88 completed, 22 unknown, 10 recruiting, 9 terminated. 46 Phase 2, 43 Not applicable, 31 Phase 3, 27 Phase 1, 14 Phase 4.
Follow Mannitol: new trials by email Literature Review of Mannitol trials Research Report on Mannitol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Novel endOvascular Therapy With beVAcizumab and Cannabinoids for Glioblastoma Bevacizumab - GBM | Phase 1 | Not yet recruiting | Unity Health Toronto | 6 | 2026-12-01 | 2026-11-02 |
| Comparison of Hyperosmolar Agent in Reduction of Increased Intracranial Pressure in Patients With Traumatic Brain Injury Using Ultrasonography Mannitol (20%), Hypertonic Saline ( 3% Sodium Chloride Saline) - TBI (Traumatic Brain Injury), ICP (Intracranial Pressure) Increase | Not applicable | Not yet recruiting | Assiut University | 100 | 2026-10-01 | 2026-08-25 |
| A Dose-ranging Study of TTI-0102 in Adults and Children With Leigh Syndrome Spectrum (LSS) TTI-0102: cysteamine-pantetheine disulfide, D-Mannitol - Leigh Syndrome | Phase 2 | Not yet recruiting | Thiogenesis Therapeutics, Inc. | 18 | 2026-10-01 | 2026-07-24 |
| The Impact of Intraoperative Diuretic Use on Delayed Graft Function Following Deceased Donor Renal Transplantation Furosemide, Mannitol - Delayed Graft Function, Kidney Transplantation | Not applicable | Recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 160 | 2026-09-01 | 2026-09-18 |
| Copeptin Measurement After Mannitol and Hypertonic Saline for the Diagnosis of Polyuria-polydipsia Syndrome Mannitol, Hypertonic Saline - Arginine Vasopressin Deficiency, Primary Polydipsia | Not applicable | Recruiting | University Hospital, Basel, Switzerland | 144 | 2026-06-16 | 2026-06-18 |
| Smart AFO and 5-Azacitidine to Enhance Mobility in Children With Cerebral Palsy Smart Ankle-Foot Orthosis, 5-Azacitidine, Placebo - Cerebral Palsy | Phase 2 | Recruiting | Shirley Ryan AbilityLab | 60 | 2026-05-28 | 2026-06-01 |
| tSCS and 5-Azacitidine for Enhanced Motor Outcomes in Cerebral Palsy tSCS, 5-Azacitidine, Mannitol - Cerebral Palsy | Phase 2 | Recruiting | Shirley Ryan AbilityLab | 80 | 2026-05-28 | 2026-11-05 |
| Effect of Intravenous Mannitol on Anterior Chamber Depth and Intraocular Pressure. Mannitol, Placebo - Cataract | Not applicable | Completed | Muhammad Aamir Latif | 60 | 2026-01-01 | 2026-07-22 |
| Clinical Trial on Bowel Preparation Comparing Mannitol 100g to Plenvu Both in a Same Day Regimen (CLEARWAY) 100g of Mannitol, 1L PEG-Asc - Elective Colonoscopy | Phase 3 | Recruiting | NTC srl | 412 | 2025-09-02 | 2026-03-13 |
| Manipulating the Peri-Infarct Area Using Maraviroc to Enhance Motor Skills After Stroke Maraviroc, Mannitol - Ischemic Stroke, Stroke | Phase 2 | Recruiting | Emmanuel Carrera | 80 | 2025-07-14 | 2025-08-12 |
| Memantine as an Additive Therapy in Patients With Traumatic Brain Injury Memantine, Mannitol - Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury (TBI) | Phase 2 / Phase 3 | Not yet recruiting | Mansoura University | 80 | 2025-03-25 | 2025-04-06 |
| Effect of Mannitol on Propofol Level mannitol, Saline - Mannitol Adverse Reaction | Phase 4 | Recruiting | Cukurova University | 40 | 2025-03-20 | 2025-09-02 |
| A Dose-Image Optimization Trial Evaluating Mannitol and Voluven as Adjuncts for Indocyanine Green Voluven-assisted Indocyanine green fluorescence guided sentinel lymph node biopsy for breast cancer, Mannitol (20%) - Breast Cancer Early Stage Breast Cancer (Stage 1-3) | Phase 1 / Phase 2 | Enrolling by invitation | National Taiwan University Hospital | 30 | 2025-01-01 | 2025-04-16 |
