554 completed, 100 unknown, 33 not yet recruiting, 31 recruiting. 201 Not applicable, 141 Phase 2, 136 Phase 3, 119 Phase 4, 104 Phase 1.
Follow Acne Vulgaris: new trials by email Literature Review of Acne Vulgaris trials Research Report on Acne Vulgaris
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Role of Akkermansia Muciniphila in Acne Vulgaris Akkermansia Muciniphila, Clostridium Beijerinckii, Anaerobutyricum Hallii, Clostridium Butyricum, Bifidobacterium Infantis Probiotic Capsule - Acne | Early Phase 1 | Not yet recruiting | Medical University of South Carolina | 34 | 2027-03-01 | 2026-05-12 |
| Clascoterone Versus Clindamycin Added to Adapalene/Benzoyl Peroxide for Moderate Facial Acne Clascoterone 1% cream, Clindamycin 1% lotion, Adapalene 0.1%/benzoyl peroxide 2.5% gel - Acne Vulgaris | Phase 4 | Not yet recruiting | Allied Hospital Faisalabad | 118 | 2026-11-01 | 2026-10-19 |
| Safety of the Acne mRNA Vaccine in Adolescents 12 to 17 Years of Age With Moderate to Severe Acne Acne mRNA (messenger ribonucleic acid) vaccine, Placebo - Acne | Phase 2 | Not yet recruiting | Sanofi | 410 | 2026-10-30 | 2026-09-18 |
| Comparison of Topical Clascoterone 1% Cream Versus Adapalene 0.1% Cream in the Treatment of Mild-to-Moderate Acne Vulgaris Clascoterone 1% cream, Adapalene 0.1% cream - Acne Vulgaris | Not applicable | Recruiting | Pak Emirates Military Hospital | 130 | 2026-10-08 | 2026-10-22 |
| Study to Determine Efficacy, Safety, and Tolerability of B244 as a Topical Spray in Subjects With Moderate to Severe Acne Vulgaris B244, Vehicle - Acne Vulgaris | Phase 2 | Not yet recruiting | AOBiome LLC | 176 | 2026-10-01 | 2026-10-08 |
| Phase 3 Study of Denifanstat in Participants With Moderate to Severe Acne (AURORA) Denifanstat, Placebo - Acne Vulgaris | Phase 3 | Recruiting | Sagimet Biosciences Inc. | 800 | 2026-10-01 | 2026-10-22 |
| Demodex Mites in Acne Patients and Herbal Extract Susceptibility Acne, Demodex Infestation | Not yet recruiting | Assiut University | 80 | 2026-09-26 | 2026-09-28 | |
| Radiofrequency Treatment Versus Topical Therapy for Facial Acne Vulgaris Adapalene 0.1% and Benzoyl Peroxide 2.5% gel, Sequential Radiofrequency Treatment - Acne Vulgaris | Not applicable | Recruiting | Jeisys Medical Inc | 60 | 2026-09-15 | 2026-09-04 |
| Investigating the Efficacy of Oral Probiotics Versus Placebo in Pakistani Patients With Moderate Acne on Acne Lesion Count and Systemic Inflammation Probiotics, Placebo - Acne Vulgaris | Not applicable | Not yet recruiting | Foundation University Islamabad | 64 | 2026-09-01 | 2026-04-20 |
| A Randomised Controlled Trial of ePROM-Guided Flexible Scheduling in Dermatology Flexible ePROM-guided Scheduling System, electronic patient reported outcome measures (ePROMs) - Chronic Dermatological Conditions, Eczema | Not applicable | Not yet recruiting | National University Hospital, Singapore | 250 | 2026-09-01 | 2026-07-01 |
| Study of New Antiandrogenic Progestogen + Low-dose Estrogen for Moderate Acne Vulgaris Placebo of the experimental drug, Experimental drug - Acne Vulgaris, Acne Vulgaris on the Face | Phase 3 | Recruiting | Eurofarma Laboratorios S.A. | 531 | 2026-08-24 | 2026-09-22 |
| Comparison of Topical Clascoterone and Adapalene for Mild Acne Vulgaris Clascoterone Cream 1%, Adapalene 0,1% cgel - Acne Vulgaris | Early Phase 1 | Not yet recruiting | Khyber Teaching Hospital | 60 | 2026-08-15 | 2026-06-29 |
| Prevalence of Polyendocrine Metabolic Ovarian Syndrome in Patients Diagnosed With Acne Vulgaris in Sohag University Hospital Polyendocrine Metabolic Ovarian Syndrome, Acne Vulgaris | Recruiting | Sohag University | 90 | 2026-08-09 | 2026-09-16 | |
| Photodynamic Therapy With Topical Application of a Zn(II) Phthalocyanine (RLP068/Cl) and Red Light for the Treatment of Moderate-to-severe Acne Vulgaris Zn(II)-phthalocyanine gel - Acne | Not applicable | Not yet recruiting | Università degli Studi di Brescia | 10 | 2026-08-01 | 2026-05-04 |
| Clinical Observation of Skin Condition in Patients With Acne Vulgaris Using Ubiquinol, Pomegranate Peel Extract, Ceramide, and Salicylic Acid Emulsion Acne | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 40 | 2026-07-20 | 2026-07-29 | |
