79 completed, 50 recruiting, 30 not yet recruiting, 12 active not recruiting. 126 Not applicable, 26 Phase 2, 9 Phase 1, 8 Phase 3, 3 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD transcutaneous auricular vagus nerve stimulation, sham transcutaneous auricular vagus nerve stimulation - PTSD - Post Traumatic Stress Disorder | Early Phase 1 | Not yet recruiting | Wayne State University | 60 | 2027-04-01 | 2026-07-13 |
| Inhaled Cannabis for Treatment of PTSD High THC Cannabis, Placebo cannabis - Post Traumatic Stress Disorder PTSD | Phase 2 | Not yet recruiting | Multidisciplinary Association for Psychedelic Studies | 320 | 2027-02-01 | 2026-08-11 |
| Assessment of the Preventive Effect of Defusing on Traumatic Kindling Defusing, Psychological First Aid (PFA) - Acute Stress Disorder, Post Traumatic Stress Disorder PTSD | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 70 | 2026-11-01 | 2026-09-30 |
| Adaptation of the STAIR-NT for First Responders Adapted STAIR-NT - PTSD - Post Traumatic Stress Disorder, TBI-Traumatic Brain Injury | Not applicable | Not yet recruiting | Florida State University | 80 | 2026-11-01 | 2026-08-25 |
| ONE-P TMS Military Veterans D-Cycloserine (DCS), Placebo, Intermittent Theta Burst Stimulation (iTBS) - PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | Fidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA | 50 | 2026-11-01 | 2026-08-20 |
| ONE-P TMS First Responders D-Cycloserine (DCS), Placebo, Intermittent Theta Burst Stimulation (iTBS) - PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | Fidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA | 50 | 2026-11-01 | 2026-08-19 |
| Clinical Trial of MDMA-Assisted Therapy for Military Service Members With Posttraumatic Stress Disorder TREATMENT ARM: Full dose, CONTROL ARM: Active-controlled - PTSD, Post Traumatic Stress Disorder PTSD | Phase 2 | Not yet recruiting | U.S. Army Medical Research and Development Command | 86 | 2026-10-01 | 2026-07-15 |
| Psilocybin-assisted Therapy for Post-Traumatic Stress Disorder in Survivors of Intimate Partner Violence Psilocybin - Post Traumatic Stress Disorder PTSD, Intimate Partner Violence (IPV) | Phase 2 | Not yet recruiting | University of Calgary | 76 | 2026-10-01 | 2026-09-08 |
| Deep TMS for PTSD With Suicidal Ideation Deep Transcranial Magnetic Stimulation (DTMS) - Post Traumatic Stress Disorder PTSD, Suicidal Ideation | Not applicable | Not yet recruiting | D.R. Rut Zaks OHAYON | 72 | 2026-10-01 | 2026-10-19 |
| Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI) Virtual Reality, Standard Psychotherapy - Traumatic Brain Injuries, TBI (Traumatic Brain Injury) | Phase 1 | Recruiting | Johns Hopkins University | 30 | 2026-10-01 | 2026-10-26 |
| Dexmedetomidine Combined With Transcutaneous Vagus Nerve Stimulation (taVNS) Can Reduce the Incidence of PTSD in Trauma Patients After Surgery Dexmedetomidine 0.1μg/kg/h, tavns - PTSD - Post Traumatic Stress Disorder, taVNS | Not applicable | Recruiting | Affiliated Hospital of Nantong University | 300 | 2026-09-12 | 2026-09-17 |
| HBOT Effects on First Responders' Cognition and Well-Being Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 54 | 2026-09-11 | 2026-10-01 |
| Suvorexant 3 - PE-PC Suvorexant, Placebo, Prolonged Exposure Therapy for Primary Care (PE-PC) - PTSD - Post Traumatic Stress Disorder, Insomnia | Phase 4 | Not yet recruiting | Northern California Institute of Research and Education | 142 | 2026-09-01 | 2026-07-07 |
| CBITS-RTM Pilot Study Adapted Cognitive Behavioral Intervention for Trauma in Schools (CBITS) with a Racial Trauma Module (RTM) - PTSD - Post Traumatic Stress Disorder, Substance Use | Not applicable | Not yet recruiting | University of California, San Francisco | 28 | 2026-09-01 | 2026-07-06 |
| Deaf CBT-TS to Reduce Suicide Risk Deaf CBT-TS - Depression - Major Depressive Disorder, Anxiety | Not applicable | Not yet recruiting | University of Rochester | 110 | 2026-09-01 | 2026-06-22 |
