11 completed, 6 unknown, 1 active not recruiting, 1 not yet recruiting. 21 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 21 | Completed 11, Unknown 6, Active not recruiting 1, Not yet recruiting 1, Recruiting 1, Terminated 1 |
Follow cyclopia sequence: new trials by email Literature Review of cyclopia sequence trials Research Report on cyclopia sequence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Optimizing H. Pylori Eradication Regimen Under Intensified Acid Suppression Keverprazan Hydrochloride 20 mg TID, Minocycline 100 mg (10-Day Regimen), Keverprazan Hydrochloride 20 mg BID - HELICOBACTER PYLORI INFECTIONS | Phase 4 | Not yet recruiting | Qilu Hospital of Shandong University | 316 | 2026-08-01 | 2026-08-06 |
| Antihypertensive Mechanisms of Minocycline in Resistant Hypertension Minocycline Hydrochloride, Placebo - Hypertension, Resistant to Conventional Therapy | Phase 4 | Recruiting | University of Florida | 120 | 2025-01-08 | 2026-10-13 |
| PRF + Minocycline vs Arestin in Non-surgical Perio Therapy Arestin, PRF + M - Non-surgical Periodontal Therapy | Phase 4 | Completed | Center for Advanced Rejuvenation and Esthetics | 15 | 2024-12-01 | 2026-05-28 |
| High-dose Dual Therapy and Minocycline-cotaining Quadruple Therapy for Helicobacter Pylori Infection Vonoprazan, Amoxicillin, Bismuth Potassium Citrate - Helicobacter Pylori Infection | Phase 4 | Unknown | Shanghai Jiao Tong University School of Medicine | 200 | 2024-08-21 | 2024-12-30 |
| Optimization of Minocycline for Helicobacter Pylori Rescue Treatment Vonoprazan, Bismuth Potassium Citrate, Tetracycline,Metronidazole - Helicobacter Pylori Infection | Phase 4 | Completed | Shanghai Jiao Tong University School of Medicine | 480 | 2024-08-21 | 2026-03-25 |
| Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori. esomeprazole, Bismuth, Amoxicillin - Helicobacter Pylori Infection, Chronic Gastritis | Phase 4 | Unknown | Xijing Hospital of Digestive Diseases | 548 | 2023-11-20 | 2024-09-19 |
| Efficacy and Safety of Tranilast Combined With Minocycline in the Treatment of Rosacea minocycline, tranilast - Rosacea | Phase 4 | Unknown | Second Affiliated Hospital of Xi'an Jiaotong University | 45 | 2023-10-16 | 2024-03-12 |
| Minocycline for Acute Ischemic Stroke Undergoing Endovascular Treatment Due to Basilar Artery Occlusion (MIST-B) Minocycline - Ischemic Stroke, Acute, Minocycline | Phase 4 | Active not recruiting | Xijing Hospital | 90 | 2023-03-04 | 2025-05-30 |
| Efficacy of Colistin Monotherapy Versus Colistin Plus Minocycline for Carbapenem-Resistant A. Baumannii Infection Colistin, Minocycline, Placebo - Acinetobacter Infections | Phase 4 | Unknown | Mahidol University | 94 | 2023-01-10 | 2023-01-18 |
| Efficacy of Combination Therapy With Minocycline for Treatment of Stenotrophomonas Maltophilia Infections Minocycline, Levofloxacin or Cotrimoxazole, Placebo - Hospital Infections | Phase 4 | Unknown | Mahidol University | 112 | 2022-11-24 | 2023-01-10 |
| Effects of Minocycline on Patients With Ischemic Stroke Undergoing Intravenous Thrombectomy Minocycline - Ischemic Stroke, Acute | Phase 4 | Completed | Xijing Hospital | 189 | 2022-11-01 | 2026-07-29 |
| Effectiveness of Minocycline-Containing Bismuth Quadruple Therapy for Helicobacter Pylori Eradication Minocycline hydrochloride capsule, Clarithromycin, Amoxicillin - Helicobacter Pylori Eradication | Phase 4 | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 339 | 2022-01-05 | 2022-01-13 |
| Rescue Therapy for Helicobacter Pylori Eradication Treatment Esomeprazole, Bismuth Potassium Citrate, Tetracycline,Metronidazole - Helicobacter Pylori Infection | Phase 4 | Completed | Shanghai Jiao Tong University School of Medicine | 368 | 2020-10-15 | 2024-12-30 |
