25 completed, 3 unknown, 1 recruiting, 1 terminated. 10 Not applicable, 10 Phase 1, 10 Phase 2, 1 Early Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Completed 8, Unknown 2 |
| Phase 1 | 10 | Completed 9, Withdrawn 1 |
| Phase 2 | 10 | Completed 8, Recruiting 1, Unknown 1 |
| Early Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV Tesamorelin, Placebo, Exercise - HIV-1-infection, Frailty | Phase 2 | Recruiting | Massachusetts General Hospital | 100 | 2025-07-10 | 2026-05-19 |
| Effects of Ghrelin Administration on Motivation Ghrelin, Saline - Major Depressive Disorder | Not applicable | Completed | University Hospital Tuebingen | 24 | 2024-09-02 | 2025-12-22 |
| RCT of Ghrelin in Stroke Patients Ghrelin - Stroke, Ischemic | Phase 2 | Unknown | Rijnstate Hospital | 80 | 2023-10-01 | 2023-07-25 |
| Effects of Ghrelin Administration on Dopamine and Effort Ghrelin, Placebo - Major Depressive Disorder | Phase 1 / Phase 2 | Completed | University Hospital Tuebingen | 26 | 2022-02-21 | 2025-12-22 |
| The Importance of Ghrelin for Glucose Metabolism After Sleeve Gastrectomy Ghrelin, Placebo - Bariatric Surgery Candidate, Glucose Metabolism Disorders | Not applicable | Completed | Hvidovre University Hospital | 22 | 2022-01-14 | 2023-11-01 |
| Ghrelin (OXE--103) for Acute Concussion Management Ghrelin (OXE-103), Placebo - Concussion, Brain, Traumatic Brain Injury | Phase 2 | Completed | Michael Rippee | 23 | 2020-10-20 | 2024-05-21 |
| Unacylated Ghrelin to Improve Functioning in PAD Ghrelin, Placebo - Peripheral Artery Disease | Phase 2 | Completed | Northwestern University | 25 | 2020-07-08 | 2026-06-01 |
| Physiological Responses to Laparoscopic Sleeve Gastrectomy: Focusing on Ghrelin Placebo, Ghrelin - Bariatric Surgery | Not applicable | Completed | Hvidovre University Hospital | 12 | 2020-02-28 | 2024-02-28 |
| Effect of Ghrelin on Decision-Making Ghrelin, Saline - Healthy Volunteers, Obesity | Phase 1 | Withdrawn | Jenny Tong, MD, MPH | 2019-10-01 | 2020-01-27 | |
| Nutrition and Growth in Very Preterm Infants Oral nutritional intake - Premature, Growth | Completed | Children's Hospital of Fudan University | 180 | 2019-08-01 | 2023-02-08 | |
| Influence of Dairy Protein Breakfast on Glycemia, Weight Loss and Clock Genes in T2D Continuous glucose monitoring CGM, Clock Genes m RNA expression, Postprandial Glucose - Type2 Diabetes, Healthy Obesity, Metabolically | Not applicable | Unknown | Tel Aviv University | 60 | 2018-12-28 | 2018-12-11 |
| Validation of the Concept of the Autoantibodies Directed Against the Neuropeptides Involved in Food Intake Regulation on the Incidental Cases of Eating Disorders Evaluation of the rates of the autoantibodies directed against the neuropeptides (ghrelin and alpha-MSH) controlling involved in food intake regulation - Eating Disorder | Not applicable | Completed | University Hospital, Rouen | 211 | 2018-05-24 | 2026-02-06 |
| Ghrelintrial With Patients With Stroke Ghrelin - DEMMMI, Nine-Hole-PEG-Test, mRS, Stroke, Acute | Terminated | Kantonsspital Winterthur KSW | 6 | 2017-04-01 | 2019-03-01 | |