| Women Who Are Victims of Violence: Treatment of PTSD Through Reactivation of Traumatic Memories Using Propranolol Propranolol, Psychotherapy - Post-Traumatic Stress Disorder, PTSD | Phase 3 | Not yet recruiting | University Hospital, Toulouse | 70 | 2026-09-01 | 2026-08-28 |
| Self-Compassion, Health, and Empowerment The Self-Compassion, Health, and Empowerment (SHE) Intervention, Health and Nutrition Program - Intimate Partner Violence (IPV), Depression and/or Anxiety Symptoms | Not applicable | Not yet recruiting | Yang Li | 364 | 2026-09-01 | 2026-07-30 |
| Propranolol for Early Secondary Prevention of Post-Traumatic Stress Disorder in Women Victims of Sexual Violence Propranolol, 120mg, Placebo - PTSD - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | University Hospital, Tours | 34 | 2026-09-01 | 2026-03-05 |
| Accelerated iTBS for PTSD and Depression Accelerated intermittent theta burst stimulation - Post Traumatic Stress Disorder PTSD, Major Depressive Disorder (MDD) | Not applicable | Recruiting | Lawson Research Institute of St. Joseph's | 16 | 2026-09-01 | 2026-09-18 |
| Redefine Study: A Study Evaluating the Efficacy, Safety, and Tolerability of COMP360 in Participants With Post-traumatic Stress Disorder COMP360 psilocybin - PTSD - Post Traumatic Stress Disorder, PTSD | Phase 2 / Phase 3 | Recruiting | COMPASS Pathways | 300 | 2026-09-01 | 2026-10-23 |
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Stress Disorders, Post-Traumatic (125) · Anxiety Disorders (28) · Depression (25) · Wounds and Injuries (23) · Psychological Well-Being (14) · Stress Disorders, Traumatic (14) · Brain Injuries, Traumatic (11) · Sleep Initiation and Maintenance Disorders (11) · Substance-Related Disorders (9) · Depressive Disorder, Major (7) · Mental Disorders (7) · Alcoholism (6) · Borderline Personality Disorder (4) · Brain Injuries (4)
Trauma and Stressor Related Disorders (192) · Mental Disorders (186) · Stress Disorders, Traumatic (179) · Behavior (51) · Behavioral Symptoms (31) · Nervous System Diseases (31) · Pathological Conditions, Signs and Symptoms (21) · Brain Diseases (17) · Central Nervous System Diseases (17) · Signs and Symptoms (17) · Chemically-Induced Disorders (15) · Craniocerebral Trauma (14) · Personal Satisfaction (14) · Trauma, Nervous System (14) · Wounds and Injuries (14)
Cognitive Behavioral Therapy (7) · Eye Movement Desensitization Reprocessing (6) · Implosive Therapy (6) · Cycloserine (4) · Prazosin (4) · Psilocybin (4) · Art Therapy (3) · Hyperbaric Oxygenation (3) · Propranolol (3) · Sugars (3) · Transcranial Magnetic Stimulation (3) · Waiting Lists (3) · 2-cyclohexylidenhydrazo-4-phenyl-thiazole (2) · Exercise (2) · Methoxydimethyltryptamines (2)
US Department of Veterans Affairs (8) · VA Office of Research and Development (8) · The University of Texas Health Science Center at San Antonio (6) · NightWare (4) · University of Pennsylvania (4) · Assistance Publique - Hôpitaux de Paris (3) · United States Naval Medical Center, San Diego (3) · Yale University (3) · Asad Ullah Jan (2) · Columbia University (2) · Fidel Vila-Rodriguez, MD, PhD, FRCPC, DFAPA (2) · INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium (2) · Johns Hopkins University (2) · Karolinska Institutet (2) · Medical University of South Carolina (2)
United States (110) · Canada (11) · France (11) · Israel (9) · Sweden (5) · Ukraine (4) · Germany (3) · Netherlands (3) · Norway (3) · Switzerland (3) · Turkey (Türkiye) (3) · China (2) · Denmark (2) · Jordan (2) · Pakistan (2)
Daniel R Karlin, MD MA (4) · Alan L Peterson, PhD (2) · Fidel Vila-Rodriguez, M.D., PhD, FRCPC, DFAPA (2) · Greg Reger, PhD (2) · Gregory A Gahm, PhD (2) · Murray Raskind, MD (2) · Abdallah Alzoubi, MD, PhD (1) · Abraham Zangen, Professor (1) · Albert R Powers, MD, PhD (1) · Alice J Wuermli, PhD (1) · Alison B Hamilton, PhD MPH (1) · Allyson C Rosen, PhD (1) · Ana Lisa Carmo (1) · Anna Harwood-Gross, PhD (1)
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2025 (2), P30AG064198 (2), 1IK2RX001136-01A2 (1), 1IK2RX001298-01A2 (1), 2019 (1), 2023 (1), K23DA016574 (1), K23HD115845 (1), K23MH137406 (1), P20AA017839 (1), R01DA059549 (1), R01HD106413 (1), R01MH135376 (1), R01NR022445 (1), R21HD069832 (1)