15 completed, 3 terminated, 3 unknown, 3 withdrawn. 26 Phase 1, 12 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 26 | Completed 15, Terminated 3, Unknown 3, Withdrawn 3, Recruiting 1, Suspended 1 |
| Phase 2 | 12 | Completed 7, Withdrawn 2, Recruiting 1, Terminated 1, Unknown 1 |
Follow cyclopia sequence: new trials by email Literature Review of cyclopia sequence trials Research Report on cyclopia sequence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Pilot Comparative Bioavailability Study of Levodopa Administered Via Levodopa Cyclops® Relative to INBRIJA® Levodopa Cyclops®, INBRIJA® - Parkinson, Parkinson Disease | Phase 1 | Completed | PureIMS B.V. | 26 | 2023-09-25 | 2025-05-31 |
| Minocycline Accelerates Intracerebral Hemorrhage Absorption Minocycline, starch - Intracerebral Hemorrhage | Phase 1 | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 90 | 2023-01-01 | 2022-11-29 |
| Minocycline Augmentation of Clozapine for Treatment Resistant Schizophrenia Minocycline - Schizophrenia, Schizoaffective Disorder | Phase 1 | Unknown | Pakistan Institute of Living and Learning | 60 | 2022-08-30 | 2022-04-29 |
| Minocycline for Chronic Autoimmune Uveitis minocycline - Minocycline, Uveitis | Phase 1 / Phase 2 | Recruiting | Sun Yat-sen University | 10 | 2021-12-01 | 2023-04-18 |
| Intra-Arterial Neuroprotective Agents and Cold Saline in Ischemic Stroke Intervention Intra-arterial cold saline, minocycline, and magnesium - Stroke, Ischemic | Phase 1 | Withdrawn | Northwell Health | 2021-06-01 | 2026-04-06 | |
| Neuroimmune Dysfunction in Alcohol Use Disorder Minocycline, Sugar pill - Alcohol Drinking, Alcohol-Related Disorders | Phase 1 | Completed | University of Maryland, Baltimore | 142 | 2020-02-03 | 2023-12-01 |
| A Proof-of-Concept Study of Minocycline in Autism Minocycline, Placebos - Autism Spectrum Disorder, Autism | Phase 1 | Completed | Children's Hospital Medical Center, Cincinnati | 53 | 2019-04-19 | 2020-12-08 |
| Minocycline Treatment for Cystoid Macular Edema minocycline - Minocycline, Cystoid Macular Edema | Phase 1 / Phase 2 | Unknown | Sun Yat-sen University | 5 | 2019-01-01 | 2023-04-19 |
| Minocycline for Alcohol Use Disorder Minocycline, Sugar pill - Alcohol Use Disorder, Inflammation | Phase 1 / Phase 2 | Withdrawn | University of California, Los Angeles | 2018-01-15 | 2019-01-24 | |
| Measuring Brain Inflammation in Autism Minocycline - Autism Spectrum Disorder | Phase 1 | Suspended | University of California, Los Angeles | 30 | 2017-04-11 | 2020-08-10 |
| Minocycline Therapy for Management of Adverse Radiation Effects Minocycline - Irradiation; Adverse Effect | Phase 1 | Terminated | University of Pittsburgh | 1 | 2015-11-01 | 2018-06-25 |
| Minocycline's Effects on Alcohol Responses in Humans Minocycline, Placebo (for Minocycline) - Alcohol Dependence | Phase 1 | Completed | Yale University | 54 | 2015-07-01 | 2020-03-09 |
| The Safety of High Dose Minocycline in the Patient Population Undergoing Carotid Revascularization Administration of minocycline - Stroke | Phase 1 | Terminated | University of Pittsburgh | 6 | 2014-07-01 | 2017-06-09 |
| Study of Oral Minocycline in Treating Bilateral Cystoid Macular Edema Associated With Retinitis Pigmentosa Minocycline - Retinitis Pigmentosa | Phase 1 / Phase 2 | Completed | National Eye Institute (NEI) | 7 | 2014-05-01 | 2024-04-17 |
