121 completed, 55 recruiting, 19 unknown, 18 active not recruiting. 98 Not applicable, 39 Phase 2, 30 Phase 1, 13 Phase 3, 7 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Unstuck-Early Childhood Effectiveness & Implementation Trial Unstuck and On Target for Early Childhood - Executive Function Deficits (EFD) | Not applicable | Not yet recruiting | Children's National Research Institute | 90 | 2027-08-01 | 2026-09-21 |
| A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus) Glycerol Tributyrate - MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus) | Phase 1 / Phase 2 | Not yet recruiting | George Washington University | 24 | 2027-03-01 | 2026-10-05 |
| UltraTrac Clinical Pilot Study Noninvasive Hemodynamic Monitoring System - Hemodynamic Monitoring | Not yet recruiting | AcQumen Medical, Inc. | 50 | 2026-10-01 | 2026-10-08 | |
| Blood-Brain Barrier Disruption Using Exablate Magnetic Resonance-Guided Low Intensity Focused Ultrasound With Microbubbles in Combination With T-Cell Infusion in Patients With Newly Diagnosed Diffuse Midline Glioma (LIFT) TAA-T Cell, BBB Disruption - DMG, DIPG | Phase 1 | Recruiting | Children's National Research Institute | 45 | 2026-10-01 | 2026-10-16 |
| Ultra-Rapid Profiling and Drug Screening for Treatment Selection in Patients With Relapsed or Recurrent Rare Brain Tumors Personalized Treatment Recommendation - Rare CNS Tumor, FOXR2-activated | Not applicable | Recruiting | Adriana Fonseca | 20 | 2026-10-01 | 2026-10-13 |
| Pre-pubertal Low Dose Transdermal Estradiol in Turner Syndrome Estradiol transdermal patch 0.025mg/24 hours- 1/8th fractionated patch - Turner Syndrome, Primary Ovarian Insufficiency | Phase 2 | Not yet recruiting | Children's National Research Institute | 15 | 2026-09-01 | 2026-08-25 |
| NgFUS NIVO: NeuroNavigation-Guided Focused Ultrasound With Nivolumab in Relapsed and Progressive DMG and Other High Grade Brain Tumors NeuroNavigation-Guided Focused Ultrasound (NgFUS), Lumason, Nivolumab - Diffuse Midline Glioma or Diffuse Intrinsic Pontine Glioma, High Grade Gliomas | Phase 1 | Recruiting | Children's National Research Institute | 30 | 2026-09-01 | 2026-09-09 |
| Early Phase Study Evaluating MEK and MDM2 Inhibition in Patients With NF1 and MPNST APG-115, Selumetinib - Malignant Peripheral Nerve Sheath Tumor (MPNST), Neurofibromatosis 1 (NF1) | Phase 1 / Phase 2 | Recruiting | AeRang Kim | 45 | 2026-06-01 | 2026-07-27 |
| Impact of AI Care Summaries on Caregiver Comprehension AI Care Summary - Health Literacy, Comprehension | Not applicable | Recruiting | Children's National Research Institute | 100 | 2026-05-05 | 2026-09-21 |
| Pupillary Dilation Reflex in Healthy Volunteers No intervention (observational study) - Healthy Participants | Recruiting | Children's National Research Institute | 60 | 2026-04-29 | 2026-08-04 | |
| Ketamine add-on Therapy for Established Status Epilepticus Treatment Trial (KESETT) Levetiracetam (LEV) (60 mg/Kg) + 1 mg/kg Ketamine (KET), Levetiracetam (LEV) (60 mg/Kg) + 3 mg/kg Ketamine (KET), Levetiracetam (LEV) (60 mg/Kg) - Status Epilepticus | Phase 3 | Recruiting | University of Virginia | 770 | 2026-03-06 | 2026-09-17 |
| Cleft Lip Scarring After Botox Botulinum Toxin Type A (BOTOX) Injection, Normal Saline - Cleft Lip, Cleft Lip Scar | Phase 2 | Recruiting | Children's National Research Institute | 40 | 2026-02-19 | 2026-10-19 |
| Selective Antigen Specific T Cells and CAR T Cells in Subjects With Relapsed/Refractory Embryonal Tumors (SABRE) Selective Antigen Specific dTβRII-expressing T cells combined with B7-H3 CAR T cells - Rhabdomyosarcoma, Ewing Sarcoma | Phase 1 | Recruiting | Children's National Research Institute | 18 | 2026-01-27 | 2026-08-13 |
