67 completed, 23 unknown, 13 terminated, 9 recruiting. 51 Phase 2, 27 Phase 3, 26 Phase 1, 21 Phase 4, 11 Not applicable.
Follow cyclopia sequence: new trials by email Literature Review of cyclopia sequence trials Research Report on cyclopia sequence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Topical Minocycline for CARP Topical Minocycline Foam FXFM244, Control - Confluent and Reticulated Papillomatosis (CARP) | Early Phase 1 | Not yet recruiting | Medical University of South Carolina | 35 | 2026-12-15 | 2026-10-22 |
| Optimizing H. Pylori Eradication Regimen Under Intensified Acid Suppression Keverprazan Hydrochloride 20 mg TID, Minocycline 100 mg (10-Day Regimen), Keverprazan Hydrochloride 20 mg BID - HELICOBACTER PYLORI INFECTIONS | Phase 4 | Not yet recruiting | Qilu Hospital of Shandong University | 316 | 2026-08-01 | 2026-08-06 |
| Efficacy and Safety of Minocycline in Patients With Acute Ischaemic Stroke Receiving Intravenous Thrombolysis Minocycline Hydrochloride Capsule (50 mg per capsule), Placebo of Minocycline Hydrochloride Capsule (50 mg per capsule, containing 0 mg of minocycline) - Ischaemic Stroke | Phase 3 | Recruiting | Beijing Tiantan Hospital | 934 | 2026-06-05 | 2026-07-01 |
| Minocycline After Successful Endovascular Thrombectomy Recanalization in Acute Anterior Circulation Large Vessel Occlusion (ATTRACTION-MINOA) Minocycline hydrochloride capsule, Placebo capsules of Minocycline hydrochloride capsules - Acute Ischemic Stroke, Vessel Occlusion | Phase 2 / Phase 3 | Recruiting | Xiang Luo | 860 | 2026-05-21 | 2026-05-27 |
| Minocycline After Successful Endovascular Thrombectomy Recanalization in Posterior Circulation Arterial Occlusion (ATTRACTION-MINOP) Minocycline hydrochloride capsule, Placebo capsules of Minocycline hydrochloride capsules - Acute Ischemic Stroke, Endovascular Thrombectomy | Phase 2 / Phase 3 | Recruiting | Xiang Luo | 234 | 2026-05-19 | 2026-05-22 |
| Clinical Study of Minocycline Hydrochloride Injectable Hydrogel for the Treatment of Periodontitis treatment group - Periodontitis | Not applicable | Not yet recruiting | The First Affiliated Hospital of Xinxiang Medical College | 80 | 2026-05-01 | 2026-05-28 |
| Efficacy and Safety of Minocycline in Acute Spontaneous Intracerebral Hemorrhage Minocycline hydrochloride capsules, Placebo capsules of Minocycline hydrochloride capsules - Intracerebral Hemorrhage | Phase 3 | Recruiting | Beijing Tiantan Hospital | 1192 | 2026-04-02 | 2026-04-23 |
| Effect of Arestin-Enhanced SRP on Periodontal and Glycemic Outcomes in Diabetics local antibiotic application of topical minocycline, Scaling and Root Planing - Periodontitis, Diabetes Mellitus Type 2 | Early Phase 1 | Recruiting | Case Western Reserve University | 42 | 2026-02-06 | 2026-02-19 |
| Minocycline in Stroke Study at Maimonides Minocycline 200mg - Stroke, Ischemia Stroke | Phase 2 / Phase 3 | Recruiting | Joyce Chen | 1164 | 2026-02-02 | 2026-03-19 |
| Minocycline Efficacy in Improving Neurological Outcome of Patients Who Undergo Endovascular Revascularization for Acute Ischemic Stroke Minocyclin - Acute Ischemic Stroke | Phase 2 | Withdrawn | State University of New York at Buffalo | 2025-12-01 | 2026-03-06 | |
| Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery Amiodarone, Minocycline - Atrial Fibrillation | Phase 2 | Withdrawn | Baystate Medical Center | 2025-09-03 | 2026-09-30 | |
| A Multicenter, Randomized, Double-Blind, Controlled Clinical Study of Minocycline for the Treatment of Retinitis Pigmentosa Minocycline 100mg, Minocycline 200mg, Placebo - Retinitis Pigmentosa, Inherited Retinal Dystrophy | Phase 3 | Not yet recruiting | Zhongshan Ophthalmic Center, Sun Yat-sen University | 126 | 2025-07-15 | 2025-07-24 |
| Antihypertensive Mechanisms of Minocycline in Resistant Hypertension Minocycline Hydrochloride, Placebo - Hypertension, Resistant to Conventional Therapy | Phase 4 | Recruiting | University of Florida | 120 | 2025-01-08 | 2026-10-13 |
| PRF + Minocycline vs Arestin in Non-surgical Perio Therapy Arestin, PRF + M - Non-surgical Periodontal Therapy | Phase 4 | Completed | Center for Advanced Rejuvenation and Esthetics | 15 | 2024-12-01 | 2026-05-28 |
| High-dose Dual Therapy and Minocycline-cotaining Quadruple Therapy for Helicobacter Pylori Infection Vonoprazan, Amoxicillin, Bismuth Potassium Citrate - Helicobacter Pylori Infection | Phase 4 | Unknown | Shanghai Jiao Tong University School of Medicine | 200 | 2024-08-21 | 2024-12-30 |
