146 completed, 25 terminated, 16 unknown, 9 withdrawn. 70 Phase 2, 53 Phase 3, 36 Phase 1, 31 Phase 4, 27 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Psilocybin for Depression in Veterans Psilocybin, modafinil, zolpidem - Major Depression | Phase 2 | Not yet recruiting | VA Office of Research and Development | 150 | 2027-01-01 | 2026-10-26 |
| Efficacy and Safety of Modafinil to Treat Fatigue in People With Mitochondrial Disease. Modafinil (M), Placebo - Mitochondrial Disease | Phase 3 | Not yet recruiting | Kenneth Myers, MD | 15 | 2026-12-01 | 2026-10-26 |
| Modafinil for Debilitating Fatigue in Quiescent Inflammatory Bowel Disease MODIFI-IBD Trial) Modafinil, Placebo - Inflammatory Bowel Disease (Crohn's Disease and Ulcerative Colitis), Chronic Fatigue | Phase 2 / Phase 3 | Recruiting | Radboud University Medical Center | 60 | 2026-08-03 | 2026-09-14 |
| Cognitive Strategies in Early Psychosis 2 Modafinil, D-serine solution, Placebo - Psychosis, Schizophrenia Disorder | Phase 3 | Recruiting | University of Minnesota | 24 | 2026-07-17 | 2026-07-23 |
| Modafinil to Improve Fatiguability Modafinil, Placebo - Cancer-related Cognitive Difficulties, Cancer-related Problem/Condition | Phase 1 / Phase 2 | Recruiting | Ottawa Hospital Research Institute | 40 | 2026-03-16 | 2026-07-27 |
| Impact of Medically Supervised Performance-Enhancing Substances (PES) on Elite Athletes Testosterone Enanthate, Testosterone Cypionate, Testosterone Propionate - Safety and Impact of Medically Supervised Performance Enhancing Substance Usage in Healthy Elite Athletes | Not applicable | Enrolling by invitation | Enhanced Emirates Limited | 60 | 2026-03-12 | 2026-05-06 |
| Reliability of Standardized IQ Testing Under Modafinil, Racetam-Class Compounds, Sleep Restriction and Daily Activity Modafinil, Oxiracetam, Pramiracetam - Healthy, Cognition | Phase 1 | Completed | Abdulraheem Mohamed Gouda | 70 | 2026-03-09 | 2026-10-01 |
| Modafinil For Fatigue in IBD: A Feasibility Randomised Controlled Trial Modafinil, Placebo - Crohn Disease (CD), Ulcerative Colitis (UC) | Phase 2 | Not yet recruiting | Imperial College London | 70 | 2026-02-01 | 2025-12-22 |
| Cognitive Strategies in Early Psychosis 1 Modafinil - Cognition, Healthy Participants | Phase 3 | Recruiting | University of Minnesota | 103 | 2025-10-31 | 2026-02-17 |
| Modafinil and Exercise for Post Stroke Fatigue Modafinil 200mg, Placebo, Exercise - Stroke, Fatigue | Phase 3 | Not yet recruiting | University Health Network, Toronto | 212 | 2025-09-01 | 2025-06-10 |
| Modafinil to Optimize the Performance of Cold-Stressed Sleep-Deprived Personnel Modafinil (M), 200 mg Microcrystalline Cellulose - Sleep Deprivation, Cold Exposure | Phase 4 | Recruiting | United States Army Research Institute of Environmental Medicine | 33 | 2025-02-18 | 2026-09-21 |
| RECOVER-SLEEP: Platform Protocol, Appendix_A (Hypersomnia) Modafinil, Modafinil Placebo, Solriamfetol - Long COVID, Long COVID-19 | Phase 2 | Completed | Duke University | 361 | 2024-08-12 | 2026-06-03 |
| RECOVER-SLEEP: Platform Protocol Modafinil, Modafinil Placebo, Solriamfetol - Long COVID, Long COVID-19 | Phase 2 | Completed | Duke University | 830 | 2024-07-31 | 2026-01-22 |
| A Study of MK-6552 in Sleep Deprived Healthy Participants (MK-6552-003) MK-6552, MK-6552 placebo, Modafinil - Healthy, Narcolepsy | Phase 1 | Completed | Merck Sharp & Dohme LLC | 18 | 2024-03-19 | 2024-10-01 |
| Study Effects of Preoperative Modafinil on Recovery Profile of Morbidly Obese Patients Scheduled for Bariatric Surgery if it Can Enhance Recovery From Anesthesia Modafinil - Obese Adolescents, Bariatric Surgery | Not applicable | Completed | Ain Shams University | 20 | 2024-01-01 | 2025-08-19 |
