2876 completed, 875 unknown, 768 recruiting, 311 terminated. 2276 Not applicable, 827 Phase 2, 556 Phase 1, 378 Phase 3, 204 Phase 4.
Follow Basal Ganglia Diseases: new trials by email Literature Review of Basal Ganglia Diseases trials Research Report on Basal Ganglia Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Terazosin And Metabolic Energetics in Parkinson's Disease Terazosin 5 MG, Placebo - Parkinson's Disease (PD) | Phase 2 | Suspended | Ergun Y. Uc | 120 | 2028-07-01 | 2026-10-09 |
| Double-Blind Clinical Trial of Subthalamic Nucleus Deep Brain Stimulation in Early-Stage Parkinson's Disease active subthalamic nucleus deep brain stimulation plus optimal drug therapy, inactive subthalamic nucleus deep brain stimulation plus optimal drug therapy - Parkinson Disease | Not applicable | Not yet recruiting | Mallory Hacker | 40 | 2028-01-01 | 2026-02-20 |
| Study to Evaluate the Safety, Tolerability, Efficacy, and PK of FHL-301 in Parkinson's Disease Patients. Gemfibrozil, Placebo - Parkinson Disease | Phase 2 | Withdrawn | Forest Hills Lab | 2027-11-01 | 2026-08-19 | |
| Terazosin for Dementia With Lewy Bodies Terazosin Hydrochloride, Placebo - Dementia With Lewy Bodies | Phase 1 / Phase 2 | Not yet recruiting | Qiang Zhang | 40 | 2027-10-01 | 2026-03-12 |
| A Study to Evaluate the Safety, Tolerability and Efficacy of MT101-5 in Subjects With Early Parkinson's Disease MT101-5 - Parkinson's Disease | Phase 2 | Not yet recruiting | Mthera Pharma Co., Ltd. | 120 | 2027-09-01 | 2026-10-16 |
| Function-based Accelerated Stimulation Therapy (FAST-therapy) for Freezing of Gait (FOG) After Parkinson's Disease (PD) rTMS - Parkinson Disease | Not applicable | Not yet recruiting | University of Michigan | 20 | 2027-09-01 | 2026-10-20 |
| Gastrointestinal Dopamine Decarboxylase and Levodopa Pharmacokinetics Levodopa (L-dopa) - Parkinson's Disease | Phase 4 | Not yet recruiting | Beth Israel Deaconess Medical Center | 40 | 2027-07-01 | 2026-08-28 |
| Fecal MicrobiotaTransplant for the Treatment of Parkinson's Disease Fecal Microbiota Transplant - Parkinson Disease | Phase 1 | Not yet recruiting | ProgenaBiome | 10 | 2027-07-01 | 2026-10-09 |
| Engage-PD: a Physical Activity Coaching Program Via Telehealth for People With Parkinson's Disease. A Single-cohort Study in Spain. Physical Activity Coaching - PARKINSON DISEASE (Disorder) | Not applicable | Not yet recruiting | Hospital Clinic of Barcelona | 30 | 2027-06-01 | 2026-10-05 |
| Sustained Release Oral Formulation For Treatment Of Parkinsons Disease Formulation A, Formulation B, Formulation C - Healthy Volunteers | Phase 1 / Phase 2 | Not yet recruiting | University of Minnesota | 32 | 2027-04-01 | 2026-10-01 |
| Multi-Modal Digital Monitoring of Disease Symptoms Huntington's Disease Huntington Disease | Not yet recruiting | BioSensics | 75 | 2027-01-31 | 2026-10-13 | |
| A Study of AB-1005 Gene Therapy in Japanese Adults With Moderate Parkinson's Disease (J-REGENERATE-PD) AB-1005 - Parkinson Disease | Phase 2 | Not yet recruiting | Bayer | 8 | 2027-01-25 | 2026-07-29 |
| Digital Health Technologies for Progressive Supranuclear Palsy and Dementia With Lewy Bodies Progressive Supranuclear Palsy(PSP), Dementia With Lewy Bodies (DLB) | Not yet recruiting | BioSensics | 60 | 2027-01-15 | 2026-10-13 | |
| Exploring the Efficacy of the Effortful Swallow Maneuver for Improving Swallowing in People With PD Effortful swallow - Dysphagia, Parkinson Disease (PD) | Not applicable | Not yet recruiting | University of Alberta | 74 | 2027-01-01 | 2026-08-19 |
| A Trial of ONO-2808 in Participants With the Parkinsonian Subtype of Multiple System Atrophy (MSA-P) ONO-2808, Placebo - Multiple System Atrophy, Parkinson Variant | Phase 3 | Not yet recruiting | Ono Pharmaceutical Co., Ltd. | 486 | 2027-01-01 | 2026-09-17 |
| Probing Gut-Brain Communication in Parkinson's Disease taVNS, Sham taVNS - Parkinson Disease (PD) | Not applicable | Not yet recruiting | Spaulding Rehabilitation Hospital | 45 | 2027-01-01 | 2026-10-08 |
| Disease-modifying Efficacy of Sitagliptin Therapy in Early-stage Parkinson's Disease Sitagliptin, Sitagliptin placebo - Parkinson Disease | Phase 2 | Not yet recruiting | Yonsei University | 160 | 2026-12-15 | 2026-09-10 |
| Utilization of Aerobic Exercise to Maintain Neurologic Health Aerobic Exercise - Parkinson's Disease | Not applicable | Not yet recruiting | The Cleveland Clinic | 100 | 2026-12-15 | 2026-10-20 |
| Decoding the Neural Mechanisms Underlying Postural Instability and Gait Dysfunction in Parkinson's Disease Multiple Deep Brain Stimulation (DBS) Conditions, Moving Overground in a Virtual Environment (MOVE), Cleveland Clinic Stair Ambulation and Functional Evaluation of Gait (SAFE-Gait) - Parkinson Disease, Freezing of Gait | Not applicable | Recruiting | The Cleveland Clinic | 5 | 2026-12-09 | 2026-10-26 |
| Brain Iron in Beta-Propeller Protein Associated Neurodegeneration (BPAN) Standardized brain MRI including specific sequences usable for Quantitative Susceptibility Mapping (QSM) - Neurodegeneration With Brain Iron Accumulation (NBIA), Iron Metabolism Disorders | Not applicable | Not yet recruiting | University Hospital, Bordeaux | 3 | 2026-12-01 | 2026-10-09 |
Showing 20 of 5491. Sign in to see all of them.
