Post-Concussion Syndrome: Clinical Trials

62 completed, 24 unknown, 20 recruiting, 13 terminated. 84 Not applicable, 20 Phase 2, 8 Phase 1, 3 Early Phase 1, 3 Phase 3.

By phase and status

Phase	Trials	Status
Not applicable	84	Completed 37, Unknown 17, Recruiting 12, Active not recruiting 5, Withdrawn 5, Not yet recruiting 4, Terminated 4
Phase 2	20	Completed 9, Recruiting 5, Terminated 3, Active not recruiting 1, Unknown 1, Withdrawn 1
Phase 1	8	Completed 4, Terminated 2, Recruiting 1, Unknown 1
Early Phase 1	3	Completed 2, Unknown 1
Phase 3	3	Unknown 2, Recruiting 1
Phase 4	2	Not yet recruiting 1, Terminated 1

Follow Post-Concussion Syndrome: new trials by email Literature Review of Post-Concussion Syndrome trials Research Report on Post-Concussion Syndrome

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Intravenous Metoclopramide Versus Intravenous Acetaminophen for Acute Concussion Treatment Metoclopramide 10mg, Acetaminophen - Concussion Post Syndrome, Head Trauma Injury	Phase 4	Not yet recruiting	Montefiore Medical Center	200	2026-10-01	2026-10-01
Hyperbaric Oxygen Therapy for Veterans With TBI and PCS: A Biomarker Study Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury (TBI) Patients, Post Concussive Symptoms	Phase 2	Recruiting	Summit Hyperbarics and Wellness	34	2026-10-01	2026-09-30
Cognitive Effects of Hyperbaric Oxygen Therapy (HBOT) After a Traumatic Brain Injury Hyperbaric Oxygen Therapy - HBOT - Traumatic Brain Injury, Post-Concussion Syndrome		Not yet recruiting	Assaf-Harofeh Medical Center	1000	2026-10-01	2026-10-23
HBOT Effects on First Responders' Cognition and Well-Being Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder	Phase 2	Recruiting	Summit Hyperbarics and Wellness	54	2026-09-11	2026-10-01
Effect of Vestibular Rehabilitation on Gait, Balance, and Coordination in Post Concussion Combat Athletes Vestibular Rehabilitation Program, Conventional Post-Concussion Rehabilitation - Concussion Post Syndrome, Concussion	Not applicable	Not yet recruiting	Riphah International University	44	2026-07-01	2026-07-21
Long-Term Outcomes Following HBOT Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury, Post-Concussive Symptoms	Phase 2	Recruiting	Summit Hyperbarics and Wellness	35	2026-06-18	2026-07-28
Post-Concussion Sleep and Brain-heart Functions CBT-pI, Sleep Hygiene - Insomnia, Concussion Post Syndrome	Not applicable	Not yet recruiting	University of Ottawa	70	2026-06-01	2026-06-11
Evaluating Altius Tinted Contact Lenses as an Option Managing for Post-Concussion Visual Syndrome ALTIUS® daily disposable performance-tinted contact lenses - Post Concussion Symptoms	Not applicable	Completed	Southern College of Optometry	10	2026-05-27	2026-10-13
Effects of Vestibular Rehabilitation and Routine Physical Therapy in Athletes With Post Concussion Syndrome Intervention 1, Control Arm (Conventional Therapy) - Post Concussion Syndrome	Not applicable	Not yet recruiting	Lahore University of Biological and Applied Sciences	34	2026-03-22	2026-02-10
GyroStim for Post Concussion Syndrome Sensorimotor Multi-axis Automated Rotational Therapy (SMART) utilizing GyroStim device, Physical therapy and speech therapy/cognitive rehabilitation therapy - Post Concussion Syndrome	Not applicable	Recruiting	Neuroscience Group	128	2026-03-16	2026-06-10
Female Concussion Head Cooling Brain Cooling - Concussion (Diagnosis), Concussion Post Syndrome	Not applicable	Not yet recruiting	Penn State University	32	2026-01-15	2025-12-26
Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline Functional near-infrared spectroscopy (fNIRS), V1 stimulation electrodes, Magnetic Resonance Imaging (MRI) - Mild Traumatic Brain Injury, Post Concussion Syndrome	Not applicable	Recruiting	University of Wisconsin, Madison	55	2025-11-13	2026-05-06
Veterans' Cognitive Function, Mental Health, and Quality of Life After Hyperbaric Oxygen Therapy Hyperbaric Oxygen Therapy - TBI Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder	Phase 2	Recruiting	Summit Hyperbarics and Wellness	54	2025-10-01	2025-10-09
Effect of Mental Imagery in Patients With Persistent Post-concussion Symptoms Provocation Test for Symptoms Using Mental Imagery - Mild Traumatic Brain Injury, Concussion, Post Concussive Syndrome, Chronic	Not applicable	Recruiting	Reuth Rehabilitation Hospital	60	2025-09-07	2026-08-12
Effects of tDCS for Enhancing Cognitive Function in Individuals With Persistent Post-Concussion Syndrome tDCS with cognitive training programme - Transcranial Direct Current Stimulation, Post-Concussion Syndrome	Not applicable	Recruiting	The Hong Kong Polytechnic University	40	2025-09-01	2026-09-25
Accelerated Transcranial Magnetic Stimulation Intervention for Post-Concussion Syndrome Post Concussive Syndrome, Chronic, Post Concussion Symptoms		Completed	Cognitive FX	11	2025-05-01	2025-10-10
RTL Concussion Communication InjureFree - Concussion, Mild, Post Concussion Symptoms	Not applicable	Withdrawn	University of Florida		2024-08-28	2024-10-23
Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric) Active tDCS and Cognitive Training Intervention, Sham tDCS and Cognitive Training Intervention - Brain Concussion, Brain Trauma	Not applicable	Recruiting	United States Naval Medical Center, San Diego	160	2024-07-25	2025-11-12
Quetiapine to Reduce Post Concussive Syndrome After Mild Traumatic Brain Injury (mTBI) Quetiapine Fumarate, TAU - Mild Traumatic Brain Injury	Phase 3	Recruiting	Foundation for Advancing Veterans' Health Research	146	2024-07-09	2025-07-11
mHealth Technology in the Treatment of Post-concussion Symptoms MyHeadHealth online application, Standard of Care - Post Concussion Syndrome	Not applicable	Unknown	McMaster University	88	2024-06-01	2023-05-09