| Open-label Study to Assess Reduction of Background Asthma Medication While Sustaining Asthma Control and Clinical Remission With Tezepelumab in Patients 12-80yrs With Severe Asthma. Tezepelumab, Budesonide/formoterol, Albuterol/budesonide (AIRSUPRA®) - Severe Asthma | Phase 3 | Active not recruiting | AstraZeneca | 310 | 2024-09-30 | 2026-10-13 |
| Adding Dexmedetomidine to Mannitol to Attenuate the Increase of Intracranial Pressure Dexmedetomidine with Mannitol, Mannitol (20%) - Dexmedetomidine | Phase 2 / Phase 3 | Completed | Cairo University | 60 | 2024-07-12 | 2026-01-21 |
| A Study to Select the Dose and Evaluate the Effectiveness and Safety of the Drug Refralon®, Tablets, 1 mg for Long-term Use to Prevent Recurrence of Atrial Fibrillation/Flutter After Terminating Its Persistent Form 4-Nitro-N-[(1RS)-1-(4-fluorophenyl)-2-(1-ethylpiperidin-4-yl)ethyl]benzamide hydrochloride, Mannitol - Atrial Fibrillation, Atrial Flutter | Phase 2 | Active not recruiting | National Medical Research Center for Cardiology, Ministry of Health of Russian Federation | 175 | 2024-06-03 | 2026-04-08 |
| Budesonide as a Treatment for Functional Dyspepsia budesonide, Mannitol - Functional Dyspepsia | Phase 4 | Recruiting | Universitaire Ziekenhuizen KU Leuven | 56 | 2024-05-01 | 2025-02-24 |
| Effect of Paracetamol and Mannitol Injection on Postoperative Analgesia in Patients With Thoracoscopic Lobectomy Paracetamol and Mannitol Injection, Parecoxib - Postoperative Analgesia | Not applicable | Unknown | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 90 | 2024-03-15 | 2024-03-12 |
| Effect of Mannitol on Recovery Pattern After Orthognathic Surgery Mannitol, Ringer's Lactate - Orthognathic Surgery | Not applicable | Unknown | National Cancer Institute, Egypt | 60 | 2024-03-01 | 2024-07-23 |
| U-LABA/ICS Effects on Exercise Performance, Formoterol Symbicort, Formoterol, Placebo - Exercise Performance | Not applicable | Completed | Morten Hostrup, PhD | 20 | 2024-01-05 | 2024-08-13 |
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Syntara (10) · OHSU Knight Cancer Institute (4) · University of British Columbia (4) · Ain Shams University (3) · Istanbul University (3) · Prof. Dominique de Quervain, MD (3) · University of Saskatchewan (3) · Asan Medical Center (2) · Brigham and Women's Hospital (2) · Cairo University (2) · Celtaxsys, Inc. (2) · Chelsea Therapeutics (2) · Institute of Liver and Biliary Sciences, India (2) · Shandong University (2) · Shirley Ryan AbilityLab (2)
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Edward A Neuwelt (3) · Claudio Perret, Dr. sc. nat. (2) · Helene Bertrand, MD, CM, CCFP (2) · Yanqing Li, PhD, MD (2) · Achikam Oren-Grinberg, MD (1) · Agostino Mattei, Ass. Prof. (1) · Ahmed M Soliman (1) · Andre Lamy, MD (1) · Andrew Bush, FRCPCH (1) · Andrew Humberstone (1) · Anne Munck, Dr (1) · Aria P Hayanto, Sp.An-TI (1) · Arun Jayaraman, PhD (1) · Augusto Paranhos Jr, MD (1)
PMID 33735508, PMID 10961490, PMID 10961491, PMID 11818776, PMID 12794404, PMID 15644669, PMID 17122580, PMID 17337677, PMID 17511554, PMID 17958887, PMID 18073543, PMID 18972410, PMID 19535188, PMID 19564319, PMID 19996349, PMID 20345336, PMID 21478216, PMID 21998259, PMID 22150036, PMID 22236612, PMID 22438232, PMID 23237936, PMID 23354336, PMID 23429964, PMID 23987192, PMID 24326693, PMID 24352085, PMID 24702886, PMID 24746974, PMID 25142813, PMID 25212745, PMID 25512466, PMID 25978942, PMID 26218852, PMID 26445777, PMID 27009167, PMID 27538531, PMID 27540904, PMID 27654000, PMID 27776149, PMID 27777873, PMID 28065396, PMID 28153869, PMID 28494751, PMID 28544917, PMID 28822586, PMID 29083790, PMID 29489154, PMID 30003579, PMID 30138355
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