Parkinson Disease (4476) · Huntington Disease (291) · Lewy Body Disease (236) · Tourette Syndrome (232) · Alzheimer Disease (231) · Parkinsonian Disorders (213) · Multiple System Atrophy (204) · Movement Disorders (182) · Supranuclear Palsy, Progressive (170) · Cognitive Dysfunction (167) · Motor Activity (166) · Dementia (153) · Neurodegenerative Diseases (143) · Dyskinesias (115) · Depression (104)
Central Nervous System Diseases (5439) · Brain Diseases (5431) · Nervous System Diseases (5407) · Movement Disorders (5293) · Neurodegenerative Diseases (5275) · Synucleinopathies (4715) · Parkinsonian Disorders (4481) · Mental Disorders (1213) · Pathological Conditions, Signs and Symptoms (1135) · Signs and Symptoms (962) · Neurologic Manifestations (822) · Neurocognitive Disorders (781) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (657) · Genetic Diseases, Inborn (645)
Deep Brain Stimulation (93) · Levodopa (90) · Exercise (82) · carbidopa, levodopa drug combination (74) · Transcranial Direct Current Stimulation (57) · Transcranial Magnetic Stimulation (56) · Pramipexole (47) · rasagiline (47) · rotigotine (43) · opicapone (42) · Physical Therapy Modalities (37) · Carbidopa (35) · Control Groups (29) · Apomorphine (27) · Blood Specimen Collection (26)
National Institute of Neurological Disorders and Stroke (NINDS) (77) · Bial - Portela C S.A. (56) · University of Florida (51) · Boehringer Ingelheim (44) · VA Office of Research and Development (42) · Assistance Publique - Hôpitaux de Paris (41) · Oregon Health and Science University (40) · University Hospital, Toulouse (40) · University of Minnesota (39) · Washington University School of Medicine (37) · Radboud University Medical Center (36) · AbbVie (33) · University of Colorado, Denver (33) · Vanderbilt University Medical Center (33) · Institut National de la Santé Et de la Recherche Médicale, France (32)
United States (2083) · France (579) · Italy (415) · Germany (367) · China (350) · United Kingdom (350) · Canada (346) · Spain (283) · Turkey (Türkiye) (174) · Netherlands (146) · Taiwan (139) · Israel (133) · Poland (113) · Brazil (108) · Austria (105)
Giuseppe Frazzitta, MD (18) · Italo Biaggioni, MD (15) · Danna Jennings, MD (12)
PMID 36602886, PMID 38588457, PMID 40680102, PMID 31356217, PMID 36463457, PMID 38489195, PMID 25623333, PMID 29480210, PMID 30741694, PMID 31127735, PMID 32250312, PMID 10816186, PMID 19126811, PMID 27538531, PMID 28494751, PMID 31381524, PMID 34816053, PMID 36811812, PMID 38825840, PMID 41626017, PMID 11253156, PMID 12112073, PMID 12360555, PMID 12498954, PMID 1454205, PMID 15097290, PMID 16267188, PMID 16401616, PMID 16436781, PMID 17941858, PMID 19025984, PMID 19058133, PMID 20457959, PMID 20483969, PMID 20519680, PMID 20574039, PMID 20582993, PMID 20841416, PMID 20937936, PMID 20946640, PMID 21484867, PMID 21542016, PMID 22209649, PMID 22750016, PMID 22850494, PMID 22868933, PMID 23263599, PMID 23667214, PMID 23860343, PMID 24001701
2016 (20), 2023 (19), 2019 (18), 2018 (17), 2025 (16), 2014 (15), 2017 (14), 2009 (13), 2008 (12), 2015 (10), 2004 (7), 2005 (4), R01AG085029 (3), R01HL144568 (3), U01NS043128 (3)