30 completed, 8 terminated, 5 unknown, 4 recruiting. 51 Phase 2, 12 Phase 1, 7 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 51 | Completed 30, Terminated 8, Unknown 5, Recruiting 4, Withdrawn 4 |
| Phase 1 | 12 | Completed 7, Withdrawn 2, Recruiting 1, Terminated 1, Unknown 1 |
| Phase 3 | 7 | Recruiting 3, Unknown 3, Terminated 1 |
Follow cyclopia sequence: new trials by email Literature Review of cyclopia sequence trials Research Report on cyclopia sequence
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Minocycline After Successful Endovascular Thrombectomy Recanalization in Acute Anterior Circulation Large Vessel Occlusion (ATTRACTION-MINOA) Minocycline hydrochloride capsule, Placebo capsules of Minocycline hydrochloride capsules - Acute Ischemic Stroke, Vessel Occlusion | Phase 2 / Phase 3 | Recruiting | Xiang Luo | 860 | 2026-05-21 | 2026-05-27 |
| Minocycline After Successful Endovascular Thrombectomy Recanalization in Posterior Circulation Arterial Occlusion (ATTRACTION-MINOP) Minocycline hydrochloride capsule, Placebo capsules of Minocycline hydrochloride capsules - Acute Ischemic Stroke, Endovascular Thrombectomy | Phase 2 / Phase 3 | Recruiting | Xiang Luo | 234 | 2026-05-19 | 2026-05-22 |
| Minocycline in Stroke Study at Maimonides Minocycline 200mg - Stroke, Ischemia Stroke | Phase 2 / Phase 3 | Recruiting | Joyce Chen | 1164 | 2026-02-02 | 2026-03-19 |
| Minocycline Efficacy in Improving Neurological Outcome of Patients Who Undergo Endovascular Revascularization for Acute Ischemic Stroke Minocyclin - Acute Ischemic Stroke | Phase 2 | Withdrawn | State University of New York at Buffalo | 2025-12-01 | 2026-03-06 | |
| Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery Amiodarone, Minocycline - Atrial Fibrillation | Phase 2 | Withdrawn | Baystate Medical Center | 2025-09-03 | 2026-09-30 | |
| Efficacy of Noisome as A Carrier of Locally Delivered Minocycline Hydrochloride Gel Minocycline hydrochloride with noisome carrier, Minocycline Hydrochloride only - Periodontitis | Phase 2 / Phase 3 | Unknown | Ain Shams University | 30 | 2024-02-25 | 2024-02-12 |
| Maimonides Minocycline in Stroke Study Minocycline - Stroke, Acute, Ischemic Stroke | Phase 2 / Phase 3 | Terminated | Maimonides Medical Center | 2 | 2023-11-01 | 2025-12-17 |
| Efficacy and Safety of Adjunctive Minocycline in the Treatment of Autoimmune Encephalitis Minocycline - Autoimmune Encephalitis | Phase 2 | Completed | Xijing Hospital | 60 | 2023-10-01 | 2025-08-14 |
| Pharmacokinetic Study of Minocycline in Patients With Pulmonary Nontuberculous Mycobacterial Disease Minocycline - Mycobacterium Avium Complex Pulmonary Disease | Phase 2 | Terminated | Radboud University Medical Center | 12 | 2023-05-08 | 2025-06-29 |
| Minocycline for Chronic Autoimmune Uveitis minocycline - Minocycline, Uveitis | Phase 1 / Phase 2 | Recruiting | Sun Yat-sen University | 10 | 2021-12-01 | 2023-04-18 |
| Effect of Minocycline on Delirium Incidence in Critically Ill Patients Minocycline, Placebos - Delirium, Coma | Phase 2 | Completed | Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude | 160 | 2020-01-30 | 2022-05-31 |
| Minocycline Treatment in Retinitis Pigmentosa Minocycline - Retinitis Pigmentosa, Inherited Retinal Dystrophy | Phase 2 | Completed | Sun Yat-sen University | 35 | 2019-08-25 | 2023-12-27 |
| Study to Evaluate the Safety and Efficacy of Minocycline Ointment in Subjects With Inflamed Meibomian Gland Dysfunction 0.3% Topical Minocycline Ointment, 1% Topical Minocycline Ointment, Topical Vehicle Ointment - Meibomian Gland Dysfunction, MGD-Meibomian Gland Dysfunction | Phase 2 | Completed | Hovione Scientia Limited | 270 | 2019-04-02 | 2021-03-05 |
| Minocycline Treatment for Cystoid Macular Edema minocycline - Minocycline, Cystoid Macular Edema | Phase 1 / Phase 2 | Unknown | Sun Yat-sen University | 5 | 2019-01-01 | 2023-04-19 |
