175 completed, 25 terminated, 23 unknown, 11 withdrawn. 74 Phase 3, 62 Phase 2, 59 Phase 4, 27 Phase 1, 22 Not applicable.
Follow this drug Literature Review of Topiramate trials Research Report on Topiramate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparing Migraine Preventive Therapies vs. Anti-CGRP Therapies for Tinnitus in Patients With Migraine (COMPACT-PM) Galcanezumab, Erenumab 70 mg, Eptinezumab - Migraine Associated Vertigo, Tinnitus | Phase 4 | Not yet recruiting | Stanford University | 120 | 2026-07-01 | 2026-06-17 |
| Retrospective Evaluation of Sibutramine-Topiramate Therapy for Obesity in Real-World Outpatient Practice Sibutramine + Topiramate - Obesity & Overweight | Completed | Falquetomed | 278 | 2026-06-01 | 2026-09-02 | |
| Idiopathic Intracranial Hypertension: Prognostic Factors and Multidisciplinary Management lumbo-peritoneal shunt, Conservative Management: Centered on lifestyle modifications for weight reduction, alongside targeted medical therapies including carbonic anhydrase inhibitors (e.g., acetazolamide) and/or topiramate. - Idiopathic Intracranial Hypertension | Not applicable | Active not recruiting | Sohag University | 30 | 2026-06-01 | 2026-07-21 |
| Combining Latency Reversing Agents to Address the HIV Reservoir Pyrimethamine (PYR), Lenalidomide, Topiramate (drug) - HIV (Human Immunodeficiency Virus), HIV -1 Infection | Phase 1 / Phase 2 | Not yet recruiting | Erasmus Medical Center | 30 | 2026-04-01 | 2026-02-03 |
| Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease Transjugular Intrahepatic Portosystemic Shunt (TIPS), Sleeve Gastrectomy, Anti-Obesity Pharmacotherapy (Class Effect) - Liver Cirrhoses, Portal Hypertension Related to Cirrhosis | Phase 4 | Recruiting | The Cleveland Clinic | 70 | 2025-12-17 | 2025-12-23 |
| Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study Atogepant 60 mg, Propranolol 160 mg, Topiramate 100 mg - Migraine | Phase 4 | Recruiting | Mayo Clinic | 1335 | 2025-07-09 | 2026-10-19 |
| Beneficial Side Effects of Topiramate in Obese Patients Undergoing Total Joint Arthroplasty Topamax, Gabapentin - Weight Loss, Pain, Postoperative | Early Phase 1 | Withdrawn | Stanford University | 2025-07-01 | 2025-04-11 | |
| Management of Acute Tinnitus With Migraine Medications Nortriptyline, Topiramate, Paroxetine - Tinnitus | Phase 4 | Active not recruiting | University of California, Irvine | 100 | 2025-06-01 | 2025-10-10 |
| Comparison of the Effectiveness of First-line Preventive Treatment of Migraine in Primary Care Topiramate, Flunarizine, Amitriptyline - Migraine | Phase 4 | Not yet recruiting | Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | 460 | 2024-10-01 | 2024-07-12 |
| Studying Topiramate for Re-Activating the HIV-1 Reservoir Topiramate - HIV-1-infection, Hiv | Phase 1 / Phase 2 | Unknown | Erasmus Medical Center | 12 | 2024-09-01 | 2024-02-28 |
| Ultrasound-guided Stellate Ganglion Block for Treatment of Chronic Migraine in Adult Stellate Ganglion Block (SGB), standardized drug treatment - Chronic Migraine | Not applicable | Recruiting | Beijing Tiantan Hospital | 206 | 2024-06-01 | 2025-01-17 |
| Zonisamide Versus Topiramate in Migraine Zonisamide 50 MG, Topiramate 50 MG - Migraine | Phase 3 | Completed | Kafrelsheikh University | 600 | 2024-04-01 | 2026-05-27 |
| Lacosamide Versus Topiramate in Migraine Lacosamide 50 MG, Topiramate 50Mg Tab - Migraine Disorders | Phase 3 | Unknown | Kafrelsheikh University | 600 | 2024-02-01 | 2024-03-29 |
| Comparative Study of Oral Atogepant Versus Oral Topiramate to Assess Adverse Events in Adult Participants With Migraine Atogepant, Placebo for Atogepant, Topiramate - Migraine | Phase 3 | Completed | AbbVie | 545 | 2023-10-07 | 2026-07-02 |