| The Effects of Minocycline in Humans Sugar pill, Minocycline - Memory Impairment | Phase 1 | Completed | Yale University | 10 | 2013-07-08 | 2019-09-19 |
| Minocycline Bioequivalence Study Minocycline - Skin Diseases | Phase 1 | Completed | GlaxoSmithKline | 28 | 2013-05-01 | 2013-11-18 |
| Symptom Burden in Head and Neck Cancer Placebo, Armodafinil, Minocycline - Head And Neck Cancer | Phase 1 / Phase 2 | Terminated | M.D. Anderson Cancer Center | 1 | 2013-03-01 | 2015-02-10 |
| A Pilot Study of Minocycline in Intracerebral Hemorrhage Patients Minocycline - Intracerebral Hemorrhage | Phase 1 / Phase 2 | Completed | Augusta University | 16 | 2013-02-01 | 2018-04-26 |
| Minocycline to Treat Branch Retinal Vein Occlusion Minocycline, Placebo, Bevacizumab - Retinal Vein Occlusion | Phase 1 / Phase 2 | Completed | National Eye Institute (NEI) | 9 | 2012-03-28 | 2022-01-26 |
| Bioequivalence Minocycline Bioequivalence Minocycline 100mg - Skin Infections (Acne) | Phase 1 | Completed | GlaxoSmithKline | 25 | 2011-06-17 | 2017-06-22 |
Showing 20 of 26. Sign in to see all of them.
Alcoholism (3) · Macular Edema (3) · Stroke (3) · Alcohol Drinking (2) · Autism Spectrum Disorder (2) · Cerebral Hemorrhage (2) · Cognition Disorders (2) · Inflammation (2) · Mental Disorders (2) · Schizophrenia (2) · Acne Vulgaris (1) · Alcohol-Related Disorders (1) · Aneurysm (1) · Arteriovenous Malformations (1)
Nervous System Diseases (10) · Brain Diseases (9) · Central Nervous System Diseases (9) · Cardiovascular Diseases (7) · Pathological Conditions, Signs and Symptoms (7) · Vascular Diseases (7) · Cerebrovascular Disorders (5) · Mental Disorders (5) · Pathologic Processes (5) · Eye Diseases (4) · Retinal Diseases (4) · Macular Degeneration (3) · Neoplasms (3) · Neoplasms by Site (3) · Retinal Degeneration (3)
Minocycline (25) · Sugars (3) · Bupropion (2) · Modafinil (2) · Bevacizumab (1) · Curcumin (1) · Dihydroxyphenylalanine (1) · Doxycycline (1) · Magnesium (1) · Starch (1) · Surveys and Questionnaires (1) · Tetracycline (1)
National Eye Institute (NEI) (3) · GlaxoSmithKline (2) · M.D. Anderson Cancer Center (2) · Sun Yat-sen University (2) · University of California, Los Angeles (2) · University of Pittsburgh (2) · Yale University (2) · Augusta University (1) · Children's Hospital Medical Center, Cincinnati (1) · David Hess, MD (1) · Northwell Health (1) · Pakistan Institute of Living and Learning (1) · PureIMS B.V. (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Stanley Medical Research Institute (1)
United States (16) · China (2) · Pakistan (2) · Brazil (1) · Bulgaria (1) · Mexico (1) · United Kingdom (1)
Catherine A Cukras, M.D. (2) · Ajay Niranjan, MD, MBA (1) · Allen Lamb, DO (1) · Catherine A Cukras, MD, PhD (1) · Craig Erickson (1) · Dan Liang (1) · David C Hess, MD (1) · David I. Rosenthal, MD, MA, BA (1) · Dr.Inti Qurashi, MD (1) · Georgios A Zenonos, MD (1) · Imran B Chaudhry, MD (1) · Ismene Petrakis, M.D. (1) · Ivo Bogdanov, MD (1)
PMID 18212521, PMID 20705929, PMID 22589436, PMID 28887388, PMID 30744442, PMID 36882562, PMID 36912792, PMID 36999619, PMID 40483726
K01AA026005 (2), 2023 (1), R21AA023150 (1)