4 completed, 4 unknown, 3 recruiting, 2 not yet recruiting. 14 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 14 | Completed 4, Unknown 4, Recruiting 3, Not yet recruiting 2, Terminated 1 |
| Phase 2 | 4 | Not yet recruiting 2, Recruiting 1, Unknown 1 |
Follow Head Injuries, Closed: new trials by email Literature Review of Head Injuries, Closed trials Research Report on Head Injuries, Closed
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimized, Neuroplasticity-Enhanced-Depression (ONE-D) Transcranial Magnetic Stimulation (TMS) Treatment for Female Athletes With Co-morbid Depression and Concussion ONE-D TMS protocol and d-cycloserine (125 mg) - Concussion, Depression | Phase 2 / Phase 3 | Not yet recruiting | University of Florida | 35 | 2026-09-01 | 2026-08-18 |
| Randomized Controlled Trial of Treatment to Optimize Heart Rate Variability for Persistent Post-Concussion Symptoms HRV Coherence Ratio, NSI, Pittsburgh Sleep Quality Index (PSQI) - Autonomic Nervous System Disease, Concussive Injury | Phase 2 / Phase 3 | Recruiting | Virginia Commonwealth University | 148 | 2025-09-02 | 2026-09-22 |
| Memantine as an Additive Therapy in Patients With Traumatic Brain Injury Memantine, Mannitol - Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury (TBI) | Phase 2 / Phase 3 | Not yet recruiting | Mansoura University | 80 | 2025-03-25 | 2025-04-06 |
| Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD) Somatropin, Placebo - Adult Growth Hormone Deficiency, Mild Traumatic Brain Injury | Phase 3 | Recruiting | VA Office of Research and Development | 172 | 2025-01-13 | 2026-10-13 |
| Quetiapine to Reduce Post Concussive Syndrome After Mild Traumatic Brain Injury (mTBI) Quetiapine Fumarate, TAU - Mild Traumatic Brain Injury | Phase 3 | Recruiting | Foundation for Advancing Veterans' Health Research | 146 | 2024-07-09 | 2025-07-11 |
| Memantine Hydrochloride for Treatment of Cognitive Dysfunction Due to Traumatic Brain Injury Memantine Hydrochloride - Treatment of Cognitive Deficits After Traumatic Brain Injury | Phase 3 | Completed | Assiut University | 60 | 2024-01-01 | 2024-08-07 |
| Interventions for Convergence Insufficiency in Concussed Children Standard Community Concussion Care (SC), SC plus Simple Convergence Exercises (SC+), SC plus Office-based Vergence/Accommodative Therapy (SC+OBVAT) - Concussion, Convergence Insufficiency | Phase 3 | Unknown | Mitchell Scheiman | 264 | 2021-04-01 | 2020-10-23 |
| International Trial of Efficacy of Cytoflavin in Head Trauma Cytoflavin ((Inosine + Nicotinamide + Riboflavin + Succinic Acid), Placebo - Head Trauma,Closed | Phase 3 | Completed | POLYSAN Scientific & Technological Pharmaceutical Company | 166 | 2020-11-22 | 2025-04-18 |
| Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy Somatropin - Traumatic Brain Injury, Fatigue | Phase 3 | Completed | The University of Texas Medical Branch, Galveston | 72 | 2018-08-06 | 2025-03-05 |
| Hyperbaric Oxygen Treatment to Treat Mild Traumatic Brain Injury (mTBI)/Persistent Post-Concussion Syndrome (PPCS) Hyperbaric Oxygen, No Hyperbaric Oxygen - Post-Concussion Syndrome, Traumatic Brain Injury | Phase 3 | Unknown | Louisiana State University Health Sciences Center in New Orleans | 59 | 2014-05-01 | 2017-04-18 |
| Treatment of Chronic Post-Traumatic Headache With OnabotulinumtoxinA OnabotulinumtoxinA - Chronic Post Traumatic Headache | Phase 3 | Terminated | University of Washington | 13 | 2014-05-01 | 2018-10-23 |
| PLAY GAME: Post-concussion Syndrome in Youth - Assessing the GABAergic Effects of Melatonin Melatonin, Sugar pill - Post-concussion Syndrome, Post-concussive Symptoms | Phase 2 / Phase 3 | Unknown | University of Calgary | 99 | 2013-09-01 | 2017-04-18 |
| Study of Sand Versus Wood Chip Surfaces on School Playgrounds to Minimize Injury in School Children school playgrounds - Wounds and Injuries, Closed Head Injury | Phase 3 | Unknown | The Hospital for Sick Children | 34 | 2005-01-01 | 2013-08-15 |
| Magnesium Sulfate For Brain Injury magnesium sulfate - Brain Injuries, Head Injury | Phase 3 | Completed | University of Washington | 1998-08-01 | 2011-10-28 |
Brain Concussion (12) · Brain Injuries, Traumatic (7) · Post-Concussion Syndrome (3) · Craniocerebral Trauma (2) · Stress Disorders, Post-Traumatic (2) · Brain Injuries (1) · COVID-19 (1) · Cognitive Dysfunction (1) · Depression (1) · Dwarfism, Pituitary (1) · Fatigue (1) · Fractures, Bone (1) · Ocular Motility Disorders (1) · Wounds and Injuries (1)
Nervous System Diseases (14) · Trauma, Nervous System (14) · Wounds, Nonpenetrating (14) · Brain Diseases (13) · Central Nervous System Diseases (13) · Wounds and Injuries (13) · Brain Injuries (12) · Craniocerebral Trauma (12) · Brain Injuries, Traumatic (6) · Mental Disorders (3) · Stress Disorders, Traumatic (2) · Trauma and Stressor Related Disorders (2) · Behavior (1) · Behavioral Symptoms (1)
Human Growth Hormone (2) · Memantine (2) · Botulinum Toxins, Type A (1) · Hyperbaric Oxygenation (1) · Inosine (1) · Magnesium Sulfate (1) · Mannitol (1) · Melatonin (1) · Niacinamide (1) · Patient Health Questionnaire (1) · Quetiapine Fumarate (1) · Riboflavin (1) · Succinic Acid (1) · Sugars (1) · Therapeutics (1)
University of Washington (2) · Assiut University (1) · Foundation for Advancing Veterans' Health Research (1) · Louisiana State University Health Sciences Center in New Orleans (1) · Mansoura University (1) · Mitchell Scheiman (1) · POLYSAN Scientific & Technological Pharmaceutical Company (1) · The Hospital for Sick Children (1) · The University of Texas Medical Branch, Galveston (1) · University of Calgary (1) · University of Florida (1) · VA Office of Research and Development (1) · Virginia Commonwealth University (1)
United States (9) · Canada (2) · Egypt (2) · Kazakhstan (1) · Russia (1)
Alexander V Savello, Prof (1) · Andrew W Howard, MD, MSc (1) · James Burch (1) · Jose M. Garcia, MD PhD (1) · Karen M Barlow, MB.ChB (1) · Mitchell Scheiman, OD, PhD (1) · Nancy Temkin, Ph.D. (1) · Paul G Harch, MD (1) · Randall J Urban, MD (1) · Sara Gould, MD (1) · Sylvia Lucas, MD, PhD (1) · Taras A Skoromets, Prof (1)
PMID 17166799, PMID 32189664, PMID 32217739, PMID 32772826, PMID 38894576, PMID 41551305
2018 (1)