1706 completed, 358 terminated, 294 recruiting, 275 unknown. 2939 Phase 3, 461 Phase 2.
Follow Brain Diseases: new trials by email Literature Review of Brain Diseases trials Research Report on Brain Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Aspirin for the Prevention of Ischemic Complications in Giant Cell Arteritis Acetyl Salicylic Acid (ASA), Placebo - Giant Cell Arteritis (GCA), Acute Coronary Syndrome (ACS) | Phase 3 | Not yet recruiting | Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal | 120 | 2027-10-01 | 2026-10-30 |
| GV1001 Subcutaneous for the Treatment of Moderate to Severe Alzheimer's Disease(AD) GV1001 Placebo, GV1001 1.12mg - Moderate to Severe Alzheimer's Disease | Phase 3 | Not yet recruiting | Samsung Pharmaceutical Co., Ltd. | 750 | 2027-07-01 | 2026-06-10 |
| Tricaprilin Phase 3 ALTER-AD (Alternative-Alzheimer Disease) Study Tricaprilin, Placebo - Alzheimer Disease | Phase 3 | Not yet recruiting | Cerecin | 535 | 2027-07-01 | 2026-10-30 |
| Valproic AcId for Traumatic BRAin INjury Trial Valproic Acid (VPA), Standard of care treatment + normal saline - Moderate Traumatic Brain Injury (TBI), Severe Traumatic Brain Injury | Phase 2 / Phase 3 | Not yet recruiting | Northwestern University | 432 | 2027-05-01 | 2026-11-05 |
| Intranasal Stem Cells to Treat Perinatal Brain Injury to Combat Cerebral Palsy MSC, marrow, Placebo - Perinatal Arterial Ischemic Stroke, Perinatal Asphyxia | Phase 2 / Phase 3 | Not yet recruiting | UMC Utrecht | 162 | 2027-04-01 | 2026-09-21 |
| Tenecteplase Bridging Thrombolysis Prior to Inter-hospital Transfer for Endovascular Therapy in Anterior Circulation Large Vessel Occlusion Stroke Within 4.5-24 Hours Tenecteplase (rhTNK-tPA) (0.25 mg/kg, to maximum of 25mg) - Acute Ischemic Stroke, Large Vessel Occlusion | Phase 3 | Not yet recruiting | Fujian Medical University Union Hospital | 1266 | 2027-04-01 | 2026-11-03 |
| Phase 3 Long Term Safety Extension Study of LUM-201 in Children With Growth Hormone Deficiency LUM-201 - Growth Hormone Deficiency (GHD) | Phase 3 | Not yet recruiting | Lumos Pharma | 150 | 2027-02-01 | 2026-07-08 |
| A Trial of ONO-2808 in Participants With the Parkinsonian Subtype of Multiple System Atrophy (MSA-P) ONO-2808, Placebo - Multiple System Atrophy, Parkinson Variant | Phase 3 | Not yet recruiting | Ono Pharmaceutical Co., Ltd. | 486 | 2027-01-01 | 2026-09-17 |
| Efficacy and Safety of Tenecteplase Among acutE Ischemic Stroke Patients With Recent Ingestion of Direct Oral Anticoagulant Intravenous tenecteplase (TNK), Placebo - Acute Ischemic Stroke | Phase 3 | Not yet recruiting | Hackensack Meridian Health | 660 | 2027-01-01 | 2026-06-02 |
| CiLostAzol for pReventIon of Recurrent sTroke in Africa Cilostazol 100 mg - Stroke | Phase 3 | Not yet recruiting | Northern California Institute of Research and Education | 1100 | 2027-01-01 | 2026-11-12 |
| A Multicenter, Open-label, Randomized, Non-inferiority Clinical Trial With Blinded Endpoint Assessment of Early Tirofiban After Intravenous Thrombolysis in Acute Ischemic Stroke Tirofiban Injection - Acute Ischemic Stroke | Phase 2 / Phase 3 | Not yet recruiting | Xinqiao Hospital of Chongqing | 1192 | 2026-12-19 | 2026-11-06 |
| INTRA-ARTERIAL MeVO TREATMENT (IMP-ACT) Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632 Mechanical Endovascular Thrombectomy, Intravenous Thrombolysis, Tenecteplase/Alteplase- depending upon availability at each treating centre - Stroke, Acute Ischemic, Medium Vessel Occlusion | Phase 3 | Not yet recruiting | University of Calgary | 800 | 2026-12-15 | 2026-10-30 |
| The Efficacy and Safety of Venglustat Compared With Cerezyme in Pediatric Participants 2 to 11 Years of Age With Gaucher Disease Type 3 (GD3) Venglustat, Imiglucerase - Gaucher's Disease Type III | Phase 3 | Not yet recruiting | Sanofi | 18 | 2026-12-11 | 2026-11-10 |
| Long-Term Safety and Tolerability of Nizubaglustat in Participants With Rare Lysosomal Disorders AZ-3102 - Niemann-Pick Disease Type C, GM2 Gangliosidosis | Phase 2 / Phase 3 | Not yet recruiting | Azafaros B.V. | 218 | 2026-12-10 | 2026-10-21 |
| IMPT Versus IMRT for Diffuse Intrinsic Pontine Glioma Intensity-Modulated Proton Therapy (IMPT), Intensity-Modulated Radiation Therapy (IMRT) - Diffuse Intrinsic Pontine Gliomas (DIPG) | Phase 3 | Not yet recruiting | Shandong Cancer Hospital and Institute | 142 | 2026-12-01 | 2026-10-09 |
