119 completed, 36 terminated, 18 withdrawn, 16 unknown. 54 Phase 2, 50 Phase 4, 47 Phase 3, 27 Phase 1, 15 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of iNO in Patients With Submassive and Massive PE inhaled nitric oxide (iNO) - Pulmonary Embolism, Pulmonary Embolism Subacute Massive | Phase 2 | Withdrawn | University of California, Los Angeles | 2026-06-01 | 2026-03-18 | |
| Extracorporeal Photopheresis in Early Diffuse Cutaneous Systemic Sclerosis Extracorporeal Photopheresis (ECP), UVADEX - Diffuse Cutaneous Systemic Sclerosis | Phase 2 | Recruiting | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 15 | 2025-05-14 | 2026-10-01 |
| Inhaled Nitric Oxide for ARDS-related Pulmonary Hypertension Nitric Oxide - Acute Respiratory Distress Syndrome, Pulmonary Hypertension | Early Phase 1 | Unknown | Yuri Matusov | 20 | 2024-02-01 | 2024-02-08 |
| NO During CPB in Neonates to Reduce Risk of AKI Nitric Oxide, Oxygen - AKI, CHD - Congenital Heart Disease | Phase 3 | Recruiting | Children's Hospital Medical Center, Cincinnati | 40 | 2023-01-10 | 2026-08-05 |
| Use of CXCL9 as a Biomarker of Acthar Efficacy Acthar gel - Sarcoidosis | Phase 4 | Terminated | University of California, San Francisco | 2 | 2022-11-03 | 2026-04-30 |
| Impact of Photopheresis in the Prevention of Acute Rejection in Highly Sensitized de Novo Kidney Transplant Recipients Extracorporeal Photopheresis - Kidney Transplant Rejection | Not applicable | Unknown | Fundacion Clinic per a la Recerca Biomédica | 30 | 2022-08-17 | 2023-07-06 |
| MNK-6105 for Patients With Cirrhosis and High Ammonia Levels Affecting Brain Function MNK-6105, Placebo, Standard of Care - Hepatic Encephalopathy | Phase 3 | Withdrawn | Mallinckrodt | 2021-11-01 | 2021-09-22 | |
| Nitric Oxide During CPB to Reduce AKI in Neonates NO gas delivered during cardiac surgery, placebo gas delivered during cardiac surgery - Congenital Heart Disease, Acute Kidney Injury | Phase 1 | Withdrawn | Fabio Savorgnan | 2021-10-01 | 2021-12-01 | |
| Photopheresis in Early-stage Mycosis Fungoides UVADEX® (methoxsalen) Sterile Solution in conjunction with the THERAKOS® CELLEX Photopheresis, THERAKOS® CELLEX photopheresis system - Cutaneous T Cell Lymphoma, Mycosis Fungoides | Phase 2 | Recruiting | Columbia University | 74 | 2021-05-08 | 2026-04-27 |
| ECP Combination Study Ruxolitinib, Extracorporeal photopheresis, Ibrutinib - Steroid Refractory GVHD | Completed | European Society for Blood and Marrow Transplantation | 319 | 2021-04-13 | 2024-03-28 | |
| Acthar for Treatment of Post-transplant FSGS Acthar - FSGS, Renal Transplantation | Phase 4 | Withdrawn | University of North Carolina, Chapel Hill | 2021-03-01 | 2021-08-30 | |
| Standardized Home Spirometry Method in Normal Population Investigational Mobile Medical Software Application & IT Dashboard Application, FDA approved Bluetooth spirometer, FDA approved pulse oximeter - Mobile Applications, Healthy Volunteers | Not applicable | Completed | Washington University School of Medicine | 9 | 2021-01-20 | 2022-12-23 |
| Study of Photopheresis in the Treatment of Erythrodermic MF and SS Methoxsalen, THERAKOS CELLEX Photopheresis System - Lymphoma, T-Cell, Cutaneous, Mycosis Fungoides/Sezary Syndrome | Phase 2 | Withdrawn | European Organisation for Research and Treatment of Cancer - EORTC | 2020-12-01 | 2021-09-08 | |
| Impact of Acthar on Everyday Life of Participants With Severe Keratitis Acthar - Keratitis | Phase 4 | Completed | Mallinckrodt | 36 | 2019-11-13 | 2021-08-18 |
| Decreasing Parental Stress of Caregivers of Infants With Infantile Spasms by Using Telemedicine Technology Remote monitoring - Infantile Spasms, Non-Intractable | Not applicable | Unknown | University of Colorado, Denver | 40 | 2019-10-10 | 2022-05-04 |
| Adrenocorticotropic Hormone (ACTH) for Post-op Inflammation in Proliferative Vitreoretinopathy (PVR) Adrenocorticotropic Hormone - Proliferative Vitreoretinopathy | Early Phase 1 | Completed | Johns Hopkins University | 11 | 2019-08-19 | 2023-08-08 |
| Inhaled Nitric Oxide for Pulmonary Hypertension and Bronchopulmonary Dysplasia inhaled nitric oxide, Placebo - Pulmonary Hypertension, Bronchopulmonary Dysplasia | Phase 1 / Phase 2 | Terminated | AdventHealth | 32 | 2019-07-15 | 2025-01-15 |
| Localized Effects of PBM and Exogenous NO on CREST Patients Calcinosis Cutis & Raynaud Phenomenon INOMAX - CREST Syndrome, Calcinosis Cutis | Unknown | RoseLab Skin Optics Laboratory | 5 | 2019-06-20 | 2019-06-03 | |
| A Study of Acthar Gel Alone or With Tacrolimus to Reduce Proteinuria in Fibrillary Glomerulopathy Patients Acthar Gel 80 UNT/ML Injectable Solution - Fibrillary Glomerulonephritis | Phase 4 | Unknown | NephroNet, Inc. | 34 | 2019-03-14 | 2022-10-31 |
| ACTHAR Therapy for Central Nervous System Sarcoidosis Repository Corticotropin Injection - Sarcoidosis | Phase 4 | Withdrawn | The Cleveland Clinic | 2019-02-01 | 2020-11-20 |
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PMID 34778952, PMID 36633470, PMID 37143199, PMID 37302573, PMID 40704461, PMID 24009220, PMID 26614499, PMID 28370090, PMID 30633959, PMID 33687069, PMID 38695613, PMID 14993550, PMID 16598645, PMID 17307536, PMID 18471513, PMID 18621929, PMID 18784730, PMID 19183804, PMID 20405117, PMID 20429852, PMID 20655106, PMID 21054515, PMID 21353105, PMID 21364138, PMID 21575927, PMID 22005573, PMID 22722778, PMID 23228403, PMID 23940237, PMID 24159603, PMID 24351079, PMID 24533048, PMID 24916507, PMID 25157951, PMID 25350473, PMID 25458801, PMID 25913923, PMID 26077436, PMID 26254451, PMID 26431718, PMID 26506138, PMID 26589907, PMID 26896734, PMID 27464593, PMID 28046032, PMID 28353116, PMID 28454823, PMID 28538037, PMID 28542675, PMID 28973344
2004 (2), 1UM1HL113203-01A1 (1), 2014 (1), 2018 (1), 2019 (1), M01RR000070 (1), M01RR000633 (1), M01RR000750 (1), M01RR000997 (1), M01RR001032 (1), M01RR006022 (1), M01RR008084 (1), M01RR016587 (1), U01HD019897 (1), U10HD021364 (1)