1646 completed, 407 recruiting, 323 unknown, 139 not yet recruiting. 1805 Not applicable, 340 Phase 2, 135 Phase 3, 134 Phase 1, 110 Phase 4.
Follow this condition Literature Review of Stress Disorders, Traumatic trials Research Report on Stress Disorders, Traumatic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Development of a Transdiagnostic Intervention to Improve Social Functioning and Intimate Relationships Among Veterans Acceptance and Commitment Therapy for Social Health, Achievement, and Relationship Effectiveness (ACT-SHARE) - Alcohol Problems, Post-Traumatic Stress Disorder | Not applicable | Not yet recruiting | VA Office of Research and Development | 29 | 2028-07-03 | 2025-11-19 |
| Department of Defense PTSD Adaptive Platform Trial - Intervention D - SLS-002 Intervention D SLS-002, Intervention D Placebo - Post Traumatic Stress Disorder | Phase 2 | Suspended | Global Coalition for Adaptive Research | 200 | 2028-05-01 | 2026-05-20 |
| ACT for Veterans With IBD and Mental Health Challenges Acceptance and Commitment Therapy - Inflammatory Bowel Diseases, Crohn's Disease | Not applicable | Not yet recruiting | VA Office of Research and Development | 50 | 2028-01-01 | 2026-02-09 |
| Department of Defense PTSD Adaptive Platform Trial - Intervention B - Vilazodone Intervention B Vilazodone Hydrochloride (HCl), Intervention B Placebo - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | Global Coalition for Adaptive Research | 200 | 2027-08-01 | 2026-05-20 |
| Identification of Physiological Sleep Indices That Reflect Clinical Improvement and Reduction in Stress Biomarkers After Stellate Ganglion Block in Patients With Posttraumatic Stress Disorder (PTSD) Stellate ganglion block - Post Traumatic Stress Disorder | Not applicable | Not yet recruiting | sara dichtwald | 60 | 2027-08-01 | 2026-10-07 |
| Cognitive Training for Functioning in PTSD COGENT (Cognitive ENhancement Training), ST (Sham Training) - Posttraumatic Stress Disorder | Not applicable | Not yet recruiting | VA Office of Research and Development | 176 | 2027-07-01 | 2026-07-16 |
| Salience Network Informed rTMS for PTSD Active MRI-Guided intermittent theta burst stimulation (iTBS), Sham MRI-Guided intermittent theta burst stimulation (iTBS) - Stress Disorders, Post-Traumatic | Phase 2 | Not yet recruiting | VA Office of Research and Development | 84 | 2027-07-01 | 2026-10-21 |
| Remotely Administered tDCS to Improve Cognitive Function in Veterans With mTBI and PTSD Principal Investigator Transcranial direct current stimulation (tDCS), Cognitive training - Cognition, Brain Injuries | Phase 2 | Not yet recruiting | VA Office of Research and Development | 46 | 2027-05-24 | 2026-02-17 |
| A Mobile Health Intervention to Improve Psychosocial Functioning in Veterans With Posttraumatic Stress Disorder and Depression Symptoms Self-Guided STAIR Coach with Real-Time Assessment, Real-Time Assessment - Psychosocial Functioning, Stress Disorders, Post-Traumatic | Not applicable | Not yet recruiting | VA Office of Research and Development | 40 | 2027-04-01 | 2026-10-06 |
| Mantram Repetition Versus Health Education for Veterans With PTSD and Chronic Pain Mantram Repetition Program for PTSD + Pain, Health Education while Living with Pain - Stress Disorders, Post-Traumatic, Pain, Chronic | Not applicable | Not yet recruiting | VA Office of Research and Development | 170 | 2027-04-01 | 2026-07-27 |
| Understanding Non-invasive Vagus Nerve Stimulation Effects in PTSD transcutaneous auricular vagus nerve stimulation, sham transcutaneous auricular vagus nerve stimulation - PTSD - Post Traumatic Stress Disorder | Early Phase 1 | Not yet recruiting | Wayne State University | 60 | 2027-04-01 | 2026-07-13 |
| Assessing Trauma-related Links Between Affective and Metabolic Systems prazosin - Posttraumatic Stress Disorder, Metabolic Syndrome | Phase 4 | Not yet recruiting | VA Office of Research and Development | 70 | 2027-03-01 | 2026-10-15 |
| PTSD and Alcohol Couples Treatment for Veterans COPE + BFIT - PTSD, AUD | Early Phase 1 | Not yet recruiting | VA Office of Research and Development | 80 | 2027-03-01 | 2026-02-10 |
| Self-Help Intervention for Post 9/11 Veterans With Depression or PTSD Symptoms Resilience Training for Veterans (REST-V), Usual resources - Depression, Stress Disorders, Post-Traumatic | Not applicable | Not yet recruiting | VA Office of Research and Development | 200 | 2027-03-01 | 2026-09-01 |
| Inhaled Cannabis for Treatment of PTSD High THC Cannabis, Placebo cannabis - Post Traumatic Stress Disorder PTSD | Phase 2 | Not yet recruiting | Multidisciplinary Association for Psychedelic Studies | 320 | 2027-02-01 | 2026-08-11 |
