80 completed, 44 unknown, 30 recruiting, 25 terminated. 100 Not applicable, 44 Phase 2, 19 Phase 1, 17 Phase 3, 8 Phase 4.
Follow Hyperbaric Oxygenation: new trials by email Literature Review of Hyperbaric Oxygenation trials Research Report on Hyperbaric Oxygenation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HBOT for Perianal Crohn's Disease Hyperbaric Oxygen Therapy (HBOT) - Perianal Crohn Disease | Not applicable | Not yet recruiting | Barts & The London NHS Trust | 10 | 2027-07-01 | 2026-11-13 |
| Retrospective Analysis of CPET and Cognitive Tests of Healthy Individuals, Treated With 60 Treatment of HBOT Hyperbaric Oxygen Therapy - HBOT - Hyperbaric Oxygenation, Cardiorespiratory Fitness | Not yet recruiting | Assaf-Harofeh Medical Center | 1000 | 2026-12-01 | 2026-05-19 | |
| Effect of HBOT on Femoral Head Avascular Necrosis (AVN) Hyperbaric Oxygen Therapy - Osteonecrosis, Avascular Necrosis | Not applicable | Not yet recruiting | Yale University | 400 | 2026-12-01 | 2026-07-01 |
| Cognitive Effects of Hyperbaric Oxygen Therapy (HBOT) After a Traumatic Brain Injury Hyperbaric Oxygen Therapy - HBOT - Traumatic Brain Injury, Post-Concussion Syndrome | Not yet recruiting | Assaf-Harofeh Medical Center | 1000 | 2026-10-01 | 2026-10-23 | |
| Hyperbaric Oxygen Therapy for Veterans With TBI and PCS: A Biomarker Study Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury (TBI) Patients, Post Concussive Symptoms | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 34 | 2026-10-01 | 2026-09-30 |
| HBOT Effects on First Responders' Cognition and Well-Being Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury, PTSD - Post Traumatic Stress Disorder | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 54 | 2026-09-11 | 2026-10-01 |
| Hyperbaric Oxygen Therapy as Adjunctive Treatment for Fracture-Related Infection Hyperbaric Oxygen Therapy - Fracture Related Infection, Hyperbaric Oxygenation | Phase 2 | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 50 | 2026-08-01 | 2026-04-16 |
| Hyperbaric Oxygen After Stroke Thrombectomy: A Multicenter Randomized Trial on Safety and Efficacy Hyperbaric Oxygen Therapy, Conventional therapy group - Acute Ischemic Stroke | Not applicable | Recruiting | Beijing Chao Yang Hospital | 424 | 2026-07-22 | 2026-07-24 |
| Hyperbaric Oxygen Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) Hyperbaric oxygen therapy, SHAM treatment - Chronic Fatigue Syndrome, ME/CFS | Not applicable | Recruiting | Assaf-Harofeh Medical Center | 74 | 2026-07-19 | 2026-08-21 |
| Long-Term Outcomes Following HBOT Hyperbaric Oxygen Therapy (HBOT) - Traumatic Brain Injury, Post-Concussive Symptoms | Phase 2 | Recruiting | Summit Hyperbarics and Wellness | 35 | 2026-06-18 | 2026-07-28 |
| HBO After Thrombectomy for AIS With LVO Hyperbaric oxygen therapy plus standard medical treatment, Standard medical treatment - Acute Ischemic Stroke From Large Vessel Occlusion | Not applicable | Recruiting | Beijing Tiantan Hospital | 420 | 2026-06-01 | 2026-06-04 |
| Addtional Effect of Hyperbaric Oxygen to Programmed Physical Activity on Musckoloskeletal Pain in Breast Cancer Elderly hyperbaric therapy and exercise, exercise - Breast Cancer | Not applicable | Recruiting | Cairo University | 40 | 2026-05-07 | 2026-06-23 |
| Hyperbaric Oxygen Therapy to Improve Autologous Fat Graft Intake in Irradiated Breast Hyperbaric Oxygen Therapy, Control - Breast Reconstruction, Lipofilling | Not applicable | Recruiting | University Hospital, Geneva | 16 | 2026-03-01 | 2026-05-14 |
| the Efficacy of Hyperbaric Oxygen on Acute Ankle Sprain hyperbaric oxygen therapy, non Hyperbaric Oxygen Therapy - Ankle Sprain | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 208 | 2026-03-01 | 2026-02-12 |
| Hyperbaric Oxygen Therapy for Post Traumatic Stress Disorder - a Pragmatic, Double Blinded Randomized Trial Hyperbaric Oxygen Therapy - PTSD - Post Traumatic Stress Disorder | Not applicable | Recruiting | Medical Corps, Israel Defense Force | 72 | 2026-03-01 | 2026-03-16 |
