10 unknown, 8 completed, 6 recruiting, 2 not yet recruiting. 28 Phase 3, 7 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 28 | Unknown 10, Completed 8, Recruiting 6, Not yet recruiting 2, Terminated 2 |
| Phase 2 | 7 | Recruiting 3, Unknown 3, Terminated 1 |
Follow cyclopia sequence: new trials by email Literature Review of cyclopia sequence trials Research Report on cyclopia sequence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Minocycline Add-on in Patients With Neurosyphilis Minocycline, Minocycline placebo, Aqueous crystalline penicillin G - Neurosyphilis | Phase 3 | Not yet recruiting | Beijing Ditan Hospital | 778 | 2026-11-15 | 2026-10-29 |
| Efficacy and Safety of Minocycline in Patients With Acute Ischaemic Stroke Receiving Intravenous Thrombolysis Minocycline Hydrochloride Capsule (50 mg per capsule), Placebo of Minocycline Hydrochloride Capsule (50 mg per capsule, containing 0 mg of minocycline) - Ischaemic Stroke | Phase 3 | Recruiting | Beijing Tiantan Hospital | 934 | 2026-06-05 | 2026-07-01 |
| Minocycline After Successful Endovascular Thrombectomy Recanalization in Acute Anterior Circulation Large Vessel Occlusion (ATTRACTION-MINOA) Minocycline hydrochloride capsule, Placebo capsules of Minocycline hydrochloride capsules - Acute Ischemic Stroke, Vessel Occlusion | Phase 2 / Phase 3 | Recruiting | Xiang Luo | 860 | 2026-05-21 | 2026-05-27 |
| Minocycline After Successful Endovascular Thrombectomy Recanalization in Posterior Circulation Arterial Occlusion (ATTRACTION-MINOP) Minocycline hydrochloride capsule, Placebo capsules of Minocycline hydrochloride capsules - Acute Ischemic Stroke, Endovascular Thrombectomy | Phase 2 / Phase 3 | Recruiting | Xiang Luo | 234 | 2026-05-19 | 2026-05-22 |
| Efficacy and Safety of Minocycline in Acute Spontaneous Intracerebral Hemorrhage Minocycline hydrochloride capsules, Placebo capsules of Minocycline hydrochloride capsules - Intracerebral Hemorrhage | Phase 3 | Recruiting | Beijing Tiantan Hospital | 1192 | 2026-04-02 | 2026-04-23 |
| Minocycline in Stroke Study at Maimonides Minocycline 200mg - Stroke, Ischemia Stroke | Phase 2 / Phase 3 | Recruiting | Joyce Chen | 1164 | 2026-02-02 | 2026-03-19 |
| A Multicenter, Randomized, Double-Blind, Controlled Clinical Study of Minocycline for the Treatment of Retinitis Pigmentosa Minocycline 100mg, Minocycline 200mg, Placebo - Retinitis Pigmentosa, Inherited Retinal Dystrophy | Phase 3 | Not yet recruiting | Zhongshan Ophthalmic Center, Sun Yat-sen University | 126 | 2025-07-15 | 2025-07-24 |
| Efficacy of Noisome as A Carrier of Locally Delivered Minocycline Hydrochloride Gel Minocycline hydrochloride with noisome carrier, Minocycline Hydrochloride only - Periodontitis | Phase 2 / Phase 3 | Unknown | Ain Shams University | 30 | 2024-02-25 | 2024-02-12 |
| Maimonides Minocycline in Stroke Study Minocycline - Stroke, Acute, Ischemic Stroke | Phase 2 / Phase 3 | Terminated | Maimonides Medical Center | 2 | 2023-11-01 | 2025-12-17 |
| INflammation-based Stratification for Immune-Targeted Augmentation in Major Depressive Disorder Celecoxib, Minocyclin, Placebo - Major Depressive Disorder, Inflammation | Phase 3 | Recruiting | Universiteit Antwerpen | 240 | 2023-09-21 | 2024-10-15 |
| Efficacy and Safety of Minocycline in Patients With Moderate to Severe Acute Ischemic Stroke Minocycline hydrochloride capsule, Placebo capsules of Minocycline hydrochloride capsules - Ischemic Stroke, Acute | Phase 3 | Completed | Beijing Tiantan Hospital | 1724 | 2023-05-19 | 2025-05-14 |
| Minocycline as Adjunctive Treatment for Treatment Resistant Depression Minocycline - Treatment Resistant Depression | Phase 3 | Completed | Centre for Addiction and Mental Health | 76 | 2020-02-01 | 2026-03-27 |