Showing 20 of 137. Sign in to see all of them.

Narrower conditions

Brain Concussion (74)  ·  Brain Injuries, Traumatic (40)  ·  Stress Disorders, Post-Traumatic (15)  ·  Headache (11)  ·  Post-Traumatic Headache (10)  ·  Motor Activity (8)  ·  Craniocerebral Trauma (7)  ·  Depression (7)  ·  Brain Injuries (6)  ·  Anxiety Disorders (5)  ·  Sleep Initiation and Maintenance Disorders (5)  ·  Combat Disorders (4)  ·  Chronic Pain (3)  ·  Dizziness (3)

Broader conditions

Nervous System Diseases (137)  ·  Trauma, Nervous System (137)  ·  Wounds and Injuries (137)  ·  Wounds, Nonpenetrating (137)  ·  Head Injuries, Closed (135)  ·  Craniocerebral Trauma (130)  ·  Brain Diseases (99)  ·  Central Nervous System Diseases (99)  ·  Brain Injuries (89)  ·  Brain Concussion (63)  ·  Brain Injuries, Traumatic (53)  ·  Mental Disorders (28)  ·  Pathological Conditions, Signs and Symptoms (24)  ·  Signs and Symptoms (20)  ·  Behavior (18)

Interventions

Hyperbaric Oxygenation (11)  ·  Cognitive Behavioral Therapy (4)  ·  Acetaminophen (3)  ·  Exercise (3)  ·  Low-Level Light Therapy (3)  ·  Manipulation, Osteopathic (3)  ·  Sildenafil Citrate (3)  ·  Transcranial Direct Current Stimulation (3)  ·  Metoclopramide (2)  ·  Neurofeedback (2)  ·  Ondansetron (2)  ·  Therapeutics (2)  ·  Transcranial Magnetic Stimulation (2)  ·  Acceptance and Commitment Therapy (1)  ·  Acoustic Stimulation (1)

Sponsors

University of Calgary (5)  ·  St. Olavs Hospital (4)  ·  Summit Hyperbarics and Wellness (4)  ·  Boston Children's Hospital (3)  ·  Uniformed Services University of the Health Sciences (3)  ·  University Health Network, Toronto (3)  ·  University of Aarhus (3)  ·  University of Arizona (3)  ·  VA Eastern Colorado Health Care System (3)  ·  Western University, Canada (3)  ·  Assaf-Harofeh Medical Center (2)  ·  Children's Hospital of Eastern Ontario (2)  ·  Children's Hospital of Orange County (2)  ·  Danish Headache Center (2)  ·  McGill University Health Centre/Research Institute of the McGill University Health Centre (2)

Countries

United States (76)  ·  Canada (29)  ·  Norway (6)  ·  Denmark (5)  ·  Israel (4)  ·  France (2)  ·  Brazil (1)  ·  Hong Kong (1)  ·  Pakistan (1)  ·  Switzerland (1)  ·  United Kingdom (1)

Top investigators

Carmela Tartaglia, MD (2)  ·  Charles Tator, MD, PhD (2)  ·  James P Dickey, PhD (2)  ·  Pratik Mukherjee, MD, PhD (2)  ·  Renee M Pazdan, MD (2)  ·  Sara P Chrisman, MD MPH (2)  ·  Steve Wyman, MD (2)  ·  Ahmed Qazi (1)  ·  Alan Lowe, MD (1)  ·  Alex P Chapman, Ph.D. (1)  ·  Alice Rose (1)  ·  Allen E Thornton, Ph.D. (1)  ·  Allen Thornton (1)  ·  Alphonsa Thomas, DO (1)

Results publications

PMID 31394602, PMID 31394603, PMID 34873185, PMID 12703651, PMID 16179657, PMID 16443717, PMID 17019673, PMID 22026588, PMID 24059443, PMID 24328800, PMID 25136325, PMID 25401463, PMID 25560444, PMID 25668305, PMID 25723660, PMID 26048614, PMID 26085968, PMID 26645307, PMID 27120294, PMID 27479847, PMID 27747793, PMID 28006970, PMID 28365025, PMID 28420362, PMID 28512443, PMID 28768069, PMID 28768070, PMID 28768071, PMID 28768072, PMID 28768073, PMID 28768075, PMID 28771392, PMID 29734566, PMID 30098189, PMID 30099354, PMID 30314512, PMID 30729729, PMID 31246882, PMID 31394600, PMID 31394601, PMID 31603218, PMID 31620073, PMID 31737275, PMID 31790877, PMID 31891145, PMID 32024486, PMID 32189664, PMID 32217739, PMID 32493206, PMID 32766808

NIH funding

1IK2RX001136-01A2 (1), 2018 (1), 2025 (1), P20GM109089 (1), R01HD094722 (1)