| Preprandial Ghrelin Effect Ghrelin, Saline - Type 2 Diabetes | Phase 1 | Completed | Jenny Tong, MD, MPH | 80 | 2017-01-11 | 2019-03-12 |
| Effect of Ghrelin on Glucose Metabolism After Bariatric Surgery Oral Glucose Tolerance Test (OGTT), Human Ghrelin, Saline - Obesity | Phase 1 | Completed | Vanderbilt University Medical Center | 70 | 2016-09-01 | 2023-02-08 |
| Progesterone Amplifies Estrogen-stimulated Growth Hormone Secretion in Older Women IM Saline Placebo (0.25 ml), IM Estradiol valerate (2.5 mg), IM Saline Placebo (0.5 ml) - Healthy | Phase 1 | Completed | Mayo Clinic | 47 | 2014-12-01 | 2018-03-22 |
| Ghrelin Plus Strength Training in Frail Elderly Study Ghrelin, Placebo - Frailty Syndrome | Phase 2 | Completed | University of Pennsylvania | 16 | 2013-07-01 | 2019-12-11 |
| Translational and Clinical Aspects of Metabolic, Anabolic and Endothelial Dysfunction in Heart Failure Ghrelin, Placebo - Heart Failure With Reduced Ejection Fraction HFrEF | Phase 1 / Phase 2 | Completed | Lars Lund | 31 | 2013-02-17 | 2024-10-23 |
| Ghrelin Repeated Dose Study ghrelin - Frailty in Aging | Phase 2 | Completed | University of Pennsylvania | 5 | 2013-02-01 | 2015-10-08 |
| Ghrelin for Alcohol Use in Non-Treatment-Seeking Heavy Drinkers Ghrelin, Placebo, fMRI - fMRI, Alcohol Drinking | Phase 2 | Completed | National Institute on Alcohol Abuse and Alcoholism (NIAAA) | 17 | 2012-12-13 | 2018-08-03 |
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Obesity (4) · Depressive Disorder, Major (3) · Alcoholism (2) · Diabetes Mellitus, Type 2 (2) · Frailty (2) · Alcohol Drinking (1) · Anhedonia (1) · Behavior, Addictive (1) · Body Weight (1) · Brain Concussion (1) · Brain Injuries, Traumatic (1) · Cachexia (1) · Cystic Fibrosis (1) · Feeding and Eating Disorders (1) · Glucose Metabolism Disorders (1)
University of Aarhus (3) · Hvidovre University Hospital (2) · Jenny Tong, MD, MPH (2) · University Hospital Tuebingen (2) · University of Pennsylvania (2) · Baker Heart and Diabetes Institute (1) · Brown University (1) · Cantonal Hospital of St. Gallen (1) · Children's Hospital of Fudan University (1) · Esben Thyssen Vestergaard (1) · Göteborg University (1) · Kantonsspital Winterthur KSW (1) · Lars Lund (1) · Massachusetts General Hospital (1) · Max-Planck-Institute of Psychiatry (1)
United States (12) · Denmark (5) · Germany (3) · Switzerland (2) · Australia (1) · China (1) · France (1) · Israel (1) · Netherlands (1) · Sweden (1) · United Kingdom (1)
Anne Cappola, MD, ScM (1) · Anne R. Cappola, M.D.,Sc.M. (1) · Esben T Vestergaard, PhD (1) · Esben T. Vestergaard, MD PhD (1) · Florian Strasser, PD Dr. MD (1) · Jenny Tong, MD (1) · Jenny Tong, MD, MPH (1) · Jens Otto L. Jorgensen, MD (1) · Kent Lundholm, MD, prof (1) · Kristine M. Erlandson, MD (1) · Lindsay T. Fourman, MD (1) · Lorenzo Leggio, M.D. (1) · Mary McDermott, MD (1) · Michael Rippee, MD (1)
PMID 22259063, PMID 23592479, PMID 24775991, PMID 28736944, PMID 29133954, PMID 31608930, PMID 35724307, PMID 36588397, PMID 36916707, PMID 41329966, PMID 41546024, PMID 41578008, PMID 42224086, PMID 42419889
R01DK091748 (2), R01DK097550 (1), R21AG063076 (1)