355 completed, 108 unknown, 107 recruiting, 51 terminated. 438 Not applicable, 50 Phase 2, 27 Phase 1, 14 Phase 3, 7 Early Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Outcomes of MUSE Stem Cell Therapy in Individuals With Traumatic Brain Injury MUSE Stem Cell Therapy - Traumatic Brain Injury, Traumatic Brain Injury (TBI) Patients | Not yet recruiting | Healing Hope International | 10 | 2028-01-01 | 2026-03-10 | |
| Supplementary Neuromuscular Rehabilitation During Acute Concussion Recovery Exercise, Return to Activity Progression - Concussion (Diagnosis), Gait Abnormality | Early Phase 1 | Not yet recruiting | Northern Illinois University | 30 | 2027-08-02 | 2026-09-03 |
| Memantine Targeting Neurovascular Dysfunction After Mild and Moderate Traumatic Brain Injury (MEND) Memantine - Traumatic Brain Injury, Mild Traumatic Brain Injury | Phase 2 | Not yet recruiting | Nova Scotia Health Authority | 45 | 2027-06-01 | 2026-10-09 |
| Sleep MAPP in the Polytrauma/TBI System of Care Sleep MAPP Care Pathway - Insomnia Disorder, Mild Traumatic Brain Injury | Not applicable | Not yet recruiting | VA Office of Research and Development | 900 | 2027-01-01 | 2026-10-21 |
| Crisis Response Planning in Military Personnel With Mild Traumatic Brain Injury Crisis Response Planning - Mild Traumatic Brain Injury, Suicide Prevention | Not applicable | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 120 | 2026-12-01 | 2026-01-08 |
| Natural History of MTBI-related Convergence Insufficiency & Effectiveness of Vision Therapy for MTBI-related CI Office-Based Vergence/Accommodative Therapy with Movement (OBVAM) - Convergence Insufficiency | Phase 2 | Not yet recruiting | Salus University | 100 | 2026-11-01 | 2025-02-27 |
| Mindful RAVANS Study Cala-RAVANS (Model CR-2), Sham - mTBI - Mild Traumatic Brain Injury, Posttraumatic Stress Disorder | Not applicable | Not yet recruiting | Spaulding Rehabilitation Hospital | 20 | 2026-11-01 | 2026-10-14 |
| Retraining Neural Pathways Improves Cognitive Skills After A Mild Traumatic Brain Injury PATH + DigitMemory (DM) neurotraining - MTBI - Mild Traumatic Brain Injury | Not applicable | Recruiting | Perception Dynamics Institute | 90 | 2026-10-05 | 2026-10-08 |
| Intravenous Metoclopramide Versus Intravenous Acetaminophen for Acute Concussion Treatment Metoclopramide 10mg, Acetaminophen - Concussion Post Syndrome, Head Trauma Injury | Phase 4 | Not yet recruiting | Montefiore Medical Center | 200 | 2026-10-01 | 2026-10-01 |
| Kids Injury Detection Study Using the i-STAT i-STAT TBI Cartridge with the i-STAT Alinity System - Mild Traumatic Brain Injury, Pediatric Traumatic Brain Injury | Not applicable | Not yet recruiting | Children's Healthcare of Atlanta | 700 | 2026-10-01 | 2026-09-23 |
| Hyperbaric Oxygen Therapy for Veterans With TBI and PCS: A Biomarker Study Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury (TBI) Patients, Post Concussive Symptoms | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 34 | 2026-10-01 | 2026-09-30 |
| The PIONEER Comparative Effectiveness Study - Project 2 Clinical pathway 1: Guidelines plus biomarkers, Clinical guidelines only - Head Injury Trauma, Traumatic Brain Injury, Mild | Not applicable | Not yet recruiting | University of Michigan | 3000 | 2026-10-01 | 2026-10-20 |
| Cognitive Effects of Hyperbaric Oxygen Therapy (HBOT) After a Traumatic Brain Injury Hyperbaric Oxygen Therapy - HBOT - Traumatic Brain Injury, Post-Concussion Syndrome | Not yet recruiting | Assaf-Harofeh Medical Center | 1000 | 2026-10-01 | 2026-10-23 | |
| Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI) Virtual Reality, Standard Psychotherapy - Traumatic Brain Injuries, TBI (Traumatic Brain Injury) | Phase 1 | Recruiting | Johns Hopkins University | 30 | 2026-10-01 | 2026-10-26 |
| Group-based Emotional Awareness and Expression Therapy to Support Recovery After Acquired Brain Injury: A Clinical Development and Evaluation Study TAU + Group Therapy (EAET), Treatment as Usual (TAU) - Aquired Brain Injury, Stroke | Not applicable | Recruiting | Uppsala University | 110 | 2026-09-15 | 2026-10-01 |
| HBOT Effects on First Responders' Cognition and Well-Being Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 54 | 2026-09-11 | 2026-10-01 |
| Examining the Efficacy of the Man Therapy Platform in Reducing Problematic Anger Among Military Service Members With and Without a TBI History Man Therapy - Mild Traumatic Brain Injury (mTBI), Traumatic Brain Injury | Not applicable | Recruiting | University of Colorado, Denver | 226 | 2026-09-01 | 2026-09-16 |
| Evaluating Huddles as a Novel Approach to Improving Concussion Safety Pre-Game Safety Huddles - Mild Traumatic Brain Injury | Not applicable | Not yet recruiting | Seattle Children's Hospital | 2000 | 2026-09-01 | 2026-03-20 |
| Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athletes With Co-morbid Depression and Concussion ONE-D TMS protocol and d-cycloserine (125 mg) - Concussion, Depression | Phase 2 / Phase 3 | Not yet recruiting | University of Florida | 35 | 2026-09-01 | 2026-08-18 |
| Rehabilitation, Education, and SElf-management for Adolescents After Mild Traumatic Brain Injury Mindfulness-based intervention, Health Education - Brain Concussion, Mild Traumatic Brain Injury | Not applicable | Not yet recruiting | Molly Cairncross | 72 | 2026-09-01 | 2026-07-13 |
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