203 completed, 25 unknown, 21 terminated, 18 withdrawn. 109 Phase 2, 85 Phase 1, 60 Not applicable, 15 Phase 3, 11 Phase 4.
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Department of Defense PTSD Adaptive Platform Trial - Intervention D - SLS-002 Intervention D SLS-002, Intervention D Placebo - Post Traumatic Stress Disorder | Phase 2 | Suspended | Global Coalition for Adaptive Research | 200 | 2028-05-01 | 2026-05-20 |
| Department of Defense PTSD Adaptive Platform Trial - Intervention B - Vilazodone Intervention B Vilazodone Hydrochloride (HCl), Intervention B Placebo - Post Traumatic Stress Disorder | Phase 2 | Not yet recruiting | Global Coalition for Adaptive Research | 200 | 2027-08-01 | 2026-05-20 |
| Clinical Trial of MDMA-Assisted Therapy for Military Service Members With Posttraumatic Stress Disorder TREATMENT ARM: Full dose, CONTROL ARM: Active-controlled - PTSD, Post Traumatic Stress Disorder PTSD | Phase 2 | Not yet recruiting | U.S. Army Medical Research and Development Command | 86 | 2026-10-01 | 2026-07-15 |
| e-Health Psychosocial Stress and Symptom Management (ePSMI) for Pancreatic Cancer Patients ePSMI - Pancreatic Cancer | Not applicable | Recruiting | University of Miami | 60 | 2026-08-13 | 2026-08-26 |
| TRACK-TBI Precision Medicine Part 3 - Option II Cyclosporine (CsA), Placebo - Traumatic Brain Injury | Phase 2 | Enrolling by invitation | University of California, San Francisco | 26 | 2026-07-02 | 2026-07-29 |
| Living Well With Brain Cancer: A Group-Based Intervention to Promote Whole-Person Well-Being Group Self-Management Sessions, Educational Materials Only - Brain Cancer | Not applicable | Not yet recruiting | University of Colorado, Denver | 64 | 2026-06-01 | 2026-06-05 |
| Extracorporeal Shockwave Therapy (ESWT) for the Management of Stress Fractures and High-grade Bone Stress Injuries (BSIs) Extracorporeal shockwave treatment (ESWT)., Sham Device - Bones Stress Injury, Bone Stress Fracture | Not applicable | Recruiting | University of California, Los Angeles | 140 | 2025-05-01 | 2026-09-11 |
| Modafinil to Optimize the Performance of Cold-Stressed Sleep-Deprived Personnel Modafinil (M), 200 mg Microcrystalline Cellulose - Sleep Deprivation, Cold Exposure | Phase 4 | Recruiting | United States Army Research Institute of Environmental Medicine | 33 | 2025-02-18 | 2026-09-21 |
| SAFETY: Stabilization Points to Third Hospital Line Assessment oF the Impact of the usE of Infrascanner Model 2500 to Provide Decision Support for Diagnosis/Screening of Traumatic Brain InjurY in Ukraine Handheld brain hematoma detector - Traumatic Brain Hemorrhage | Completed | InfraScan, Inc. | 600 | 2025-01-17 | 2026-09-02 | |
| Non-surgical Spinal Decompression Therapy and Outcomes NSSD, Sham NSSD - Low Back Pain, Herniation, Disc | Not applicable | Active not recruiting | University of South Florida | 42 | 2025-01-07 | 2026-05-18 |
| Transdiagnostic Behavior Therapy Vs TAU for Adjustment Disorder Following Traumatic Event Exposure Transdiagnostic Behavior Therapy (TBT), Treatment as Usual-Problem Solving Therapy (TAU-PST) - Adjustment Disorders, Mental Disorder | Not applicable | Recruiting | The University of Texas Health Science Center, Houston | 150 | 2024-10-08 | 2024-12-06 |
| Military Health and Nutrition Examination Study Hypertension, Type 2 Diabetes | Completed | Pennington Biomedical Research Center | 648 | 2024-08-24 | 2026-07-17 | |
| Adaptions and Resiliency to Multi-Stressor OpeRations Goserelin 3.6 MG, Multi-Stressor Training, Testosterone gel (AndroGel 5g) - Musculoskeletal Injury, Hypogonadism | Phase 4 | Recruiting | Bradley Nindl | 120 | 2024-07-15 | 2026-08-18 |
| Evaluation of Safety and Immunogenicity of Ad26.Mos4.HIV and CH505 TF chTrimer Combination in Healthy Adults Ad26.Mos4.HIV in CH505 TF chTrimer + ALFQ [Arm 1a], CH505 TF chTrimer + ALFQ [Arm 1a], Placebo [Arm 1a] - Human Immunodeficiency Virus | Phase 1 | Recruiting | U.S. Army Medical Research and Development Command | 78 | 2024-01-30 | 2025-10-07 |
