51 completed, 26 unknown, 16 terminated, 12 recruiting. 38 Phase 3, 35 Phase 4, 26 Not applicable, 11 Phase 2, 4 Phase 1.
Follow Amiodarone: new trials by email Literature Review of Amiodarone trials Research Report on Amiodarone
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pragmatic Amiodarone Trial to Reduce Postoperative Atrial Fibrillation in Patients Undergoing Cardiac Surgery Amiodarone - Surgery, Cardiac, Atrial Fibrillation | Phase 4 | Not yet recruiting | Massachusetts General Hospital | 242 | 2027-01-01 | 2026-06-30 |
| Randomized Interventional Clinical Trial on the Prevention of Atrial Fibrillation Using Colchicine, Amiodarone And a Posterior Pericardiotomy. Colchicine, Amiodarone, Posterior pericardiotomy - Atrial Fibrillation (AF) | Phase 3 | Not yet recruiting | Elsan | 636 | 2027-01-01 | 2026-10-21 |
| Vernakalant Versus Amiodarone for Post-operative Atrial Fibrillation in Cardiac Surgery Patients Vernakalant, Amiodarone - Atrial Fibrillation, Post-cardiac Surgery | Phase 3 | Not yet recruiting | University of Calgary | 50 | 2026-09-01 | 2026-06-03 |
| Flecainide Safety in Patients With Coronary Artery Disease and Atrial Fibrillation flecainide, Sotalol or Amiodarone - Atrial Fibrillation (AF), Coronary Artery Disease | Phase 4 | Recruiting | Universitaire Ziekenhuizen KU Leuven | 988 | 2026-09-01 | 2026-10-21 |
| Pharmacological Intervention to Prevent NOAF After TAVR Metoprolol succinate, Amiodarone - Atrial Fibrillation | Not applicable | Not yet recruiting | Shanghai East Hospital | 198 | 2026-04-07 | 2026-04-15 |
| Comparative Efficacy of 100-, 200-, & 400-mg Amiodarone in Patients With Paroxysmal AF Depending on Plasma Concentration Pharmacotherapy with amiodarone 200 mg per day, Treatment with Amiodarone at a dose 100 mg per day, Treatment with Amiodarone at a dose 400 mg per day - Paroxysmal AF, Treatment Decisions | Phase 4 | Enrolling by invitation | Tomsk National Research Medical Center of the Russian Academy of Sciences | 80 | 2026-01-12 | 2026-03-23 |
| Prophylactic Anti-aRrhythmic Therapy With Amiodarone in Critically Ill Patients Admitted for an Out-of-hospital Cardiac Arrest With Initial Shockable Rhythm Amiodarone - Ventricular Arrhythmias and Cardiac Arrest | Phase 3 | Recruiting | Versailles Hospital | 674 | 2025-11-06 | 2025-12-23 |
| Evaluation of Two Different Regimens of the Antiarrhythmic Drug Amiodarone to Maintain Normal Sinus Rhythm After Electrical Cardioversion in Patients With Persistent Atrial Fibrillation Amiodarone Hydrochloride 200 MG, Amiodarone Hydrochloride 100 MG - Persistent Atrial Fibrillation | Phase 4 | Recruiting | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 312 | 2025-11-01 | 2025-12-10 |
| Drug-Drug Interaction of JMKX003142 With Amiodarone and Febuxostat in Healthy Subjects Amiodarone Hydrochloride Tablets, Febuxostat Tablets - Autosomal Dominant Polycystic Kidney Disease (ADPKD) | Phase 1 | Not yet recruiting | Jemincare | 48 | 2025-10-30 | 2025-09-18 |
| Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery Amiodarone, Minocycline - Atrial Fibrillation | Phase 2 | Withdrawn | Baystate Medical Center | 2025-09-03 | 2026-09-30 | |
| Non-Invasive Programmed Stimulation (NIPS) to Guide the Subsequent VT Therapeutic Strategies Re-Do ventricular tachycardia ablation, Antiarrhythmic Drug Therapy (amiodarone, sotalol, or mexiletine) - Ventricular Tachycardia (VT) | Not applicable | Recruiting | IRCCS Ospedale San Raffaele | 51 | 2025-06-12 | 2026-03-27 |
| BiodEgradable Soaked Amiodarone paTch Use for the Prevention of Atrial Fibrillation After Cardiac Surgery topical amiodarone, saline solution patch - Atrial Fibrillation (AF) | Phase 3 | Recruiting | Jilin Heart Hospital | 500 | 2025-02-15 | 2025-12-09 |
| Early Amiodarone in Shockable Cardiac Arrest Amiodarone Hydrochloride Injection, Usual Care Protocol - Cardiac Arrest | Phase 3 | Recruiting | Oregon Health and Science University | 585 | 2025-01-01 | 2025-12-19 |