| Minocycline for Alcohol Use Disorder Minocycline, Sugar pill - Alcohol Use Disorder, Inflammation | Phase 1 / Phase 2 | Withdrawn | University of California, Los Angeles | 2018-01-15 | 2019-01-24 | |
| Study to Evaluate the Safety and Efficacy of Topical Minocycline Gel in Patients With Papulopustular Rosacea 1% Topical Minocycline Gel, 3% Topical Minocycline Gel, Topical Vehicle Gel - Rosacea, Papulopustular Rosacea | Phase 2 | Completed | Hovione Scientia Limited | 270 | 2017-10-30 | 2019-11-08 |
| Evaluating the Role of Neuroinflammation in Low Back Pain Minocycline Hydrochloride 100mg Capsule, Magnetic Resonance-Positron Emission Tomography Imaging, Placebo Capsule - Low Back Pain, Back Pain With Radiation | Phase 2 | Completed | Marco Loggia | 60 | 2017-10-10 | 2026-02-11 |
| Adjunct Minocyline in Treatment-resistant Depression Minocycline, Placebo - Major Depressive Disorder | Phase 2 | Completed | Charite University, Berlin, Germany | 168 | 2015-01-01 | 2020-10-19 |
| Minocycline for Postsurgical Symptom Reduction in Head and Neck Cancer Minocycline, Placebo, Questionnaires - Head And Neck Cancer | Phase 2 | Terminated | M.D. Anderson Cancer Center | 30 | 2014-05-06 | 2022-10-20 |
| Study of Oral Minocycline in Treating Bilateral Cystoid Macular Edema Associated With Retinitis Pigmentosa Minocycline - Retinitis Pigmentosa | Phase 1 / Phase 2 | Completed | National Eye Institute (NEI) | 7 | 2014-05-01 | 2024-04-17 |
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Ischemic Stroke (5) · Stroke (4) · Hemorrhagic Stroke (3) · Macular Edema (3) · Asthma (2) · Carcinoma, Non-Small-Cell Lung (2) · Cerebral Hemorrhage (2) · Depressive Disorder, Major (2) · Head and Neck Neoplasms (2) · Inflammation (2) · Lung Neoplasms (2) · Multiple Myeloma (2) · Neoplasms, Plasma Cell (2) · Pain (2)
Nervous System Diseases (19) · Pathological Conditions, Signs and Symptoms (14) · Central Nervous System Diseases (13) · Cardiovascular Diseases (11) · Neoplasms (11) · Brain Diseases (10) · Pathologic Processes (10) · Vascular Diseases (10) · Neoplasms by Site (9) · Cerebrovascular Disorders (7) · Eye Diseases (7) · Immune System Diseases (7) · Mental Disorders (7) · Respiratory Tract Diseases (6) · Lung Diseases (4)
Minocycline (45) · Sugars (7) · Surveys and Questionnaires (7) · Modafinil (3) · Bupropion (2) · Creatine (2) · Amiodarone (1) · Bevacizumab (1) · Celecoxib (1) · Curcumin (1) · Ketamine (1) · Tetracycline (1)
M.D. Anderson Cancer Center (10) · National Eye Institute (NEI) (3) · Sun Yat-sen University (3) · Vyne Therapeutics Inc. (3) · Hovione Scientia Limited (2) · State University of New York - Downstate Medical Center (2) · Xiang Luo (2) · Ain Shams University (1) · Augusta University (1) · Baystate Medical Center (1) · Charite University, Berlin, Germany (1) · Columbia University (1) · David Hess, MD (1) · Hadassah Medical Organization (1) · Huntington Medical Research Institutes (1)
United States (26) · China (6) · Israel (4) · Brazil (2) · Netherlands (2) · Spain (2) · Australia (1) · Belgium (1) · Denmark (1) · Egypt (1) · France (1) · Germany (1) · Pakistan (1) · Taiwan (1) · United Kingdom (1)
Catherine A Cukras, M.D. (2) · Rauno Joks, MD (2) · Xiang Luo (2) · Zhongxing Liao, MD (2) · Adnan H Siddiqui, MD PhD (1) · Allen Lamb, DO (1) · Avner Shemer, Prof. (1) · Barbara Tilley, Ph.D. (1) · Bill Deakin, Professor (1) · Brian D Ross (1) · Catherine A Cukras, MD, PhD (1) · Cathy Eng, MD, BA (1) · Dan Liang (1)
PMID 20705929, PMID 22323011, PMID 22589436, PMID 24711047, PMID 28887388, PMID 30126448, PMID 30744442, PMID 36657520, PMID 36882562, PMID 36912792, PMID 36999619, PMID 38043911, PMID 39627217, PMID 40839604, PMID 41902986
R01CA026582 (3), P01CA124787 (2), 2005 (1), K01AA026005 (1), R01NS095937 (1), R21CA158902 (1)