485 completed, 186 recruiting, 149 unknown, 64 terminated. 470 Not applicable, 125 Phase 2, 66 Phase 3, 56 Phase 1, 42 Phase 4.
Follow Autonomic Nervous System Diseases: new trials by email Literature Review of Autonomic Nervous System Diseases trials Research Report on Autonomic Nervous System Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ketamine and Midazolam Infusions for CRPS: Feasibility Study Ketamine, Midazolam, Normal Saline - Complex Regional Pain Syndromes | Phase 2 | Withdrawn | Stanford University | 2099-01-01 | 2024-11-22 | |
| The Impact of Improved Vagal Function on Periaqueductal Gray Connectivity breathing exercise training - Postural Tachycardia Syndrome | Not applicable | Not yet recruiting | Virginia Commonwealth University | 12 | 2028-01-01 | 2026-09-16 |
| Noninvasive CA Monitoring Validation and Autonomic Modulation in Aneurysmal Subarachnoid Hemorrhage Right-Sided Cervical Sympathetic Block at C6, Transcutaneous Auricular Vagal Nerve Stimulation (taVNS) - Subarachnoid Hemorrhage, Aneurysmal, Delayed Cerebral Ischemia | Not applicable | Not yet recruiting | University of Texas Southwestern Medical Center | 300 | 2027-07-01 | 2026-10-16 |
| A Trial of ONO-2808 in Participants With the Parkinsonian Subtype of Multiple System Atrophy (MSA-P) ONO-2808, Placebo - Multiple System Atrophy, Parkinson Variant | Phase 3 | Not yet recruiting | Ono Pharmaceutical Co., Ltd. | 486 | 2027-01-01 | 2026-09-17 |
| Ketamine HCl Prolonged Release Oral Tablets for CRPS 80mg/day Ketamine HCl Prolonged Release, 160mg/day Ketamine HCl Prolonged Release - Complex Regional Pain Syndromes | Phase 2 | Suspended | University of Southern California | 65 | 2027-01-01 | 2026-07-27 |
| NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI Glyceryl Trinitrate Only Product in Oromucosal Dose Form, Placebo sublingual spray - Spinal Cord Injuries, Autonomic Dysreflexia | Phase 2 | Not yet recruiting | Simon Fraser University | 26 | 2026-12-01 | 2026-04-23 |
| Ceasing Alpha-blockers Early After Resection of the Prostate (The CLEAR Trial) Tamsulosin hydrochloride 0.2 mg, Placebo - Benign Prostatic Hyperplasia | Phase 4 | Not yet recruiting | Shanghai East Hospital | 400 | 2026-12-01 | 2026-09-29 |
| Guanfacine and Cromolyn Sodium for POTS: The DBPOTS Trial Guanfacine (GFC), Cromolyn Sodium, Placebo - Postural Orthostatic Tachycardia Syndrome (POTS), Dysautonomia | Early Phase 1 | Not yet recruiting | Johns Hopkins University | 25 | 2026-11-15 | 2026-10-09 |
| Validity and Reliability of the Turkish Version of the Revised Bath CRPS Body Perception Disturbance Scale Complex Regional Pain Syndrome (CRPS) | Not yet recruiting | Izmir Democracy University | 42 | 2026-11-15 | 2026-10-06 | |
| Continuous and Non-invasive Measurements by Task Force® CORE/CARDIO in Autonomic Function Testing (AFT) Autonomic Function Testing - Autonomic Dysfunction, Orthostatic Intolerance | Not yet recruiting | CNSystems Medizintechnik GmbH | 75 | 2026-11-01 | 2026-03-18 | |
| The Precision Mito- Mito Map COMPASS Study Mito Map Energy Score and Home Functional Assessments - Mitochondrial Diseases, Myalgic Encephalomyelitis Chronic Fatigue Syndrome | Not yet recruiting | AI Agent Vault, Inc. d/b/a Precision Mito | 400 | 2026-11-01 | 2026-10-02 | |
| Phase 3, Open-Label Extension Study of AMBTX-01 (Neridronate) for Complex Regional Pain Syndrome Type 1 Neridronate - Complex Regional Pain Syndrome Type I | Phase 3 | Recruiting | Ambros Therapeutics, Inc. | 135 | 2026-10-13 | 2026-10-16 |
| Graded Motor Imagery Effects on Body Perception Disturbance in Complex Regional Pain Syndrome : a Randomised Controlled Trial Graded Motor Imagery + Therapeutic exercises, Sham-GMI (non-motor mental imagery) + Therapeutic exercises - Complex Regional Pain Syndromes | Not applicable | Not yet recruiting | Nantes University Hospital | 80 | 2026-10-01 | 2026-09-14 |
| Cardiovascular Autonomic Function After Resistance Training Upper-Limb Resistance Training - Spinal Cord Injury | Not applicable | Not yet recruiting | Pusan National University Yangsan Hospital | 20 | 2026-10-01 | 2026-09-03 |
| RESET-POTS: Multimodal Phenotyping and Stellate Ganglion Block in Postural Orthostatic Tachycardia Syndrome Bilateral Sequential Stellate Ganglion Block - POTS - Postural Orthostatic Tachycardia Syndrome | Not applicable | Not yet recruiting | University Medical Centre Ljubljana | 30 | 2026-10-01 | 2026-09-24 |