| Department of Defense PTSD Adaptive Platform Trial - Master Protocol Intervention A Fluoxetine Hydrochloride (HCl), Intervention A Placebo, Intervention B Vilazodone Hydrochloride (HCl) - Post Traumatic Stress Disorder | Phase 2 | Suspended | Global Coalition for Adaptive Research | 800 | 2023-11-02 | 2026-06-30 |
| Department of Defense PTSD Adaptive Platform Trial - Intervention A - Fluoxetine Intervention A Fluoxetine Hydrochloride (HCl), Intervention A Placebo - Post Traumatic Stress Disorder | Phase 2 | Suspended | Global Coalition for Adaptive Research | 200 | 2023-11-02 | 2026-05-20 |
| Department of Defense PTSD Adaptive Platform Trial - Intervention C - Daridorexant Intervention C Daridorexant, Intervention C Placebo - Post Traumatic Stress Disorder | Phase 2 | Suspended | Global Coalition for Adaptive Research | 200 | 2023-11-02 | 2026-06-30 |
| Homologous Re-infection With Dengue 1 or Dengue 3 Dengue virus 1 Live Virus Human Challenge (DENV-1-LVHC), Dengue virus 3 Live Virus Human Challenge (DENV-3-LVHC) - Dengue | Phase 1 | Completed | State University of New York - Upstate Medical University | 9 | 2023-10-30 | 2024-11-13 |
| Eye Recovery Automation for Post Injury Dysfunction (iRAPID) Virtual Eye Rotation Vision Exercise (VERVE), Sham VR Therapy - Convergence Insufficiency, Traumatic Brain Injury | Not applicable | Recruiting | New Jersey Institute of Technology | 100 | 2023-10-23 | 2026-04-14 |
| Treatment of Hemorrhagic Fever With Ribavirin Virazole - Hemorrhagic Fever | Phase 2 | Suspended | U.S. Army Medical Research and Development Command | 50 | 2022-10-31 | 2026-07-07 |
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Malaria (31) · Brain Injuries, Traumatic (30) · Stress Disorders, Post-Traumatic (26) · Dengue (18) · Malaria, Falciparum (15) · Leishmaniasis, Cutaneous (14) · Brain Concussion (12) · Leishmaniasis (10) · Breast Neoplasms (9) · Combat Disorders (9) · Virus Diseases (8) · Wounds and Injuries (8) · Diarrhea (7) · Anxiety Disorders (6) · HIV Infections (6)
Vaccines (9) · Paromomycin (6) · Desiccation (5) · Ribavirin (5) · Aluminum Hydroxide (4) · Saline Solution (4) · Standard of Care (4) · atovaquone, proguanil drug combination (4) · tafenoquine (4) · AIDSVAX (3) · AIDSVAX B-E (3) · Antimony Sodium Gluconate (3) · Chloroquine (3) · Ethanol (3) · Injections (3)
United States (237) · Thailand (13) · Germany (10) · Canada (9) · Kenya (6) · Tunisia (6) · Afghanistan (4) · Mali (4) · Israel (3) · Belgium (2) · Djibouti (2) · France (2) · Guam (2) · Iraq (2) · Japan (2)
Afif Ben Salah, M.D., Ph.D. (3) · Anthony Cardile, DO (3) · Phillip R Pittman, MD, MPH (3) · Stephen J Thomas, MD (3) · Supachai Rerks-Ngarm, MD (3) · Colby Hansen, MD (2) · David X Cifu, MD (2) · James E Moon, MD (2) · James N Baraniuk, MD (2) · Judith Epstein, MD (2) · Kristopher Paolino, MD (2) · Mark Goldberg, MD (2) · Nimfa Teneza-Mora, MD (2)
PMID 28495354, PMID 23877689, PMID 23899517, PMID 25211344, PMID 26292027, PMID 26292257, PMID 26546259, PMID 27695088, PMID 30098189, PMID 30099354, PMID 31394600, PMID 31394602, PMID 31394603, PMID 32572470, PMID 33274349, PMID 33884617, PMID 37256916, PMID 1023455, PMID 11376235, PMID 11832638, PMID 12011004, PMID 12742586, PMID 15838784, PMID 16135629, PMID 16342292, PMID 16904798, PMID 16911136, PMID 17213921, PMID 17329696, PMID 17371175, PMID 17442466, PMID 17568055, PMID 18213374, PMID 18337339, PMID 18552315, PMID 19064822, PMID 19262754, PMID 19273407, PMID 19390585, PMID 19415122, PMID 19569965, PMID 19628411, PMID 19649245, PMID 19843557, PMID 20140214, PMID 20231896, PMID 20562526, PMID 20619378, PMID 20676928, PMID 20733447
U01HL077863 (4), U01AI065683 (2), 1UL1RR029876-01 (1), K24NR015340 (1), M01RR000073 (1), N01AI085346 (1), P42ES004699 (1), U19AI065683 (1)