| Pharmacotherapy in Conjunction With Lifestyle Counseling for Management of Weight Regain After Bariatric Surgery Topiramate, Phentermine, Placebo - Obesity | Phase 4 | Recruiting | University of California, Irvine | 120 | 2023-08-29 | 2026-10-19 |
| Modified Atkins Diet Versus Topiramate In Children With Epileptic Spasms Refractory To Hormonal Treatment: A Randomized Open-Label Study Modified Atkins diet, Topiramate - Epileptic Spasms, Failed Hormonal Therapy | Phase 2 / Phase 3 | Unknown | Lady Hardinge Medical College | 70 | 2023-07-20 | 2023-07-24 |
| Anti-obesity Pharmacotherapy and Inflammation Semaglutide, Phentermine-Topiramate combination, Phentermine - Obesity | Active not recruiting | Louisiana State University Health Sciences Center in New Orleans | 30 | 2023-06-01 | 2025-09-09 | |
| Zolmitriptane as Prophylaxis for Chilhood Migraine zolmitriptanee, topiramate, Valproate - Migraine | Phase 4 | Unknown | Tanta University | 90 | 2023-01-01 | 2023-10-18 |
| The Role of Migraine Prophylaxis Agent Topiramate in Treating Patients With Sudden Sensorineural Hearing Loss Topiramate, Systemic Steroids - Sudden Deafness, Sudden Sensorineural Hearing Loss | Phase 2 | Unknown | Chang Gung Memorial Hospital | 140 | 2022-10-17 | 2024-02-16 |
| Topiramate vs Metformin on Cardio-Metabolic Profile in Schizophrenia on Atypical Antipsychotics Metformin, Topiramate - Metabolic Syndrome, Schizophrenia | Phase 4 | Completed | All India Institute of Medical Sciences, Bhubaneswar | 60 | 2022-09-20 | 2023-08-22 |
Showing 20 of 251. Sign in to see all of them.
Migraine Disorders (51) · Epilepsy (41) · Alcoholism (28) · Obesity (28) · Seizures (27) · Headache (19) · Epilepsies, Partial (15) · Bipolar Disorder (11) · Diabetes Mellitus, Type 2 (10) · Stress Disorders, Post-Traumatic (10) · Migraine with Aura (9) · Cocaine-Related Disorders (8) · Hypertension (8) · Brain Diseases (6) · Hyperlipidemias (6)
Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (50) · University of Minnesota (7) · Bankole Johnson (6) · Teva Pharmaceuticals USA (4) · University of California, Irvine (4) · University of California, San Francisco (4) · University of Pennsylvania (4) · Assistance Publique - Hôpitaux de Paris (3) · Janssen Cilag Pharmaceutica S.A.C.I., Greece (3) · Janssen Korea, Ltd., Korea (3) · Kafrelsheikh University (3) · Monarch Medical Research (3) · NYU Langone Health (3) · Ortho-McNeil Neurologics, Inc. (3) · Stanford University (3)
United States (109) · Canada (18) · France (7) · Germany (7) · Belgium (6) · Egypt (6) · Israel (6) · Poland (6) · Australia (5) · Hungary (5) · India (5) · Italy (5) · Russia (5) · Taiwan (5) · Argentina (4)
Benoit Girard, MD (3) · Donald W Lewis, MD (3) · Melissa P DelBello, MD (3) · Ortho McNeil Neurologics, Inc. Clinical Trial (3) · Steven L. Batki, MD (3) · Bankole Johnson (2) · Bankole Johnson, DSc, MD, PhD (2) · Craig Peterson (2) · Henry R Kranzler, M.D. (2) · Joseph Jankovic, MD (2)
PMID 11914403, PMID 12807523, PMID 8984084, PMID 15536230, PMID 17300356, PMID 21673279, PMID 22633629, PMID 34049101, PMID 35229945, PMID 40445294, PMID 10102256, PMID 10227614, PMID 10371538, PMID 10768306, PMID 10768307, PMID 12552030, PMID 12690085, PMID 12805393, PMID 14510929, PMID 14982912, PMID 15072107, PMID 15096395, PMID 15316798, PMID 15486569, PMID 15822542, PMID 15985582, PMID 16018851, PMID 16340383, PMID 16990078, PMID 17105455, PMID 17258690, PMID 17441971, PMID 17445114, PMID 17915969, PMID 17925516, PMID 17988947, PMID 18339115, PMID 18541827, PMID 19480669, PMID 19719543, PMID 20089937, PMID 20396496, PMID 20633037, PMID 20816027, PMID 20974598, PMID 21148119, PMID 21486110, PMID 22019576, PMID 22950861, PMID 23594025
M01RR006192 (2), 2005 (1), 2009 (1), 2018 (1), K23AA016340 (1), K23DK125668 (1), K24AA013736 (1), P01AA027057 (1), P30DK048520 (1), P60AA003510 (1), P60AA013759 (1), R01AA013964 (1), R01AA014628 (1), R01AA014657 (1), R01AA015923 (1)