| Minocycline in MS: Confirmation of Benefit Minocycline 100mg - Multiple Sclerosis, Clinically Isolated Syndrome | Phase 3 | Terminated | University of Calgary | 9 | 2020-01-31 | 2023-03-24 |
| Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium Minocycline, Placebo - Prostate Cancer, Carcinoma of the Rectum | Phase 3 | Unknown | RenJi Hospital | 750 | 2016-11-01 | 2020-01-28 |
| Minocycline add-on to Antipsychotics for the Treatment of Negative and Cognitive Symptoms in Schizophrenia Minocycline, Placebo, Probiotics - Schizophrenia | Phase 3 | Unknown | Beer Yaakov - Ness Ziona Mental Health Center | 40 | 2015-01-01 | 2016-09-20 |
| Minocycline in Acute Spinal Cord Injury (MASC) Minocycline, Placebo, Surgical spinal cord decompression - Spinal Cord Injuries | Phase 3 | Unknown | Rick Hansen Institute | 248 | 2013-06-01 | 2014-10-30 |
| Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement Minocycline, placebo - Spinal Tumors, Trauma Patients, Minocycline. | Phase 2 / Phase 3 | Unknown | Hadassah Medical Organization | 444 | 2013-05-01 | 2013-03-18 |
| An Open Label Study of Oral Minocycline for the Treatment of Patients With Co-occurring Opioid and ATS Dependence Minocycline - Heroin Dependence, Amphetamine Dependence | Phase 3 | Unknown | Universiti Sains Malaysia | 40 | 2013-04-01 | 2015-09-04 |
| Minocycline and Aspirin in the Treatment of Bipolar Depression Minocycline, Aspirin, placebo - Bipolar Disorder Depression | Phase 3 | Completed | Laureate Institute for Brain Research, Inc. | 99 | 2011-09-01 | 2018-01-11 |
| Evaluating the Efficacy of Adjunctive Minocycline for the Treatment of Bipolar Depression Minocycline - Bipolar Disorder, Bipolar Depression | Phase 3 | Completed | University Health Network, Toronto | 29 | 2011-07-01 | 2016-12-19 |
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Ischemic Stroke (6) · Pneumothorax (3) · Bipolar Disorder (2) · Cerebral Hemorrhage (2) · Depressive Disorder, Major (2) · Hemorrhagic Stroke (2) · Inflammation (2) · Multiple Sclerosis (2) · Schizophrenia (2) · Stroke (2) · Amphetamine-Related Disorders (1) · Amyotrophic Lateral Sclerosis (1) · Arterial Occlusive Diseases (1) · Brain Infarction (1)
Nervous System Diseases (16) · Central Nervous System Diseases (11) · Mental Disorders (8) · Brain Diseases (7) · Cardiovascular Diseases (7) · Cerebrovascular Disorders (7) · Pathologic Processes (7) · Pathological Conditions, Signs and Symptoms (7) · Vascular Diseases (7) · Mood Disorders (4) · Stroke (4) · Depressive Disorder (3) · Pleural Diseases (3) · Respiratory Tract Diseases (3) · Spinal Cord Diseases (3)
Minocycline (24) · Aspirin (1) · Celecoxib (1) · Dexamethasone (1) · Probiotics (1)
Beijing Tiantan Hospital (3) · National Taiwan University Hospital (3) · Xiang Luo (2) · Ain Shams University (1) · Beer Yaakov - Ness Ziona Mental Health Center (1) · Beijing Ditan Hospital (1) · Centre for Addiction and Mental Health (1) · Dr. Luanne Metz (1) · German Parkinson Study Group (GPS) (1) · Hadassah Medical Organization (1) · Joyce Chen (1) · Laureate Institute for Brain Research, Inc. (1) · Maimonides Medical Center (1) · National Institute of Neurological Disorders and Stroke (NINDS) (1) · RenJi Hospital (1)
China (8) · Canada (5) · United States (4) · Israel (3) · Taiwan (3) · Australia (1) · Austria (1) · Belgium (1) · Egypt (1) · Germany (1) · Malaysia (1)
Yung-Chie Lee, MD, PhD (3) · Xiang Luo (2) · Anxin Wang, PhD (1) · Gregor Wenning, Prof. Dr. (1) · Imran Ahmad, MBBS (1) · Ishrat Husain, MBBS, MD(Res.) (1) · Jin-Shing Chen, MD, PhD (1) · Luanne Metz, MD (1) · Luanne Metz, MD,FRCPC (1) · Manuel Morrens, MD PhD (1) · Noam Yarom, DMD (1) · Paul H. Gordon, M.D., (1) · Qingliang T. Wang, MD, PhD (1) · Rafael Stryjer, MD (1) · Richard Dodel, PD Dr. (1)
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