| Minocycline Pharmacokinetics (ACUMIN) Minocycline - Bacterial Infection | Phase 4 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 58 | 2018-03-28 | 2020-12-03 |
| Minocycline for Treatment of Posttraumatic Stress Disorder in Veterans Minocycline - PTSD | Phase 4 | Completed | Sriram Ramaswamy | 10 | 2017-05-10 | 2020-07-09 |
| Minocycline Augmentation to Clozapine Minocycline - Schizophrenia, Schizoaffective Disorder | Phase 4 | Completed | Emory University | 10 | 2015-02-01 | 2018-09-26 |
| The Response of Pathogens to the Respective or Combined Treatment of SRP and Local Minocycline in Chronic Periodontitis minocycline, surface and root planning - Chronic Periodontitis | Phase 4 | Completed | Zhejiang University | 70 | 2013-06-01 | 2015-12-02 |
| Minocycline for Bipolar Depression Minocycline - Bipolar Depression | Phase 4 | Completed | Icahn School of Medicine at Mount Sinai | 20 | 2011-05-01 | 2017-01-30 |
| Neuroprotection With Minocycline Therapy for Acute Stroke Recovery Trial Minocycline (Borymycin), Matched placebo - Acute Stroke | Phase 4 | Terminated | Singhealth Foundation | 139 | 2009-07-01 | 2013-06-03 |
| Minocycline to Treat Childhood Regressive Autism Minocycline - Autism, Minocycline | Phase 4 | Completed | National Institute of Mental Health (NIMH) | 11 | 2006-11-01 | 2015-12-11 |
Showing 20 of 21. Sign in to see all of them.
Ischemic Stroke (2) · Acinetobacter Infections (1) · Acne Vulgaris (1) · Autistic Disorder (1) · Bacterial Infections (1) · Bipolar Disorder (1) · Chronic Periodontitis (1) · Cross Infection (1) · Depression (1) · Hypertension Resistant to Conventional Therapy (1) · Mood Disorders (1) · Psychotic Disorders (1) · Rosacea (1) · Schizophrenia (1)
Mental Disorders (4) · Brain Diseases (3) · Cardiovascular Diseases (3) · Central Nervous System Diseases (3) · Cerebrovascular Disorders (3) · Infections (3) · Nervous System Diseases (3) · Vascular Diseases (3) · Bacterial Infections and Mycoses (2) · Disease Attributes (2) · Pathologic Processes (2) · Pathological Conditions, Signs and Symptoms (2) · Skin Diseases (2) · Skin and Connective Tissue Diseases (2) · Stroke (2)
Minocycline (21) · Amoxicillin (4) · Esomeprazole (3) · Metronidazole (3) · 1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine (2) · Clarithromycin (2) · Tetracycline (2) · BID protein, human (1) · Berberine (1) · Bismuth (1) · Capsules (1) · Clinical Protocols (1) · Colistin (1) · Gels (1) · Levofloxacin (1)
Shanghai Jiao Tong University School of Medicine (3) · Mahidol University (2) · Xijing Hospital (2) · Center for Advanced Rejuvenation and Esthetics (1) · Emory University (1) · Icahn School of Medicine at Mount Sinai (1) · KGL, Inc. (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · National Institute of Mental Health (NIMH) (1) · Qilu Hospital of Shandong University (1) · Second Affiliated Hospital of Xi'an Jiaotong University (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Singhealth Foundation (1) · Sriram Ramaswamy (1) · University of Florida (1)
United States (8) · China (7) · Thailand (2) · Singapore (1)
Adhiratha Boonyasiri, MD (2) · Dan V Iosifescu, MD, MSc (1) · James Leyden, MD (1) · Qin Du, master (1) · Rajinder Singh, Doctor (1) · Robert O Cotes, MD (1) · Shuli Deng, Master (1) · Sriram Ramaswamy, MD (1) · Steven M Smith, PharmD, MPH (1) · Weihui Zeng (1)
PMID 18071725, PMID 23566357, PMID 26231264, PMID 27718519, PMID 27861741, PMID 31392722, PMID 34476755, PMID 34840653, PMID 37108184, PMID 39806586, PMID 42305108, PMID 42633753
2UM1AI104681-08 (1), R01HL132448 (1)