101 completed, 18 recruiting, 18 unknown, 8 not yet recruiting. 114 Not applicable, 18 Phase 2, 13 Phase 3, 10 Phase 4, 5 Phase 1.
Follow Creatine: new trials by email Literature Review of Creatine trials Research Report on Creatine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Resistance Training and Creatine Supplementation for Head and Neck Cancer Creatine Supplementation, Resistance Training - Head and Neck Cancer, Cancer Survivorship | Not applicable | Not yet recruiting | Medical University of South Carolina | 30 | 2026-11-15 | 2026-10-06 |
| Creatine Supplementation in Pediatric Brain Injury Creatine monohydrate, Microcrystalline Cellulose - Brain Injury, Traumatic Brain Injury | Not applicable | Not yet recruiting | Spaulding Rehabilitation Hospital | 46 | 2026-10-01 | 2026-08-10 |
| The Effects of Tyrosol and Creatine on Exercise Performance and Cognition in Healthy Adults Tyrosol, Creatine Monohydrate, Resistant Dextrin - Tyrosol, Creatine | Not applicable | Recruiting | Applied Science & Performance Institute | 60 | 2026-09-04 | 2026-09-21 |
| Creatine and Perioperative Brain Health Creatine monohydrate, Placebo - Neurocognitive Disorders, Postoperative Delirium | Not applicable | Not yet recruiting | Massachusetts General Hospital | 120 | 2026-09-01 | 2026-08-10 |
| Creatine and Cognitive Health in Patients With Early-stage Breast Cancer During and After Chemotherapy Treatment Creatine, Placebo - Breast Cancer | Phase 3 | Not yet recruiting | D'Or Institute for Research and Education | 227 | 2026-08-01 | 2026-01-28 |
| Effects of Creatine and Heat Exposure on Exercise Performance and Body Water Distribution Creatine Monohydrate, Maltodextrin (Placebo) - Heat Exposure, Exercise Performance | Not applicable | Not yet recruiting | University of Windsor | 25 | 2026-07-30 | 2026-05-18 |
| Effects of Creatine and Carbohydrate Supplementation on Endurance Performance Creatine Monohydrate, Carbohydrate, Creatine Monohydrate and Carbohydrate - Exercise Performance Recovery | Not applicable | Not yet recruiting | California Polytechnic State University-San Luis Obispo | 12 | 2026-07-15 | 2026-07-21 |
| Creatine Supplementation During GLP-1a Therapy Dietary supplementation during a 12 week resistance-training program (creatine), Dietary supplementation during a 12 week resistance-training program (placebo) - Sarcopenia | Not applicable | Recruiting | University of Saskatchewan | 40 | 2026-05-25 | 2026-06-04 |
| Creatine Supplementation and Resistance Training to Improve Sarcopenia Parameters in Patients With Prostate Cancer After Androgen Deprivation Therapy Creatine Monohydrate, Maltodextrin, Resistance training - Prostate Cancer, Sarcopenia | Not applicable | Recruiting | University of Sao Paulo | 34 | 2026-05-01 | 2026-06-11 |
| Creatine Supplementation for Improved Voice Performance in the Elderly Creatine monohydrate, Placebo - Presbyphonia | Not applicable | Suspended | NYU Langone Health | 20 | 2026-05-01 | 2026-03-04 |
| Dietary Supplements and Middle Aged Women (Creatine) Creatine Monohydrate, Placebo control - Cognition, Muscle Strength | Not applicable | Recruiting | Loughborough University | 38 | 2026-05-01 | 2026-07-28 |
| Prehab and Creatine/Whey Supplementation in Frailty Among Patients With Cirrhosis HEAL-ME digital app, Creatine supplementation, Whey protein supplementation - Cirrhosis, Frailty | Not applicable | Recruiting | University of California, San Francisco | 100 | 2026-04-15 | 2026-07-15 |
| Effects of Creatine Supplementation on Cognitive Measures and Markers of Acute Kidney Injury After Exercise in the Heat Creatine Monohydrate, Maltodextrin (Placebo) - Acute Kidney Injury, Exertional Heat Illness | Not applicable | Recruiting | University of Northern Iowa | 20 | 2026-03-12 | 2026-03-16 |
