295 completed, 70 unknown, 17 recruiting, 14 not yet recruiting. 151 Phase 4, 88 Phase 1, 85 Phase 3, 58 Not applicable, 42 Phase 2.
Follow Esomeprazole: new trials by email Literature Review of Esomeprazole trials Research Report on Esomeprazole
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| This Randomized, Clinical Trial Evaluates the Efficacy of Oral Versus Sublingual Vitamin B12 Supplementation in Correcting Early-onset Vitamin B12 Deficiency in Adult Patients Using Proton Pump Inhibitors (PPIs). The Primary Outcome is the Change in Serum Vitamin B12 Levels Over a 6-week Cyanocobalamin 1000 Mcg Oral Tablet, Cyanocobalamin 1000 Mcg Sublingual Tablet, Proton Pump Inhibitor therapy only - Hypovitaminosis b 12 | Phase 3 | Not yet recruiting | Tanta University | 23 | 2026-12-30 | 2025-05-13 |
| Prophylactic PPI Use After EUS-GE Procedure Esomeprazole, Placebo - Malignant Gastric Outlet Obstruction | Not applicable | Not yet recruiting | Changhai Hospital | 273 | 2026-12-01 | 2026-10-27 |
| Predicting Response and Exposure Changes in Cirrhosis for Effectiveness Five-Drug CYP Probe Cocktail - Liver Cirrhosis | Not applicable | Not yet recruiting | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 45 | 2026-11-01 | 2026-08-11 |
| GMPA Versus PPI for Gastric Protection and aGVHD Risk Teprenone, Esomeprazole - Hematopoietic Stem Cell Transplantation (HSCT), aGVHD | Not applicable | Recruiting | First Affiliated Hospital of Zhejiang University | 198 | 2026-09-15 | 2026-08-28 |
| Mirgeal® Gel as Add-on Therapy to Esomeprazole in Adults With Non-Erosive Gastroesophageal Reflux Disease Esomeprazole 20mg, Mirgeal® Gel (manufacturer: PharmExtracta S.p.A.) - Non-Erosive Gastroesophageal Reflux Disease (NERD) | Not applicable | Not yet recruiting | Liaquat University of Medical & Health Sciences | 140 | 2026-09-07 | 2026-08-27 |
| Potassium-competitive Acid Blocker Versus Double Dose Proton Pump Inhibitors in High High-risk Peptic Ulcer Bleeding Vonoprazon, Esomeprazole - Bleeding | Not applicable | Not yet recruiting | National Cheng-Kung University Hospital | 108 | 2026-09-01 | 2026-08-20 |
| Metronidazole- Versus Tinidazole-Based Bismuth Quadruple Therapy for Helicobacter Pylori Eradication Metronidazole, Tinidazole 500mg, tetracyline - Helicobacter Pylori Infection | Not applicable | Not yet recruiting | University of Medicine and Pharmacy at Ho Chi Minh City | 600 | 2026-07-27 | 2026-08-05 |
| Assessing the Role of Proton Pump Inhibitors in Reducing Aspiration Incidence in Pediatric Laryngomalacia Cases PPI, vitamin D, feeding instruction - Laryngomalacia | Not applicable | Recruiting | Minia University | 60 | 2026-04-28 | 2026-08-06 |
| Esomeprazole Plus Sucralfate for Post-ESD Ulcer Healing Esomeprazole (Intravenous), Esomeprazole (Oral), Sucralfate Suspension - Early Gastric Cancer, Gastric Dysplasia | Phase 4 | Not yet recruiting | LanZhou University | 120 | 2026-04-20 | 2026-03-23 |
| PDO Thread Embedding Plus Binh Vi Tablets for Gastroesophageal Reflux Disease PDO Thread Embedding, Esomeprazole 40 mg Oral Tablet, Binh Vi Tablets - Gastroesophageal Reflux Disease (GERD) | Not applicable | Completed | University of Medicine and Pharmacy at Ho Chi Minh City | 86 | 2026-03-20 | 2026-11-02 |
| Efficacy and Safety of Esomeprazole 40 mg IV in Post-Surgical Patients Admitted to the ICU Esomeprazole - Stress Ulcers, Reflux Episodes | Recruiting | Asian Institute of Gastroenterology, India | 50 | 2026-02-23 | 2026-10-05 | |
| A Randomized, Three-Arm Study Comparing Vonaprazan 10 mg, Vonaprazan 20 mg, and Esomeprazole 40 mg for the Healing of LA Grade B or Higher Reflux Esophagitis at 8 Weeks Vonoprazan, Esomeprazole 40mg - GERD | Not applicable | Recruiting | Asian Institute of Gastroenterology, India | 414 | 2025-12-20 | 2026-03-06 |
| Saccharomyces Boulardii Combined With Bismuth Quadruple Therapy for Helicobacter Pylori Rescue Treatment Bismuth, Esomeprazole, Tetracycline - Gastritis, Dyspepsia | Phase 4 | Recruiting | Yongquan Shi | 1248 | 2025-10-28 | 2025-12-02 |
