10 completed, 6 recruiting, 3 terminated, 3 unknown. 27 Phase 1, 7 Phase 2.
Follow Head Injuries, Closed: new trials by email Literature Review of Head Injuries, Closed trials Research Report on Head Injuries, Closed
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI) Virtual Reality, Standard Psychotherapy - Traumatic Brain Injuries, TBI (Traumatic Brain Injury) | Phase 1 | Recruiting | Johns Hopkins University | 30 | 2026-10-01 | 2026-10-26 |
| Psychologically Informed Cervicovestibular Rehabilitation (PIC Rehab) for Mild Traumatic Brain Injury: A Feasibility Trial Psychologically Informed CVPT (PIC) Rehab, Cervicovestibular Rehabilitation (CVPT) - Mild Traumatic Brain Injury, Concussion | Phase 1 | Not yet recruiting | Sport Injury Prevention Research Centre | 34 | 2026-06-01 | 2026-06-01 |
| Treatment of Persisting Symptoms After Concussion With Psilocybin Assisted Therapy Psilocybin - Persisting Symptoms After Concussion | Phase 1 | Recruiting | University of Calgary | 40 | 2025-05-27 | 2026-09-09 |
| Regulation of Emotion, Sleep Extension, and mTBI Sleep Extension - Mild Traumatic Brain Injury | Phase 1 | Recruiting | Merrimack College | 60 | 2025-02-01 | 2025-04-09 |
| Frontal iTBS for Impulsivity and Suicidal Ideation in Veterans With Mild Traumatic Brain Injury intermittent theta burst stimulation, placebo intermittent theta burst stimulation - Mild Traumatic Brain Injury, Suicidal Ideation | Phase 1 | Recruiting | VA Office of Research and Development | 55 | 2024-05-20 | 2026-04-14 |
| Repetitive Transcranial Magnetic Stimulation for Post-concussion Headaches Repetitive Transcranial Magnetic Stimulation, Sham Repetitive Transcranial Magnetic Stimulation - Brain Concussion, Mild Traumatic Brain Injury | Phase 1 | Recruiting | State University of New York - Upstate Medical University | 60 | 2023-10-23 | 2025-10-10 |
| Tele-Rehabilitation to Improve Mild Traumatic Brain Injury Recovery and Reduce Subsequent Injury Risk Virtual Neuromuscular/Dual-Task Training - Brain Concussion | Phase 1 | Active not recruiting | University of Colorado, Denver | 88 | 2023-08-23 | 2026-05-08 |
| Modulating Exercise Dosage to Improve Concussion Recovery High Dose Exercise - Concussion, Brain, Treatment | Phase 1 / Phase 2 | Recruiting | University of Colorado, Denver | 178 | 2022-08-05 | 2026-08-31 |
| Treatment of U.S. Veterans With Mild Traumatic Brain Injury With Hyperbaric Oxygen Therapy Oxygen 100 % Gas for Inhalation, Hyperbaric Oxygen Therapy Chamber - Mild Traumatic Brain Injury, Hyperbaric Oxygen Therapy | Phase 1 | Completed | Nova Southeastern University | 40 | 2021-09-07 | 2025-08-26 |
| Imaging [18F]PI-2620 and [18F]Florbetaben in Military Service Members With Blast Related Mild Traumatic Brain Injury [18F]PI-2620 - Mild Traumatic Brain Injury | Phase 1 | Terminated | Life Molecular Imaging SA. | 18 | 2021-06-07 | 2024-05-14 |
| ATCell™ Expanded Autologous, Adipose-Derived Mesenchymal Stem Cells Deployed Via Intravenous Infusion 50 Adipose Derived Stem Cell Infusion, 150 Adipose Derived Stem Cell Infusion, 300 Adipose Derived Stem Cell Infusion - Post-Concussion Syndrome | Phase 1 | Unknown | American CryoStem Corporation | 20 | 2021-02-01 | 2023-06-09 |
| NFL LONG Prospective Study [11C] PiB, [18F] PBR111, [18F] Flortaucipir - Concussion, Brain | Phase 1 | Active not recruiting | University of North Carolina, Chapel Hill | 250 | 2020-03-12 | 2026-04-22 |
| Cerebrovascular Reactivity in American Football Players Sildenafil Citrate - Traumatic Brain Injury, Mild Traumatic Brain Injury | Phase 1 | Terminated | University of Pennsylvania | 7 | 2018-03-01 | 2022-09-21 |
| rTMS Treatment of Persistent Headache and Post Concussion Symptoms Attributed to Mild Traumatic Injury to the Head rTMS - Real Air Film Coil, rTMS - Sham Coil - Brain Injuries, Traumatic, Concussion, Brain | Phase 1 / Phase 2 | Completed | University of Calgary | 20 | 2017-04-15 | 2019-04-22 |