| Evaluating Whether Hyperbaric Oxygen Therapy Can Improve VO₂-Max and Reduce Inflammation Markers in Healthy Adults Ages 30-60. Hyperbaric Oxygen Therapy - Cardiovascular Fitness, Inflammation | Not applicable | Recruiting | University of Texas at Austin | 30 | 2026-01-01 | 2026-01-23 |
| Recovering From COVID-19 Lingering Symptoms Adaptive Integrative Medicine Trial - Effect of Hyperbaric Oxygen Therapy for the Treatment of Post COVID Condition Hyperbaric Oxygen therapy - Long COVID, Post Acute Sequelae of COVID-19 | Not applicable | Recruiting | University Health Network, Toronto | 120 | 2026-01-01 | 2026-02-23 |
| A Prospective, Single-center, Randomized Controlled Clinical Study Evaluating the Efficacy and Safety of Hyperbaric Oxygen Therapy as an Adjunctive Treatment for Chronic Heart Failure hyperbaric oxygen therapy - Chronic Heart Failure With Reduced Ejection Fraction | Not applicable | Not yet recruiting | Fujian Medical University | 150 | 2025-12-15 | 2025-12-30 |
| Concept-verification Clinical Trial on the Inhibition of Breast Cancer Lung Metastasis Progression by Hyperbaric Oxygen Hyperbaric Oxygen Therapy - Breast Cancer, Lung Metastasis | Not applicable | Enrolling by invitation | Jinan Central Hospital | 10 | 2025-11-24 | 2026-04-07 |
| Hyperbaric Oxygen Treatment for Necrotizing Fasciitis and Necrotizing Soft Tissue Infections Hyperbaric Oxygen Therapy - Necrotizing Fascitis | Not applicable | Not yet recruiting | Corewell Health West | 160 | 2025-11-14 | 2025-09-12 |
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Brain Injuries, Traumatic (15) · COVID-19 (11) · Post-Concussion Syndrome (11) · Stroke (11) · Autistic Disorder (9) · Carbon Monoxide Poisoning (8) · Diabetes Mellitus (8) · Inflammation (7) · Breast Neoplasms (6) · Cognitive Dysfunction (6) · Diabetic Foot (6) · Post-Acute COVID-19 Syndrome (6) · Stress Disorders, Post-Traumatic (6) · Brain Concussion (5) · Brain Injuries (5)
Assaf-Harofeh Medical Center (32) · Cairo University (4) · Duke University (4) · Summit Hyperbarics and Wellness (4) · Intermountain Health Care, Inc. (3) · Legacy Health System (3) · National Baromedical Services (3) · Paul G. Harch, M.D. (3) · University Health Network, Toronto (3) · Wonju Severance Christian Hospital (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (2) · Barrett Cancer Center (2) · Beijing Tiantan Hospital (2) · Dartmouth-Hitchcock Medical Center (2) · David Grant U.S. Air Force Medical Center (2)
United States (69) · Israel (32) · China (18) · Canada (9) · Egypt (9) · Netherlands (8) · Denmark (7) · France (5) · Germany (5) · Sweden (5) · United Kingdom (4) · Australia (3) · Austria (3) · Italy (3) · Norway (3)
Enoch Huang, MD (3) · Paul G Harch, M.D. (3) · Amir Hadanny, MD (2) · Daniel A Rossignol, MD (2) · David W Harrison, MD,CCFP(EM),FRCPC (2) · Dick Clarke, CHT (2) · Lindell K Weaver, MD (2) · Lindell K. Weaver, MD (2) · Lone Forner, DDS, PhD (2) · Matthias Knobe, MD (2) · Peter Lindholm, MD, PhD (2) · Rita Katznelson, MD (2) · Steve Wyman, MD (2) · Ahmed Khocht, DDS (1)
PMID 19949909, PMID 23335971, PMID 10685584, PMID 12577851, PMID 15183555, PMID 16457083, PMID 16510383, PMID 16554123, PMID 17439697, PMID 18005455, PMID 19284641, PMID 19298750, PMID 20129356, PMID 20456243, PMID 20497028, PMID 20680427, PMID 20954243, PMID 22513920, PMID 23682548, PMID 23863187, PMID 23992903, PMID 24260334, PMID 24471697, PMID 25401463, PMID 26010952, PMID 26650550, PMID 26740639, PMID 27524654, PMID 28029181, PMID 28357821, PMID 28545109, PMID 28982834, PMID 29453383, PMID 30158840, PMID 30402285, PMID 30831142, PMID 31002414, PMID 31394602, PMID 31394603, PMID 31409407, PMID 31537473, PMID 31916854, PMID 32189664, PMID 32574226, PMID 32574506, PMID 32947434, PMID 33246494, PMID 33518452, PMID 34074856, PMID 34226219
2019 (2), 2017 (1), R37CA225791 (1), U01DK134321 (1)