| Efficacy and Safety of Intravenous + Oral Vs. Oral Amiodarone in Preventing Recurrence After Catheter Ablation in Patients with Persistent Atrial Fibrillation Amiodarone Injection, Sodium Chloride Injection 0.9% - Atrial Fibrillation (AF) | Not applicable | Not yet recruiting | Shanghai Chest Hospital | 418 | 2024-12-16 | 2024-12-19 |
| Evaluation of Cardioverter Capacity of Amiodarone Pre-electrical Cardioversion in Persistent Atrial Fibrillation Amiodarone (Antiarrhythmic drug) - Atrial Fibrillation (AF) | Phase 4 | Not yet recruiting | Institut Investigacio Sanitaria Pere Virgili | 122 | 2024-12-10 | 2024-12-02 |
| Role of Eplerenone in Reducing Recurrence of Atrial Fibrillation in Patients With Structural Heart Disease Eplereone - Atrial Fibrillation | Phase 1 | Unknown | Assiut University | 100 | 2024-08-10 | 2024-08-16 |
| Heart Rhythm Changes in Patients With Atrial Fibrillation After Cardiopulmonary Bypass: a Retrospective Analysis The tetralogy of medication regimen - Atrial Fibrillation | Completed | Chinese Academy of Medical Sciences, Fuwai Hospital | 106 | 2024-08-01 | 2025-08-22 | |
| Amiodarone for the Prevention of Atrial Fibrillation After Minimally Invasive Esophagectomy in Patients With Esophageal Cancer Amiodarone Hydrochloride, Saline - Atrial Fibrillation, Esophageal Carcinoma | Phase 2 | Recruiting | OHSU Knight Cancer Institute | 90 | 2024-06-21 | 2026-05-22 |
| Short Term Anti-aRrhythmic Therapy for Post-Operative AF in Cardiac Surgery Patients Pilot Trial Amiodarone Hydrochloride 200 MG - Atrial Fibrillation New Onset | Phase 3 | Recruiting | Population Health Research Institute | 400 | 2024-06-13 | 2026-09-04 |
| Effectiveness of Repeated Amiodarone Dosing Regimen Versus Standard Dosing Regimen in Atrial Fibrillation Patient With Rapid Ventricular Response Amiodarone - Atrial Fibrillation | Phase 4 | Completed | Police General Hospital, Thailand | 24 | 2024-05-01 | 2025-01-22 |
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Atrial Fibrillation (68) · Arrhythmias, Cardiac (15) · Tachycardia, Ventricular (14) · Heart Arrest (7) · Heart Diseases (7) · Heart Failure (6) · Ventricular Fibrillation (6) · Cardiovascular Diseases (5) · Atrial Flutter (4) · Death, Sudden, Cardiac (4) · Myocardial Ischemia (4) · Cardiomyopathies (3) · Sepsis (3) · COVID-19 (2) · Chagas Cardiomyopathy (2)
Mayo Clinic (3) · National Heart, Lung, and Blood Institute (NHLBI) (3) · Population Health Research Institute (3) · University of Calgary (3) · Advanz Pharma (2) · Assiut University (2) · Duke University (2) · Hospital General Universitario Gregorio Marañon (2) · Icahn School of Medicine at Mount Sinai (2) · Indiana University (2) · John Sapp (2) · Ottawa Hospital Research Institute (2) · Prism Pharmaceuticals (2) · Sanofi (2) · Shanghai Chest Hospital (2)
United States (35) · Canada (19) · France (10) · China (9) · Spain (7) · Finland (6) · Italy (6) · Netherlands (6) · Denmark (5) · Poland (5) · Russia (5) · Czechia (4) · Germany (4) · Norway (4) · Sweden (4)
Andrea Natale, MD (2) · H. Greene (2) · James E Tisdale, PharmD (2) · William G Stevenson, MD (2) · Alexandre Soeiro, MD (1) · Alfred Hallstrom (1) · Andrea Natale, M.D. (1) · Andrew JE Seely, MD, PhD (1) · Angel Arenal, MD, PhD (1) · Anson Lee, MD (1) · Anthony L Tang, MD FRCPC (1) · Anthony S Tang, MSc, MD, FRCPC (1)
PMID 10073786, PMID 10091823, PMID 10193563, PMID 10395122, PMID 10858380, PMID 11395591, PMID 12372573, PMID 12466507, PMID 12576943, PMID 12767648, PMID 12914883, PMID 15226218, PMID 1563883, PMID 15644659, PMID 15831645, PMID 15872201, PMID 16216756, PMID 16380589, PMID 17051439, PMID 1729329, PMID 17804851, PMID 18294562, PMID 18371559, PMID 18497594, PMID 18497597, PMID 18854540, PMID 19029470, PMID 19699916, PMID 19704100, PMID 19903189, PMID 19917887, PMID 19934423, PMID 20200016, PMID 20381077, PMID 20384650, PMID 20553056, PMID 2057525, PMID 2063768, PMID 20723644, PMID 20802247, PMID 20884379, PMID 21135293, PMID 21232669, PMID 21844082, PMID 22032709, PMID 22082672, PMID 22226423, PMID 2245612, PMID 22770549, PMID 23280225
2008 (3), 2025 (2), 2005 (1), 2023 (1), K23HL173647 (1), R01HL031472 (1), R34HL138110 (1), U01HL055766 (1), U01HL077863 (1), U01HL088942 (1)