| Biological Signatures, Probiotic Among Those With mTBI and PTSD of Lactobacillus reuteri (L. reuteri; DSM 17938), Sunflower and medium chain triglyceride oils - Mild Traumatic Brain Injury, Post Traumatic Stress Disorder | Phase 1 | Completed | VA Office of Research and Development | 75 | 2016-08-01 | 2020-08-18 |
| Chronic Postconcussive Headache: A Placebo-Controlled Treatment Trial of Prazosin prazosin hydrochloride, placebo - Posttraumatic Headache, Combat Disorders | Phase 1 / Phase 2 | Completed | VA Office of Research and Development | 89 | 2016-01-04 | 2026-03-30 |
| Growth Hormone or Sildenafil as Therapies for Fatigue in Mild- Traumatic-brain-injury (MTBI) Growth Hormone, Sildenafil, Placebo - Traumatic Brain Injury | Phase 1 | Completed | The University of Texas Medical Branch, Galveston | 34 | 2014-12-12 | 2018-02-05 |
| Effects of Anesthesia on Pediatric Surgical Patients With a History of Concussion - Phase I Concussion Questionnaire - Post Concussion Symptoms | Phase 1 | Completed | Boston Children's Hospital | 125 | 2014-05-01 | 2016-12-06 |
| DHA For The Treatment of Pediatric Concussion Related to Sports Injury Docosahexaenoic acid (DHA), Placebo - Concussion, Mild Traumatic Brain Injury | Phase 1 | Completed | University of Texas Southwestern Medical Center | 40 | 2013-09-01 | 2021-01-11 |
| Ondansetron for Pediatric Mild Traumatic Brain Injury Ondansetron, PLacebo - Traumatic Brain Injury, Brain Concussion | Phase 1 | Completed | St. Justine's Hospital | 16 | 2013-03-01 | 2015-09-29 |
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Brain Concussion (21) · Brain Injuries, Traumatic (12) · Post-Concussion Syndrome (8) · Craniocerebral Trauma (5) · Headache (3) · Stress Disorders, Post-Traumatic (3) · Brain Diseases (2) · Brain Injuries (2) · Combat Disorders (2) · Depression (2) · Inflammation (2) · Post-Traumatic Headache (2) · Suicide (2) · Anxiety Disorders (1)
Trauma, Nervous System (27) · Wounds, Nonpenetrating (27) · Nervous System Diseases (26) · Wounds and Injuries (26) · Central Nervous System Diseases (24) · Brain Diseases (23) · Brain Injuries (22) · Craniocerebral Trauma (22) · Brain Injuries, Traumatic (12) · Pathological Conditions, Signs and Symptoms (11) · Mental Disorders (6) · Signs and Symptoms (6) · Pathologic Processes (5) · Behavior (4)
Mannitol (2) · Sildenafil Citrate (2) · Transcranial Magnetic Stimulation (2) · ((18)F)PI-2620 (1) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (1) · 2-(6-chloro-2-(4-(3-fluoropropoxy)phenyl)imidazo(1,2-a)pyridin-3-yl)-N,N-diethylacetamide (1) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (1) · Docosahexaenoic Acids (1) · Exercise (1) · Gabapentin (1) · Gases (1) · Growth Hormone (1) · Human Growth Hormone (1) · Inhalation (1) · Lithium Carbonate (1)
VA Office of Research and Development (3) · University of Calgary (2) · University of Colorado, Denver (2) · Abela Pharmaceuticals, Inc. (1) · American CryoStem Corporation (1) · Boston Children's Hospital (1) · Dalhousie University (1) · Johns Hopkins University (1) · Life Molecular Imaging SA. (1) · Massachusetts General Hospital (1) · Merrimack College (1) · Nova Southeastern University (1) · Paul G. Harch, M.D. (1) · Simon Fraser University (1) · Sport Injury Prevention Research Centre (1)
United States (20) · Canada (6)
David R Howell, PhD (2) · Alex P Chapman, Ph.D. (1) · Alexandra L Aaronson, MD (1) · Alison C Bested, MD FRCPC (1) · Allen E Thornton, Ph.D. (1) · Brent Masel, MD (1) · Brian P Walcott, MD (1) · Brian V Nahed, MD (1) · Chantel Debert, MD MSc FRCPC (1) · Chantel T Debert, MD MSc FRCPC (1) · Cynthia L Mayer, DO (1) · David Cox, Ph.D. (1) · Durga Roy, MD (1) · Jason Mihalik, PhD (1) · Jocelyn Gravel, MD (1)
PMID 22026588, PMID 31530227, PMID 33192959, PMID 35722886, PMID 39671573, PMID 39760650, PMID 40297050, PMID 40887012, PMID 40990413, PMID 41019467, PMID 41593831, PMID 41622533, PMID 41956449, PMID 42245142, PMID 42284615
1IK2RX001136-01A2 (1), R01HD108133 (1), R15MH136612 (1)