| Empowered Relief for Caregivers Empowered Relief for Caregivers (ER-CY) - Chronic Pain, Musculoskeletal Pain | Not applicable | Not yet recruiting | Stanford University | 80 | 2026-10-01 | 2026-08-20 |
| Effects of Non-invasive Brain Stimulation on Pain Avoidance Behavior in Chronic Pain Patients transcranial alternating current stimulation (tACS) - Complex Regional Pain Syndrome (CRPS) | Not applicable | Recruiting | The Cleveland Clinic | 30 | 2026-10-01 | 2026-08-28 |
| Time-Domain Heart Rate Variability and QT Interval in Children With Epilepsy Epilepsy, Pediatric Epilepsy | Not yet recruiting | Assiut University | 60 | 2026-10-01 | 2026-09-22 | |
| Open-Label Access to ATH434 for Patients Who Completed Study ATH434-201 in France ATH434 - Multiple System Atrophy | Phase 2 | Enrolling by invitation | Alterity Therapeutics | 7 | 2026-10-01 | 2026-10-09 |
| Presentation of Young Adults With and Without Joint Hypermobility Hypermobile Ehlers-Danlos Syndrome, Postural Orthostatic Tachycardia Syndrome (POTS) | Enrolling by invitation | Clarkson University | 100 | 2026-09-23 | 2026-10-22 |
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Multiple System Atrophy (204) · Complex Regional Pain Syndromes (203) · Hypotension, Orthostatic (149) · Parkinson Disease (134) · Postural Orthostatic Tachycardia Syndrome (134) · Primary Dysautonomias (131) · Syncope, Vasovagal (88) · Orthostatic Intolerance (62) · Spinal Cord Injuries (61) · Supranuclear Palsy, Progressive (58) · Pure Autonomic Failure (56) · Chronic Pain (53) · Syncope (51) · Pain (48)
Nervous System Diseases (1043) · Primary Dysautonomias (600) · Pathological Conditions, Signs and Symptoms (481) · Signs and Symptoms (415) · Neurologic Manifestations (394) · Central Nervous System Diseases (361) · Orthostatic Intolerance (331) · Brain Diseases (310) · Cardiovascular Diseases (289) · Neuromuscular Diseases (288) · Vascular Diseases (268) · Basal Ganglia Diseases (254) · Movement Disorders (247) · Neurodegenerative Diseases (243)
Midodrine (25) · Droxidopa (21) · Exercise (16) · Saline Solution (16) · Sodium Chloride (15) · Pyridostigmine Bromide (9) · Blood Specimen Collection (8) · Lidocaine (8) · Propranolol (8) · Transcranial Magnetic Stimulation (8) · Atomoxetine Hydrochloride (7) · Carbidopa (7) · Ketamine (7) · Phenylephrine (7) · Physical Therapy Modalities (7)
Vanderbilt University Medical Center (32) · Vanderbilt University (28) · University of Calgary (19) · NYU Langone Health (17) · National Institute of Neurological Disorders and Stroke (NINDS) (17) · Stanford University (14) · James J. Peters Veterans Affairs Medical Center (13) · Wake Forest University Health Sciences (13) · Mayo Clinic (12) · University of British Columbia (12) · University Hospital, Bordeaux (11) · University of Colorado, Denver (9) · VA Office of Research and Development (8) · Hospital for Special Surgery, New York (7) · University Hospital, Toulouse (7)
United States (478) · Canada (81) · France (78) · Italy (48) · United Kingdom (43) · Germany (41) · China (40) · Spain (34) · Turkey (Türkiye) (32) · South Korea (28) · Denmark (26) · Poland (25) · Israel (20) · Netherlands (20) · Sweden (19)
Italo Biaggioni, MD (24) · Satish R Raj, MD MSCI (16) · Horacio Kaufmann, MD (8) · Jill Wecht, EdD (5) · Alfredo J Gamboa, MD (4) · Andrei Krassioukov, MD,PhD,FRCPC (4) · Charles Tegeler, MD (4) · Cyndya Shibao, M.D (4) · David Robertson, MD (4) · David S Goldstein, M.D. (4) · Horacio C Kaufmann, MD (4) · Italo Biaggioni, M.D. (4)
PMID 15670960, PMID 21712276, PMID 36114133, PMID 38036236, PMID 21762873, PMID 22565936, PMID 27538531, PMID 28494751, PMID 30354289, PMID 11927799, PMID 12020526, PMID 12119802, PMID 15710782, PMID 15738343, PMID 18426998, PMID 19797151, PMID 20965657, PMID 22275485, PMID 26165391, PMID 26411271, PMID 27402231, PMID 29562304, PMID 30338504, PMID 31330187, PMID 31439288, PMID 33279955, PMID 33739123, PMID 34339231, PMID 34446089, PMID 34854473, PMID 35579382, PMID 35687369, PMID 42475649, PMID 10037110, PMID 10214756, PMID 10406987, PMID 10527042, PMID 10568846, PMID 10636366, PMID 10662747, PMID 10851208, PMID 10853813, PMID 10863041, PMID 10979878, PMID 11018167, PMID 11076832, PMID 11146266, PMID 11210997, PMID 11231036, PMID 11400186
2023 (4), R01HL102387 (4), 2009 (3), 2015 (3), 2018 (3), 2019 (3), 2025 (3), P01HL056693 (3), P01NS044233 (3), R01HL144568 (3), U54NS065736 (3), 2014 (2), 2016 (2), 2017 (2), K23RR020783 (2)