| A Clinical Trial to Investigate the Efficacy and Safety of GenLabs' Social Renew on Improving Acne Symptoms and Skin Repair Among Healthy Adults Social Renew, Placebo - Acne | Not applicable | Not yet recruiting | GenCanna Acquisition Corp | 150 | 2026-07-01 | 2026-06-30 |
| Low-Dose Versus Conventional-Dose Oral Isotretinoin for Acne Vulgaris Isotretinoin - Acne Vulgaris | Phase 4 | Not yet recruiting | Pakistan Institute of Medical Sciences | 164 | 2026-07-01 | 2026-06-10 |
| Safety and Efficacy of Skincare Products for Managing Mild to Moderate Acne in Individuals With Sensitive Skin Cleanser, Toner, Serum - Acne | Not applicable | Recruiting | USMARI Research & Innovation Centre | 34 | 2026-06-01 | 2026-08-06 |
| Exploring Acne Treatments Through Clinical Research Participation Acne | Not yet recruiting | Power Life Sciences Inc. | 500 | 2026-06-01 | 2025-06-08 | |
| 1% Clascoterone Cream for the Treatment Acne Vulgaris 1% Clascoterone Cream, Placebo - Acne Vulgaris | Phase 3 | Not yet recruiting | Zhejiang Sunshine Mandi Pharmaceutical Co.,Ltd. | 692 | 2026-05-04 | 2026-03-09 |
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Cicatrix (16) · Psoriasis (15) · Dermatitis, Atopic (13) · Rosacea (13) · Hyperpigmentation (11) · Skin Diseases (10) · Eczema (9) · Dermatitis (8) · Hidradenitis Suppurativa (8) · Alopecia (7) · Dermatitis, Seborrheic (6) · Facies (5) · Inflammation (5) · Erythema (4)
Skin and Connective Tissue Diseases (778) · Acneiform Eruptions (777) · Sebaceous Gland Diseases (776) · Skin Diseases (768) · Pathological Conditions, Signs and Symptoms (58) · Pathologic Processes (41) · Skin Diseases, Eczematous (25) · Immune System Diseases (23) · Dermatitis (22) · Infections (21) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (20) · Skin Diseases, Papulosquamous (20) · Hypersensitivity (19) · Hypersensitivity, Immediate (18) · Pigmentation Disorders (18)
Gels (64) · Adapalene (63) · Benzoyl Peroxide (51) · Clindamycin (36) · Isotretinoin (29) · Tretinoin (29) · Doxycycline (23) · Adapalene, Benzoyl Peroxide Drug Combination (21) · Dapsone (19) · Clascoterone (16) · tazarotene (16) · Minocycline (15) · clindamycin phosphate (15) · berdazimer sodium (13) · clindamycin phosphate benzoyl peroxide combination (13)
Galderma R&D (45) · Stiefel, a GSK Company (29) · Bausch Health Americas, Inc. (27) · Sun Pharmaceutical Industries, Inc. (22) · Assiut University (18) · Cosmetique Active International (13) · GlaxoSmithKline (13) · Novan, Inc. (13) · Allergan (11) · Integrative Skin Science and Research (9) · Pierre Fabre Dermo Cosmetique (9) · Sohag University (9) · Almirall, S.A. (8) · Bayer (8) · Dermira, Inc. (7)
United States (368) · Canada (58) · Egypt (36) · China (35) · France (24) · Poland (23) · Germany (18) · Spain (17) · Brazil (16) · Indonesia (15) · Turkey (Türkiye) (13) · Belize (12) · Israel (12) · Australia (11) · India (10)
Anya Loncaric (13) · Michael Graeber, MD (7) · Natalie Yantovskiy (6) · Joyce Rico, MD (5) · Anya Loncaric, MS (4) · Beth Zib (4) · John J Voorhees, MD (4) · Robert Bissonnette, MD (4) · Amy Paller, MD (3)
PMID 40377868, PMID 20684151, PMID 27518661, PMID 27847545, PMID 29380251, PMID 30500139, PMID 30500140, PMID 30500141, PMID 32320027, PMID 32886337, PMID 34607697, PMID 36745367, PMID 38724841, PMID 39141589, PMID 10951254, PMID 11488820, PMID 12095065, PMID 12243706, PMID 12553848, PMID 12839559, PMID 16247244, PMID 16575387, PMID 1699862, PMID 17314442, PMID 17616769, PMID 18249468, PMID 18394082, PMID 18472984, PMID 18532922, PMID 18720689, PMID 18827119, PMID 19075138, PMID 19376456, PMID 19439902, PMID 19746769, PMID 19911678, PMID 20213916, PMID 20214175, PMID 20404229, PMID 20677537, PMID 20981308, PMID 21108671, PMID 21143923, PMID 21288628, PMID 21572783, PMID 21880356, PMID 22168326, PMID 22253996, PMID 22341881, PMID 22678562
2023 (4), 2025 (3), 2016 (2), 2014 (1), 2017 (1), 2018 (1), 2019 (1), R01AR053542 (1), R01HD065029 (1), U01AR079752 (1)