2667 completed, 956 unknown, 780 recruiting, 335 terminated. 2985 Not applicable, 519 Phase 2, 296 Phase 1, 235 Phase 3, 165 Phase 4.
Follow Trauma, Nervous System: new trials by email Literature Review of Trauma, Nervous System trials Research Report on Trauma, Nervous System
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Patient-centered Assessment of the Effects of Powered Exoskeleton Use in People With Spinal Cord Injury Rehabilitation - Spinal Cord Injuries | Not applicable | Suspended | Istituto Nazionale Assicurazione contro gli Infortuni sul Lavoro | 18 | 2030-01-01 | 2026-03-27 |
| Device for Bladder Control for Men With SCI Noninvasive electrical stimulation device to improve bladder control - Neurogenic Bladder | Phase 1 / Phase 2 | Not yet recruiting | VA Office of Research and Development | 12 | 2028-06-01 | 2026-06-25 |
| Efficacy of iPSC-Derived Motor Neuron Cells (XS228) in Subacute Spinal Cord Injury: A Phase II Randomized Controlled Trial Allogeneic Human Induced Pluripotent Stem Cell (iPSC)-Derived Motor Neuron Progenitor Cells, Placebo - Spinal Cord Injury, Safety | Phase 2 | Not yet recruiting | XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd. | 60 | 2028-05-25 | 2025-11-25 |
| Sodium Lactate in Severe TBI Sodium Lactate, placebo - Traumatic Brain Injury | Phase 2 | Not yet recruiting | University of California, Los Angeles | 264 | 2028-01-10 | 2026-01-16 |
| Safety and Outcomes of MUSE Stem Cell Therapy in Individuals With Traumatic Brain Injury MUSE Stem Cell Therapy - Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients | Not yet recruiting | Healing Hope International | 10 | 2028-01-01 | 2026-03-10 | |
| Testosterone Therapy With or Without Finasteride After Spinal Cord Injury: TRT-SCI Trial testosterone cypionate, finasteride, placebo injection - Spinal Cord Injury, Spinal Cord Injuries | Phase 2 / Phase 3 | Not yet recruiting | VA Office of Research and Development | 300 | 2027-10-01 | 2026-08-04 |
| Behavior Therapy vs Education for Persistent Headache After Mild TBI Headache reprocessing, Headache education - Post-Traumatic Headache | Not applicable | Not yet recruiting | VA Office of Research and Development | 60 | 2027-10-01 | 2025-12-26 |
| Self-Management Training Among Individuals With TBI Participants will be referred to a community based self-management training program - Traumatic Brain Injury | Not applicable | Not yet recruiting | Boston University Charles River Campus | 85 | 2027-09-01 | 2026-08-03 |
| Combining Low Oxygen Therapy and an Adenosine A2a Receptor Antagonist to Improve Functional Mobility After Spinal Cord Injury Istradefylline, low oxygen therapy - Spinal Cord Injuries, Myelopathy | Phase 1 / Phase 2 | Not yet recruiting | Randy Trumbower, PT, PhD | 40 | 2027-09-01 | 2026-03-20 |
| Supplementary Neuromuscular Rehabilitation During Acute Concussion Recovery Exercise, Return to Activity Progression - Concussion (Diagnosis), Gait Abnormality | Early Phase 1 | Not yet recruiting | Northern Illinois University | 30 | 2027-08-02 | 2026-09-03 |
| Empowerment Program to Reduce Treatment of Asymptomatic Bacteriuria in Veterans With Spinal Cord Injury Empowerment Program - Spinal Cord Injury, Spinal Cord Disease | Not applicable | Not yet recruiting | VA Office of Research and Development | 30 | 2027-08-02 | 2026-08-19 |
| Prospective Observational Multimodal Neuromonitoring During High-Risk Adult Surgery Postoperative Cognitive Complications, Delirium | Not yet recruiting | University of Texas Southwestern Medical Center | 300 | 2027-07-01 | 2026-10-23 | |
| Prospective Observational Multimodal Neuromonitoring in Adult NSICU Patients Subarachnoid Hemorrhage, Aneurysmal, Brain Injuries, Traumatic | Not yet recruiting | University of Texas Southwestern Medical Center | 300 | 2027-07-01 | 2026-10-23 | |
| Correlation and Rapid Analysis of Neurological Injury Using Markers Traumatic Brain Injury (TBI) Patients | Not yet recruiting | Università Vita-Salute San Raffaele | 200 | 2027-06-01 | 2026-04-29 | |
| Memantine Targeting Neurovascular Dysfunction After Mild and Moderate Traumatic Brain Injury (MEND) Memantine - Traumatic Brain Injury, Mild Traumatic Brain Injury | Phase 2 | Not yet recruiting | Nova Scotia Health Authority | 45 | 2027-06-01 | 2026-10-09 |
| Cardiocentric Inotropic Optimization in Spinal Cord Injury Dobutamine crossover - SCI - Spinal Cord Injury | Early Phase 1 | Not yet recruiting | University of British Columbia | 8 | 2027-06-01 | 2026-10-13 |
| Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD Principal Investigator Transcranial direct current stimulation (tDCS), Cognitive training - Cognition, Brain Injuries | Phase 2 | Not yet recruiting | VA Office of Research and Development | 46 | 2027-05-24 | 2026-02-17 |
| Concurrent Trials on Nature-Based Therapy for Inpatients in Dementia and Rehabilitation Medicine Wards Nature Immersion Therapy - Dementia, Acquired Brain Injury Including Stroke | Not applicable | Not yet recruiting | Changi General Hospital | 1600 | 2027-05-01 | 2026-03-23 |
| Valproic AcId for Traumatic BRAin INjury Trial Valproic Acid (VPA), Standard of care treatment + normal saline - Moderate Traumatic Brain Injury (TBI), Severe Traumatic Brain Injury | Phase 2 / Phase 3 | Not yet recruiting | Northwestern University | 432 | 2027-05-01 | 2026-08-13 |
| Combined rTMS and tSCS for Upper Limb Recovery in Cervical SCI Transcranial Magnetic Stimulation, Transcutaneous Spinal Cord Stimulation - Spinal Cord Injuries (SCI) | Not applicable | Not yet recruiting | National University Hospital, Singapore | 24 | 2027-03-30 | 2026-05-14 |
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Spinal Cord Injuries (1931) · Brain Injuries, Traumatic (1681) · Brain Injuries (918) · Brain Concussion (634) · Stroke (357) · Craniocerebral Trauma (232) · Quadriplegia (154) · Post-Concussion Syndrome (137) · Stress Disorders, Post-Traumatic (129) · Wounds and Injuries (123) · Motor Activity (111) · Hematoma, Subdural, Chronic (110) · Multiple Sclerosis (109) · Cognitive Dysfunction (107) · Paraplegia (102)
Nervous System Diseases (5466) · Wounds and Injuries (5400) · Central Nervous System Diseases (4900) · Craniocerebral Trauma (3294) · Brain Diseases (3163) · Brain Injuries (1945) · Spinal Cord Diseases (1883) · Pathological Conditions, Signs and Symptoms (1699) · Signs and Symptoms (1215) · Neurologic Manifestations (1023) · Cardiovascular Diseases (815) · Vascular Diseases (795) · Wounds, Nonpenetrating (726) · Cerebrovascular Disorders (700)
Transcranial Direct Current Stimulation (64) · Exercise (56) · Sodium Chloride (42) · Rehabilitation (41) · Transcranial Magnetic Stimulation (39) · Therapeutics (36) · Saline Solution (32) · Standard of Care (31) · Blood Specimen Collection (29) · Control Groups (28) · Physical Therapy Modalities (26) · Botulinum Toxins, Type A (24) · Surveys and Questionnaires (24) · Magnetic Resonance Imaging (23) · Hyperbaric Oxygenation (22)
VA Office of Research and Development (161) · Kessler Foundation (83) · University of British Columbia (64) · University of Miami (58) · University of Washington (58) · Shirley Ryan AbilityLab (55) · US Department of Veterans Affairs (52) · Swiss Paraplegic Research, Nottwil (45) · University of Pittsburgh (42) · The University of Texas Health Science Center, Houston (41) · James J. Peters Veterans Affairs Medical Center (38) · Assistance Publique - Hôpitaux de Paris (37) · Craig Hospital (35) · Spaulding Rehabilitation Hospital (34) · Cairo University (33)
United States (2504) · Canada (413) · France (297) · China (221) · Switzerland (180) · United Kingdom (172) · Italy (156) · Spain (138) · Egypt (127) · Denmark (109) · Turkey (Türkiye) (107) · Germany (104) · Israel (74) · Taiwan (70) · Netherlands (61)
Gregory D Myer, PhD (12) · Mark S Nash, PhD (12) · William Bauman, MD (11) · Ramon Diaz-Arrastia, MD, PhD (10) · Eric M Wassermann, M.D. (9) · Andrei Krassioukov, MD,PhD,FRCPC (7) · Flora Hammond, MD (7) · Thomas J Schnitzer, MD, PhD (7) · Edelle C Field-Fote, PT, PhD (6) · Gail F Forrest, PhD (6) · Jian-Xin Zhou, MD (6) · Jocelyne Bloch, MD (6) · Karen Hux, Ph.D. (6) · Kerri A Morgan, PhD (6)
PMID 28899825, PMID 30413559, PMID 18406958, PMID 21762873, PMID 25001669, PMID 29717652, PMID 30247091, PMID 30407030, PMID 31405391, PMID 32228157, PMID 35622535, PMID 39134021, PMID 39446982, PMID 42152086, PMID 10569435, PMID 15224087, PMID 1527657, PMID 16543552, PMID 17335974, PMID 19027233, PMID 19406289, PMID 19406290, PMID 20722504, PMID 20825903, PMID 21303266, PMID 21515904, PMID 21675055, PMID 21876461, PMID 22224835, PMID 22330108, PMID 22771222, PMID 22985379, PMID 23002086, PMID 23085704, PMID 23141478, PMID 23359586, PMID 24040943, PMID 24574549, PMID 24713270, PMID 25082923, PMID 25325609, PMID 25504883, PMID 25727167, PMID 26199618, PMID 26364279, PMID 26452709, PMID 26537996, PMID 26604914, PMID 26663726, PMID 26866876
2018 (10), 2023 (9), 2016 (8), 2017 (7), 2019 (7), 2025 (6), UL1TR001412 (4), 2009 (3), 2014 (3), R61MH138612 (3), 2008 (2), 2015 (2), R01HD081274 (2), R01HL150581 (2), R01NS041503 (2)