| Psilocybin Therapy for Chronic Low Back Pain Psilocybin therapy with Zolpidem and Modafinil, Psilocybin therapy with Zolpidem, Psilocybin therapy with Modafinil - Chronic Low-back Pain | Phase 1 / Phase 2 | Completed | Joshua Woolley, MD, PhD | 40 | 2023-12-01 | 2026-11-04 |
| Investigation of Locus Coeruleus Function in Sustained Attention Modafinil - Attention - no Condition is Being Assessed - Healthy Adults | Phase 4 | Recruiting | University of California, Davis | 40 | 2023-10-01 | 2026-06-18 |
| A Clinical Study of MK-6552 and Modafinil in Healthy Men (MK-6552-005) MK-6552, Modafinil - Healthy, Narcolepsy | Phase 1 | Completed | Merck Sharp & Dohme LLC | 12 | 2023-09-20 | 2024-10-30 |
| Central Nervous System Stimulants and Physical Function in Children With Cerebral Palsy Methylphenidate, Modafinil, Placebo - Neurodevelopmental Disorders, Cerebral Palsy | Early Phase 1 | Not yet recruiting | Kuwait University | 30 | 2023-05-01 | 2023-03-08 |
| Bioequivalence Study of Modafinil From Bravamax 200 mg Scored Tablets (Chemipharm Pharmaceutical Industries, Egypt) Versus Vigil 200 mg Tablets (Teva GmbH, Germany) Bravamax 200 mg (Modafinil), Vigil 200 mg (Modafinil) - Healthy | Phase 1 | Completed | Genuine Research Center, Egypt | 30 | 2022-11-15 | 2023-05-11 |
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Fatigue (42) · Disorders of Excessive Somnolence (25) · Cocaine-Related Disorders (22) · Narcolepsy (19) · Schizophrenia (13) · Depression (11) · Sleep Apnea, Obstructive (11) · Cataplexy (6) · Cognitive Dysfunction (6) · Depressive Disorder, Major (6) · Neoplasms (6) · Psychotic Disorders (6) · Sleep Apnea Syndromes (6) · Sleep Deprivation (6) · Brain Injuries, Traumatic (5)
Cephalon (27) · M.D. Anderson Cancer Center (7) · The University of Texas Health Science Center, Houston (5) · University of Arkansas (5) · Duke University (4) · National Institute on Drug Abuse (NIDA) (4) · New York State Psychiatric Institute (4) · Yale University (4) · Bioprojet (3) · California Pacific Medical Center Research Institute (3) · Cephalon, Inc. (3) · Medical University of South Carolina (3) · Merck Sharp & Dohme LLC (3) · University of California, Los Angeles (3) · University of Rochester (3)
United States (154) · Canada (11) · France (8) · Germany (7) · Australia (5) · Bulgaria (4) · Italy (4) · Spain (4) · Switzerland (4) · United Kingdom (4) · Argentina (3) · Finland (3) · Hungary (3) · Netherlands (3) · Poland (3)
Caroline Demro, Ph.D. (2) · Christina Barkauskas, MD (2) · Claudio Bassetti (2) · Gantt Galloway, PharmD (2) · Joy M Schmitz, PhD (2) · Joy M. Schmitz, PhD (2) · Richard P Mattick, PhD (2) · Sophia Vinogradov, MD (2) · Susan Redline, MD MPH (2) · Thomas S Clark, M.D. (2) · Yanping Zheng, MD (2)
PMID 41170811, PMID 20564068, PMID 20565514, PMID 25325609, PMID 10662747, PMID 11904109, PMID 11927799, PMID 12119802, PMID 12832331, PMID 15066944, PMID 15710782, PMID 15738343, PMID 15911704, PMID 16880771, PMID 16895262, PMID 17515447, PMID 17515448, PMID 19149817, PMID 19270033, PMID 19318599, PMID 19416039, PMID 19687359, PMID 19689921, PMID 19880686, PMID 20051221, PMID 20092966, PMID 20492840, PMID 20530317, PMID 20585000, PMID 20673554, PMID 20816042, PMID 20837887, PMID 21035624, PMID 21046171, PMID 21176784, PMID 21206549, PMID 21641776, PMID 21777715, PMID 21840138, PMID 22104981, PMID 22178084, PMID 22217949, PMID 22311903, PMID 22445683, PMID 22687392, PMID 22969732, PMID 23251870, PMID 23935959, PMID 24002370, PMID 24107292
2009 (4), P50DA009262 (4), 2008 (2), P50MH119569 (2), R01MH072383 (2), U10CA081920 (2), 1RC1DA028387 (1), 2015 (1), 2017 (1), 2019 (1), 5UL1TR000445-07 (1), F32MH075583 (1), K07CA132916 (1), K23DA016743 (1), P20GM103425 (1)