| Drug Interaction Study on Linaprazan Glurate Capsules Linaprazan Glurate Capsules, Bismuth Potassium Citrate Capsules, Amoxicillin Capsules - Healthy Volunteers, Patients | Phase 1 | Completed | Jiangsu Sinorda Biomedicine Co., Ltd | 56 | 2025-09-08 | 2026-01-06 |
| Prospective Study of Frontline Antibiotics Therapy in the Treatment of Early-stage HP-negative Gastric MALT Lymphoma Esomeprazole, Bismuth tripotassium dicitrate, Tetracycline, and Metronidazole - MALT Lymphoma of Stomach | Phase 2 | Not yet recruiting | National Taiwan University Hospital | 40 | 2025-09-01 | 2025-08-27 |
| A Study to Assess the Effect of Itraconazole, Rifampin, and Acid-Reducing Agents on INCB161734 Pharmacokinetics When Administered Orally in Healthy Participants INCB161734, Itraconazole, Rifampin - Healthy Participants | Phase 1 | Completed | Incyte Corporation | 63 | 2025-07-16 | 2025-11-26 |
| Heartburn, Gastroesophageal Reflux Disease Zastaprazan, Esomeprazole - GERD | Phase 4 | Recruiting | Incheon St.Mary's Hospital | 160 | 2025-07-07 | 2025-12-23 |
| Vonaprazan Versus Esomeprazole for Healing of LA Grade B or Higher Esophagitis After POEM Vonoprazan, Esomeprazole 40mg - GERD | Not applicable | Recruiting | Asian Institute of Gastroenterology, India | 300 | 2025-04-30 | 2026-04-27 |
| Non Steroidal Anti-inflammatory Drugs in the Prevention of Bone Pain Flares After Palliative Radiotherapy Naproxen (Proxen S), Placebo, Esomeprazole 20mg once daily - Bone Pain Flare, Bone Metastasis | Phase 2 | Not yet recruiting | American University of Beirut Medical Center | 385 | 2025-04-01 | 2025-04-04 |
| The Efficacy and Safety of CDK4/6 Inhibitors in Combination with Endocrine Therapy in the Neoadjuvant Treatment Ribociclib; abemaciclib; palbociclib; Dalpiciclib - Breast Cancer Stage III, Breast Cancer Stage II | Not applicable | Not yet recruiting | Hongmei Zheng, PhD | 40 | 2025-04-01 | 2025-03-17 |
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Gastroesophageal Reflux (98) · Dyspepsia (22) · Heartburn (22) · Stomach Ulcer (16) · Peptic Ulcer (15) · Gastritis (13) · Esophagitis, Peptic (9) · Gastrointestinal Hemorrhage (8) · Peptic Ulcer Hemorrhage (8) · Stomach Neoplasms (8) · Barrett Esophagus (7) · Duodenal Ulcer (7) · Helicobacter Infections (7) · Non-Erosive Reflux Disease (6) · Hemorrhage (5)
AstraZeneca (87) · Shanghai Jiao Tong University School of Medicine (13) · Takeda (10) · HK inno.N Corporation (9) · Xijing Hospital of Digestive Diseases (9) · Chinese University of Hong Kong (8) · Shandong University (8) · Chang Gung Memorial Hospital (5) · Damascus Hospital (5) · Kaohsiung Veterans General Hospital. (5) · National Cheng-Kung University Hospital (5) · National Taiwan University Hospital (5) · Pfizer (5) · Yuhan Corporation (5) · Asian Institute of Gastroenterology, India (4)
United States (98) · China (78) · South Korea (44) · Germany (26) · Taiwan (24) · Canada (21) · France (19) · United Kingdom (14) · Italy (13) · Australia (12) · Belgium (12) · Japan (12) · Sweden (12) · Netherlands (11) · Norway (11)
Paula Fernstrom (17) · Tore Lind, MD (5) · Bor-Shyang Sheu, MD (3) · Hong Lu, M.D. (3) · Marouf M Alhalabi, MD (3) · Xiuli Zuo, MD,PhD (3) · Yongquan Shi, Ph. D (3) · Bin Cheng, Doctor (2)
PMID 27707777, PMID 32348007, PMID 15371921, PMID 15691312, PMID 17391505, PMID 21114792, PMID 25141241, PMID 25478944, PMID 25741163, PMID 27331882, PMID 27875488, PMID 28456631, PMID 29788903, PMID 29914954, PMID 31297231, PMID 34836916, PMID 11197288, PMID 12039901, PMID 12161727, PMID 12526935, PMID 16441468, PMID 16481828, PMID 16948806, PMID 17305763, PMID 17499604, PMID 17697200, PMID 17697201, PMID 17854602, PMID 18446147, PMID 18493207, PMID 19058002, PMID 19210493, PMID 19221370, PMID 19236727, PMID 19357404, PMID 19577008, PMID 19601705, PMID 19661245, PMID 19788600, PMID 19922626, PMID 20110554, PMID 20151726, PMID 20223367, PMID 20230209, PMID 20456300, PMID 20458079, PMID 20525969, PMID 20540767, PMID 20551454, PMID 20706150
2023 (4), 2014 (2), 2018 (2), 2004 (1), 2015 (1), 2017 (1), 2019 (1), N01CN35000 (1), U01HL072968 (1)