| Creating a Flexible Curriculum Tool for Pediatric Palliative Care Rotating Learners Rotation Using Flexible Education Tool, Standard Palliative Care Education - Palliative Care Education | Not applicable | Enrolling by invitation | Children's National Research Institute | 30 | 2026-01-01 | 2026-02-13 |
| A Phase 0/1 Study of cDNA for TP53, Checkpoint Inhibition and Radiation in Children With Recurrent, Progressive or Refractory CNS Malignancies. SGT-53, hypofractionated radiotherapy with immunotherapy, Nivolumab - CNS Malignancies, Medulloblastoma Recurrent | Early Phase 1 | Recruiting | Children's National Research Institute | 18 | 2025-12-16 | 2026-04-29 |
| Characterization of Acute Pain AlgometRx Nociometer - Acute Pain, Postoperative, Postoperative Pain | Recruiting | Children's National Research Institute | 100 | 2025-12-02 | 2026-01-14 | |
| Palliative Care Needs of Children With Rare Diseases and Their Families Family Centered pediatric palliative care for family caregivers of children with rare diseases. - Trisomy 13 Syndrome, Arthrogryposis Congenita Multiplex With Intestinal Atresia | Not applicable | Enrolling by invitation | Children's National Research Institute | 480 | 2025-10-02 | 2026-01-28 |
| Pragmatic Clinic-Based Trial of a Mindfulness Based Intervention for Mood Concerns in Youth With Type 1 Diabetes BREATHE-T1D, HealthEd-T1D - Type 1 Diabetes (T1D) | Not applicable | Recruiting | Children's National Research Institute | 200 | 2025-05-15 | 2025-07-08 |
| Adoptive T Cell Therapy, DC Vaccines, and Hematopoietic Stem Cells Combined With Immune checkPOINT Blockade in Patients With Medulloblastoma TTRNA-DC vaccines with GM-CSF, TTRNA-xALT, Td vaccine - Recurrent Group 3 Medulloblastoma, Recurrent Group 4 (Non-SHH/Non-WNT) Medulloblastoma | Phase 1 | Recruiting | University of Florida | 12 | 2025-05-05 | 2026-08-07 |
| Advancing Feasibility and Acceptability of Digital Cognitive Rehabilitation in Sickle Cell Disease Cogmed+ - Sickle Cell Disease | Not applicable | Recruiting | Children's National Research Institute | 50 | 2025-03-05 | 2025-02-13 |
Showing 20 of 250. Sign in to see all of them.
Anemia, Sickle Cell (13) · Diabetes Mellitus, Type 1 (13) · Anxiety Disorders (7) · Depression (7) · Ornithine Carbamoyltransferase Deficiency Disease (7) · Urea Cycle Disorders, Inborn (7) · Neurofibromatosis 1 (6) · Obesity (6) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (6) · Attention Deficit Disorder with Hyperactivity (5) · HIV Infections (5) · Heart Defects, Congenital (5) · Rare Diseases (5) · Argininosuccinic Aciduria (4) · Autism Spectrum Disorder (4)
Saline Solution (7) · Sirolimus (4) · Dexmedetomidine (3) · Exercise (3) · Hydroxyurea (3) · Nivolumab (3) · Sodium Chloride (3) · Therapeutics (3) · Acetaminophen (2) · Cognitive Behavioral Therapy (2) · Cryotherapy (2) · Dexamethasone (2) · Epoetin Alfa (2) · Erlotinib Hydrochloride (2) · Erythropoietin (2)
United States (233) · Canada (7) · Australia (4) · Brazil (2) · Colombia (2) · Italy (2) · Sweden (2) · Uganda (2) · United Kingdom (2) · Argentina (1) · Chile (1) · China (1) · Cyprus (1) · Germany (1) · India (1)
AeRang Kim, MD, PhD (3) · Julia C Finkel, MD (3) · Karun Sharma, MD, PhD (3) · Laura Olivieri, MD (3) · Maureen E Lyon, PhD (3) · Mendel Tuchman, MD (3) · Adriana Fonseca, MD (2) · Andrea L Gropman, M.D. (2) · Catherine Bollard, MD (2) · Frank Rauch, M.D. (2) · James Chamberlain, MD (2) · Lauren Kenworthy, PhD (2) · Lindsay Burrage, MD, PhD (2) · Michael R DeBaun, MD, MPH (2) · Monika Goyal (2)
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K01MD018636 (1), P50HD105328 (1), R01AI165327 (1), R01AI168090 (1), R01AT011008 (1), R01DK070917 (1), R01DK080102 (1), R01DK102561 (1), R01DK119246 (1), R01DK137859 (1), R01EB021396 (1), R01HD089289 (1), R01HD094213 (1), R01HD101528 (1), R01HD102445 (1)