| Intraoperative Ultrasound for Brain Tumor Surgery Enhanced by AI BrainUS-AI real-time intraoperative ultrasound segmentation system - Brain Tumor Adult | Phase 3 | Not yet recruiting | Hospital del Rio Hortega | 100 | 2026-12-01 | 2026-09-17 |
| Sovateltide for the Treatment of Acute Traumatic Brain Injury Placebo, Sovateltide - Traumatic Brain Injury | Phase 3 | Not yet recruiting | Pharmazz, Inc. | 214 | 2026-12-01 | 2026-10-13 |
| A Study to Learn How Well Lucerastat Works and How Safe it is in Untreated Adult Male Participants With Fabry Disease Lucerastat - Fabry Disease | Phase 3 | Recruiting | Idorsia Pharmaceuticals Ltd. | 16 | 2026-12-01 | 2026-11-03 |
| Effect of Botulinum Toxin on Resting Tremor of the Refractory Upper Limb in Parkinsonians Injection of Dysport then placebo, Injection of placebo then Dysport - PARKINSON DISEASE (Disorder) | Phase 3 | Not yet recruiting | University Hospital, Toulouse | 39 | 2026-12-01 | 2026-11-04 |
| Recombinant Human Prourokinase for Acute Ischemic Stroke in the Extended Window Selected by CT-Based Artificial Intelligence Recombinant Human Prourokinase for Injection (rhPro-UK), Matching Placebo for Recombinant Human Prourokinase - Acute Ischemic Stroke | Phase 3 | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 826 | 2026-12-01 | 2026-10-28 |
Showing 20 of 2939. Sign in to see all of them.
Stroke (411) · Alzheimer Disease (346) · Ischemic Stroke (328) · Parkinson Disease (289) · Epilepsy (262) · Migraine Disorders (243) · Brain Neoplasms (149) · Dementia (138) · Seizures (130) · Brain Injuries, Traumatic (91) · Headache (73) · Cognitive Dysfunction (68) · Epilepsies, Partial (68) · Dwarfism, Pituitary (57) · Cerebral Palsy (51)
Central Nervous System Diseases (2908) · Nervous System Diseases (2906) · Vascular Diseases (921) · Cardiovascular Diseases (915) · Cerebrovascular Disorders (864) · Pathological Conditions, Signs and Symptoms (862) · Neurodegenerative Diseases (739) · Signs and Symptoms (529) · Mental Disorders (497) · Neurologic Manifestations (482) · Neurocognitive Disorders (451) · Basal Ganglia Diseases (375) · Pathologic Processes (369) · Movement Disorders (367)
Aspirin (72) · Botulinum Toxins, Type A (48) · Saline Solution (48) · Levetiracetam (47) · Tenecteplase (47) · Clopidogrel (46) · Sodium Chloride (42) · Topiramate (39) · Tissue Plasminogen Activator (35) · Human Growth Hormone (30) · Lacosamide (30) · Donepezil (27) · Rivaroxaban (26) · Radiotherapy (25) · brivaracetam (25)
Pfizer (69) · GlaxoSmithKline (49) · UCB Pharma (49) · Assistance Publique - Hôpitaux de Paris (42) · Beijing Tiantan Hospital (39) · Eli Lilly and Company (36) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (35) · Novartis Pharmaceuticals (35) · Kafrelsheikh University (27) · Teva Branded Pharmaceutical Products R&D, Inc. (24) · Boehringer Ingelheim (23) · AbbVie (22) · H. Lundbeck A/S (22) · Otsuka Pharmaceutical Development & Commercialization, Inc. (22) · Eisai Inc. (21)
United States (1289) · Canada (550) · Germany (528) · France (503) · Spain (458) · United Kingdom (457) · Italy (412) · China (381) · Australia (358) · Poland (351) · Japan (254) · Belgium (252) · Netherlands (251) · Czechia (215) · Hungary (213)
PMID 31867054, PMID 39498781, PMID 18190818, PMID 12807523, PMID 40603145, PMID 20451898, PMID 11914403, PMID 2375765, PMID 26899665, PMID 33825230, PMID 36700520, PMID 22108357, PMID 34218211, PMID 33461041, PMID 34022170, PMID 34487721, PMID 34515113, PMID 35224730, PMID 37870112, PMID 39800465, PMID 39982105, PMID 8984084, PMID 16731270, PMID 21899409, PMID 26120369, PMID 26402769, PMID 33189083, PMID 35285519, PMID 35978286, PMID 40681915, PMID 41533472, PMID 41961243, PMID 11284464, PMID 24144944, PMID 26387127, PMID 26898852, PMID 27265725, PMID 27335114, PMID 27538531, PMID 27589414, PMID 27608437, PMID 27839979, PMID 27988967, PMID 28004320, PMID 28236727, PMID 28279891, PMID 28494751, PMID 29318278, PMID 29414542, PMID 29908435
2014 (34), 2023 (34), 2015 (32), 2018 (32), 2016 (30), 2019 (27), 2025 (25), 2017 (22), 2008 (21), 2009 (20), 2004 (15), U10EY011751 (14), 2005 (8), U01AG010483 (5), U01AG059798 (5)