed | Essentia Health | 20 | 2022-06-28 | 2026-10-15 |
| Sphenopalatine Ganglion Block for Headache After Concussion Lidocaine in SphenoCath device, Saline Solution in SphenoCath device - Concussion, Headache | Phase 2 | Terminated | University of Michigan | 2 | 2021-03-18 | 2022-09-14 |
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Brain Concussion (37) · Brain Injuries, Traumatic (20) · Post-Concussion Syndrome (20) · Stress Disorders, Post-Traumatic (8) · Headache (6) · Craniocerebral Trauma (5) · Depression (4) · Post-Traumatic Headache (4) · Anxiety Disorders (3) · Combat Disorders (3) · Alcoholism (2) · Brain Injuries (2) · Inflammation (2) · Autonomic Nervous System Diseases (1)
Trauma, Nervous System (50) · Wounds, Nonpenetrating (50) · Nervous System Diseases (49) · Wounds and Injuries (49) · Brain Diseases (47) · Central Nervous System Diseases (47) · Brain Injuries (45) · Craniocerebral Trauma (45) · Brain Injuries, Traumatic (26) · Mental Disorders (15) · Pathological Conditions, Signs and Symptoms (13) · Brain Concussion (10) · Stress Disorders, Traumatic (10) · Trauma and Stressor Related Disorders (10)
Hyperbaric Oxygenation (7) · Mannitol (3) · Melatonin (2) · Memantine (2) · Sildenafil Citrate (2) · Transcranial Magnetic Stimulation (2) · erenumab (2) · Acetaminophen (1) · Amino Acids (1) · Atorvastatin (1) · Cognitive Behavioral Therapy (1) · Docosahexaenoic Acids (1) · Exercise (1) · Fish Oils (1) · Ghrelin (1)
Summit Hyperbarics and Wellness (4) · VA Office of Research and Development (3) · Akiva Cohen (2) · U.S. Army Medical Research and Development Command (2) · University of Calgary (2) · University of Michigan (2) · University of Texas Southwestern Medical Center (2) · University of Virginia (2) · Virginia Commonwealth University (2) · ANSwers Neuroscience, Inc. (1) · Abela Pharmaceuticals, Inc. (1) · Baylor College of Medicine (1) · Center for Neurological Studies (1) · Children's Hospital of Philadelphia (1) · Children's National Research Institute (1)
United States (36) · Canada (7) · Australia (2) · Brazil (1) · Denmark (1) · Egypt (1)
Amy A Herrold, PhD BA (2) · Daniel Corwin, MD (2) · Steve Wyman, MD (2) · Alex Hishaw, MD (1) · Alex P Chapman, Ph.D. (1) · Alice Rose (1) · Allen E Thornton, Ph.D. (1) · Allen Thornton (1) · Alon Friedman, MD PhD (1) · Ann E Glang, PhD (1) · Brad Hallam (1) · Brett Hart, MD (1) · Brian O'Neil, MD (1) · Brian P Walcott, MD (1) · Brian V Nahed, MD (1)
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