178 completed, 47 recruiting, 42 unknown, 31 terminated. 80 Not applicable, 73 Phase 3, 49 Phase 2, 38 Phase 4, 14 Phase 1.
Follow Epilepsies, Partial: new trials by email Literature Review of Epilepsies, Partial trials Research Report on Epilepsies, Partial
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Accelerated iTBS for Depression and Suicidality Accelerated Intermittent Theta Burst (aiTBS), Electroconvulsive therapy (ECT) - Major Depressive Disorder, Suicide | Not applicable | Not yet recruiting | University of Iowa | 50 | 2026-12-01 | 2025-05-20 |
| Studying Heart Rhythms With a Wearable Sensor to Detect and Predict Seizures in People With Epilepsy Textile-based wearable electrocardiography - Epilepsy, Temporal Lobe, Drug Resistant Epilepsy | Not yet recruiting | Acibadem University | 40 | 2026-10-15 | 2026-09-23 | |
| Overnight TI in TLE Non-invasive Temporal Interference (TI) Stimulation Targeting Bilateral Hippocampi - Temporal Lobe Epilepsy (TLE), Drug Resistant Epilepsy | Not applicable | Recruiting | Duke University | 20 | 2026-10-15 | 2026-10-16 |
| RNS System for Drug-Resistant Focal Epilepsy in Adolescents: A Real-World Study NeuroPace RNS System - Focal Epilepsy, Drug-resistant Focal Epilepsy | Enrolling by invitation | NeuroPace | 100 | 2026-09-14 | 2026-09-16 | |
| Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures RAP-219, Placebo - Focal Seizure, Epilepsy | Phase 3 | Recruiting | Rapport Therapeutics Inc. | 312 | 2026-09-01 | 2026-10-15 |
| High-density Flexible μECoG for Epilepsy Surgery - A Single-Arm ECT Using High-density Flexible microElectrocorticography for intraoperative monitoring - Focal Epilepsy, Intraoperative Monitoring | Not applicable | Recruiting | Beijing Tiantan Hospital | 85 | 2026-09-01 | 2026-08-13 |
| Study of the Pharmacokinetics, Safety, and Tolerability of ZONISADE in Children 1 Month to 17 Years of Age With Partial-onset Seizures Zonisamide Oral Product - Seizures, Seizures, Focal | Phase 4 | Not yet recruiting | Azurity Pharmaceuticals | 40 | 2026-09-01 | 2026-09-15 |
| Prognosis of Epilepsy With Post-traumatic Stress Disorder and Surgery Baseline PTSD status, Psychiatric questionnaires - Epilepsies, Focal, Drug Restistant Epilepsie | Not yet recruiting | Assistance Publique Hopitaux De Marseille | 42 | 2026-09-01 | 2026-07-22 | |
| Efficacy of Probenecid on Cluster Seizures During Anti Seizure Medication Withdrawal in Presurgical Focal Epilepsy Video-EEG Monitoring Probenecid, Placebo - Focal Epilepsy | Phase 2 | Recruiting | Fondation Ophtalmologique Adolphe de Rothschild | 600 | 2026-08-24 | 2026-10-05 |
| A Study to Evaluate the Safety, Efficacy, and PK of ONO-2017 in Japanese Patients With POS 2 to 17 Year Olds Cenobamate (tablet) for 12 to < 18 year olds, Cenobamate (syrup) for 2 to < 18 year olds - Partial Epilepsy | Phase 3 | Recruiting | Ono Pharmaceutical Co., Ltd. | 20 | 2026-06-10 | 2026-10-09 |
| Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures FOCUS-1 RAP-219, Placebo - Focal Seizure, Epilepsy | Phase 3 | Recruiting | Rapport Therapeutics Inc. | 333 | 2026-06-05 | 2026-10-21 |
| MRI Volumetry and Diffusion Tensor Imaging in Temporal Lobe Epilepsy MRI - Temporal Lobe Epilepsy (TLE) | Not yet recruiting | Assiut University | 78 | 2026-04-01 | 2026-02-03 | |
| Randomized Clinical Trial Evaluating the Efficacy and Safety of Vormatrigine in Adults With Focal Seizures 40 mg/day vormatrogine for 12 weeks, 30 mg/day vormatrogine for 12 weeks, 20 mg/day vormatrogine for 12 weeks - Focal Epilepsy | Phase 3 | Active not recruiting | Praxis Precision Medicines | 300 | 2026-01-29 | 2026-08-03 |
| Optimizing Therapy in Epilepsy Using Seizure Forecasts Via EEG and Wearables UNEEG SubQ device, seizure forecasts, nasal diazepam, Preventative Medication (PM) - Focal Epilepsy, Generalized Seizure | Early Phase 1 | Recruiting | Mayo Clinic | 12 | 2026-01-20 | 2026-09-25 |
| A Long-term Study of the Safety and Effectiveness of RAP-219 in Adults With Focal Onset Seizures RAP-219 - Focal Epilepsy, Epilepsy | Phase 2 | Recruiting | Rapport Therapeutics Inc. | 30 | 2025-12-15 | 2026-01-23 |
| Prospective Study of Eslicarbazepine in Adults With Focal-Onset Seizures Eslicarbazepine acetate - Focal-Onset Seizures | Recruiting | King Edward Medical University | 1500 | 2025-12-02 | 2026-09-09 | |