| Optimization of Minocycline for Helicobacter Pylori Rescue Treatment Vonoprazan, Bismuth Potassium Citrate, Tetracycline,Metronidazole - Helicobacter Pylori Infection | Phase 4 | Completed | Shanghai Jiao Tong University School of Medicine | 480 | 2024-08-21 | 2026-03-25 |
| Efficacy of Noisome as A Carrier of Locally Delivered Minocycline Hydrochloride Gel Minocycline hydrochloride with noisome carrier, Minocycline Hydrochloride only - Periodontitis | Phase 2 / Phase 3 | Unknown | Ain Shams University | 30 | 2024-02-25 | 2024-02-12 |
| Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori. esomeprazole, Bismuth, Amoxicillin - Helicobacter Pylori Infection, Chronic Gastritis | Phase 4 | Unknown | Xijing Hospital of Digestive Diseases | 548 | 2023-11-20 | 2024-09-19 |
| Maimonides Minocycline in Stroke Study Minocycline - Stroke, Acute, Ischemic Stroke | Phase 2 / Phase 3 | Terminated | Maimonides Medical Center | 2 | 2023-11-01 | 2025-12-17 |
| Efficacy and Safety of Tranilast Combined With Minocycline in the Treatment of Rosacea minocycline, tranilast - Rosacea | Phase 4 | Unknown | Second Affiliated Hospital of Xi'an Jiaotong University | 45 | 2023-10-16 | 2024-03-12 |
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Ischemic Stroke (11) · Schizophrenia (7) · Stroke (7) · Depressive Disorder, Major (5) · Inflammation (5) · Cerebral Hemorrhage (4) · Pneumothorax (4) · Acne Vulgaris (3) · Alcoholism (3) · Bipolar Disorder (3) · Carcinoma, Non-Small-Cell Lung (3) · Depression (3) · Depressive Disorder, Treatment-Resistant (3) · Hemorrhagic Stroke (3)
Nervous System Diseases (43) · Central Nervous System Diseases (29) · Pathological Conditions, Signs and Symptoms (28) · Mental Disorders (26) · Brain Diseases (23) · Cardiovascular Diseases (22) · Vascular Diseases (21) · Pathologic Processes (19) · Cerebrovascular Disorders (17) · Neoplasms (14) · Neoplasms by Site (12) · Immune System Diseases (10) · Respiratory Tract Diseases (10) · Signs and Symptoms (10) · Skin and Connective Tissue Diseases (10)
Minocycline (106) · Sugars (10) · Surveys and Questionnaires (8) · Tetracycline (5) · Amoxicillin (4) · Modafinil (4) · Celecoxib (3) · Esomeprazole (3) · Metronidazole (3) · 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine (2) · Bupropion (2) · Clarithromycin (2) · Creatine (2) · Amiodarone (1) · Aspirin (1)
M.D. Anderson Cancer Center (11) · National Taiwan University Hospital (4) · Shanghai Jiao Tong University School of Medicine (4) · Beijing Tiantan Hospital (3) · National Eye Institute (NEI) (3) · Sun Yat-sen University (3) · Vyne Therapeutics Inc. (3) · Xijing Hospital (3) · GlaxoSmithKline (2) · Hovione Scientia Limited (2) · Mahidol University (2) · Second Affiliated Hospital, Zhejiang University, School of Medicine (2) · State University of New York - Downstate Medical Center (2) · University of Calgary (2) · University of California, Los Angeles (2)
United States (53) · China (20) · Israel (6) · Canada (5) · Taiwan (4) · Pakistan (3) · Australia (2) · Belgium (2) · Brazil (2) · Germany (2) · Netherlands (2) · Spain (2) · Thailand (2) · Austria (1) · Bulgaria (1)
Yung-Chie Lee, MD, PhD (4) · Zhongxing Liao, MD (3) · Adhiratha Boonyasiri, MD (2) · Catherine A Cukras, M.D. (2) · Jin-Shing Chen, MD, PhD (2) · Rauno Joks, MD (2) · Xiang Luo (2) · Adnan H Siddiqui, MD PhD (1) · Ajay Niranjan, MD, MBA (1) · Allen Lamb, DO (1) · Anxin Wang, PhD (1) · Avner Shemer, Prof. (1)
PMID 28887388, PMID 34487721, PMID 10557349, PMID 11306611, PMID 11880505, PMID 15536785, PMID 15760647, PMID 16033424, PMID 17909152, PMID 17980667, PMID 18071725, PMID 18212521, PMID 19628804, PMID 19895780, PMID 20705929, PMID 21169826, PMID 21450915, PMID 21450917, PMID 21450918, PMID 21737808, PMID 21909339, PMID 22057194, PMID 22323011, PMID 2234831, PMID 22357572, PMID 22589436, PMID 22632907, PMID 22943144, PMID 22967863, PMID 23085382, PMID 23489754, PMID 23566357, PMID 23970502, PMID 24711047, PMID 25003359, PMID 25348221, PMID 25491305, PMID 25888869, PMID 26231264, PMID 26396030, PMID 26510778, PMID 27019421, PMID 27673305, PMID 27718519, PMID 27861741, PMID 28275199, PMID 28564557, PMID 28929560, PMID 29232823, PMID 29444972
R01CA026582 (3), K01AA026005 (2), P01CA124787 (2), 2005 (1), 2023 (1), 2UM1AI104681-08 (1), R01HL132448 (1), R01NS095937 (1), R21AA023150 (1), R21CA158902 (1)