| Neuromuscular and Multi-Omics Synergy of Combined Creatine × HMB Supplementation Plus Exercise to Improve Muscle Function in Sarcopenic Frailty Placebo (Cellulose), Creatine Monohydrate, Multicomponent Exercise Program - Frailty, Sarcopenia | Not applicable | Active not recruiting | Universidad de Burgos | 50 | 2026-03-10 | 2026-05-04 |
| Intradialytic Exercise Combined With Creatine Monohydrate in Patients With Chronic Kidney Disease Undergoing Hemodialysis. Group A with creatine monohydrate, Group B placebo, Group C Intradialytic Exercise Program - Chronic Kidney Disease 5D | Phase 1 / Phase 2 | Recruiting | Pedro Julian Flores Moreno | 48 | 2026-03-02 | 2026-06-24 |
| Effects of Short-term Acute Creatine Supplementation on Power, Speed and Muscular Strengths in Young Football Players Creatine Monohydrate, Placebo - Performance Enhancement | Not applicable | Not yet recruiting | St. Mary's University, Twickenham | 20 | 2026-03-01 | 2026-03-16 |
| Antioxidant Supplementation and Muscle Recovery From DOMS in Trained Women Creatine Monohydrate, Omega 3 FA (Fish Oil), N-Acetyl Cysteine (NAC) - Delayed Onset Muscle Soreness, Exercise-induced Muscle Damage | Not applicable | Completed | Antonio Molina Lopez | 60 | 2026-02-19 | 2026-10-16 |
| Effects of 7-Day Creatine Supplementation on Cognitive Function After High-Intensity Interval Training in Active Young Men Creatine Monohydrate, Placebo, High Intensity Interval Training - Creatine Supplementation, Exercise Ergogenics | Not applicable | Completed | Universitas Negeri Malang | 20 | 2026-02-07 | 2026-04-16 |
| EFICAC-TTR Trial: Exercise and Nutritional Supplementation in Transthyretin Cardiac Amyloidosis Home-Based Multicomponent Exercise Program, Microcrystalline Cellulose Control Supplementation, Creatine and HMB Supplementation - Transthyretin Cardiac Amyloidosis | Not applicable | Completed | Universidad de Burgos | 47 | 2026-02-03 | 2026-09-25 |
| Effects of Soy Protein and Creatine Supplementation on Certain Parameters in Men Performing Resistance Exercise soy protein, Creatine Monohydrate - Healthy Men Doing Resistance Training | Not applicable | Completed | Yakup Enes Çam | 54 | 2026-01-05 | 2026-07-30 |
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Depressive Disorder, Major (12) · Depression (9) · Motor Activity (9) · Sarcopenia (9) · Huntington Disease (6) · Amyotrophic Lateral Sclerosis (5) · Osteoarthritis, Knee (5) · Brain Concussion (4) · Breast Neoplasms (4) · Muscle Weakness (4) · Fatigue (3) · Frailty (3) · Muscular Atrophy (3) · Osteoporosis (3) · Prostatic Neoplasms (3)
University of Sao Paulo (14) · University of Utah (8) · Massachusetts General Hospital (6) · Perry Renshaw (6) · University of Regina (5) · University of Saskatchewan (5) · Applied Science & Performance Institute (3) · Florida State University (3) · Foundation University Islamabad (3) · GlaxoSmithKline (3) · Bangor University (2) · California Polytechnic State University-San Luis Obispo (2) · Columbia University (2) · National Center for Complementary and Integrative Health (NCCIH) (2) · National Center for Research Resources (NCRR) (2)
United States (69) · Canada (19) · Brazil (16) · Spain (9) · United Kingdom (6) · Denmark (3) · Pakistan (3) · Turkey (Türkiye) (3) · Australia (2) · Chile (2) · Greece (2) · Israel (2) · Netherlands (2) · South Korea (2) · Austria (1)
Bruno Gualano, PhD (5) · Diana Rosas, MD, MS (4) · Bruno Gualano, Professor (3) · Perry F Renshaw, MD, PhD, MBA (3) · Perry Renshaw, MD, PhD, MBA (3) · Steven M Hersch, MD, PhD (3) · Darren Candow (2) · Darren Candow, Ph.D. (2) · Darren G Candow, PhD (2) · Douglas Kondo, MD (2) · Eric Sikorski, PhD (2) · Juan Mielgo-Ayuso, PhD (2) · Muhammad Osama, PhD* (2) · Philip Chilibeck, Ph.D. (2)
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M01RR000036 (1), P01NS058793 (1), P30CA042014 (1), R01CA133595 (1), R01CA281759 (1), U01AT000613 (1), U01NS043128 (1), UL1TR001082 (1)