| Thalamic Recordings in Children Undergoing SEEG Additional electrodes into bilateral anterior, centromedian and pulvinar thalamic nuclei - Focal Epilepsy | Not applicable | Recruiting | Great Ormond Street Hospital for Children NHS Foundation Trust | 30 | 2025-09-01 | 2026-02-02 |
| Butylphthalide for Cognitive Impairment in Elderly Patients With Focal Epilepsy Butylphthalide, Placebo - Focal Epilepsy, Cognitive Impairment | Phase 4 | Recruiting | First Affiliated Hospital of Wenzhou Medical University | 220 | 2025-09-01 | 2025-09-25 |
| An Open-label Study to Evaluate Safety, Tolerability, and Efficacy of CB03-154 in Subjects Diagnosed With Epilepsy CB03-154 - Focal Epilepsy | Phase 2 | Recruiting | Shanghai Zhimeng Biopharma, Inc. | 144 | 2025-08-14 | 2025-11-20 |
| Wearable Epileptic Seizure Prediction and Alert Glasses Based on Neuromorphic Computing Wearable seizure prediction and alert glasses - Epilepsy, Epileptic Seizures | Not applicable | Active not recruiting | Oman Ministry of Health | 47 | 2025-08-10 | 2025-10-07 |
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Epilepsy (148) · Seizures (87) · Epilepsy, Temporal Lobe (62) · Drug Resistant Epilepsy (30) · Epilepsy, Rolandic (22) · Epilepsy, Complex Partial (16) · Epilepsy, Generalized (10) · Brain Diseases (9) · Depression (8) · Epilepsy, Frontal Lobe (5) · Epilepsy, Partial, Motor (5) · Anxiety Disorders (4) · Depressive Disorder, Major (4) · Epilepsy, Tonic-Clonic (4)
Nervous System Diseases (328) · Central Nervous System Diseases (327) · Brain Diseases (319) · Epilepsy (180) · Pathological Conditions, Signs and Symptoms (104) · Neurologic Manifestations (102) · Signs and Symptoms (101) · Epileptic Syndromes (91) · Mental Disorders (20) · Behavior (15) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (10) · Behavioral Symptoms (8) · Congenital Abnormalities (6) · Genetic Diseases, Inborn (6)
Levetiracetam (23) · Pregabalin (20) · Topiramate (16) · Lacosamide (13) · Oxcarbazepine (10) · eslicarbazepine acetate (9) · Cenobamate (8) · Gabapentin (7) · Lamotrigine (7) · S-2-O-carbamoyl-1-o-chlorophenyl-ethanol (7) · Carbamazepine (5) · ganaxolone (5) · Zonisamide (4) · ezogabine (4) · perampanel (4)
National Institute of Neurological Disorders and Stroke (NINDS) (18) · UCB Pharma (17) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (15) · SK Life Science, Inc. (13) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (12) · Pfizer (8) · Bial - Portela C S.A. (7) · GlaxoSmithKline (7) · Hospices Civils de Lyon (7) · Supernus Pharmaceuticals, Inc. (6) · Marinus Pharmaceuticals (5) · Second Affiliated Hospital, Zhejiang University, School of Medicine (5) · Fondation Ophtalmologique Adolphe de Rothschild (4) · King's College London (4) · Mayo Clinic (4)
United States (136) · France (51) · Germany (35) · Poland (26) · Canada (23) · Spain (23) · United Kingdom (23) · Australia (21) · Belgium (20) · China (20) · Italy (20) · Mexico (20) · Hungary (19) · South Korea (19) · Netherlands (17)
William H Theodore, M.D. (5) · Marc Kamin, MD (3) · Daniel Lowenstein, MD (2) · Janet K Johnson, PhD (2) · Liankun Ren, MD (2) · Maciej Gasior, MD, PhD (2) · Project Leader (2)
PMID 33338829, PMID 34870321, PMID 19863578, PMID 21095488, PMID 35965432, PMID 10768307, PMID 12552030, PMID 12690085, PMID 17369059, PMID 19001248, PMID 19243423, PMID 19702752, PMID 20041945, PMID 20089937, PMID 20331461, PMID 20462804, PMID 20547106, PMID 21095980, PMID 21140291, PMID 21320109, PMID 21391767, PMID 21673279, PMID 21889410, PMID 22372628, PMID 22396514, PMID 22399764, PMID 22633629, PMID 22708895, PMID 22813235, PMID 23219031, PMID 23223279, PMID 24111974, PMID 24370818, PMID 24415567, PMID 24754318, PMID 24902473, PMID 24962242, PMID 25176152, PMID 25377429, PMID 25461210, PMID 25564232, PMID 25663221, PMID 25684224, PMID 25741734, PMID 25769377, PMID 25854635, PMID 25948717, PMID 26143305, PMID 26399310, PMID 26526971
2014 (6), 2004 (3), 2023 (3), 2009 (2), 2018 (2), 2019 (2), 1UG3NS112826-01 (1), 2005 (1), 2008 (1), 2015 (1), DP1MH116506 (1), K23AT001933 (1), K23NS116110 (1), R01NS047530 (1), R01NS065840 (1)