| Pregnenolone to Target Concurrent PTSD and Stress Induced Alcohol Use in Veterans: A Dose Finding Study Brexanolone - Alcohol Use Disorder (AUD), Post Traumatic Stress Disorder (PTSD) | Phase 2 | Not yet recruiting | Pharmacotherapies for Alcohol and Substance Use Disorders Alliance | 40 | 2027-01-15 | 2026-09-21 |
| Improving Mental Healthcare Outcomes for Minoritized Veterans Through a Peer-led, Patient Navigation Program (PARTNER-MH 2.0) PARTNER-MH, Educational Brochure - Diagnoses of Depression, Anxiety | Not applicable | Not yet recruiting | VA Office of Research and Development | 268 | 2027-01-04 | 2026-06-16 |
| An Interrupted Time-Series Pilot Trial of LGBTQ-Affirming Cognitive Processing Therapy for Interpersonal and Developmental Trauma Cognitive Processing Therapy - Post-Traumatic Stress Disorder, Chronic, Depressed Mood | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 25 | 2027-01-01 | 2026-10-15 |
| Treatment of Fibromyalgia and PTSD With Live and Inactive Vagus Nerve Stimulation With PEPC tAN plus PEPC, sham plus PEPC - Fibromyalgia (FM), Posttraumatic Stress Disorder (PTSD) | Not applicable | Not yet recruiting | VA Office of Research and Development | 180 | 2027-01-01 | 2026-09-29 |
| Cognitive Processing Therapy for Posttraumatic Stress Disorder and Co-occurring Lived Experience Stress Standard CPT, CPT-LEAP - Post Traumatic Stress Disorder | Not applicable | Not yet recruiting | Boston University | 52 | 2027-01-01 | 2026-09-30 |
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Stress Disorders, Post-Traumatic (2644) · Depression (500) · Anxiety Disorders (467) · Wounds and Injuries (220) · Combat Disorders (192) · Psychological Trauma (137) · Substance-Related Disorders (131) · Psychological Well-Being (108) · Alcoholism (105) · Brain Injuries, Traumatic (92) · Depressive Disorder, Major (90) · Sleep Initiation and Maintenance Disorders (81) · Mental Disorders (69) · COVID-19 (59)
Trauma and Stressor Related Disorders (2873) · Mental Disorders (2838) · Behavior (798) · Behavioral Symptoms (599) · Nervous System Diseases (344) · Pathological Conditions, Signs and Symptoms (294) · Chemically-Induced Disorders (256) · Signs and Symptoms (210) · Neurologic Manifestations (169) · Central Nervous System Diseases (163) · Mood Disorders (163) · Brain Diseases (157) · Wounds and Injuries (153) · Trauma, Nervous System (133)
Therapeutics (109) · Cognitive Behavioral Therapy (87) · Eye Movement Desensitization Reprocessing (47) · N-Methyl-3,4-methylenedioxyamphetamine (38) · 2-cyclohexylidenhydrazo-4-phenyl-thiazole (32) · Ketamine (32) · Transcranial Magnetic Stimulation (30) · Sertraline (29) · Propranolol (28) · Psilocybin (25) · Prazosin (24) · Psychotherapy (23) · Exercise (21) · Implosive Therapy (21) · Paroxetine (18)
VA Office of Research and Development (266) · US Department of Veterans Affairs (56) · Medical University of South Carolina (47) · University of Washington (37) · Yale University (35) · Karolinska Institutet (34) · Emory University (33) · Stanford University (30) · The University of Texas Health Science Center at San Antonio (30) · Duke University (29) · Massachusetts General Hospital (29) · University of Konstanz (28) · Assistance Publique - Hôpitaux de Paris (24) · NYU Langone Health (21) · University of California, Los Angeles (21)
United States (1761) · France (160) · Canada (134) · Israel (106) · Germany (58) · Sweden (55) · United Kingdom (50) · Norway (47) · Switzerland (42) · Turkey (Türkiye) (40) · Netherlands (34) · Denmark (30) · China (28) · Spain (27) · Italy (21)
Joseph Zohar, MD (9) · Yuval Neria, PhD (7) · Charles Marmar, MD (6) · JoAnn Difede, PhD (6) · Yair Bar-Haim, PhD (6) · Douglas Zatzick, MD (5) · James S Gordon, MD (5) · Lori L Davis, MD (5) · Thomas Elbert, Prof. Dr. (5) · Adriana Feder, MD (4) · Alan L Peterson, PhD (4) · Casey Straud, PsyD (4) · Christine E Marx, MD, MA (4) · Daniel R Karlin, MD MA (4)
PMID 37795783, PMID 38767196, PMID 35141873, PMID 31065731, PMID 31572236, PMID 32500209, PMID 32368793, PMID 26606250, PMID 33972795, PMID 34480016, PMID 12182270, PMID 17503104, PMID 18279507, PMID 19101777, PMID 21946660, PMID 24506079, PMID 24740528, PMID 24893322, PMID 25441015, PMID 25706090, PMID 28239485, PMID 28453969, PMID 28569390, PMID 29746232, PMID 29793970, PMID 31092670, PMID 31343205, PMID 32034416, PMID 32077948, PMID 32608505, PMID 33431807, PMID 33587394, PMID 33947471, PMID 34015141, PMID 34672659, PMID 34941354, PMID 35395811, PMID 35833254, PMID 35901423, PMID 36938380, PMID 36987703, PMID 37146219, PMID 37709999, PMID 37833734, PMID 38805199, PMID 40387497, PMID 40811121, PMID 41460640, PMID 41464305, PMID 6880820
2023 (8), 2019 (7), 2025 (5), P30AG064198 (5), 2016 (3), 2017 (3), K23DA016574 (2), P20AA017839 (2), P50MH058911 (2), P50MH115837 (2), R01AA028776 (2), R01MH051509 (2), R01MH064662 (2), R01MH066348 (2), R01MH122867 (2)